Rattus norvegicus

204 known processes

Shc1

SHC (Src homology 2 domain containing) transforming protein 1

(Aliases: P66shc)

Shc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
enzyme linked receptor protein signaling pathway GO:0007167 116 0.206
regulation of signal transduction GO:0009966 318 0.198
intracellular signal transduction GO:0035556 314 0.190
oxoacid metabolic process GO:0043436 290 0.173
cellular amino acid metabolic process GO:0006520 107 0.166
organic acid metabolic process GO:0006082 292 0.156
cellular response to stress GO:0033554 269 0.126
Worm
regulation of intracellular signal transduction GO:1902531 218 0.125
signal transduction by phosphorylation GO:0023014 144 0.122
response to mechanical stimulus GO:0009612 134 0.119
amine metabolic process GO:0009308 38 0.119
cellular response to oxygen containing compound GO:1901701 386 0.116
positive regulation of intracellular signal transduction GO:1902533 138 0.112
regulation of cellular protein metabolic process GO:0032268 267 0.111
negative regulation of protein metabolic process GO:0051248 114 0.110
developmental process involved in reproduction GO:0003006 159 0.110
regulation of protein metabolic process GO:0051246 289 0.110
response to metal ion GO:0010038 253 0.105
Worm
single organism reproductive process GO:0044702 297 0.105
regulation of cellular amine metabolic process GO:0033238 8 0.105
peptidyl tyrosine phosphorylation GO:0018108 72 0.104
cellular response to hormone stimulus GO:0032870 247 0.103
reproductive system development GO:0061458 128 0.103
cellular response to nitrogen compound GO:1901699 210 0.102
positive regulation of signal transduction GO:0009967 175 0.100
carboxylic acid metabolic process GO:0019752 289 0.099
positive regulation of mapk cascade GO:0043410 92 0.096
cellular response to insulin stimulus GO:0032869 81 0.091
positive regulation of cell communication GO:0010647 271 0.091
regulation of protein phosphorylation GO:0001932 183 0.091
cellular response to peptide GO:1901653 133 0.086
positive regulation of signaling GO:0023056 270 0.085
reproductive structure development GO:0048608 128 0.083
reproductive process GO:0022414 372 0.081
positive regulation of response to stimulus GO:0048584 285 0.080
positive regulation of phosphorus metabolic process GO:0010562 262 0.076
cellular ketone metabolic process GO:0042180 51 0.076
olfactory learning GO:0008355 1 0.072
cellular amine metabolic process GO:0044106 38 0.071
negative regulation of cellular metabolic process GO:0031324 281 0.071
regulation of protein modification process GO:0031399 194 0.071
cellular response to peptide hormone stimulus GO:0071375 120 0.070
negative regulation of signaling GO:0023057 157 0.070
negative regulation of molecular function GO:0044092 133 0.069
negative regulation of macromolecule metabolic process GO:0010605 260 0.069
negative regulation of metabolic process GO:0009892 331 0.068
response to insulin GO:0032868 133 0.066
carbohydrate derivative metabolic process GO:1901135 346 0.065
peptidyl amino acid modification GO:0018193 126 0.065
protein phosphorylation GO:0006468 345 0.064
negative regulation of signal transduction GO:0009968 83 0.062
regulation of cellular ketone metabolic process GO:0010565 27 0.059
regulation of phosphorylation GO:0042325 248 0.058
epithelium development GO:0060429 96 0.058
regulation of cellular amino acid metabolic process GO:0006521 2 0.058
homeostatic process GO:0042592 331 0.056
erbb signaling pathway GO:0038127 23 0.053
Mouse Fly
response to nutrient GO:0007584 248 0.052
apoptotic process GO:0006915 381 0.052
central nervous system development GO:0007417 311 0.051
mapk cascade GO:0000165 140 0.050
rhythmic process GO:0048511 156 0.050
response to peptide GO:1901652 292 0.049
cell motility GO:0048870 202 0.049
response to ethanol GO:0045471 162 0.047
protein heterooligomerization GO:0051291 89 0.047
olfactory behavior GO:0042048 2 0.047
nucleobase containing small molecule metabolic process GO:0055086 316 0.047
programmed cell death GO:0012501 392 0.047
positive regulation of phosphate metabolic process GO:0045937 262 0.046
chemosensory behavior GO:0007635 2 0.043
negative regulation of cell communication GO:0010648 158 0.042
