Rattus norvegicus

84 known processes

Serpinf2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Serpinf2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ion transmembrane transport GO:0034220 365 0.217
response to inorganic substance GO:0010035 377 0.194
Rat
regeneration GO:0031099 163 0.187
cellular amino acid metabolic process GO:0006520 107 0.179
regulation of molecular function GO:0065009 398 0.178
wound healing GO:0042060 122 0.156
oxoacid metabolic process GO:0043436 290 0.138
negative regulation of multicellular organismal process GO:0051241 203 0.126
organic acid metabolic process GO:0006082 292 0.118
response to extracellular stimulus GO:0009991 380 0.116
catabolic process GO:0009056 351 0.110
cation transport GO:0006812 382 0.103
coagulation GO:0050817 28 0.095
carboxylic acid metabolic process GO:0019752 289 0.092
intracellular signal transduction GO:0035556 314 0.090
Human
immune system process GO:0002376 204 0.089
regulation of protein metabolic process GO:0051246 289 0.086
response to camp GO:0051591 91 0.086
metal ion transport GO:0030001 289 0.085
transmembrane transport GO:0055085 412 0.082
plasminogen activation GO:0031639 2 0.081
Human
rhythmic process GO:0048511 156 0.078
Rat
positive regulation of blood coagulation GO:0030194 4 0.077
response to wounding GO:0009611 254 0.076
regulation of phosphate metabolic process GO:0019220 349 0.071
Human
gland development GO:0048732 155 0.070
negative regulation of macromolecule metabolic process GO:0010605 260 0.069
apoptotic process GO:0006915 381 0.069
regulation of body fluid levels GO:0050878 90 0.066
response to nutrient levels GO:0031667 370 0.065
regulation of anatomical structure morphogenesis GO:0022603 141 0.064
organic substance catabolic process GO:1901575 316 0.064
negative regulation of molecular function GO:0044092 133 0.063
cellular amide metabolic process GO:0043603 44 0.063
hemostasis GO:0007599 26 0.063
response to estrogen GO:0043627 232 0.060
proteolysis GO:0006508 175 0.060
response to peptide GO:1901652 292 0.059
developmental growth GO:0048589 100 0.058
regulation of programmed cell death GO:0043067 341 0.054
response to organophosphorus GO:0046683 102 0.054
negative regulation of wound healing GO:0061045 8 0.054
protein processing GO:0016485 68 0.053
Human
response to peptide hormone GO:0043434 278 0.051
regulation of signal transduction GO:0009966 318 0.050
Human
blood coagulation GO:0007596 26 0.050
organophosphate metabolic process GO:0019637 370 0.049
metal ion homeostasis GO:0055065 186 0.046
regulation of cellular amine metabolic process GO:0033238 8 0.046
regulation of protein modification process GO:0031399 194 0.045
response to cytokine GO:0034097 215 0.044
response to metal ion GO:0010038 253 0.043
Rat
negative regulation of developmental process GO:0051093 125 0.043
cellular amine metabolic process GO:0044106 38 0.043
inorganic cation transmembrane transport GO:0098662 202 0.043
fibrinolysis GO:0042730 2 0.043
response to estradiol GO:0032355 164 0.041
regulation of apoptotic process GO:0042981 335 0.041
negative regulation of cell differentiation GO:0045596 99 0.040
cellular catabolic process GO:0044248 295 0.040
regulation of intracellular signal transduction GO:1902531 218 0.040
Human
cellular component assembly GO:0022607 360 0.040
Human
response to purine containing compound GO:0014074 126 0.039
amine metabolic process GO:0009308 38 0.039
regulation of cellular protein metabolic process GO:0032268 267 0.038
liver development GO:0001889 90 0.038
cellular ketone metabolic process GO:0042180 51 0.038
regulation of cell development GO:0060284 263 0.038
Rat
secretion GO:0046903 307 0.037
homeostatic process GO:0042592 331 0.037
Rat
growth GO:0040007 165 0.037
carboxylic acid transport GO:0046942 115 0.037
reproduction GO:0000003 245 0.037
Rat
protein maturation GO:0051604 68 0.036
Human
organic anion transport GO:0015711 132 0.036
regulation of hydrolase activity GO:0051336 143 0.036
locomotion GO:0040011 237 0.036
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
response to mechanical stimulus GO:0009612 134 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
