Rattus norvegicus

170 known processes

Slc6a4

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Slc6a4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to oxidative stress GO:0006979 186 0.211
organic acid metabolic process GO:0006082 292 0.210
regulation of secretion by cell GO:1903530 208 0.151
transcription dna templated GO:0006351 377 0.139
aging GO:0007568 241 0.138
Rat
alkaloid metabolic process GO:0009820 3 0.127
organic hydroxy compound metabolic process GO:1901615 115 0.122
cellular chemical homeostasis GO:0055082 247 0.108
Rat
regulation of hormone levels GO:0010817 187 0.104
nitrogen compound transport GO:0071705 229 0.104
response to metal ion GO:0010038 253 0.100
Rat
fatty acid derivative metabolic process GO:1901568 38 0.097
leukocyte activation GO:0045321 76 0.096
response to radiation GO:0009314 137 0.093
cell projection organization GO:0030030 302 0.087
positive regulation of signaling GO:0023056 270 0.085
anion transport GO:0006820 178 0.082
Rat
isoprenoid metabolic process GO:0006720 45 0.081
regulation of cellular localization GO:0060341 263 0.080
response to peptide hormone GO:0043434 278 0.080
reproductive process GO:0022414 372 0.080
oxoacid metabolic process GO:0043436 290 0.080
icosanoid metabolic process GO:0006690 38 0.079
response to acid chemical GO:0001101 222 0.079
response to reactive oxygen species GO:0000302 120 0.077
peptide transport GO:0015833 97 0.077
positive regulation of transport GO:0051050 245 0.077
Rat
secretion by cell GO:0032940 248 0.073
single organism reproductive process GO:0044702 297 0.073
response to inorganic substance GO:0010035 377 0.070
Rat
carboxylic acid metabolic process GO:0019752 289 0.070
rna metabolic process GO:0016070 406 0.068
inorganic ion transmembrane transport GO:0098660 229 0.067
Rat
positive regulation of developmental process GO:0051094 283 0.067
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.061
regulation of anion transport GO:0044070 43 0.060
Rat
s shaped body morphogenesis GO:0072050 2 0.059
response to nutrient levels GO:0031667 370 0.059
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.059
lipid biosynthetic process GO:0008610 128 0.058
positive regulation of multicellular organismal process GO:0051240 387 0.058
positive regulation of biosynthetic process GO:0009891 319 0.057
cellular lipid metabolic process GO:0044255 208 0.054
cellular ion homeostasis GO:0006873 184 0.054
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.053
negative regulation of metabolic process GO:0009892 331 0.053
response to ethanol GO:0045471 162 0.053
Rat
anatomical structure morphogenesis GO:0009653 298 0.052
response to ionizing radiation GO:0010212 59 0.051
cellular component biogenesis GO:0044085 368 0.051
regulation of cellular component organization GO:0051128 368 0.050
dendrite development GO:0016358 72 0.050
cellular homeostasis GO:0019725 252 0.049
Rat
tongue morphogenesis GO:0043587 3 0.049
positive regulation of secretion GO:0051047 140 0.049
Rat
cell part morphogenesis GO:0032990 123 0.049
negative regulation of cellular biosynthetic process GO:0031327 161 0.049
cellular modified amino acid metabolic process GO:0006575 61 0.048
cellular ketone metabolic process GO:0042180 51 0.048
protein complex subunit organization GO:0071822 302 0.048
long chain fatty acid metabolic process GO:0001676 32 0.048
regulation of organic acid transport GO:0032890 35 0.046
Rat
regulation of secretion GO:0051046 224 0.045
Rat
cation transport GO:0006812 382 0.045
unsaturated fatty acid metabolic process GO:0033559 39 0.044
positive regulation of transcription dna templated GO:0045893 197 0.044
positive regulation of cellular biosynthetic process GO:0031328 295 0.043
mesenchymal to epithelial transition GO:0060231 3 0.042
macromolecular complex subunit organization GO:0043933 339 0.041
peptide hormone secretion GO:0030072 84 0.041
regulation of response to external stimulus GO:0032101 106 0.040
neuron differentiation GO:0030182 368 0.039
regulation of neuron differentiation GO:0045664 208 0.039
cell adhesion GO:0007155 110 0.039
positive regulation of nucleic acid templated transcription GO:1903508 197 0.039
regulation of ion transport GO:0043269 245 0.038
Rat
embryonic skeletal system morphogenesis GO:0048704 3 0.037
hormone transport GO:0009914 121 0.037
t cell activation GO:0042110 29 0.037
positive regulation of gene expression GO:0010628 244 0.036
negative regulation of metanephros development GO:0072217 2 0.036
phenol containing compound metabolic process GO:0018958 30 0.035
response to wounding GO:0009611 254 0.035
response to hypoxia GO:0001666 231 0.035
secretion GO:0046903 307 0.035
Rat
monocarboxylic acid metabolic process GO:0032787 152 0.035