cellular response to endogenous stimulus GO:0071495 377 0.042
cellular response to organonitrogen compound GO:0071417 197 0.042
regulation of protein kinase activity GO:0045859 105 0.041
regulation of cellular component organization GO:0051128 368 0.041
response to estrogen GO:0043627 232 0.040
regulation of rna metabolic process GO:0051252 391 0.039
Fly
nucleic acid templated transcription GO:0097659 379 0.037
Fly
negative regulation of phosphorus metabolic process GO:0010563 80 0.037
regulation of programmed cell death GO:0043067 341 0.036
response to extracellular stimulus GO:0009991 380 0.036
ovulation cycle GO:0042698 67 0.036
response to growth factor GO:0070848 189 0.035
peptidyl tyrosine modification GO:0018212 72 0.035
transcription dna templated GO:0006351 377 0.035
Fly
cognition GO:0050890 92 0.035
sulfur compound metabolic process GO:0006790 70 0.035
cellular response to abiotic stimulus GO:0071214 85 0.034
cellular component assembly GO:0022607 360 0.033
reactive oxygen species metabolic process GO:0072593 37 0.033
regulation of nucleic acid templated transcription GO:1903506 380 0.032
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.032
heterocycle catabolic process GO:0046700 167 0.032
regulation of phosphate metabolic process GO:0019220 349 0.032
regulation of cell differentiation GO:0045595 320 0.031
nitrogen compound transport GO:0071705 229 0.031
response to inorganic substance GO:0010035 377 0.030
organophosphate biosynthetic process GO:0090407 143 0.030
regulation of interleukin 6 production GO:0032675 12 0.030
nucleoside phosphate biosynthetic process GO:1901293 102 0.029
cellular catabolic process GO:0044248 295 0.029
nucleoside phosphate metabolic process GO:0006753 283 0.029
gonad development GO:0008406 104 0.029
positive regulation of developmental process GO:0051094 283 0.029
regulation of phosphorus metabolic process GO:0051174 349 0.029
multicellular organismal reproductive process GO:0048609 233 0.029
glial cell differentiation GO:0010001 65 0.028
nucleotide metabolic process GO:0009117 279 0.028
regulation of cell morphogenesis GO:0022604 77 0.028
regulation of cell proliferation GO:0042127 359 0.028
regulation of kinase activity GO:0043549 117 0.028
organophosphate metabolic process GO:0019637 370 0.027
small gtpase mediated signal transduction GO:0007264 36 0.027
ras protein signal transduction GO:0007265 29 0.027
negative regulation of response to stimulus GO:0048585 155 0.027
negative regulation of programmed cell death GO:0043069 183 0.027
negative regulation of gene expression GO:0010629 199 0.026
regulation of mapk cascade GO:0043408 116 0.026
response to oxidative stress GO:0006979 186 0.026
response to cytokine GO:0034097 215 0.026
positive regulation of transport GO:0051050 245 0.026
organonitrogen compound biosynthetic process GO:1901566 167 0.025
positive regulation of gene expression GO:0010628 244 0.025
positive regulation of cell proliferation GO:0008284 249 0.025
carbohydrate derivative biosynthetic process GO:1901137 124 0.025
astrocyte activation GO:0048143 4 0.025
blood circulation GO:0008015 183 0.025
positive regulation of rna metabolic process GO:0051254 203 0.025
tissue development GO:0009888 252 0.025
response to nutrient levels GO:0031667 370 0.025
regulation of apoptotic process GO:0042981 335 0.024
regulation of molecular function GO:0065009 398 0.024
regulation of transcription dna templated GO:0006355 374 0.024
Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.023
interleukin 12 production GO:0032615 3 0.023
interleukin 6 production GO:0032635 12 0.023
response to lipopolysaccharide GO:0032496 191 0.023
defense response GO:0006952 194 0.023
Fly
negative regulation of apoptotic process GO:0043066 181 0.023
development of primary sexual characteristics GO:0045137 107 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.023
multicellular organism reproduction GO:0032504 233 0.023
chemical homeostasis GO:0048878 292 0.022
tissue morphogenesis GO:0048729 22 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
neuron projection development GO:0031175 273 0.022
response to peptide hormone GO:0043434 278 0.022
sex differentiation GO:0007548 113 0.022
response to wounding GO:0009611 254 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