carboxylic acid biosynthetic process GO:0046394 83 0.035
negative regulation of response to wounding GO:1903035 23 0.035
tissue regeneration GO:0042246 36 0.034
blood circulation GO:0008015 183 0.034
Mouse
carbohydrate derivative metabolic process GO:1901135 346 0.034
response to external biotic stimulus GO:0043207 221 0.034
cellular response to nitrogen compound GO:1901699 210 0.034
regulation of blood vessel size GO:0050880 89 0.034
Mouse
cofactor metabolic process GO:0051186 95 0.033
macromolecular complex subunit organization GO:0043933 339 0.032
Human Mouse
regulation of response to stress GO:0080134 126 0.032
nucleoside phosphate metabolic process GO:0006753 283 0.031
ribonucleotide metabolic process GO:0009259 231 0.031
regulation of protein processing GO:0070613 50 0.031
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.031
ribonucleoside metabolic process GO:0009119 174 0.031
circadian rhythm GO:0007623 88 0.031
regulation of cell proliferation GO:0042127 359 0.031
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 122 0.031
cell migration GO:0016477 197 0.030
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.030
Human
anatomical structure morphogenesis GO:0009653 298 0.030
Mouse
positive regulation of coagulation GO:0050820 5 0.029
positive regulation of hemostasis GO:1900048 4 0.029
regulation of neuron differentiation GO:0045664 208 0.029
Rat
inflammatory response GO:0006954 150 0.029
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.028
hepatocyte proliferation GO:0072574 3 0.028
cellular response to organonitrogen compound GO:0071417 197 0.028
nucleotide metabolic process GO:0009117 279 0.028
cellular response to abiotic stimulus GO:0071214 85 0.027
regulation of hemostasis GO:1900046 9 0.027
regulation of cell growth GO:0001558 85 0.027
organ regeneration GO:0031100 101 0.026
negative regulation of biomineral tissue development GO:0070168 2 0.026
anion transport GO:0006820 178 0.026
immune response GO:0006955 104 0.026
nitrogen compound transport GO:0071705 229 0.026
regulation of blood coagulation GO:0030193 9 0.026
response to decreased oxygen levels GO:0036293 237 0.026
regulation of protein maturation GO:1903317 50 0.025
cellular response to endogenous stimulus GO:0071495 377 0.025
Rat
anatomical structure formation involved in morphogenesis GO:0048646 83 0.025
cellular response to cytokine stimulus GO:0071345 127 0.025
organic acid transport GO:0015849 116 0.025
organelle organization GO:0006996 266 0.024
Human
organic cyclic compound catabolic process GO:1901361 175 0.024
regulation of coagulation GO:0050818 11 0.024
purine nucleotide metabolic process GO:0006163 229 0.024
negative regulation of metabolic process GO:0009892 331 0.024
cellular cation homeostasis GO:0030003 180 0.024
regulation of ion transport GO:0043269 245 0.024
cell morphogenesis involved in differentiation GO:0000904 119 0.024
cellular nitrogen compound catabolic process GO:0044270 163 0.024
regulation of cellular component organization GO:0051128 368 0.024
Human Rat
cellular response to oxygen containing compound GO:1901701 386 0.023
Rat
positive regulation of response to stimulus GO:0048584 285 0.023
regulation of cell projection organization GO:0031344 175 0.023
Rat
divalent inorganic cation transport GO:0072511 134 0.023
hepaticobiliary system development GO:0061008 90 0.023
regulation of immune response GO:0050776 55 0.022
purine containing compound metabolic process GO:0072521 253 0.022
ribonucleoside triphosphate metabolic process GO:0009199 141 0.022
single organism biosynthetic process GO:0044711 342 0.022
Human Mouse
negative regulation of catalytic activity GO:0043086 103 0.022
aging GO:0007568 241 0.022
Rat
cation transmembrane transport GO:0098655 263 0.022
negative regulation of protein metabolic process GO:0051248 114 0.022
negative regulation of endopeptidase activity GO:0010951 36 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
regulation of calcium ion transport GO:0051924 77 0.022
neuron projection development GO:0031175 273 0.022
Rat
regulation of rna biosynthetic process GO:2001141 381 0.021
