Rattus norvegicus

0 known processes

Sh2b1

SH2B adaptor protein 1

(Aliases: Sh2bpsm1,Sh2-b,Sh2b)

Sh2b1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of nucleic acid templated transcription GO:1903506 380 0.276
transcription dna templated GO:0006351 377 0.181
intracellular signal transduction GO:0035556 314 0.176
regulation of rna biosynthetic process GO:2001141 381 0.156
regulation of phosphorus metabolic process GO:0051174 349 0.149
nucleic acid templated transcription GO:0097659 379 0.134
rna biosynthetic process GO:0032774 380 0.133
regulation of rna metabolic process GO:0051252 391 0.130
positive regulation of signal transduction GO:0009967 175 0.129
regulation of transcription dna templated GO:0006355 374 0.125
regulation of signal transduction GO:0009966 318 0.125
rna metabolic process GO:0016070 406 0.123
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.122
regulation of intracellular signal transduction GO:1902531 218 0.118
positive regulation of gene expression GO:0010628 244 0.104
regulation of cellular localization GO:0060341 263 0.098
mapk cascade GO:0000165 140 0.091
transcription from rna polymerase ii promoter GO:0006366 252 0.091
protein phosphorylation GO:0006468 345 0.088
positive regulation of transcription dna templated GO:0045893 197 0.087
negative regulation of macromolecule metabolic process GO:0010605 260 0.082
regulation of mapk cascade GO:0043408 116 0.078
regulation of phosphorylation GO:0042325 248 0.073
regulation of phosphate metabolic process GO:0019220 349 0.072
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.070
regulation of canonical wnt signaling pathway GO:0060828 4 0.069
heart morphogenesis GO:0003007 3 0.066
positive regulation of signaling GO:0023056 270 0.066
negative regulation of transcription dna templated GO:0045892 116 0.065
positive regulation of rna metabolic process GO:0051254 203 0.062
negative regulation of cellular metabolic process GO:0031324 281 0.062
tissue development GO:0009888 252 0.062
positive regulation of intracellular signal transduction GO:1902533 138 0.058
positive regulation of transferase activity GO:0051347 81 0.057
regulation of protein modification process GO:0031399 194 0.056
positive regulation of response to stimulus GO:0048584 285 0.056
protein complex biogenesis GO:0070271 263 0.053
neurological system process GO:0050877 219 0.053
cellular response to endogenous stimulus GO:0071495 377 0.053
signal transduction by phosphorylation GO:0023014 144 0.052
regulation of system process GO:0044057 208 0.051
establishment of tissue polarity GO:0007164 2 0.051
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.051
positive regulation of phosphorus metabolic process GO:0010562 262 0.050
positive regulation of biosynthetic process GO:0009891 319 0.049
organelle organization GO:0006996 266 0.049
protein localization GO:0008104 191 0.047
positive regulation of protein metabolic process GO:0051247 178 0.047
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.047
negative regulation of cell communication GO:0010648 158 0.046
protein transport GO:0015031 132 0.046
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.045
enzyme linked receptor protein signaling pathway GO:0007167 116 0.045
negative regulation of nucleic acid templated transcription GO:1903507 117 0.045
positive regulation of phosphorylation GO:0042327 177 0.045
multi multicellular organism process GO:0044706 138 0.044
negative regulation of rna metabolic process GO:0051253 123 0.044
negative regulation of gene expression GO:0010629 199 0.044
negative regulation of signaling GO:0023057 157 0.044
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.044
negative regulation of rna biosynthetic process GO:1902679 118 0.040
positive regulation of secretion by cell GO:1903532 128 0.040
negative regulation of cellular biosynthetic process GO:0031327 161 0.040
positive regulation of nucleic acid templated transcription GO:1903508 197 0.040
mesoderm development GO:0007498 2 0.039
negative regulation of signal transduction GO:0009968 83 0.039
g protein coupled receptor signaling pathway GO:0007186 242 0.039
regulation of transferase activity GO:0051338 123 0.039
regulation of kinase activity GO:0043549 117 0.039
regulation of multicellular organismal development GO:2000026 376 0.039
positive regulation of molecular function GO:0044093 230 0.038
regulation of molecular function GO:0065009 398 0.038
homeostatic process GO:0042592 331 0.037
locomotion GO:0040011 237 0.037
macromolecule localization GO:0033036 252 0.036
secretion GO:0046903 307 0.036
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
anterior posterior pattern specification GO:0009952 1 0.036
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.036
