Rattus norvegicus

13 known processes

Slc1a6

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

(Aliases: MGC114297,EAAT4)

Slc1a6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell cell signaling GO:0007267 335 0.457
transmembrane transport GO:0055085 412 0.194
multi multicellular organism process GO:0044706 138 0.172
inorganic cation transmembrane transport GO:0098662 202 0.141
cation transmembrane transport GO:0098655 263 0.136
cellular response to organic cyclic compound GO:0071407 202 0.124
positive regulation of multicellular organismal process GO:0051240 387 0.121
regulation of epithelial cell proliferation GO:0050678 49 0.119
carboxylic acid metabolic process GO:0019752 289 0.103
regulation of growth GO:0040008 105 0.102
neurological system process GO:0050877 219 0.093
ion transmembrane transport GO:0034220 365 0.088
organic acid metabolic process GO:0006082 292 0.088
response to peptide GO:1901652 292 0.083
cellular response to oxygen containing compound GO:1901701 386 0.080
female pregnancy GO:0007565 122 0.075
cellular homeostasis GO:0019725 252 0.072
positive regulation of cell proliferation GO:0008284 249 0.065
cellular catabolic process GO:0044248 295 0.064
cellular response to stress GO:0033554 269 0.064
intracellular signal transduction GO:0035556 314 0.063
response to extracellular stimulus GO:0009991 380 0.063
regulation of molecular function GO:0065009 398 0.063
response to mineralocorticoid GO:0051385 49 0.063
programmed cell death GO:0012501 392 0.062
growth GO:0040007 165 0.062
epithelial cell proliferation GO:0050673 54 0.061
cellular response to endogenous stimulus GO:0071495 377 0.061
regulation of phosphorylation GO:0042325 248 0.060
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.059
regulation of cell development GO:0060284 263 0.058
cell growth GO:0016049 104 0.057
neuron projection development GO:0031175 273 0.055
positive regulation of phosphate metabolic process GO:0045937 262 0.055
regulation of ion transport GO:0043269 245 0.055
cellular component assembly GO:0022607 360 0.052
response to nutrient levels GO:0031667 370 0.052
response to ketone GO:1901654 182 0.052
regulation of cellular protein metabolic process GO:0032268 267 0.051
carboxylic acid transport GO:0046942 115 0.051
cellular potassium ion transport GO:0071804 72 0.050
chemical homeostasis GO:0048878 292 0.049
cellular chemical homeostasis GO:0055082 247 0.048
transmission of nerve impulse GO:0019226 42 0.048
regulation of phosphate metabolic process GO:0019220 349 0.047
organic anion transport GO:0015711 132 0.047
regulation of cellular ketone metabolic process GO:0010565 27 0.047
sodium ion transport GO:0006814 82 0.047
regulation of blood circulation GO:1903522 110 0.046
positive regulation of developmental process GO:0051094 283 0.046
neuron neuron synaptic transmission GO:0007270 60 0.046
response to ethanol GO:0045471 162 0.045
protein phosphorylation GO:0006468 345 0.045
response to nutrient GO:0007584 248 0.045
response to external biotic stimulus GO:0043207 221 0.045
regulation of cell proliferation GO:0042127 359 0.045
organelle organization GO:0006996 266 0.045
regulation of developmental growth GO:0048638 45 0.044
regulation of apoptotic process GO:0042981 335 0.043
response to estradiol GO:0032355 164 0.043
blood circulation GO:0008015 183 0.043
cation transport GO:0006812 382 0.043
negative regulation of transport GO:0051051 136 0.042
developmental growth GO:0048589 100 0.042
regulation of anatomical structure size GO:0090066 135 0.042
brain development GO:0007420 247 0.042
synaptic transmission GO:0007268 235 0.042
response to corticosterone GO:0051412 40 0.041
reproductive process GO:0022414 372 0.041
regulation of neurological system process GO:0031644 43 0.041
potassium ion transport GO:0006813 97 0.041
regulation of protein phosphorylation GO:0001932 183 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.040
cell projection organization GO:0030030 302 0.040
regulation of cell growth GO:0001558 85 0.040
response to growth factor GO:0070848 189 0.039
multicellular organism reproduction GO:0032504 233 0.039
regulation of purine nucleotide catabolic process GO:0033121 65 0.039
