Rattus norvegicus

192 known processes

Serpinf1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

(Aliases: Pedf,Dmrs91)

Serpinf1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tissue development GO:0009888 252 0.249
homeostatic process GO:0042592 331 0.153
apoptotic process GO:0006915 381 0.140
cellular lipid metabolic process GO:0044255 208 0.137
lipid metabolic process GO:0006629 283 0.116
regulation of programmed cell death GO:0043067 341 0.107
cellular response to hormone stimulus GO:0032870 247 0.087
bmp signaling pathway GO:0030509 4 0.086
reproductive process GO:0022414 372 0.085
oxoacid metabolic process GO:0043436 290 0.080
hormone metabolic process GO:0042445 69 0.080
cellular response to endogenous stimulus GO:0071495 377 0.079
cardiovascular system development GO:0072358 134 0.078
Human
programmed cell death GO:0012501 392 0.070
response to peptide hormone GO:0043434 278 0.065
response to glucocorticoid GO:0051384 223 0.064
circulatory system development GO:0072359 134 0.064
Human
cellular catabolic process GO:0044248 295 0.063
regeneration GO:0031099 163 0.063
regulation of apoptotic process GO:0042981 335 0.062
negative regulation of cell death GO:0060548 229 0.061
developmental growth GO:0048589 100 0.058
regulation of hormone levels GO:0010817 187 0.056
regulation of fat cell differentiation GO:0045598 3 0.055
positive regulation of multicellular organismal process GO:0051240 387 0.055
positive regulation of developmental process GO:0051094 283 0.054
cell growth GO:0016049 104 0.054
response to oxygen levels GO:0070482 265 0.053
response to corticosteroid GO:0031960 235 0.053
multi multicellular organism process GO:0044706 138 0.052
positive regulation of transport GO:0051050 245 0.052
response to extracellular stimulus GO:0009991 380 0.052
growth GO:0040007 165 0.050
response to peptide GO:1901652 292 0.050
chemical homeostasis GO:0048878 292 0.050
regulation of cell proliferation GO:0042127 359 0.049
heart morphogenesis GO:0003007 3 0.048
regulation of multicellular organismal development GO:2000026 376 0.048
positive regulation of cell proliferation GO:0008284 249 0.048
response to fluoride GO:1902617 3 0.047
cellular response to peptide hormone stimulus GO:0071375 120 0.046
positive regulation of cell death GO:0010942 184 0.045
organ morphogenesis GO:0009887 75 0.045
monosaccharide metabolic process GO:0005996 61 0.045
cellular amino acid metabolic process GO:0006520 107 0.044
response to toxic substance GO:0009636 133 0.043
negative regulation of programmed cell death GO:0043069 183 0.042
response to nutrient levels GO:0031667 370 0.042
vasculature development GO:0001944 70 0.042
Human
positive regulation of apoptotic process GO:0043065 154 0.042
macromolecule localization GO:0033036 252 0.042
rna biosynthetic process GO:0032774 380 0.042
regulation of nervous system development GO:0051960 264 0.040
response to inorganic substance GO:0010035 377 0.040
negative regulation of multicellular organismal process GO:0051241 203 0.039
regulation of neuron death GO:1901214 115 0.039
multi organism reproductive process GO:0044703 262 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.038
catabolic process GO:0009056 351 0.037
cellular response to organic cyclic compound GO:0071407 202 0.037
regulation of cell motility GO:2000145 131 0.037
cellular component assembly GO:0022607 360 0.036
protein oligomerization GO:0051259 191 0.036
positive regulation of secretion GO:0051047 140 0.036
secretion GO:0046903 307 0.036
behavior GO:0007610 205 0.035
regulation of cellular component organization GO:0051128 368 0.035
cellular amine metabolic process GO:0044106 38 0.035
organic acid metabolic process GO:0006082 292 0.035
ossification GO:0001503 70 0.035
liver development GO:0001889 90 0.034
metal ion transport GO:0030001 289 0.034
response to biotic stimulus GO:0009607 226 0.034
regulation of anatomical structure morphogenesis GO:0022603 141 0.034
Human
cell type specific apoptotic process GO:0097285 134 0.033
positive regulation of cell communication GO:0010647 271 0.033
transcription dna templated GO:0006351 377 0.033
cellular modified amino acid metabolic process GO:0006575 61 0.033
negative regulation of apoptotic process GO:0043066 181 0.033
response to alkaloid GO:0043279 132 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.033
inflammatory response GO:0006954 150 0.032
signal transduction by phosphorylation GO:0023014 144 0.032
single organism catabolic process GO:0044712 283 0.031
carbohydrate metabolic process GO:0005975 130 0.031
response to radiation GO:0009314 137 0.031
intracellular signal transduction GO:0035556 314 0.031
multicellular organismal reproductive process GO:0048609 233 0.031
positive regulation of programmed cell death GO:0043068 157 0.031