tube development GO:0035295 89 0.036
regulation of cellular protein metabolic process GO:0032268 267 0.036
single organism reproductive process GO:0044702 297 0.035
immune system process GO:0002376 204 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
cellular component movement GO:0006928 248 0.035
cellular component assembly GO:0022607 360 0.034
positive regulation of phosphate metabolic process GO:0045937 262 0.034
regulation of cell differentiation GO:0045595 320 0.034
central nervous system development GO:0007417 311 0.034
amine metabolic process GO:0009308 38 0.034
positive regulation of transport GO:0051050 245 0.034
positive regulation of cellular protein metabolic process GO:0032270 167 0.034
positive regulation of protein phosphorylation GO:0001934 135 0.034
negative regulation of metabolic process GO:0009892 331 0.033
cellular amino acid metabolic process GO:0006520 107 0.032
renal system development GO:0072001 67 0.032
negative regulation of protein metabolic process GO:0051248 114 0.032
negative regulation of cell differentiation GO:0045596 99 0.032
digestive system development GO:0055123 41 0.032
neuron projection development GO:0031175 273 0.032
cellular response to oxygen containing compound GO:1901701 386 0.031
positive regulation of neurogenesis GO:0050769 165 0.031
regulation of protein metabolic process GO:0051246 289 0.031
response to metal ion GO:0010038 253 0.031
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.031
cell adhesion GO:0007155 110 0.031
cell morphogenesis involved in differentiation GO:0000904 119 0.031
positive regulation of nervous system development GO:0051962 178 0.031
response to wounding GO:0009611 254 0.030
cell cell signaling GO:0007267 335 0.030
cellular component biogenesis GO:0044085 368 0.030
cellular response to lipid GO:0071396 201 0.030
proteolysis GO:0006508 175 0.030
positive regulation of mapk cascade GO:0043410 92 0.029
negative regulation of multicellular organismal process GO:0051241 203 0.029
peptidyl amino acid modification GO:0018193 126 0.029
secretion by cell GO:0032940 248 0.028
regulation of protein phosphorylation GO:0001932 183 0.028
positive regulation of protein modification process GO:0031401 142 0.028
positive regulation of cellular component organization GO:0051130 200 0.028
neuron development GO:0048666 286 0.028
regulation of protein kinase activity GO:0045859 105 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.027
regulation of cell proliferation GO:0042127 359 0.027
catabolic process GO:0009056 351 0.027
establishment of protein localization GO:0045184 141 0.027
positive regulation of kinase activity GO:0033674 77 0.026
protein complex assembly GO:0006461 263 0.026
cell projection organization GO:0030030 302 0.026
axon development GO:0061564 96 0.026
neuron differentiation GO:0030182 368 0.026
cellular amine metabolic process GO:0044106 38 0.026
response to growth factor GO:0070848 189 0.026
motor neuron axon guidance GO:0008045 1 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
regulation of map kinase activity GO:0043405 53 0.025
positive regulation of protein kinase activity GO:0045860 73 0.025
reproductive system development GO:0061458 128 0.025
positive regulation of map kinase activity GO:0043406 46 0.025
negative regulation of response to stimulus GO:0048585 155 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
positive regulation of rna biosynthetic process GO:1902680 197 0.024
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.024
regulation of catalytic activity GO:0050790 304 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
regulation of cell projection organization GO:0031344 175 0.024
negative regulation of transport GO:0051051 136 0.024
tube formation GO:0035148 3 0.024
head development GO:0060322 247 0.024
cardiovascular system development GO:0072358 134 0.023
regulation of smooth muscle cell proliferation GO:0048660 75 0.023
female pregnancy GO:0007565 122 0.023
regulation of nucleotide metabolic process GO:0006140 117 0.023
regulation of protein transport GO:0051223 68 0.023
protein complex subunit organization GO:0071822 302 0.023
gastrulation GO:0007369 2 0.023
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.022
regulation of cell development GO:0060284 263 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
organ morphogenesis GO:0009887 75 0.022
muscle system process GO:0003012 115 0.022
embryonic skeletal system development GO:0048706 3 0.022
response to ketone GO:1901654 182 0.022
negative regulation of developmental process GO:0051093 125 0.022
single organism organelle organization GO:1902589 180 0.022
positive regulation of developmental process GO:0051094 283 0.022