regulation of neurogenesis GO:0050767 247 0.039
positive regulation of the force of heart contraction by norepinephrine GO:0003061 1 0.039
multi organism reproductive process GO:0044703 262 0.038
anion transmembrane transport GO:0098656 77 0.038
secretion GO:0046903 307 0.037
response to glucocorticoid GO:0051384 223 0.036
apoptotic process GO:0006915 381 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.036
striated muscle contraction GO:0006941 44 0.036
response to nicotine GO:0035094 51 0.036
response to inorganic substance GO:0010035 377 0.035
positive regulation of response to stimulus GO:0048584 285 0.035
synaptic transmission gabaergic GO:0051932 22 0.035
regulation of catalytic activity GO:0050790 304 0.035
small gtpase mediated signal transduction GO:0007264 36 0.034
single organism reproductive process GO:0044702 297 0.034
regulation of synaptic transmission GO:0050804 141 0.034
regulation of system process GO:0044057 208 0.034
multicellular organismal signaling GO:0035637 44 0.034
head development GO:0060322 247 0.033
response to corticosteroid GO:0031960 235 0.033
regulation of cellular component organization GO:0051128 368 0.033
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 2 0.032
protein complex biogenesis GO:0070271 263 0.032
action potential GO:0001508 54 0.032
cardiac muscle tissue growth GO:0055017 20 0.032
cellular ketone metabolic process GO:0042180 51 0.031
nitrogen compound transport GO:0071705 229 0.031
regulation of kinase activity GO:0043549 117 0.030
positive regulation of amine transport GO:0051954 26 0.029
regulation of programmed cell death GO:0043067 341 0.029
response to alkaloid GO:0043279 132 0.029
positive regulation of protein modification process GO:0031401 142 0.029
positive regulation of growth GO:0045927 55 0.029
oxoacid metabolic process GO:0043436 290 0.029
response to peptide hormone GO:0043434 278 0.029
macromolecular complex subunit organization GO:0043933 339 0.028
tissue development GO:0009888 252 0.028
cellular component movement GO:0006928 248 0.028
purine nucleoside catabolic process GO:0006152 124 0.028
lipid biosynthetic process GO:0008610 128 0.028
positive regulation of transport GO:0051050 245 0.028
lens fiber cell differentiation GO:0070306 3 0.028
regulation of synaptic transmission glutamatergic GO:0051966 26 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
regulation of membrane potential GO:0042391 110 0.027
protein complex subunit organization GO:0071822 302 0.027
aging GO:0007568 241 0.027
lipid metabolic process GO:0006629 283 0.027
negative regulation of metabolic process GO:0009892 331 0.027
positive regulation of programmed cell death GO:0043068 157 0.027
heart morphogenesis GO:0003007 3 0.027
response to biotic stimulus GO:0009607 226 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
ras protein signal transduction GO:0007265 29 0.026
protein oligomerization GO:0051259 191 0.026
purine nucleotide metabolic process GO:0006163 229 0.026
monovalent inorganic cation transport GO:0015672 172 0.026
amine metabolic process GO:0009308 38 0.026
organophosphate catabolic process GO:0046434 148 0.026
regulation of signal transduction GO:0009966 318 0.025
response to vitamin GO:0033273 131 0.025
organonitrogen compound biosynthetic process GO:1901566 167 0.025
synapse assembly GO:0007416 29 0.025
circulatory system process GO:0003013 183 0.025
l glutamate import GO:0051938 2 0.025
positive regulation of blood circulation GO:1903524 65 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
negative regulation of signaling GO:0023057 157 0.024
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.024
neuron development GO:0048666 286 0.024
cell adhesion GO:0007155 110 0.024
positive regulation of nervous system development GO:0051962 178 0.024
negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 2 0.024
cellular response to histamine GO:0071420 3 0.024
response to metal ion GO:0010038 253 0.024
regulation of protein metabolic process GO:0051246 289 0.024
positive regulation of ion transport GO:0043270 94 0.023
response to estrogen GO:0043627 232 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