brain development GO:0007420 247 0.034
positive regulation of nervous system development GO:0051962 178 0.034
negative regulation of rna biosynthetic process GO:1902679 118 0.034
regulation of phosphorylation GO:0042325 248 0.034
positive regulation of protein metabolic process GO:0051247 178 0.034
response to extracellular stimulus GO:0009991 380 0.033
positive regulation of cell development GO:0010720 176 0.032
intracellular signal transduction GO:0035556 314 0.031
rna biosynthetic process GO:0032774 380 0.031
negative regulation of multicellular organismal process GO:0051241 203 0.031
regulation of cell differentiation GO:0045595 320 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
oxidation reduction process GO:0055114 304 0.030
cellular protein localization GO:0034613 122 0.030
transmembrane transport GO:0055085 412 0.030
response to peptide GO:1901652 292 0.030
response to transition metal nanoparticle GO:1990267 122 0.030
Rat
central nervous system development GO:0007417 311 0.030
developmental process involved in reproduction GO:0003006 159 0.030
amine metabolic process GO:0009308 38 0.030
neuron development GO:0048666 286 0.030
positive regulation of cellular protein metabolic process GO:0032270 167 0.030
neuron projection development GO:0031175 273 0.029
regulation of multicellular organismal development GO:2000026 376 0.029
arachidonic acid metabolic process GO:0019369 20 0.029
lymphocyte activation GO:0046649 43 0.029
response to ketone GO:1901654 182 0.029
transcription from rna polymerase ii promoter GO:0006366 252 0.029
organonitrogen compound biosynthetic process GO:1901566 167 0.028
regulation of transcription dna templated GO:0006355 374 0.028
regulation of rna metabolic process GO:0051252 391 0.028
lipid metabolic process GO:0006629 283 0.028
multicellular organismal reproductive process GO:0048609 233 0.028
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.028
sexual reproduction GO:0019953 148 0.028
regulation of nucleic acid templated transcription GO:1903506 380 0.028
negative regulation of cell differentiation GO:0045596 99 0.028
regulation of neurogenesis GO:0050767 247 0.028
positive regulation of hormone secretion GO:0046887 65 0.027
organic acid transport GO:0015849 116 0.027
Rat
single organism organelle organization GO:1902589 180 0.027
anterior posterior pattern specification GO:0009952 1 0.027
regulation of protein metabolic process GO:0051246 289 0.027
positive regulation of cellular component organization GO:0051130 200 0.027
cellular response to acid chemical GO:0071229 75 0.027
cellular component assembly GO:0022607 360 0.027
regulation of protein modification process GO:0031399 194 0.027
programmed cell death GO:0012501 392 0.027
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.026
lymphocyte proliferation GO:0046651 29 0.026
head development GO:0060322 247 0.026
terpenoid metabolic process GO:0006721 37 0.026
cellular divalent inorganic cation homeostasis GO:0072503 162 0.026
ion transmembrane transport GO:0034220 365 0.026
cellular amine metabolic process GO:0044106 38 0.025
cytosolic calcium ion homeostasis GO:0051480 140 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
peptide secretion GO:0002790 86 0.025
diterpenoid metabolic process GO:0016101 33 0.025
ossification GO:0001503 70 0.024
regulation of rna biosynthetic process GO:2001141 381 0.024
leukocyte cell cell adhesion GO:0007159 4 0.024
positive regulation of rna metabolic process GO:0051254 203 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.024
protein complex assembly GO:0006461 263 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.023
macromolecular complex assembly GO:0065003 273 0.023
positive regulation of peptide hormone secretion GO:0090277 50 0.023
cellular cation homeostasis GO:0030003 180 0.023
protein phosphorylation GO:0006468 345 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.023
positive regulation of cell proliferation GO:0008284 249 0.023
amide transport GO:0042886 105 0.023
positive regulation of cell differentiation GO:0045597 217 0.023
development of primary sexual characteristics GO:0045137 107 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
negative regulation of macromolecule metabolic process GO:0010605 260 0.022
organ formation GO:0048645 3 0.022
calcium ion homeostasis GO:0055074 162 0.022
dna metabolic process GO:0006259 96 0.022
chemical homeostasis GO:0048878 292 0.022
Rat
positive regulation of lymphocyte proliferation GO:0050671 20 0.022
cation homeostasis GO:0055080 195 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
ion homeostasis GO:0050801 212 0.021
mononuclear cell proliferation GO:0032943 29 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.021