response to radiation GO:0009314 137 0.022
positive regulation of nucleic acid templated transcription GO:1903508 197 0.022
regeneration GO:0031099 163 0.021
protein oligomerization GO:0051259 191 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
response to transition metal nanoparticle GO:1990267 122 0.021
inflammatory response GO:0006954 150 0.021
learning or memory GO:0007611 90 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
multicellular organism growth GO:0035264 1 0.021
nucleotide biosynthetic process GO:0009165 98 0.020
brain development GO:0007420 247 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.020
secretion by cell GO:0032940 248 0.020
regulation of transferase activity GO:0051338 123 0.020
response to vitamin GO:0033273 131 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
Fly
organic anion transport GO:0015711 132 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.019
regulation of reactive oxygen species metabolic process GO:2000377 26 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
rna metabolic process GO:0016070 406 0.019
Fly
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
cell morphogenesis GO:0000902 142 0.019
negative regulation of catalytic activity GO:0043086 103 0.018
regulation of neuron death GO:1901214 115 0.018
metal ion homeostasis GO:0055065 186 0.018
cellular response to acid chemical GO:0071229 75 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
ion homeostasis GO:0050801 212 0.018
circulatory system process GO:0003013 183 0.018
gliogenesis GO:0042063 93 0.017
response to decreased oxygen levels GO:0036293 237 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
organic substance catabolic process GO:1901575 316 0.017
oxidation reduction process GO:0055114 304 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
negative regulation of protein phosphorylation GO:0001933 44 0.016
cellular response to cytokine stimulus GO:0071345 127 0.016
ion transmembrane transport GO:0034220 365 0.016
cytokine mediated signaling pathway GO:0019221 43 0.016
morphogenesis of an epithelium GO:0002009 20 0.016
cellular component biogenesis GO:0044085 368 0.016
gland development GO:0048732 155 0.016
single organism carbohydrate metabolic process GO:0044723 118 0.016
protein complex assembly GO:0006461 263 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
reproduction GO:0000003 245 0.016
catabolic process GO:0009056 351 0.016
single organism behavior GO:0044708 130 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
response to ketone GO:1901654 182 0.015
salivary gland development GO:0007431 3 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
development of primary female sexual characteristics GO:0046545 56 0.015
macromolecular complex assembly GO:0065003 273 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
negative regulation of developmental process GO:0051093 125 0.015
transmembrane transport GO:0055085 412 0.015
cell activation GO:0001775 97 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.015
neuron projection morphogenesis GO:0048812 122 0.015
regulation of anatomical structure size GO:0090066 135 0.015
female sex differentiation GO:0046660 59 0.015
cation homeostasis GO:0055080 195 0.015
cellular response to alcohol GO:0097306 87 0.015
axis specification GO:0009798 4 0.015
liver development GO:0001889 90 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
negative regulation of cell cycle g1 s phase transition GO:1902807 2 0.014
single organism biosynthetic process GO:0044711 342 0.014
regulation of organelle organization GO:0033043 80 0.014
negative regulation of cell cycle phase transition GO:1901988 4 0.014
response to estradiol GO:0032355 164 0.014
muscle cell proliferation GO:0033002 84 0.014
ribonucleotide biosynthetic process GO:0009260 85 0.013
cytokine biosynthetic process GO:0042089 3 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
learning GO:0007612 33 0.013
regulation of blood vessel size GO:0050880 89 0.013
regulation of cellular localization GO:0060341 263 0.013
anion transport GO:0006820 178 0.013
axon development GO:0061564 96 0.013
muscle structure development GO:0061061 87 0.013
placenta development GO:0001890 22 0.013
