Rattus norvegicus

0 known processes

Sh2d1a

SH2 domain protein 1A

(Aliases: RGD1562408)

Sh2d1a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
transcription dna templated GO:0006351 377 0.171
regulation of rna biosynthetic process GO:2001141 381 0.170
regulation of rna metabolic process GO:0051252 391 0.159
immune system process GO:0002376 204 0.159
Mouse
rna biosynthetic process GO:0032774 380 0.146
rna metabolic process GO:0016070 406 0.144
regulation of nucleic acid templated transcription GO:1903506 380 0.136
regulation of transcription dna templated GO:0006355 374 0.131
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.108
negative regulation of rna metabolic process GO:0051253 123 0.085
transcription from rna polymerase ii promoter GO:0006366 252 0.085
negative regulation of cellular metabolic process GO:0031324 281 0.082
positive regulation of multicellular organismal process GO:0051240 387 0.079
chemical homeostasis GO:0048878 292 0.077
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.075
negative regulation of biosynthetic process GO:0009890 168 0.072
positive regulation of transport GO:0051050 245 0.071
positive regulation of regulatory t cell differentiation GO:0045591 2 0.070
response to extracellular stimulus GO:0009991 380 0.069
response to nutrient levels GO:0031667 370 0.067
regulation of cellular localization GO:0060341 263 0.067
response to nutrient GO:0007584 248 0.065
negative regulation of metabolic process GO:0009892 331 0.064
immune response GO:0006955 104 0.063
Mouse
positive regulation of biosynthetic process GO:0009891 319 0.063
positive regulation of gene expression GO:0010628 244 0.062
cellular divalent inorganic cation homeostasis GO:0072503 162 0.061
response to biotic stimulus GO:0009607 226 0.060
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.058
divalent inorganic cation homeostasis GO:0072507 165 0.056
response to wounding GO:0009611 254 0.055
regulation of molecular function GO:0065009 398 0.055
metal ion homeostasis GO:0055065 186 0.054
nucleic acid templated transcription GO:0097659 379 0.054
positive regulation of rna biosynthetic process GO:1902680 197 0.053
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.052
cellular ion homeostasis GO:0006873 184 0.052
response to growth factor GO:0070848 189 0.052
cellular calcium ion homeostasis GO:0006874 160 0.051
homeostatic process GO:0042592 331 0.051
regulation of regulatory t cell differentiation GO:0045589 2 0.051
positive regulation of cellular biosynthetic process GO:0031328 295 0.051
negative regulation of nucleic acid templated transcription GO:1903507 117 0.049
negative regulation of cellular biosynthetic process GO:0031327 161 0.048
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.047
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.046
secretion GO:0046903 307 0.046
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 2 0.046
Mouse
cellular chemical homeostasis GO:0055082 247 0.044
regulation of neurogenesis GO:0050767 247 0.044
cellular homeostasis GO:0019725 252 0.044
response to cytokine GO:0034097 215 0.043
regulation of alpha beta t cell activation GO:0046634 2 0.043
positive regulation of response to stimulus GO:0048584 285 0.042
Mouse
cellular response to growth factor stimulus GO:0071363 162 0.042
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.042
protein complex subunit organization GO:0071822 302 0.042
response to peptide hormone GO:0043434 278 0.041
cytosolic calcium ion homeostasis GO:0051480 140 0.041
negative regulation of macromolecule metabolic process GO:0010605 260 0.040
leukocyte differentiation GO:0002521 30 0.040
response to external biotic stimulus GO:0043207 221 0.039
regulation of secretion GO:0051046 224 0.039
macromolecular complex subunit organization GO:0043933 339 0.039
behavior GO:0007610 205 0.038
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.037
ion homeostasis GO:0050801 212 0.037
cell activation GO:0001775 97 0.037
negative regulation of cell death GO:0060548 229 0.037
negative regulation of gene expression GO:0010629 199 0.036
cellular cation homeostasis GO:0030003 180 0.035
cellular component movement GO:0006928 248 0.035
regulation of immune response to tumor cell GO:0002837 3 0.035
negative regulation of rna biosynthetic process GO:1902679 118 0.035
immune effector process GO:0002252 53 0.035
Mouse
regulation of lymphocyte chemotaxis GO:1901623 1 0.034
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.034
regulation of protein modification process GO:0031399 194 0.034
positive regulation of transcription dna templated GO:0045893 197 0.033
response to molecule of bacterial origin GO:0002237 194 0.033
leukocyte activation GO:0045321 76 0.033
localization of cell GO:0051674 202 0.033
aging GO:0007568 241 0.033
nitrogen compound transport GO:0071705 229 0.033
positive regulation of cell proliferation GO:0008284 249 0.032
positive regulation of nucleic acid templated transcription GO:1903508 197 0.032
organophosphate metabolic process GO:0019637 370 0.032
inflammatory response GO:0006954 150 0.032
secretion by cell GO:0032940 248 0.032
cellular component biogenesis GO:0044085 368 0.031