multicellular organism growth GO:0035264 1 0.023
cellular amine metabolic process GO:0044106 38 0.023
positive regulation of cell development GO:0010720 176 0.023
response to monosaccharide GO:0034284 159 0.023
homeostatic process GO:0042592 331 0.023
regulation of neuron differentiation GO:0045664 208 0.023
protein heterooligomerization GO:0051291 89 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.022
regulation of tube size GO:0035150 89 0.022
regulation of organ growth GO:0046620 13 0.022
positive regulation of phosphorus metabolic process GO:0010562 262 0.022
metal ion homeostasis GO:0055065 186 0.022
peptidyl amino acid modification GO:0018193 126 0.021
regeneration GO:0031099 163 0.021
cellular component biogenesis GO:0044085 368 0.021
negative regulation of organ growth GO:0046621 3 0.021
potassium ion transmembrane transport GO:0071805 71 0.021
positive regulation of apoptotic process GO:0043065 154 0.021
negative regulation of cell communication GO:0010648 158 0.021
regulation of hormone levels GO:0010817 187 0.021
response to progesterone GO:0032570 48 0.020
mapk cascade GO:0000165 140 0.020
positive regulation of neuron differentiation GO:0045666 126 0.020
phasic smooth muscle contraction GO:0014821 3 0.020
positive regulation of phosphorylation GO:0042327 177 0.020
regulation of multicellular organismal development GO:2000026 376 0.020
defense response GO:0006952 194 0.020
protein localization GO:0008104 191 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.020
pancreatic a cell differentiation GO:0003310 1 0.020
cellular response to organonitrogen compound GO:0071417 197 0.020
cation homeostasis GO:0055080 195 0.020
purine ribonucleoside catabolic process GO:0046130 124 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
neuron differentiation GO:0030182 368 0.020
positive regulation of catalytic activity GO:0043085 184 0.019
regulation of protein modification process GO:0031399 194 0.019
oxidation reduction process GO:0055114 304 0.019
g protein coupled receptor signaling pathway GO:0007186 242 0.019
response to ammonium ion GO:0060359 71 0.019
regulation of nervous system development GO:0051960 264 0.019
positive regulation of catabolic process GO:0009896 78 0.019
regulation of cellular localization GO:0060341 263 0.019
positive regulation of neuron projection development GO:0010976 99 0.019
single organism biosynthetic process GO:0044711 342 0.019
unsaturated fatty acid metabolic process GO:0033559 39 0.019
response to cocaine GO:0042220 39 0.019
regulation of cell differentiation GO:0045595 320 0.019
regulation of transcription dna templated GO:0006355 374 0.019
regulation of cellular response to stress GO:0080135 49 0.019
inorganic ion transmembrane transport GO:0098660 229 0.019
cellular response to lipid GO:0071396 201 0.019
acid secretion GO:0046717 48 0.019
formation of primary germ layer GO:0001704 1 0.018
purine nucleoside triphosphate catabolic process GO:0009146 122 0.018
axon development GO:0061564 96 0.018
reproduction GO:0000003 245 0.018
anion transport GO:0006820 178 0.018
protein complex assembly GO:0006461 263 0.018
purine containing compound catabolic process GO:0072523 138 0.018
amine transport GO:0015837 57 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
positive regulation of long term synaptic potentiation GO:1900273 4 0.018
single organism membrane organization GO:0044802 74 0.018
regulation of muscle system process GO:0090257 79 0.018
ribonucleoside monophosphate catabolic process GO:0009158 55 0.018
nucleotide metabolic process GO:0009117 279 0.018
response to acid chemical GO:0001101 222 0.018
regulation of intracellular signal transduction GO:1902531 218 0.018
positive regulation of signaling GO:0023056 270 0.018
cellular response to hormone stimulus GO:0032870 247 0.017
regulation of nucleic acid templated transcription GO:1903506 380 0.017
metal ion transport GO:0030001 289 0.017
purine containing compound metabolic process GO:0072521 253 0.017
purine nucleotide catabolic process GO:0006195 136 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
synaptic transmission glycinergic GO:0060012 2 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
