Rattus norvegicus

190 known processes

Shh

sonic hedgehog

Shh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transcription dna templated GO:0045893 197 0.369
Human Rat
cellular amide metabolic process GO:0043603 44 0.350
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.348
rna metabolic process GO:0016070 406 0.248
Human Rat
regulation of rna metabolic process GO:0051252 391 0.231
Human Rat
negative regulation of metabolic process GO:0009892 331 0.226
negative regulation of nucleic acid templated transcription GO:1903507 117 0.222
negative regulation of cellular metabolic process GO:0031324 281 0.207
cell part morphogenesis GO:0032990 123 0.193
cellular component biogenesis GO:0044085 368 0.177
transcription dna templated GO:0006351 377 0.173
Human Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.167
Rat
response to metal ion GO:0010038 253 0.167
regulation of nucleic acid templated transcription GO:1903506 380 0.165
Human Rat
response to corticosteroid GO:0031960 235 0.153
regulation of programmed cell death GO:0043067 341 0.146
head development GO:0060322 247 0.142
cellular component morphogenesis GO:0032989 155 0.141
negative regulation of macromolecule metabolic process GO:0010605 260 0.134
response to nutrient levels GO:0031667 370 0.128
cation transport GO:0006812 382 0.127
positive regulation of nucleic acid templated transcription GO:1903508 197 0.126
Human Rat
negative regulation of gene expression GO:0010629 199 0.118
negative regulation of rna biosynthetic process GO:1902679 118 0.116
anatomical structure morphogenesis GO:0009653 298 0.112
protein complex assembly GO:0006461 263 0.110
transmembrane transport GO:0055085 412 0.100
cell morphogenesis involved in differentiation GO:0000904 119 0.097
monovalent inorganic cation transport GO:0015672 172 0.096
response to purine containing compound GO:0014074 126 0.093
neuron differentiation GO:0030182 368 0.093
rna biosynthetic process GO:0032774 380 0.092
Human Rat
aging GO:0007568 241 0.092
apoptotic process GO:0006915 381 0.089
cell projection organization GO:0030030 302 0.088
macromolecular complex subunit organization GO:0043933 339 0.087
divalent metal ion transport GO:0070838 132 0.085
positive regulation of programmed cell death GO:0043068 157 0.085
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.083
Human Rat
negative regulation of rna metabolic process GO:0051253 123 0.083
programmed cell death GO:0012501 392 0.082
positive regulation of rna metabolic process GO:0051254 203 0.081
Human Rat
negative regulation of cellular biosynthetic process GO:0031327 161 0.078
cellular component assembly GO:0022607 360 0.075
positive regulation of biosynthetic process GO:0009891 319 0.075
Human Rat
response to organophosphorus GO:0046683 102 0.074
brain development GO:0007420 247 0.074
nucleic acid templated transcription GO:0097659 379 0.073
Human Rat
central nervous system development GO:0007417 311 0.073
negative regulation of transcription dna templated GO:0045892 116 0.071
positive regulation of gene expression GO:0010628 244 0.070
Human Rat
response to inorganic substance GO:0010035 377 0.070
response to peptide hormone GO:0043434 278 0.069
positive regulation of rna biosynthetic process GO:1902680 197 0.068
Human Rat
macromolecular complex assembly GO:0065003 273 0.063
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.063
Human Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.062
Rat
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.061
neuron projection morphogenesis GO:0048812 122 0.059
protein phosphorylation GO:0006468 345 0.059
cell projection morphogenesis GO:0048858 123 0.059
peptide metabolic process GO:0006518 32 0.059
neuron projection development GO:0031175 273 0.058
calcium ion transport GO:0006816 131 0.057
regulation of cellular component organization GO:0051128 368 0.056
regulation of rna biosynthetic process GO:2001141 381 0.055
Human Rat
protein homooligomerization GO:0051260 91 0.054
oxoacid metabolic process GO:0043436 290 0.053
cell morphogenesis GO:0000902 142 0.053
single organism reproductive process GO:0044702 297 0.052
intestinal absorption GO:0050892 3 0.052
negative regulation of response to stimulus GO:0048585 155 0.052
Rat
cellular response to nitrogen compound GO:1901699 210 0.052
negative regulation of programmed cell death GO:0043069 183 0.049
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.048
cellular homeostasis GO:0019725 252 0.047
response to glucocorticoid GO:0051384 223 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.046
Human Rat
positive regulation of cellular component organization GO:0051130 200 0.046
cellular metal ion homeostasis GO:0006875 172 0.044