amine metabolic process GO:0009308 38 0.030
response to estrogen GO:0043627 232 0.030
wound healing GO:0042060 122 0.029
Rat
regulation of rna metabolic process GO:0051252 391 0.029
rna metabolic process GO:0016070 406 0.029
response to molecule of bacterial origin GO:0002237 194 0.029
multicellular organism reproduction GO:0032504 233 0.029
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.029
isoprenoid metabolic process GO:0006720 45 0.029
terpenoid metabolic process GO:0006721 37 0.029
gland development GO:0048732 155 0.029
organonitrogen compound biosynthetic process GO:1901566 167 0.028
jak stat cascade GO:0007259 26 0.028
response to estradiol GO:0032355 164 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.028
regulation of growth GO:0040008 105 0.028
small gtpase mediated signal transduction GO:0007264 36 0.027
cellular response to growth factor stimulus GO:0071363 162 0.027
reproduction GO:0000003 245 0.027
positive regulation of biosynthetic process GO:0009891 319 0.027
regulation of cell development GO:0060284 263 0.027
proteolysis GO:0006508 175 0.026
Rat
regulation of response to external stimulus GO:0032101 106 0.026
response to acid chemical GO:0001101 222 0.026
response to ethanol GO:0045471 162 0.025
carboxylic acid catabolic process GO:0046395 49 0.025
cell migration GO:0016477 197 0.025
positive regulation of nervous system development GO:0051962 178 0.025
response to insulin GO:0032868 133 0.025
cellular amino acid biosynthetic process GO:0008652 32 0.025
response to external biotic stimulus GO:0043207 221 0.025
immune system process GO:0002376 204 0.025
response to other organism GO:0051707 220 0.024
transmembrane transport GO:0055085 412 0.024
regulation of signal transduction GO:0009966 318 0.024
secretion by cell GO:0032940 248 0.024
calcium ion transport GO:0006816 131 0.024
response to lipopolysaccharide GO:0032496 191 0.024
cellular hormone metabolic process GO:0034754 49 0.024
response to hypoxia GO:0001666 231 0.024
cellular response to stress GO:0033554 269 0.023
response to dexamethasone GO:0071548 49 0.023
regulation of cell differentiation GO:0045595 320 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.023
blood circulation GO:0008015 183 0.023
female pregnancy GO:0007565 122 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
angiogenesis GO:0001525 53 0.022
Human
cellular response to mechanical stimulus GO:0071260 48 0.022
multicellular organism growth GO:0035264 1 0.022
response to decreased oxygen levels GO:0036293 237 0.022
small molecule catabolic process GO:0044282 59 0.022
regulation of ion transport GO:0043269 245 0.022
protein complex biogenesis GO:0070271 263 0.022
sexual reproduction GO:0019953 148 0.022
cellular response to peptide GO:1901653 133 0.021
prostate gland epithelium morphogenesis GO:0060740 2 0.021
immune response GO:0006955 104 0.021
cation transmembrane transport GO:0098655 263 0.021
transcription from rna polymerase ii promoter GO:0006366 252 0.021
cellular component biogenesis GO:0044085 368 0.021
urogenital system development GO:0001655 78 0.021
divalent inorganic cation transport GO:0072511 134 0.021
positive regulation of cell projection organization GO:0031346 111 0.021
organic substance catabolic process GO:1901575 316 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
organic hydroxy compound metabolic process GO:1901615 115 0.021
protein complex assembly GO:0006461 263 0.020
cellular response to organonitrogen compound GO:0071417 197 0.020
response to glucose GO:0009749 136 0.020
neuron death GO:0070997 127 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
hexose metabolic process GO:0019318 58 0.020
cellular biogenic amine metabolic process GO:0006576 30 0.020
regulation of molecular function GO:0065009 398 0.020
Rat
ethanolamine containing compound metabolic process GO:0042439 14 0.020
heterocycle catabolic process GO:0046700 167 0.019
regulation of cell projection organization GO:0031344 175 0.019
prostate gland morphogenesis GO:0060512 2 0.019
macromolecular complex assembly GO:0065003 273 0.019
alcohol metabolic process GO:0006066 77 0.019
single organism reproductive process GO:0044702 297 0.019
divalent metal ion transport GO:0070838 132 0.019
regulation of nucleic acid templated transcription GO:1903506 380 0.019
gamete generation GO:0007276 124 0.019
regulation of catalytic activity GO:0050790 304 0.019
Rat
response to bacterium GO:0009617 200 0.019
connective tissue development GO:0061448 33 0.019
response to activity GO:0014823 73 0.019
aging GO:0007568 241 0.018
sulfur compound metabolic process GO:0006790 70 0.018
ras protein signal transduction GO:0007265 29 0.018
regulation of secretion GO:0051046 224 0.018
positive regulation of intracellular signal transduction GO:1902533 138 0.018
