Rattus norvegicus

159 known processes

Sema5a

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

Sema5a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of signal transduction GO:0009966 318 0.094
intracellular signal transduction GO:0035556 314 0.075
regulation of phosphorus metabolic process GO:0051174 349 0.071
regulation of phosphate metabolic process GO:0019220 349 0.070
protein phosphorylation GO:0006468 345 0.070
cellular component movement GO:0006928 248 0.062
cation transport GO:0006812 382 0.059
regulation of phosphorylation GO:0042325 248 0.057
divalent metal ion transport GO:0070838 132 0.054
apoptotic process GO:0006915 381 0.054
cellular component morphogenesis GO:0032989 155 0.053
regulation of cellular protein metabolic process GO:0032268 267 0.053
neuron differentiation GO:0030182 368 0.050
positive regulation of phosphorylation GO:0042327 177 0.050
positive regulation of phosphate metabolic process GO:0045937 262 0.048
regulation of cellular component organization GO:0051128 368 0.047
regulation of cellular amine metabolic process GO:0033238 8 0.047
organic acid metabolic process GO:0006082 292 0.044
regulation of cell differentiation GO:0045595 320 0.043
regulation of cellular amino acid metabolic process GO:0006521 2 0.043
oxoacid metabolic process GO:0043436 290 0.042
positive regulation of phosphorus metabolic process GO:0010562 262 0.042
regulation of multicellular organismal development GO:2000026 376 0.042
cellular amine metabolic process GO:0044106 38 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.040
regulation of programmed cell death GO:0043067 341 0.039
cell projection morphogenesis GO:0048858 123 0.039
cellular metal ion homeostasis GO:0006875 172 0.039
regulation of canonical wnt signaling pathway GO:0060828 4 0.038
positive regulation of cell communication GO:0010647 271 0.038
regulation of cell proliferation GO:0042127 359 0.037
amine metabolic process GO:0009308 38 0.037
cellular component biogenesis GO:0044085 368 0.037
positive regulation of signal transduction GO:0009967 175 0.037
g protein coupled receptor signaling pathway GO:0007186 242 0.037
programmed cell death GO:0012501 392 0.036
cell projection organization GO:0030030 302 0.036
cellular ketone metabolic process GO:0042180 51 0.036
regulation of nervous system development GO:0051960 264 0.036
regulation of protein modification process GO:0031399 194 0.036
neuron projection development GO:0031175 273 0.036
cell motility GO:0048870 202 0.035
regulation of neuron projection development GO:0010975 161 0.035
calcium ion homeostasis GO:0055074 162 0.035
positive regulation of cell migration GO:0030335 96 0.035
calcium ion transport GO:0006816 131 0.035
cellular response to oxygen containing compound GO:1901701 386 0.035
cellular amino acid metabolic process GO:0006520 107 0.034
ion homeostasis GO:0050801 212 0.034
positive regulation of cell death GO:0010942 184 0.034
positive regulation of protein modification process GO:0031401 142 0.034
positive regulation of signaling GO:0023056 270 0.033
carboxylic acid metabolic process GO:0019752 289 0.033
regulation of cell development GO:0060284 263 0.033
cellular component assembly GO:0022607 360 0.033
single organism reproductive process GO:0044702 297 0.032
positive regulation of response to stimulus GO:0048584 285 0.032
biological adhesion GO:0022610 110 0.032
central nervous system development GO:0007417 311 0.032
metal ion homeostasis GO:0055065 186 0.032
divalent inorganic cation homeostasis GO:0072507 165 0.032
heart morphogenesis GO:0003007 3 0.031
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.031
regulation of protein metabolic process GO:0051246 289 0.031
transmission of nerve impulse GO:0019226 42 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
negative regulation of cell proliferation GO:0008285 119 0.031
positive regulation of multicellular organismal process GO:0051240 387 0.030
anatomical structure morphogenesis GO:0009653 298 0.030
rna biosynthetic process GO:0032774 380 0.030
cell part morphogenesis GO:0032990 123 0.030
neuron development GO:0048666 286 0.030
regulation of neurogenesis GO:0050767 247 0.030
negative regulation of cell communication GO:0010648 158 0.030
regulation of protein phosphorylation GO:0001932 183 0.030
cytosolic calcium ion homeostasis GO:0051480 140 0.030
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.030
positive regulation of cell differentiation GO:0045597 217 0.029
homeostatic process GO:0042592 331 0.029
divalent inorganic cation transport GO:0072511 134 0.029
transmembrane transport GO:0055085 412 0.029
cell morphogenesis GO:0000902 142 0.029
brain development GO:0007420 247 0.028
response to nutrient levels GO:0031667 370 0.028
non canonical wnt signaling pathway GO:0035567 3 0.028