negative regulation of cell death GO:0060548 229 0.044
protein oligomerization GO:0051259 191 0.043
response to peptide GO:1901652 292 0.043
sex differentiation GO:0007548 113 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.042
organelle organization GO:0006996 266 0.042
response to hexose GO:0009746 144 0.042
response to glucose GO:0009749 136 0.042
cellular response to steroid hormone stimulus GO:0071383 93 0.041
chemical homeostasis GO:0048878 292 0.041
protein complex biogenesis GO:0070271 263 0.041
carboxylic acid metabolic process GO:0019752 289 0.040
regulation of multicellular organismal development GO:2000026 376 0.039
metal ion transport GO:0030001 289 0.039
divalent inorganic cation transport GO:0072511 134 0.037
regulation of cell proliferation GO:0042127 359 0.037
response to extracellular stimulus GO:0009991 380 0.037
negative regulation of apoptotic process GO:0043066 181 0.036
regulation of transcription dna templated GO:0006355 374 0.036
Human Rat
negative regulation of developmental process GO:0051093 125 0.036
ion transmembrane transport GO:0034220 365 0.036
ribonucleotide metabolic process GO:0009259 231 0.036
regulation of protein metabolic process GO:0051246 289 0.035
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.035
neuron development GO:0048666 286 0.035
cellular chemical homeostasis GO:0055082 247 0.034
positive regulation of cell death GO:0010942 184 0.034
cellular amino acid metabolic process GO:0006520 107 0.034
peptide secretion GO:0002790 86 0.033
response to other organism GO:0051707 220 0.033
response to oxidative stress GO:0006979 186 0.033
regulation of synaptic transmission GO:0050804 141 0.033
negative regulation of luteinizing hormone secretion GO:0033685 4 0.033
homeostatic process GO:0042592 331 0.033
response to hypoxia GO:0001666 231 0.032
regulation of system process GO:0044057 208 0.032
g protein coupled receptor signaling pathway GO:0007186 242 0.032
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.031
response to wounding GO:0009611 254 0.031
regulation of molecular function GO:0065009 398 0.031
regulation of calcium ion transport GO:0051924 77 0.031
organophosphate metabolic process GO:0019637 370 0.031
inorganic ion transmembrane transport GO:0098660 229 0.030
response to calcium ion GO:0051592 59 0.030
organ regeneration GO:0031100 101 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.029
cellular response to organic cyclic compound GO:0071407 202 0.029
positive regulation of cellular biosynthetic process GO:0031328 295 0.029
Human Rat
protein maturation GO:0051604 68 0.029
response to oxygen levels GO:0070482 265 0.029
dendrite development GO:0016358 72 0.028
reproductive process GO:0022414 372 0.028
cellular response to external stimulus GO:0071496 118 0.028
regulation of apoptotic process GO:0042981 335 0.028
cellular response to interleukin 6 GO:0071354 9 0.027
cellular response to organonitrogen compound GO:0071417 197 0.027
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
cell type specific apoptotic process GO:0097285 134 0.027
protein heterooligomerization GO:0051291 89 0.027
negative regulation of neuron differentiation GO:0045665 62 0.027
metal ion homeostasis GO:0055065 186 0.027
cellular response to hormone stimulus GO:0032870 247 0.026
hormone transport GO:0009914 121 0.026
axonogenesis GO:0007409 71 0.026
positive regulation of cell proliferation GO:0008284 249 0.025
motor neuron axon guidance GO:0008045 1 0.025
regulation of catalytic activity GO:0050790 304 0.025
response to bacterium GO:0009617 200 0.025
positive regulation of phosphorylation GO:0042327 177 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
regulation of metal ion transport GO:0010959 118 0.024
regulation of phosphorylation GO:0042325 248 0.024
reproductive system development GO:0061458 128 0.024
cellular response to oxygen containing compound GO:1901701 386 0.024
regulation of neuron differentiation GO:0045664 208 0.024
reproduction GO:0000003 245 0.024
synaptic transmission GO:0007268 235 0.024
positive regulation of protein metabolic process GO:0051247 178 0.024
locomotion GO:0040011 237 0.024
proteolysis GO:0006508 175 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
pancreatic stellate cell proliferation GO:0072343 2 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
regeneration GO:0031099 163 0.023
organic acid metabolic process GO:0006082 292 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
cellular component movement GO:0006928 248 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.023
positive regulation of developmental process GO:0051094 283 0.023
regulation of cell projection organization GO:0031344 175 0.023
neurotransmitter transport GO:0006836 42 0.023