Human Mouse
macromolecular complex assembly GO:0065003 273 0.021
sterol homeostasis GO:0055092 3 0.021
regulation of cell projection size GO:0032536 1 0.021
nucleoside phosphate catabolic process GO:1901292 140 0.021
lipid metabolic process GO:0006629 283 0.021
positive regulation of signaling GO:0023056 270 0.021
Human
positive regulation of neuron projection development GO:0010976 99 0.021
Rat
glycosyl compound metabolic process GO:1901657 182 0.021
alpha amino acid metabolic process GO:1901605 71 0.021
tonic smooth muscle contraction GO:0014820 4 0.021
negative regulation of peptidase activity GO:0010466 38 0.021
regulation of neuron projection development GO:0010975 161 0.020
Rat
regulation of synaptic plasticity GO:0048167 70 0.020
regulation of cellular localization GO:0060341 263 0.020
cellular chemical homeostasis GO:0055082 247 0.020
Rat
positive regulation of catalytic activity GO:0043085 184 0.020
cellular response to steroid hormone stimulus GO:0071383 93 0.020
Rat
regulation of protein phosphorylation GO:0001932 183 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
purine nucleoside triphosphate metabolic process GO:0009144 141 0.020
cellular homeostasis GO:0019725 252 0.020
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
cellular lipid metabolic process GO:0044255 208 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
Human
response to oxygen levels GO:0070482 265 0.019
defense response GO:0006952 194 0.019
Rat
cholesterol homeostasis GO:0042632 3 0.019
macromolecule localization GO:0033036 252 0.019
epithelial cell proliferation involved in liver morphogenesis GO:0072575 3 0.019
nucleoside phosphate biosynthetic process GO:1901293 102 0.019
anion transmembrane transport GO:0098656 77 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
Rat
negative regulation of response to stimulus GO:0048585 155 0.019
regulation of cell differentiation GO:0045595 320 0.019
Human Mouse Rat
reactive oxygen species biosynthetic process GO:1903409 8 0.019
cellular response to mechanical stimulus GO:0071260 48 0.018
ribonucleoside triphosphate catabolic process GO:0009203 122 0.018
regulation of fibrinolysis GO:0051917 2 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
response to corticosteroid GO:0031960 235 0.018
Rat
cellular response to lipid GO:0071396 201 0.018
Rat
ribonucleoside catabolic process GO:0042454 126 0.018
heterocycle catabolic process GO:0046700 167 0.018
protein complex assembly GO:0006461 263 0.018
cofactor biosynthetic process GO:0051188 28 0.017
regulation of catalytic activity GO:0050790 304 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
immunoglobulin mediated immune response GO:0016064 4 0.017
liver morphogenesis GO:0072576 3 0.017
purine ribonucleotide catabolic process GO:0009154 136 0.017
response to nutrient GO:0007584 248 0.017
positive regulation of molecular function GO:0044093 230 0.017
circulatory system process GO:0003013 183 0.017
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.017
Human Mouse
transcription dna templated GO:0006351 377 0.017
Human Mouse
purine nucleoside metabolic process GO:0042278 169 0.017
negative regulation of fibrinolysis GO:0051918 2 0.017
circulatory system development GO:0072359 134 0.017
Mouse
positive regulation of phosphate metabolic process GO:0045937 262 0.016
Human
pyridine nucleotide biosynthetic process GO:0019363 2 0.016
protein phosphorylation GO:0006468 345 0.016
amine transport GO:0015837 57 0.016
regulation of rna metabolic process GO:0051252 391 0.016
Human Mouse
brain development GO:0007420 247 0.016
cell adhesion GO:0007155 110 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
mapk cascade GO:0000165 140 0.016
Human
negative regulation of blood coagulation GO:0030195 6 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
protein complex subunit organization GO:0071822 302 0.016
Human Mouse
dicarboxylic acid metabolic process GO:0043648 42 0.016
negative regulation of coagulation GO:0050819 7 0.016
transmission of nerve impulse GO:0019226 42 0.016
regulation of cellular component movement GO:0051270 150 0.016
Rat