regulation of signal transduction GO:0009966 318 0.030
positive regulation of developmental process GO:0051094 283 0.030
negative regulation of transcription dna templated GO:0045892 116 0.030
positive regulation of rna metabolic process GO:0051254 203 0.030
positive regulation of cell development GO:0010720 176 0.030
response to oxidative stress GO:0006979 186 0.029
macromolecular complex assembly GO:0065003 273 0.029
cell projection organization GO:0030030 302 0.029
response to hydrogen peroxide GO:0042542 89 0.029
regulation of cell differentiation GO:0045595 320 0.029
cell motility GO:0048870 202 0.029
regulation of phosphorus metabolic process GO:0051174 349 0.028
protein complex biogenesis GO:0070271 263 0.028
positive regulation of cell migration GO:0030335 96 0.028
programmed cell death GO:0012501 392 0.028
cellular response to stress GO:0033554 269 0.028
positive regulation of neurogenesis GO:0050769 165 0.028
cellular component assembly GO:0022607 360 0.028
regulation of secretion by cell GO:1903530 208 0.027
regulation of neuron death GO:1901214 115 0.027
single organism biosynthetic process GO:0044711 342 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
protein phosphorylation GO:0006468 345 0.026
positive regulation of protein modification process GO:0031401 142 0.026
purine containing compound metabolic process GO:0072521 253 0.026
regulation of locomotion GO:0040012 148 0.026
calcium ion homeostasis GO:0055074 162 0.026
regulation of t cell chemotaxis GO:0010819 1 0.025
positive regulation of phosphate metabolic process GO:0045937 262 0.025
negative regulation of immune response to tumor cell GO:0002838 2 0.025
response to inorganic substance GO:0010035 377 0.025
regulation of programmed cell death GO:0043067 341 0.025
cellular metal ion homeostasis GO:0006875 172 0.025
anatomical structure morphogenesis GO:0009653 298 0.025
cellular response to external stimulus GO:0071496 118 0.025
protein complex assembly GO:0006461 263 0.025
t cell receptor signaling pathway GO:0050852 1 0.025
positive regulation of cellular component movement GO:0051272 102 0.025
positive regulation of cell differentiation GO:0045597 217 0.025
reproductive process GO:0022414 372 0.025
response to acid chemical GO:0001101 222 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.024
amine metabolic process GO:0009308 38 0.024
single organism intracellular transport GO:1902582 166 0.024
neuron differentiation GO:0030182 368 0.024
neuron projection development GO:0031175 273 0.024
metal ion transport GO:0030001 289 0.024
muscle system process GO:0003012 115 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
divalent inorganic cation transport GO:0072511 134 0.024
intracellular transport GO:0046907 185 0.024
cellular response to lipid GO:0071396 201 0.024
alpha beta t cell differentiation GO:0046632 2 0.024
defense response GO:0006952 194 0.024
Mouse
carbohydrate derivative metabolic process GO:1901135 346 0.023
response to tumor cell GO:0002347 4 0.023
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
positive regulation of alpha beta t cell activation GO:0046635 2 0.023
regulation of interferon gamma production GO:0032649 3 0.023
intracellular signal transduction GO:0035556 314 0.022
regulation of cell migration GO:0030334 128 0.022
regulation of cell development GO:0060284 263 0.022
cell migration GO:0016477 197 0.022
cellular response to oxygen containing compound GO:1901701 386 0.021
regulation of apoptotic process GO:0042981 335 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
positive regulation of b cell mediated immunity GO:0002714 2 0.021
positive regulation of necroptotic process GO:0060545 2 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.021
locomotion GO:0040011 237 0.021
cytoskeleton organization GO:0007010 111 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
positive regulation of immune response GO:0050778 42 0.021
Mouse
glycosyl compound metabolic process GO:1901657 182 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
response to metal ion GO:0010038 253 0.020
central nervous system development GO:0007417 311 0.020
transmembrane transport GO:0055085 412 0.020
single organism organelle organization GO:1902589 180 0.020
regulation of cytokine production GO:0001817 56 0.020
positive regulation of secretion by cell GO:1903532 128 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
immune system development GO:0002520 41 0.020
cellular amine metabolic process GO:0044106 38 0.020
biological adhesion GO:0022610 110 0.019
regulation of cell motility GO:2000145 131 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
cardiovascular system development GO:0072358 134 0.019
regulation of cellular component movement GO:0051270 150 0.019
positive regulation of t cell migration GO:2000406 1 0.019
response to reactive oxygen species GO:0000302 120 0.019
peptidyl amino acid modification GO:0018193 126 0.019
actin cytoskeleton organization GO:0030036 73 0.019
cellular response to oxidative stress GO:0034599 76 0.018
organelle organization GO:0006996 266 0.018
regulation of necroptotic process GO:0060544 2 0.018
reactive oxygen species biosynthetic process GO:1903409 8 0.018