chemical homeostasis GO:0048878 292 0.028
positive regulation of molecular function GO:0044093 230 0.028
cellular ion homeostasis GO:0006873 184 0.028
localization of cell GO:0051674 202 0.028
positive regulation of developmental process GO:0051094 283 0.027
reproductive process GO:0022414 372 0.027
cell migration GO:0016477 197 0.027
organic substance catabolic process GO:1901575 316 0.027
head development GO:0060322 247 0.027
catabolic process GO:0009056 351 0.027
cation homeostasis GO:0055080 195 0.027
cellular cation homeostasis GO:0030003 180 0.027
regulation of kinase activity GO:0043549 117 0.027
positive regulation of gene expression GO:0010628 244 0.026
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.026
establishment of tissue polarity GO:0007164 2 0.026
locomotion GO:0040011 237 0.026
response to peptide GO:1901652 292 0.026
urogenital system development GO:0001655 78 0.026
regulation of intracellular signal transduction GO:1902531 218 0.026
regulation of neuron differentiation GO:0045664 208 0.026
multicellular organismal reproductive process GO:0048609 233 0.026
nucleobase containing small molecule metabolic process GO:0055086 316 0.026
reproduction GO:0000003 245 0.026
metal ion transport GO:0030001 289 0.025
positive regulation of cellular amine metabolic process GO:0033240 3 0.025
cell adhesion GO:0007155 110 0.025
cellular chemical homeostasis GO:0055082 247 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
regulation of apoptotic process GO:0042981 335 0.025
regulation of cell projection organization GO:0031344 175 0.025
negative regulation of gene expression GO:0010629 199 0.025
regulation of catalytic activity GO:0050790 304 0.024
positive regulation of cell development GO:0010720 176 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
protein localization GO:0008104 191 0.024
axonogenesis GO:0007409 71 0.024
regulation of molecular function GO:0065009 398 0.024
positive regulation of protein phosphorylation GO:0001934 135 0.024
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.024
positive regulation of catalytic activity GO:0043085 184 0.024
ion transmembrane transport GO:0034220 365 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.023
mapk cascade GO:0000165 140 0.023
multi organism reproductive process GO:0044703 262 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.023
cellular response to lipid GO:0071396 201 0.023
single organism intracellular transport GO:1902582 166 0.023
synapse organization GO:0050808 46 0.023
inorganic cation transmembrane transport GO:0098662 202 0.023
tissue development GO:0009888 252 0.023
positive regulation of protein metabolic process GO:0051247 178 0.023
positive regulation of cellular component organization GO:0051130 200 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.022
negative regulation of metabolic process GO:0009892 331 0.022
positive regulation of programmed cell death GO:0043068 157 0.022
positive regulation of locomotion GO:0040017 102 0.022
regulation of anatomical structure morphogenesis GO:0022603 141 0.022
response to inorganic substance GO:0010035 377 0.022
regeneration GO:0031099 163 0.022
negative regulation of signaling GO:0023057 157 0.021
positive regulation of neurogenesis GO:0050769 165 0.021
response to extracellular stimulus GO:0009991 380 0.021
regulation of membrane potential GO:0042391 110 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
single organism catabolic process GO:0044712 283 0.021
signal transduction by phosphorylation GO:0023014 144 0.021
positive regulation of nervous system development GO:0051962 178 0.021
regulation of proteasomal protein catabolic process GO:0061136 4 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
motor neuron axon guidance GO:0008045 1 0.020
negative regulation of multicellular organismal process GO:0051241 203 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
response to cytokine GO:0034097 215 0.020
regulation of neuron death GO:1901214 115 0.020
cellular calcium ion homeostasis GO:0006874 160 0.020
gastrulation GO:0007369 2 0.020
regulation of cellular component movement GO:0051270 150 0.020
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
positive regulation of intracellular signal transduction GO:1902533 138 0.019
cellular protein localization GO:0034613 122 0.019
cellular response to steroid hormone stimulus GO:0071383 93 0.019
regulation of metal ion transport GO:0010959 118 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
protein complex subunit organization GO:0071822 302 0.019
proteolysis GO:0006508 175 0.019
regulation of cellular response to stress GO:0080135 49 0.019
cellular response to endogenous stimulus GO:0071495 377 0.019
nucleic acid templated transcription GO:0097659 379 0.019