organ induction GO:0001759 1 0.017
serotonin receptor signaling pathway GO:0007210 10 0.017
organonitrogen compound catabolic process GO:1901565 179 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
response to hexose GO:0009746 144 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
regulation of transferase activity GO:0051338 123 0.016
regulation of neuron projection development GO:0010975 161 0.016
regulation of cell projection organization GO:0031344 175 0.016
negative regulation of synaptic transmission glutamatergic GO:0051967 8 0.016
response to axon injury GO:0048678 59 0.016
urinary tract smooth muscle contraction GO:0014848 4 0.016
heart growth GO:0060419 20 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
sensory perception GO:0007600 101 0.016
neuron projection guidance GO:0097485 24 0.016
regulation of cardiac muscle tissue development GO:0055024 12 0.016
ribonucleotide catabolic process GO:0009261 136 0.016
single organism cellular localization GO:1902580 102 0.016
response to wounding GO:0009611 254 0.016
single organism behavior GO:0044708 130 0.016
calcium ion homeostasis GO:0055074 162 0.016
transcription dna templated GO:0006351 377 0.015
cellular response to hexose stimulus GO:0071331 65 0.015
tube development GO:0035295 89 0.015
regulation of amine transport GO:0051952 54 0.015
regulation of secretion by cell GO:1903530 208 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
developmental induction GO:0031128 2 0.015
response to carbohydrate GO:0009743 183 0.015
synaptic growth at neuromuscular junction GO:0051124 1 0.015
positive regulation of cellular component organization GO:0051130 200 0.015
regulation of fat cell proliferation GO:0070344 1 0.015
positive regulation of cellular component biogenesis GO:0044089 55 0.015
heart contraction GO:0060047 57 0.015
cytoskeleton organization GO:0007010 111 0.014
response to other organism GO:0051707 220 0.014
cerebellar purkinje cell layer development GO:0021680 2 0.014
catabolic process GO:0009056 351 0.014
organic substance catabolic process GO:1901575 316 0.014
regulation of nucleotide catabolic process GO:0030811 65 0.014
cellular cation homeostasis GO:0030003 180 0.014
neuronal action potential GO:0019228 35 0.014
amino acid transport GO:0006865 70 0.014
saliva secretion GO:0046541 3 0.014
n methyl d aspartate receptor clustering GO:0097114 2 0.014
secretion by cell GO:0032940 248 0.014
behavior GO:0007610 205 0.014
biological adhesion GO:0022610 110 0.014
positive regulation of protein kinase activity GO:0045860 73 0.014
brain renin angiotensin system GO:0002035 3 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
synaptic transmission glutamatergic GO:0035249 33 0.014
actin filament based process GO:0030029 86 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
response to bacterium GO:0009617 200 0.013
nucleotide catabolic process GO:0009166 139 0.013
membrane hyperpolarization GO:0060081 11 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
regulation of blood pressure GO:0008217 83 0.013
negative regulation of molecular function GO:0044092 133 0.013
vasoconstriction GO:0042310 54 0.013
monocarboxylic acid metabolic process GO:0032787 152 0.013
chromosome segregation GO:0007059 2 0.013
organ growth GO:0035265 24 0.013
response to decreased oxygen levels GO:0036293 237 0.013
single organism organelle organization GO:1902589 180 0.013
regulation of homotypic cell cell adhesion GO:0034110 4 0.013
regulation of heart growth GO:0060420 12 0.013
adult locomotory behavior GO:0008344 4 0.013
positive regulation of signal transduction GO:0009967 175 0.013
regulation of vasoconstriction GO:0019229 44 0.013
epithelium development GO:0060429 96 0.013
heterocycle catabolic process GO:0046700 167 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
cell cell signaling involved in cell fate commitment GO:0045168 2 0.013
regulation of blood vessel size GO:0050880 89 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
synapse organization GO:0050808 46 0.013
positive regulation of gene expression GO:0010628 244 0.013
muscle system process GO:0003012 115 0.013
organic acid biosynthetic process GO:0016053 83 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