regulation of catalytic activity GO:0050790 304 0.018
cation homeostasis GO:0055080 195 0.018
single organism reproductive process GO:0044702 297 0.018
alpha beta t cell activation GO:0046631 3 0.018
response to other organism GO:0051707 220 0.018
response to peptide GO:1901652 292 0.018
hematopoietic or lymphoid organ development GO:0048534 36 0.018
regulation of ion transport GO:0043269 245 0.018
wound healing GO:0042060 122 0.018
positive regulation of molecular function GO:0044093 230 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
negative regulation of transport GO:0051051 136 0.018
response to estrogen GO:0043627 232 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
hormone transport GO:0009914 121 0.018
immunoglobulin mediated immune response GO:0016064 4 0.018
regulation of cellular component organization GO:0051128 368 0.018
regulation of hormone levels GO:0010817 187 0.018
response to bacterium GO:0009617 200 0.018
circulatory system process GO:0003013 183 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
response to ethanol GO:0045471 162 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
negative regulation of response to tumor cell GO:0002835 2 0.017
circulatory system development GO:0072359 134 0.017
cellular response to vitamin k GO:0071307 1 0.017
immune response to tumor cell GO:0002418 3 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
positive regulation of natural killer cell mediated immunity GO:0002717 2 0.017
Mouse
positive regulation of protein phosphorylation GO:0001934 135 0.017
multi organism reproductive process GO:0044703 262 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.016
cellular response to extracellular stimulus GO:0031668 73 0.016
regulation of cell proliferation GO:0042127 359 0.016
negative regulation of natural killer cell mediated immune response to tumor cell GO:0002856 1 0.016
regulation of protein metabolic process GO:0051246 289 0.016
apoptotic process GO:0006915 381 0.016
antigen receptor mediated signaling pathway GO:0050851 1 0.016
regulation of intracellular transport GO:0032386 65 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
positive regulation of nervous system development GO:0051962 178 0.016
regulation of defense response GO:0031347 68 0.016
Mouse
negative regulation of immune system process GO:0002683 39 0.016
regulation of cd4 positive alpha beta t cell activation GO:2000514 1 0.016
cytoplasmic transport GO:0016482 115 0.016
cellular response to nitrogen compound GO:1901699 210 0.016
cd4 positive alpha beta t cell activation GO:0035710 1 0.016
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.016
positive regulation of defense response GO:0031349 37 0.016
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
pseudopodium assembly GO:0031269 3 0.015
cation transport GO:0006812 382 0.015
signal release GO:0023061 145 0.015
b cell differentiation GO:0030183 2 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.015
cytokine mediated signaling pathway GO:0019221 43 0.015
cell adhesion GO:0007155 110 0.015
nucleoside metabolic process GO:0009116 179 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
regulation of calcium ion transport GO:0051924 77 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
regulation of immune system process GO:0002682 123 0.015
Mouse
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.015
lymphocyte chemotaxis GO:0048247 3 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
reactive nitrogen species metabolic process GO:2001057 1 0.015
regulation of lymphocyte migration GO:2000401 1 0.015
response to amino acid GO:0043200 75 0.015
regulation of response to stress GO:0080134 126 0.015
Mouse
hemopoiesis GO:0030097 34 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
response to oxygen levels GO:0070482 265 0.015
response to corticosteroid GO:0031960 235 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
ras protein signal transduction GO:0007265 29 0.015
hormone secretion GO:0046879 115 0.015
regulation of membrane potential GO:0042391 110 0.015
negative regulation of homeostatic process GO:0032845 47 0.015
lipid metabolic process GO:0006629 283 0.015
neuron death GO:0070997 127 0.015
regulation of metal ion transport GO:0010959 118 0.014
nucleotide metabolic process GO:0009117 279 0.014
positive regulation of protein kinase activity GO:0045860 73 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
regulation of nervous system development GO:0051960 264 0.014
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.014
negative regulation of cell communication GO:0010648 158 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
divalent metal ion transport GO:0070838 132 0.014
response to lipopolysaccharide GO:0032496 191 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
cell cell signaling GO:0007267 335 0.014
Human
pseudopodium organization GO:0031268 3 0.014
regulation of hormone secretion GO:0046883 106 0.014
cellular response to alcohol GO:0097306 87 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
lymphocyte activation GO:0046649 43 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
regeneration GO:0031099 163 0.014