regulation of transcription dna templated GO:0006355 374 0.019
salivary gland development GO:0007431 3 0.018
regulation of establishment of planar polarity GO:0090175 2 0.018
regulation of ion transport GO:0043269 245 0.018
regulation of cell morphogenesis GO:0022604 77 0.018
taxis GO:0042330 67 0.018
cellular response to stress GO:0033554 269 0.018
regulation of cell growth GO:0001558 85 0.018
protein oligomerization GO:0051259 191 0.018
sexual reproduction GO:0019953 148 0.018
negative regulation of cell differentiation GO:0045596 99 0.018
kidney development GO:0001822 67 0.018
action potential GO:0001508 54 0.018
macromolecular complex assembly GO:0065003 273 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
positive regulation of cell motility GO:2000147 97 0.017
positive regulation of neuron projection development GO:0010976 99 0.017
response to ethanol GO:0045471 162 0.017
positive regulation of cell projection organization GO:0031346 111 0.017
macromolecule localization GO:0033036 252 0.017
response to metal ion GO:0010038 253 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
response to estradiol GO:0032355 164 0.017
regulation of neuron apoptotic process GO:0043523 83 0.016
regulation of transferase activity GO:0051338 123 0.016
multicellular organism reproduction GO:0032504 233 0.016
neurological system process GO:0050877 219 0.016
purine containing compound metabolic process GO:0072521 253 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
cellular macromolecule localization GO:0070727 122 0.016
circulatory system development GO:0072359 134 0.016
neuronal action potential GO:0019228 35 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
response to glucocorticoid GO:0051384 223 0.016
organic hydroxy compound metabolic process GO:1901615 115 0.016
gliogenesis GO:0042063 93 0.016
peptidyl amino acid modification GO:0018193 126 0.016
positive regulation of kinase activity GO:0033674 77 0.016
nucleotide metabolic process GO:0009117 279 0.016
cellular catabolic process GO:0044248 295 0.016
muscle system process GO:0003012 115 0.016
adult locomotory behavior GO:0008344 4 0.016
cellular response to alcohol GO:0097306 87 0.015
ras protein signal transduction GO:0007265 29 0.015
transcription dna templated GO:0006351 377 0.015
secretion GO:0046903 307 0.015
epithelium development GO:0060429 96 0.015
organophosphate metabolic process GO:0019637 370 0.015
organelle organization GO:0006996 266 0.015
synaptic growth at neuromuscular junction GO:0051124 1 0.015
heart development GO:0007507 72 0.015
regulation of mapk cascade GO:0043408 116 0.015
chromosome segregation GO:0007059 2 0.015
bmp signaling pathway GO:0030509 4 0.015
establishment of planar polarity GO:0001736 1 0.015
protein complex biogenesis GO:0070271 263 0.015
actin filament based process GO:0030029 86 0.014
multicellular organismal signaling GO:0035637 44 0.014
regulation of cellular localization GO:0060341 263 0.014
membrane organization GO:0061024 94 0.014
eye morphogenesis GO:0048592 4 0.014
cellular response to corticosteroid stimulus GO:0071384 69 0.014
protein complex assembly GO:0006461 263 0.014
regulation of secretion GO:0051046 224 0.014
immune response GO:0006955 104 0.014
regulation of response to stress GO:0080134 126 0.014
regulation of stem cell differentiation GO:2000736 2 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
axon development GO:0061564 96 0.014
dendrite development GO:0016358 72 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
cell type specific apoptotic process GO:0097285 134 0.014
circulatory system process GO:0003013 183 0.014
cytoplasmic transport GO:0016482 115 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
regulation of cell motility GO:2000145 131 0.013
negative regulation of developmental process GO:0051093 125 0.013
axis specification GO:0009798 4 0.013
single organism organelle organization GO:1902589 180 0.013
positive regulation of transferase activity GO:0051347 81 0.013
regulation of locomotion GO:0040012 148 0.013
response to peptide hormone GO:0043434 278 0.013
gland development GO:0048732 155 0.013
cell cell signaling GO:0007267 335 0.013
response to corticosteroid GO:0031960 235 0.013
mesoderm development GO:0007498 2 0.013
regulation of rna metabolic process GO:0051252 391 0.013
neuromuscular process GO:0050905 2 0.013
intracellular transport GO:0046907 185 0.013
response to oxygen levels GO:0070482 265 0.013
tube development GO:0035295 89 0.013
positive regulation of mapk cascade GO:0043410 92 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
gamete generation GO:0007276 124 0.013
regulation of anatomical structure size GO:0090066 135 0.013
axon guidance GO:0007411 24 0.013