negative regulation of phosphorylation GO:0042326 57 0.013
multi organism reproductive process GO:0044703 262 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
Mouse Fly
cellular response to mechanical stimulus GO:0071260 48 0.013
actin filament organization GO:0007015 42 0.013
behavior GO:0007610 205 0.013
positive regulation of biosynthetic process GO:0009891 319 0.013
response to acid chemical GO:0001101 222 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.012
regulation of hormone levels GO:0010817 187 0.012
purine containing compound metabolic process GO:0072521 253 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
response to corticosteroid GO:0031960 235 0.012
female gonad development GO:0008585 53 0.012
sexual reproduction GO:0019953 148 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
peptide transport GO:0015833 97 0.012
regulation of catabolic process GO:0009894 113 0.012
cell cycle g1 s phase transition GO:0044843 13 0.012
regulation of multicellular organismal development GO:2000026 376 0.012
lipid localization GO:0010876 62 0.012
translation GO:0006412 35 0.012
positive regulation of kinase activity GO:0033674 77 0.012
positive regulation of cell development GO:0010720 176 0.012
cellular protein complex assembly GO:0043623 44 0.012
localization of cell GO:0051674 202 0.012
single organism organelle organization GO:1902589 180 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
adult locomotory behavior GO:0008344 4 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
positive regulation of protein modification process GO:0031401 142 0.012
hepaticobiliary system development GO:0061008 90 0.012
neuron differentiation GO:0030182 368 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
female pregnancy GO:0007565 122 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
negative regulation of transferase activity GO:0051348 29 0.012
hexose transport GO:0008645 29 0.011
negative regulation of cell death GO:0060548 229 0.011
organelle organization GO:0006996 266 0.011
regulation of nervous system development GO:0051960 264 0.011
cellular response to external stimulus GO:0071496 118 0.011
growth GO:0040007 165 0.011
regulation of receptor activity GO:0010469 29 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
regulation of catalytic activity GO:0050790 304 0.011
head development GO:0060322 247 0.011
response to biotic stimulus GO:0009607 226 0.011
regulation of defense response GO:0031347 68 0.011
regulation of tumor necrosis factor production GO:0032680 13 0.011
macromolecule catabolic process GO:0009057 58 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
hair cycle GO:0042633 3 0.011
rna biosynthetic process GO:0032774 380 0.011
Fly
protein complex subunit organization GO:0071822 302 0.011
neuron death GO:0070997 127 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
carboxylic acid transport GO:0046942 115 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
regulation of system process GO:0044057 208 0.011
response to oxygen levels GO:0070482 265 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
positive regulation of synaptic transmission GO:0050806 62 0.011
embryo development GO:0009790 49 0.011
neuron neuron synaptic transmission GO:0007270 60 0.011
regulation of neurogenesis GO:0050767 247 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
embryonic pattern specification GO:0009880 1 0.010
positive regulation of cell differentiation GO:0045597 217 0.010
positive regulation of nucleotide metabolic process GO:0045981 91 0.010
regulation of smooth muscle cell proliferation GO:0048660 75 0.010
negative regulation of phosphate metabolic process GO:0045936 80 0.010
positive regulation of cellular component biogenesis GO:0044089 55 0.010
molting cycle GO:0042303 3 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.010
hemopoiesis GO:0030097 34 0.010
chordate embryonic development GO:0043009 18 0.010
negative regulation of protein kinase activity GO:0006469 23 0.010
purine containing compound biosynthetic process GO:0072522 85 0.010

Shc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
musculoskeletal system disease DOID:17 0 0.016
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
central nervous system disease DOID:331 0 0.012