regulation of nervous system development GO:0051960 264 0.022
developmental growth GO:0048589 100 0.022
response to decreased oxygen levels GO:0036293 237 0.022
gamete generation GO:0007276 124 0.021
regulation of hormone levels GO:0010817 187 0.021
regulation of skeletal muscle tissue regeneration GO:0043416 2 0.021
regulation of neuron projection development GO:0010975 161 0.021
axon development GO:0061564 96 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
axon guidance GO:0007411 24 0.021
regulation of transmembrane transport GO:0034762 122 0.020
response to mineralocorticoid GO:0051385 49 0.020
response to monosaccharide GO:0034284 159 0.020
defense response GO:0006952 194 0.020
gland development GO:0048732 155 0.020
response to cytokine GO:0034097 215 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
cation homeostasis GO:0055080 195 0.020
positive regulation of apoptotic process GO:0043065 154 0.020
response to increased oxygen levels GO:0036296 45 0.020
intracellular signal transduction GO:0035556 314 0.019
response to mechanical stimulus GO:0009612 134 0.019
erythrocyte aggregation GO:0034117 1 0.019
chromosome segregation GO:0007059 2 0.019
response to toxic substance GO:0009636 133 0.019
single organism organelle organization GO:1902589 180 0.019
cellular ion homeostasis GO:0006873 184 0.019
calcium ion homeostasis GO:0055074 162 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
multicellular organism reproduction GO:0032504 233 0.018
protein complex subunit organization GO:0071822 302 0.018
insulin secretion GO:0030073 69 0.018
cellular divalent inorganic cation homeostasis GO:0072503 162 0.018
cellular response to stress GO:0033554 269 0.018
response to estrogen GO:0043627 232 0.018
negative regulation of neurogenesis GO:0050768 78 0.018
peptide transport GO:0015833 97 0.018
response to transition metal nanoparticle GO:1990267 122 0.018
cellular ketone metabolic process GO:0042180 51 0.018
anion transport GO:0006820 178 0.018
gonad development GO:0008406 104 0.018
ribose phosphate metabolic process GO:0019693 235 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
regulation of cellular protein metabolic process GO:0032268 267 0.017
regulation of neurotransmitter uptake GO:0051580 1 0.017
regulation of neurotransmitter levels GO:0001505 42 0.017
dorsal ventral axon guidance GO:0033563 1 0.017
response to nutrient GO:0007584 248 0.017
regulation of ion transmembrane transport GO:0034765 121 0.016
cellular response to acid chemical GO:0071229 75 0.016
response to camp GO:0051591 91 0.016
protein processing GO:0016485 68 0.016
lateral ventricle development GO:0021670 1 0.016
regulation of cell differentiation GO:0045595 320 0.016
hematopoietic progenitor cell differentiation GO:0002244 2 0.016
Human
salivary gland development GO:0007431 3 0.016
urogenital system development GO:0001655 78 0.016
positive regulation of protein phosphorylation GO:0001934 135 0.016
regulation of pancreatic stellate cell proliferation GO:2000229 2 0.016
regulation of growth GO:0040008 105 0.016
localization of cell GO:0051674 202 0.015
interleukin 1 secretion GO:0050701 3 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
multicellular organismal homeostasis GO:0048871 49 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
response to acid chemical GO:0001101 222 0.015
membrane organization GO:0061024 94 0.015
cellular cation homeostasis GO:0030003 180 0.015
growth GO:0040007 165 0.015
potassium ion transport GO:0006813 97 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.015
regulation of organelle organization GO:0033043 80 0.015
gliogenesis GO:0042063 93 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
regulation of dendrite development GO:0050773 59 0.014
regulation of neurogenesis GO:0050767 247 0.014
muscle system process GO:0003012 115 0.014
canalicular bile acid transport GO:0015722 5 0.014
tissue development GO:0009888 252 0.014
thyroid gland development GO:0030878 1 0.014
cellular response to lipid GO:0071396 201 0.014
response to reactive oxygen species GO:0000302 120 0.014
regulation of synaptic plasticity GO:0048167 70 0.014
complement receptor mediated signaling pathway GO:0002430 2 0.014
negative regulation of molecular function GO:0044092 133 0.014
cell migration GO:0016477 197 0.014
epithelial cell differentiation GO:0030855 71 0.014
regulation of cell growth GO:0001558 85 0.014
hepaticobiliary system development GO:0061008 90 0.014
cellular response to fluid shear stress GO:0071498 4 0.014
sexual reproduction GO:0019953 148 0.013
regulation of protein modification process GO:0031399 194 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