regulation of cell migration GO:0030334 128 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
positive regulation of protein kinase activity GO:0045860 73 0.013
regulation of fat cell differentiation GO:0045598 3 0.012
response to vitamin GO:0033273 131 0.012
regulation of synaptic transmission GO:0050804 141 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
negative regulation of cell development GO:0010721 82 0.012
carbohydrate metabolic process GO:0005975 130 0.012
regulation of calcium ion transport GO:0051924 77 0.012
organ formation GO:0048645 3 0.012
cell growth GO:0016049 104 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
axon midline choice point recognition GO:0016199 2 0.012
chemotaxis GO:0006935 66 0.012
growth GO:0040007 165 0.012
aromatic compound catabolic process GO:0019439 168 0.012
response to decreased oxygen levels GO:0036293 237 0.012
tissue morphogenesis GO:0048729 22 0.012
rna metabolic process GO:0016070 406 0.012
peptidyl tyrosine phosphorylation GO:0018108 72 0.012
epithelial cell differentiation GO:0030855 71 0.012
response to growth factor GO:0070848 189 0.012
forebrain development GO:0030900 98 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
positive regulation of ion transport GO:0043270 94 0.012
regulation of hormone levels GO:0010817 187 0.012
response to lipopolysaccharide GO:0032496 191 0.012
hair cycle process GO:0022405 2 0.011
formation of primary germ layer GO:0001704 1 0.011
morphogenesis of a polarized epithelium GO:0001738 1 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
hair follicle development GO:0001942 2 0.011
establishment of protein localization GO:0045184 141 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
single organism cell adhesion GO:0098602 46 0.011
cardiac chamber development GO:0003205 1 0.011
response to radiation GO:0009314 137 0.011
cytoskeleton organization GO:0007010 111 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
negative regulation of molecular function GO:0044092 133 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
neuron projection morphogenesis GO:0048812 122 0.011
regulation of hydrolase activity GO:0051336 143 0.011
anion transport GO:0006820 178 0.011
protein heterooligomerization GO:0051291 89 0.011
male gamete generation GO:0048232 99 0.011
spindle organization GO:0007051 2 0.011
nucleotide catabolic process GO:0009166 139 0.011
negative regulation of cell death GO:0060548 229 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
aging GO:0007568 241 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
positive regulation of transport GO:0051050 245 0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 3 0.011
developmental process involved in reproduction GO:0003006 159 0.011
neuron projection guidance GO:0097485 24 0.011
positive regulation of catabolic process GO:0009896 78 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
cerebral cortex cell migration GO:0021795 4 0.011
reproductive structure development GO:0048608 128 0.011
cellular response to glucocorticoid stimulus GO:0071385 68 0.011
cell cycle checkpoint GO:0000075 2 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.011
response to purine containing compound GO:0014074 126 0.011
regulation of bmp signaling pathway GO:0030510 2 0.011
purine nucleotide metabolic process GO:0006163 229 0.010
purine nucleoside triphosphate metabolic process GO:0009144 141 0.010
protein transport GO:0015031 132 0.010
negative regulation of signal transduction GO:0009968 83 0.010
synaptic transmission GO:0007268 235 0.010
negative regulation of nervous system development GO:0051961 79 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
anatomical structure formation involved in morphogenesis GO:0048646 83 0.010
neuron death GO:0070997 127 0.010
regulation of catabolic process GO:0009894 113 0.010
response to carbohydrate GO:0009743 183 0.010
regulation of ossification GO:0030278 32 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
spermatogenesis GO:0007283 99 0.010
actin cytoskeleton organization GO:0030036 73 0.010
response to temperature stimulus GO:0009266 94 0.010
cellular response to organic cyclic compound GO:0071407 202 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010
rhythmic process GO:0048511 156 0.010
hair cycle GO:0042633 3 0.010
female sex differentiation GO:0046660 59 0.010
response to hypoxia GO:0001666 231 0.010
activation of protein kinase activity GO:0032147 47 0.010
cardiac ventricle development GO:0003231 1 0.010
cardiovascular system development GO:0072358 134 0.010
cerebral cortex tangential migration GO:0021800 1 0.010

Sema5a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.012
central nervous system disease DOID:331 0 0.012
organ system cancer DOID:0050686 0 0.011
urinary system disease DOID:18 0 0.011