reproductive process GO:0022414 372 0.016
Rat
regulation of reactive oxygen species metabolic process GO:2000377 26 0.016
positive regulation of ion transport GO:0043270 94 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.015
Human Mouse
regulation of growth GO:0040008 105 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
Rat
response to retinoic acid GO:0032526 63 0.015
Rat
purine containing compound catabolic process GO:0072523 138 0.015
protein activation cascade GO:0072376 12 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
Human
nucleoside metabolic process GO:0009116 179 0.015
tissue development GO:0009888 252 0.015
Rat
organonitrogen compound biosynthetic process GO:1901566 167 0.015
multi organism reproductive process GO:0044703 262 0.015
negative regulation of response to external stimulus GO:0032102 37 0.015
regulation of synaptic transmission GO:0050804 141 0.015
protein oligomerization GO:0051259 191 0.015
fatty acid transmembrane transport GO:1902001 3 0.015
response to vitamin k GO:0032571 4 0.015
negative regulation of gene expression GO:0010629 199 0.015
regulation of mapk cascade GO:0043408 116 0.015
Human
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
regulation of anatomical structure size GO:0090066 135 0.015
Mouse
nucleoside monophosphate metabolic process GO:0009123 93 0.015
negative regulation of cellular amide metabolic process GO:0034249 1 0.015
cellular modified amino acid metabolic process GO:0006575 61 0.015
multicellular organism reproduction GO:0032504 233 0.015
Rat
programmed cell death GO:0012501 392 0.015
response to bacterium GO:0009617 200 0.014
regulation of phosphorylation GO:0042325 248 0.014
Human
carbohydrate derivative catabolic process GO:1901136 147 0.014
acute inflammatory response GO:0002526 58 0.014
cellular response to glucocorticoid stimulus GO:0071385 68 0.014
Rat
regulation of neurogenesis GO:0050767 247 0.014
Rat
cell morphogenesis GO:0000902 142 0.014
regulation of secretion GO:0051046 224 0.014
response to reactive oxygen species GO:0000302 120 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
purine nucleoside monophosphate metabolic process GO:0009126 84 0.014
rna biosynthetic process GO:0032774 380 0.014
Human Mouse
regulation of system process GO:0044057 208 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
positive regulation of signal transduction GO:0009967 175 0.014
Human
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
multicellular organismal signaling GO:0035637 44 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
Human Mouse
negative regulation of hydrolase activity GO:0051346 52 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
Human
organophosphate catabolic process GO:0046434 148 0.014
glycosyl compound catabolic process GO:1901658 126 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
positive regulation of secretion by cell GO:1903532 128 0.013
rna metabolic process GO:0016070 406 0.013
Human Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
cellular response to hormone stimulus GO:0032870 247 0.013
Rat
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.013
negative regulation of hemostasis GO:1900047 6 0.013
response to hypoxia GO:0001666 231 0.013
muscle cell differentiation GO:0042692 52 0.013
regulation of immune system process GO:0002682 123 0.013
positive regulation of protein modification process GO:0031401 142 0.013
cell activation GO:0001775 97 0.013
aromatic compound catabolic process GO:0019439 168 0.013
macromolecule catabolic process GO:0009057 58 0.013
regulation of response to wounding GO:1903034 69 0.013
epithelial cell proliferation GO:0050673 54 0.013
ion homeostasis GO:0050801 212 0.013
multi multicellular organism process GO:0044706 138 0.013
response to glucose GO:0009749 136 0.013
Rat
cellular response to stress GO:0033554 269 0.013
Human
negative regulation of apoptotic process GO:0043066 181 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
pancreatic a cell differentiation GO:0003310 1 0.012
vesicle mediated transport GO:0016192 181 0.012
regulation of nervous system development GO:0051960 264 0.012