eye morphogenesis GO:0048592 4 0.018
muscle structure development GO:0061061 87 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
positive regulation of neuron differentiation GO:0045666 126 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
Rat
regulation of neurogenesis GO:0050767 247 0.017
regulation of secretion by cell GO:1903530 208 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
Human
neuron differentiation GO:0030182 368 0.017
cognition GO:0050890 92 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
regulation of neuron projection development GO:0010975 161 0.017
enzyme linked receptor protein signaling pathway GO:0007167 116 0.017
regulation of cell growth GO:0001558 85 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
cellular chemical homeostasis GO:0055082 247 0.017
cofactor metabolic process GO:0051186 95 0.017
regulation of bmp signaling pathway GO:0030510 2 0.017
head development GO:0060322 247 0.017
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.016
muscle tissue development GO:0060537 58 0.016
cellular homeostasis GO:0019725 252 0.016
ion transmembrane transport GO:0034220 365 0.016
monocarboxylic acid transport GO:0015718 52 0.016
formation of primary germ layer GO:0001704 1 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
positive regulation of molecular function GO:0044093 230 0.016
organonitrogen compound catabolic process GO:1901565 179 0.016
positive regulation of fat cell differentiation GO:0045600 2 0.016
response to hexose GO:0009746 144 0.016
chromosome segregation GO:0007059 2 0.016
regulation of locomotion GO:0040012 148 0.016
positive regulation of transcription dna templated GO:0045893 197 0.016
positive regulation of growth GO:0045927 55 0.016
response to oxidative stress GO:0006979 186 0.016
positive regulation of cellular component movement GO:0051272 102 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
cellular cation homeostasis GO:0030003 180 0.016
defense response GO:0006952 194 0.016
macromolecular complex subunit organization GO:0043933 339 0.016
response to transforming growth factor beta GO:0071559 46 0.015
renal system development GO:0072001 67 0.015
negative regulation of gene expression GO:0010629 199 0.015
organophosphate metabolic process GO:0019637 370 0.015
positive regulation of signaling GO:0023056 270 0.015
development of primary sexual characteristics GO:0045137 107 0.015
circulatory system process GO:0003013 183 0.015
spermatogenesis GO:0007283 99 0.015
phospholipid metabolic process GO:0006644 61 0.015
response to cytokine GO:0034097 215 0.015
cellular component movement GO:0006928 248 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
insulin like growth factor receptor signaling pathway GO:0048009 3 0.015
protein localization GO:0008104 191 0.015
positive regulation of cellular component organization GO:0051130 200 0.015
cellular response to oxygen containing compound GO:1901701 386 0.015
nucleotide metabolic process GO:0009117 279 0.015
retinal metabolic process GO:0042574 3 0.015
response to nutrient GO:0007584 248 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
response to ketone GO:1901654 182 0.015
protein heterooligomerization GO:0051291 89 0.014
epithelial cell proliferation GO:0050673 54 0.014
establishment of protein localization GO:0045184 141 0.014
negative regulation of cell communication GO:0010648 158 0.014
gonad development GO:0008406 104 0.014
sulfur compound biosynthetic process GO:0044272 19 0.014
anion transport GO:0006820 178 0.014
nitrogen compound transport GO:0071705 229 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
neuron development GO:0048666 286 0.014
negative regulation of metabolic process GO:0009892 331 0.014
glial cell differentiation GO:0010001 65 0.014
lipid localization GO:0010876 62 0.014
single organism biosynthetic process GO:0044711 342 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
central nervous system development GO:0007417 311 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
protein complex subunit organization GO:0071822 302 0.014
regulation of synaptic transmission GO:0050804 141 0.014
positive regulation of gene expression GO:0010628 244 0.014
anatomical structure formation involved in morphogenesis GO:0048646 83 0.014
Human
positive regulation of ion transport GO:0043270 94 0.014
response to starvation GO:0042594 59 0.013
protein transport GO:0015031 132 0.013
cellular component morphogenesis GO:0032989 155 0.013
organic acid catabolic process GO:0016054 49 0.013
carboxylic acid metabolic process GO:0019752 289 0.013
embryonic skeletal system development GO:0048706 3 0.013
negative regulation of signaling GO:0023057 157 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
lipid biosynthetic process GO:0008610 128 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