antigen processing and presentation GO:0019882 2 0.013
glucose homeostasis GO:0042593 75 0.013
regulation of response to wounding GO:1903034 69 0.013
ion homeostasis GO:0050801 212 0.013
regulation of response to stress GO:0080134 126 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
response to radiation GO:0009314 137 0.013
cellular response to drug GO:0035690 30 0.013
cell motility GO:0048870 202 0.013
male mating behavior GO:0060179 3 0.013
cellular response to hexose stimulus GO:0071331 65 0.013
cation transmembrane transport GO:0098655 263 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
multicellular organism growth GO:0035264 1 0.013
nitrogen compound transport GO:0071705 229 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
response to zinc ion GO:0010043 39 0.013
cellular response to vitamin e GO:0071306 3 0.013
regulation of signal transduction GO:0009966 318 0.013
Human Rat
peptide hormone secretion GO:0030072 84 0.013
regulation of locomotion GO:0040012 148 0.013
purine containing compound metabolic process GO:0072521 253 0.012
spermatogenesis GO:0007283 99 0.012
response to ethanol GO:0045471 162 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
actin filament depolymerization GO:0030042 3 0.012
response to carbohydrate GO:0009743 183 0.012
reproductive structure development GO:0048608 128 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
regulation of secretion by cell GO:1903530 208 0.012
response to external biotic stimulus GO:0043207 221 0.012
negative regulation of cell development GO:0010721 82 0.012
cell fate determination GO:0001709 2 0.012
sodium ion transmembrane transport GO:0035725 67 0.012
negative regulation of calcium ion import GO:0090281 2 0.012
amide transport GO:0042886 105 0.012
cardiovascular system development GO:0072358 134 0.012
cellular amine metabolic process GO:0044106 38 0.012
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
parasympathetic nervous system development GO:0048486 1 0.012
response to estradiol GO:0032355 164 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
metanephric s shaped body morphogenesis GO:0072284 2 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
Rat
blood vessel development GO:0001568 69 0.011
odontogenesis GO:0042476 32 0.011
amine metabolic process GO:0009308 38 0.011
response to starvation GO:0042594 59 0.011
regulation of transferase activity GO:0051338 123 0.011
cell cell signaling GO:0007267 335 0.011
Human
negative regulation of response to extracellular stimulus GO:0032105 7 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
regulation of axonogenesis GO:0050770 37 0.011
multicellular organismal water homeostasis GO:0050891 4 0.011
negative regulation of nervous system development GO:0051961 79 0.011
intracellular receptor signaling pathway GO:0030522 35 0.011
regulation of hydrolase activity GO:0051336 143 0.011
developmental process involved in reproduction GO:0003006 159 0.010
cellular response to estradiol stimulus GO:0071392 16 0.010
macromolecule localization GO:0033036 252 0.010
Human
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.010
neuron projection guidance GO:0097485 24 0.010
cellular macromolecule localization GO:0070727 122 0.010
Human
maintenance of location GO:0051235 17 0.010
camera type eye development GO:0043010 48 0.010
pro t cell differentiation GO:0002572 1 0.010
positive regulation of kinase activity GO:0033674 77 0.010
metanephric comma shaped body morphogenesis GO:0072278 2 0.010
regulation of response to external stimulus GO:0032101 106 0.010
bone development GO:0060348 25 0.010
neuron death GO:0070997 127 0.010
cellular response to monosaccharide stimulus GO:0071326 67 0.010
response to amine GO:0014075 46 0.010
developmental growth involved in morphogenesis GO:0060560 33 0.010
single organism membrane organization GO:0044802 74 0.010
negative regulation of immune system process GO:0002683 39 0.010
gastrulation GO:0007369 2 0.010
steroid hormone mediated signaling pathway GO:0043401 8 0.010

Shh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
urinary system disease DOID:18 0 0.058
disease of anatomical entity DOID:7 0 0.058
kidney disease DOID:557 0 0.025
nervous system disease DOID:863 0 0.023
acquired metabolic disease DOID:0060158 0 0.018
nutrition disease DOID:374 0 0.018
disease of metabolism DOID:0014667 0 0.018
obesity DOID:9970 0 0.018
overnutrition DOID:654 0 0.018
retinitis pigmentosa DOID:10584 0 0.014
eye disease DOID:5614 0 0.014
retinal disease DOID:5679 0 0.014
retinal degeneration DOID:8466 0 0.014
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
muscular disease DOID:0080000 0 0.012
musculoskeletal system disease DOID:17 0 0.012
muscle tissue disease DOID:66 0 0.012