response to decreased oxygen levels GO:0036293 237 0.014
positive regulation of cell death GO:0010942 184 0.014
sequestering of calcium ion GO:0051208 8 0.014
regulation of response to external stimulus GO:0032101 106 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
cellular response to ketone GO:1901655 51 0.014
purine containing compound catabolic process GO:0072523 138 0.013
regulation of homeostatic process GO:0032844 101 0.013
negative regulation of signaling GO:0023057 157 0.013
growth GO:0040007 165 0.013
regulation of system process GO:0044057 208 0.013
sequestering of metal ion GO:0051238 9 0.013
negative regulation of neuron death GO:1901215 69 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
organic acid metabolic process GO:0006082 292 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
cation transmembrane transport GO:0098655 263 0.013
cellular response to lipopolysaccharide GO:0071222 55 0.013
response to tumor necrosis factor GO:0034612 56 0.013
necroptotic process GO:0070266 2 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
t cell activation GO:0042110 29 0.012
aromatic compound catabolic process GO:0019439 168 0.012
negative regulation of innate immune response GO:0045824 4 0.012
sexual reproduction GO:0019953 148 0.012
regulation of fc receptor mediated stimulatory signaling pathway GO:0060368 3 0.012
catabolic process GO:0009056 351 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
positive regulation of endothelial cell migration GO:0010595 4 0.012
proteolysis GO:0006508 175 0.012
cellular ketone metabolic process GO:0042180 51 0.012
regulation of catabolic process GO:0009894 113 0.012
positive regulation of lymphocyte activation GO:0051251 25 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
acute inflammatory response GO:0002526 58 0.012
viral transcription GO:0019083 2 0.012
regulation of mesenchymal cell proliferation GO:0010464 4 0.012
oxoacid metabolic process GO:0043436 290 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
regulation of neuron projection development GO:0010975 161 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
regulation of response to wounding GO:1903034 69 0.012
tissue development GO:0009888 252 0.012
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 1 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
response to carbohydrate GO:0009743 183 0.012
salivary gland morphogenesis GO:0007435 1 0.011
lymphocyte migration GO:0072676 3 0.011
regulation of immunoglobulin mediated immune response GO:0002889 2 0.011
cellular response to reactive oxygen species GO:0034614 55 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
positive regulation of lipid kinase activity GO:0090218 2 0.011
t cell migration GO:0072678 2 0.011
heterocycle catabolic process GO:0046700 167 0.011
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.011
regulation of phosphate metabolic process GO:0019220 349 0.011
single organism catabolic process GO:0044712 283 0.011
cytokine production GO:0001816 61 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
interferon gamma production GO:0032609 3 0.011
neuron development GO:0048666 286 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
regulation of interleukin 1 alpha biosynthetic process GO:0050721 1 0.011
reproduction GO:0000003 245 0.011
regulation of peptide secretion GO:0002791 82 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
regulation of neuron differentiation GO:0045664 208 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
response to vitamin GO:0033273 131 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
negative regulation of developmental process GO:0051093 125 0.011
carboxylic acid metabolic process GO:0019752 289 0.011
negative regulation of molecular function GO:0044092 133 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
protein oligomerization GO:0051259 191 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
positive regulation of locomotion GO:0040017 102 0.011
programmed necrotic cell death GO:0097300 2 0.011
cellular response to acid chemical GO:0071229 75 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
positive regulation of signal transduction GO:0009967 175 0.011
cellular component morphogenesis GO:0032989 155 0.011
response to mechanical stimulus GO:0009612 134 0.010
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.010
macromolecule localization GO:0033036 252 0.010
actin filament based process GO:0030029 86 0.010
calcium ion transport into cytosol GO:0060402 38 0.010
nucleoside triphosphate metabolic process GO:0009141 144 0.010
nucleotide catabolic process GO:0009166 139 0.010
purine ribonucleotide catabolic process GO:0009154 136 0.010
response to hexose GO:0009746 144 0.010
response to estradiol GO:0032355 164 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010
positive regulation of cell motility GO:2000147 97 0.010
myeloid leukocyte activation GO:0002274 36 0.010
cellular response to organonitrogen compound GO:0071417 197 0.010
response to hypoxia GO:0001666 231 0.010

Sh2d1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.011
musculoskeletal system disease DOID:17 0 0.011