purine containing compound metabolic process GO:0072521 253 0.013
monocarboxylic acid metabolic process GO:0032787 152 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
regulation of cellular localization GO:0060341 263 0.013
nucleic acid templated transcription GO:0097659 379 0.013
protein homooligomerization GO:0051260 91 0.013
regulation of neuron differentiation GO:0045664 208 0.013
response to reactive oxygen species GO:0000302 120 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
glycosaminoglycan biosynthetic process GO:0006024 4 0.012
positive regulation of cell development GO:0010720 176 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
regulation of hydrolase activity GO:0051336 143 0.012
Rat
positive regulation of immune system process GO:0002684 90 0.012
regulation of transcription dna templated GO:0006355 374 0.012
regulation of jak stat cascade GO:0046425 21 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.012
response to monosaccharide GO:0034284 159 0.012
glucose metabolic process GO:0006006 52 0.012
cellular response to external stimulus GO:0071496 118 0.012
vascular process in circulatory system GO:0003018 96 0.012
cellular response to alcohol GO:0097306 87 0.012
cardiac chamber development GO:0003205 1 0.012
regulation of phosphate metabolic process GO:0019220 349 0.012
rho protein signal transduction GO:0007266 11 0.012
rhythmic process GO:0048511 156 0.012
response to camp GO:0051591 91 0.012
cerebellar granule cell precursor proliferation GO:0021930 1 0.012
limb morphogenesis GO:0035108 4 0.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 1 0.012
tube development GO:0035295 89 0.011
protein phosphorylation GO:0006468 345 0.011
regulation of rna biosynthetic process GO:2001141 381 0.011
cell proliferation in external granule layer GO:0021924 1 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
nucleoside metabolic process GO:0009116 179 0.011
synaptic transmission GO:0007268 235 0.011
hepaticobiliary system development GO:0061008 90 0.011
positive regulation of cytokine production GO:0001819 42 0.011
reproductive system development GO:0061458 128 0.011
regulation of immunoglobulin secretion GO:0051023 1 0.011
cation transport GO:0006812 382 0.011
adult locomotory behavior GO:0008344 4 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
organic acid biosynthetic process GO:0016053 83 0.011
male gamete generation GO:0048232 99 0.011
muscle cell proliferation GO:0033002 84 0.011
learning or memory GO:0007611 90 0.011
axis specification GO:0009798 4 0.011
regulation of cellular amino acid metabolic process GO:0006521 2 0.011
locomotion GO:0040011 237 0.011
glycerolipid metabolic process GO:0046486 67 0.011
organic acid transport GO:0015849 116 0.011
organ growth GO:0035265 24 0.011
regulation of phosphorus metabolic process GO:0051174 349 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
organ regeneration GO:0031100 101 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
neuron apoptotic process GO:0051402 88 0.011
organic anion transport GO:0015711 132 0.010
cell cell signaling GO:0007267 335 0.010
cellular response to corticosteroid stimulus GO:0071384 69 0.010
regulation of response to stress GO:0080134 126 0.010
negative regulation of neuron death GO:1901215 69 0.010
cellular response to hexose stimulus GO:0071331 65 0.010
response to electrical stimulus GO:0051602 56 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
regulation of cell migration GO:0030334 128 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010
glucose homeostasis GO:0042593 75 0.010
organic hydroxy compound transport GO:0015850 77 0.010
negative regulation of response to biotic stimulus GO:0002832 4 0.010
transmission of nerve impulse GO:0019226 42 0.010
smooth muscle cell proliferation GO:0048659 77 0.010
cellular response to abiotic stimulus GO:0071214 85 0.010
cellular response to nutrient levels GO:0031669 60 0.010
multicellular organismal signaling GO:0035637 44 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
response to organophosphorus GO:0046683 102 0.010
organelle organization GO:0006996 266 0.010
mapk cascade GO:0000165 140 0.010
regulation of immune system process GO:0002682 123 0.010
cellular response to extracellular stimulus GO:0031668 73 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.010

Serpinf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.046
Human
disease of anatomical entity DOID:7 0 0.046
Human
connective tissue disease DOID:65 0 0.046
Human
bone development disease DOID:0080006 0 0.039
Human
bone disease DOID:0080001 0 0.039
Human
disease of metabolism DOID:0014667 0 0.029
inherited metabolic disorder DOID:655 0 0.020
nervous system disease DOID:863 0 0.012
muscular disease DOID:0080000 0 0.011