skeletal system development GO:0001501 41 0.022
tube morphogenesis GO:0035239 23 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
response to estradiol GO:0032355 164 0.021
single organism cellular localization GO:1902580 102 0.021
anatomical structure morphogenesis GO:0009653 298 0.021
reproductive process GO:0022414 372 0.021
synaptic transmission GO:0007268 235 0.021
neuron death GO:0070997 127 0.021
circulatory system process GO:0003013 183 0.021
calcium ion homeostasis GO:0055074 162 0.020
brain development GO:0007420 247 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
oxoacid metabolic process GO:0043436 290 0.020
organ formation GO:0048645 3 0.020
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.020
regulation of stem cell differentiation GO:2000736 2 0.020
blood circulation GO:0008015 183 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
carboxylic acid metabolic process GO:0019752 289 0.019
organic substance catabolic process GO:1901575 316 0.019
multi organism reproductive process GO:0044703 262 0.019
cellular protein localization GO:0034613 122 0.019
spindle organization GO:0007051 2 0.019
cell type specific apoptotic process GO:0097285 134 0.019
forebrain development GO:0030900 98 0.019
inflammatory response GO:0006954 150 0.019
regulation of cellular catabolic process GO:0031329 101 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
nuclear transport GO:0051169 49 0.018
regulation of embryonic development GO:0045995 2 0.018
mitotic spindle organization GO:0007052 2 0.018
response to cytokine GO:0034097 215 0.018
vesicle mediated transport GO:0016192 181 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
gliogenesis GO:0042063 93 0.018
cellular response to peptide GO:1901653 133 0.018
programmed cell death GO:0012501 392 0.018
epithelium development GO:0060429 96 0.017
regulation of secretion by cell GO:1903530 208 0.017
digestive tract development GO:0048565 39 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
regulation of homeostatic process GO:0032844 101 0.017
cardiac chamber development GO:0003205 1 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
positive regulation of cell development GO:0010720 176 0.017
regulation of programmed cell death GO:0043067 341 0.017
circulatory system development GO:0072359 134 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
regulation of anatomical structure size GO:0090066 135 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
response to inorganic substance GO:0010035 377 0.017
response to glucocorticoid GO:0051384 223 0.017
cellular catabolic process GO:0044248 295 0.017
organic acid metabolic process GO:0006082 292 0.017
behavior GO:0007610 205 0.017
regulation of secretion GO:0051046 224 0.016
response to peptide hormone GO:0043434 278 0.016
ras protein signal transduction GO:0007265 29 0.016
axonogenesis GO:0007409 71 0.016
heart development GO:0007507 72 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
regulation of protein localization GO:0032880 81 0.016
regulation of apoptotic process GO:0042981 335 0.016
gland development GO:0048732 155 0.016
cognition GO:0050890 92 0.016
response to corticosteroid GO:0031960 235 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
regulation of establishment of protein localization GO:0070201 69 0.016
multicellular organism reproduction GO:0032504 233 0.016
macromolecular complex assembly GO:0065003 273 0.016
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.016
regulation of neuron projection development GO:0010975 161 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
aging GO:0007568 241 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.015
response to acid chemical GO:0001101 222 0.015
negative regulation of molecular function GO:0044092 133 0.015
cellular ketone metabolic process GO:0042180 51 0.015
reproductive structure development GO:0048608 128 0.015
cellular response to stress GO:0033554 269 0.015
mechanoreceptor differentiation GO:0042490 2 0.015
cellular component morphogenesis GO:0032989 155 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
taxis GO:0042330 67 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
regulation of membrane potential GO:0042391 110 0.015
response to transforming growth factor beta GO:0071559 46 0.014
neuron projection morphogenesis GO:0048812 122 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
glial cell differentiation GO:0010001 65 0.014
purine containing compound metabolic process GO:0072521 253 0.014
metal ion transport GO:0030001 289 0.014
embryonic pattern specification GO:0009880 1 0.014
regulation of protein import into nucleus GO:0042306 24 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