Rat
positive regulation of extracellular matrix organization GO:1903055 4 0.012
regulation of peptidase activity GO:0052547 55 0.012
regulation of b cell mediated immunity GO:0002712 2 0.012
negative regulation of cell death GO:0060548 229 0.012
Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
regulation of hormone levels GO:0010817 187 0.012
response to vitamin GO:0033273 131 0.012
regulation of response to external stimulus GO:0032101 106 0.012
angiogenesis GO:0001525 53 0.012
regulation of cell migration GO:0030334 128 0.012
Rat
single organism catabolic process GO:0044712 283 0.012
regulation of immunoglobulin mediated immune response GO:0002889 2 0.012
regulation of immunoglobulin production GO:0002637 4 0.012
cell cell signaling GO:0007267 335 0.012
organic hydroxy compound transport GO:0015850 77 0.012
glucose homeostasis GO:0042593 75 0.012
Rat
negative regulation of cell development GO:0010721 82 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
negative regulation of proteolysis GO:0045861 41 0.012
negative regulation of nervous system development GO:0051961 79 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
Human Rat
regulation of transcription dna templated GO:0006355 374 0.012
Human Mouse
positive regulation of nitric oxide biosynthetic process GO:0045429 14 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
regulation of serine type endopeptidase activity GO:1900003 1 0.011
response to acid chemical GO:0001101 222 0.011
Rat
synaptic transmission GO:0007268 235 0.011
fertilization GO:0009566 3 0.011
b cell mediated immunity GO:0019724 4 0.011
nucleotide catabolic process GO:0009166 139 0.011
catecholamine transport GO:0051937 37 0.011
renal system process GO:0003014 40 0.011
Mouse
positive regulation of neuron differentiation GO:0045666 126 0.011
Rat
nucleotide biosynthetic process GO:0009165 98 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
cytolysis GO:0019835 4 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
small molecule catabolic process GO:0044282 59 0.011
divalent metal ion transport GO:0070838 132 0.011
axis specification GO:0009798 4 0.011
response to ammonium ion GO:0060359 71 0.011
response to alkaloid GO:0043279 132 0.011
gamete generation GO:0007276 124 0.011
organic acid biosynthetic process GO:0016053 83 0.011
cell projection organization GO:0030030 302 0.011
Rat
cellular ion homeostasis GO:0006873 184 0.011
central nervous system development GO:0007417 311 0.011
response to other organism GO:0051707 220 0.011
chemical homeostasis GO:0048878 292 0.011
Rat
embryonic pattern specification GO:0009880 1 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
response to muscle activity involved in regulation of muscle adaptation GO:0014873 2 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
Mouse
regulation of kinase activity GO:0043549 117 0.011
extracellular matrix constituent secretion GO:0070278 4 0.010
cellular response to external stimulus GO:0071496 118 0.010
coenzyme metabolic process GO:0006732 86 0.010
regulation of wound healing GO:0061041 14 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
positive regulation of cell growth GO:0030307 44 0.010
ribonucleotide catabolic process GO:0009261 136 0.010
sterol catabolic process GO:0016127 1 0.010
cellular response to camp GO:0071320 26 0.010
multicellular organismal reproductive process GO:0048609 233 0.010
Rat
regulation of cell morphogenesis GO:0022604 77 0.010
spermatogenesis GO:0007283 99 0.010
regulation of metal ion transport GO:0010959 118 0.010
regulation of muscle system process GO:0090257 79 0.010
muscle tissue development GO:0060537 58 0.010
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010

Serpinf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.036
artery disease DOID:0050828 0 0.035
cerebrovascular disease DOID:6713 0 0.035
disease of anatomical entity DOID:7 0 0.035
vascular disease DOID:178 0 0.035
cardiovascular system disease DOID:1287 0 0.035
nervous system disease DOID:863 0 0.025
inherited metabolic disorder DOID:655 0 0.020
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010