lung development GO:0030324 43 0.012
carbohydrate derivative metabolic process GO:1901135 346 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
icosanoid metabolic process GO:0006690 38 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
multicellular organismal response to stress GO:0033555 25 0.012
single organism catabolic process GO:0044712 283 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
regulation of muscle tissue development GO:1901861 25 0.012
axis specification GO:0009798 4 0.012
positive regulation of epithelial cell proliferation GO:0050679 32 0.012
vascular process in circulatory system GO:0003018 96 0.012
positive regulation of biosynthetic process GO:0009891 319 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
regulation of catabolic process GO:0009894 113 0.012
renin secretion into blood stream GO:0002001 1 0.012
actin filament depolymerization GO:0030042 3 0.012
positive regulation of renin secretion into blood stream GO:1900135 1 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
organic acid transport GO:0015849 116 0.012
regulation of ion transmembrane transport GO:0034765 121 0.012
renal system process GO:0003014 40 0.012
organic hydroxy compound transport GO:0015850 77 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
response to electrical stimulus GO:0051602 56 0.011
negative regulation of cardiac muscle tissue growth GO:0055022 3 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
regulation of ion transmembrane transporter activity GO:0032412 48 0.011
cellular protein localization GO:0034613 122 0.011
negative regulation of secretion GO:0051048 82 0.011
ovulation cycle GO:0042698 67 0.011
neurotransmitter gated ion channel clustering GO:0072578 3 0.011
macromolecular complex assembly GO:0065003 273 0.011
regulation of protein homodimerization activity GO:0043496 5 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
membrane organization GO:0061024 94 0.011
tissue morphogenesis GO:0048729 22 0.011
locomotion GO:0040011 237 0.011
cellular response to glucocorticoid stimulus GO:0071385 68 0.011
regulation of transmembrane transport GO:0034762 122 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
grooming behavior GO:0007625 4 0.011
digestive system development GO:0055123 41 0.011
regulation of heart rate GO:0002027 16 0.011
regulation of amino acid transport GO:0051955 25 0.011
sex differentiation GO:0007548 113 0.011
positive regulation of transferase activity GO:0051347 81 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
central nervous system development GO:0007417 311 0.011
sodium ion transmembrane transport GO:0035725 67 0.011
cellular response to peptide GO:1901653 133 0.011
endocrine process GO:0050886 32 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
lipid storage GO:0019915 1 0.011
heart development GO:0007507 72 0.011
cell morphogenesis GO:0000902 142 0.011
dopamine transport GO:0015872 18 0.011
aromatic compound catabolic process GO:0019439 168 0.011
neuromuscular synaptic transmission GO:0007274 2 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
actin mediated cell contraction GO:0070252 12 0.010
regulation of cell cell adhesion GO:0022407 14 0.010
embryo development GO:0009790 49 0.010
regulation of response to stress GO:0080134 126 0.010
nucleic acid templated transcription GO:0097659 379 0.010
positive regulation of secretion GO:0051047 140 0.010
forebrain development GO:0030900 98 0.010
rna biosynthetic process GO:0032774 380 0.010
response to radiation GO:0009314 137 0.010
respiratory system process GO:0003016 3 0.010
response to mechanical stimulus GO:0009612 134 0.010
positive regulation of synaptic vesicle exocytosis GO:2000302 3 0.010
inorganic anion transport GO:0015698 41 0.010
gastrulation GO:0007369 2 0.010
nucleoside metabolic process GO:0009116 179 0.010
cardiac ventricle development GO:0003231 1 0.010

Slc1a6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.012
disease of anatomical entity DOID:7 0 0.012
brain disease DOID:936 0 0.012
central nervous system disease DOID:331 0 0.012
epilepsy syndrome DOID:1826 0 0.012
disease of metabolism DOID:0014667 0 0.010