regulation of neurogenesis GO:0050767 247 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
cellular macromolecular complex assembly GO:0034622 58 0.014
cell fate determination GO:0001709 2 0.014
embryonic skeletal system morphogenesis GO:0048704 3 0.014
inner ear receptor cell differentiation GO:0060113 2 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
regulation of establishment of planar polarity GO:0090175 2 0.014
epithelial cell differentiation GO:0030855 71 0.014
positive regulation of synaptic transmission GO:0050806 62 0.014
activation of protein kinase activity GO:0032147 47 0.014
cellular response to organonitrogen compound GO:0071417 197 0.013
nucleosome organization GO:0034728 1 0.013
biological adhesion GO:0022610 110 0.013
cyclic nucleotide metabolic process GO:0009187 80 0.013
cell motility GO:0048870 202 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
salivary gland development GO:0007431 3 0.013
regulation of nervous system development GO:0051960 264 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
synaptic vesicle transport GO:0048489 23 0.013
chromosome organization GO:0051276 36 0.013
cell part morphogenesis GO:0032990 123 0.013
regulation of muscle contraction GO:0006937 53 0.013
reproduction GO:0000003 245 0.013
muscle organ morphogenesis GO:0048644 1 0.013
localization of cell GO:0051674 202 0.013
protein localization to organelle GO:0033365 57 0.013
protein targeting GO:0006605 61 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
protein oligomerization GO:0051259 191 0.013
rhythmic process GO:0048511 156 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
protein autophosphorylation GO:0046777 66 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.012
axis specification GO:0009798 4 0.012
apoptotic process GO:0006915 381 0.012
cell cycle GO:0007049 101 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
response to radiation GO:0009314 137 0.012
chemical homeostasis GO:0048878 292 0.012
macromolecule catabolic process GO:0009057 58 0.012
single organism membrane organization GO:0044802 74 0.012
regulation of nucleocytoplasmic transport GO:0046822 28 0.012
divalent metal ion transport GO:0070838 132 0.012
single organism intracellular transport GO:1902582 166 0.012
single organism behavior GO:0044708 130 0.012
cell morphogenesis GO:0000902 142 0.012
regulation of neuron apoptotic process GO:0043523 83 0.012
non canonical wnt signaling pathway GO:0035567 3 0.011
cardiac ventricle development GO:0003231 1 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
protein import into nucleus GO:0006606 35 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
regulation of protein secretion GO:0050708 28 0.011
negative regulation of cell death GO:0060548 229 0.011
muscle cell proliferation GO:0033002 84 0.011
positive regulation of secretion GO:0051047 140 0.011
cellular macromolecule localization GO:0070727 122 0.011
kidney development GO:0001822 67 0.011
intracellular transport GO:0046907 185 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
inner ear morphogenesis GO:0042472 1 0.011
cartilage development GO:0051216 22 0.011
regulation of stress activated mapk cascade GO:0032872 23 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
nucleotide metabolic process GO:0009117 279 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
regulation of b cell differentiation GO:0045577 1 0.011
regulation of blood vessel size GO:0050880 89 0.011
sex differentiation GO:0007548 113 0.011
gtp metabolic process GO:0046039 72 0.011
cytoplasmic transport GO:0016482 115 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
response to peptide GO:1901652 292 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
positive regulation of protein transport GO:0051222 41 0.010
regulation of catabolic process GO:0009894 113 0.010
response to dexamethasone GO:0071548 49 0.010
urogenital system development GO:0001655 78 0.010
regulation of response to stress GO:0080134 126 0.010
regulation of fat cell differentiation GO:0045598 3 0.010
peptidyl tyrosine modification GO:0018212 72 0.010
sensory organ development GO:0007423 74 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.010
protein targeting to nucleus GO:0044744 35 0.010
lipid metabolic process GO:0006629 283 0.010
dephosphorylation GO:0016311 98 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
rna localization GO:0006403 4 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
cellular chemical homeostasis GO:0055082 247 0.010
protein secretion GO:0009306 34 0.010
regulation of ion transport GO:0043269 245 0.010

Sh2b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.016
organ system cancer DOID:0050686 0 0.016
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011