nucleic acid templated transcription GO:0097659 379 0.021
neuron fate commitment GO:0048663 4 0.021
regulation of nervous system development GO:0051960 264 0.021
cellular component morphogenesis GO:0032989 155 0.021
cell morphogenesis involved in differentiation GO:0000904 119 0.021
positive regulation of protein modification process GO:0031401 142 0.021
multi organism reproductive process GO:0044703 262 0.021
cellular component movement GO:0006928 248 0.020
reproductive system development GO:0061458 128 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
small molecule biosynthetic process GO:0044283 124 0.020
negative regulation of gene expression GO:0010629 199 0.020
organelle organization GO:0006996 266 0.020
positive regulation of protein phosphorylation GO:0001934 135 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
cell activation GO:0001775 97 0.020
response to alkaloid GO:0043279 132 0.019
Rat
organ morphogenesis GO:0009887 75 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.019
regulation of protein kinase activity GO:0045859 105 0.019
positive regulation of leukocyte activation GO:0002696 30 0.019
negative regulation of biosynthetic process GO:0009890 168 0.019
regulation of response to stress GO:0080134 126 0.019
organic hydroxy compound biosynthetic process GO:1901617 51 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
cellular amino acid biosynthetic process GO:0008652 32 0.019
organic anion transport GO:0015711 132 0.019
Rat
metal ion homeostasis GO:0055065 186 0.019
reproductive structure development GO:0048608 128 0.019
tissue development GO:0009888 252 0.018
cell fate determination GO:0001709 2 0.018
positive regulation of blood circulation GO:1903524 65 0.018
response to toxic substance GO:0009636 133 0.018
Rat
metanephric comma shaped body morphogenesis GO:0072278 2 0.018
hormone metabolic process GO:0042445 69 0.018
negative regulation of transcription dna templated GO:0045892 116 0.018
embryonic skeletal system development GO:0048706 3 0.018
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
gland development GO:0048732 155 0.017
neuron projection morphogenesis GO:0048812 122 0.017
steroid biosynthetic process GO:0006694 48 0.017
multicellular organism reproduction GO:0032504 233 0.017
negative regulation of nervous system development GO:0051961 79 0.017
eye development GO:0001654 50 0.017
female pregnancy GO:0007565 122 0.017
response to hydrogen peroxide GO:0042542 89 0.017
regulation of hormone secretion GO:0046883 106 0.017
isoquinoline alkaloid metabolic process GO:0033076 2 0.017
regulation of peptide hormone secretion GO:0090276 80 0.017
tube formation GO:0035148 3 0.017
multi multicellular organism process GO:0044706 138 0.017
response to glucocorticoid GO:0051384 223 0.017
response to hexose GO:0009746 144 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
negative regulation of apoptotic process GO:0043066 181 0.016
regulation of cell development GO:0060284 263 0.016
cell projection morphogenesis GO:0048858 123 0.016
negative regulation of rna metabolic process GO:0051253 123 0.016
regulation of anatomical structure size GO:0090066 135 0.016
positive regulation of ion transport GO:0043270 94 0.016
Rat
cellular nitrogen compound catabolic process GO:0044270 163 0.016
cell migration GO:0016477 197 0.016
cell growth GO:0016049 104 0.016
inflammatory response GO:0006954 150 0.016
positive regulation of kinase activity GO:0033674 77 0.016
organic acid biosynthetic process GO:0016053 83 0.016
bmp signaling pathway GO:0030509 4 0.015
single organism intracellular transport GO:1902582 166 0.015
morphogenesis of embryonic epithelium GO:0016331 3 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
regulation of leukocyte differentiation GO:1902105 20 0.015
single organism biosynthetic process GO:0044711 342 0.015
male sex differentiation GO:0046661 64 0.015
response to insulin GO:0032868 133 0.015
defense response GO:0006952 194 0.015
sensory organ development GO:0007423 74 0.014
sex differentiation GO:0007548 113 0.014
response to decreased oxygen levels GO:0036293 237 0.014
metanephric s shaped body morphogenesis GO:0072284 2 0.014
negative regulation of cell death GO:0060548 229 0.014
salivary gland development GO:0007431 3 0.014
response to temperature stimulus GO:0009266 94 0.014
cell fate commitment involved in pattern specification GO:0060581 2 0.014
learning or memory GO:0007611 90 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
fatty acid metabolic process GO:0006631 99 0.013
chemosensory behavior GO:0007635 2 0.013
negative regulation of neuron death GO:1901215 69 0.013
dopamine metabolic process GO:0042417 12 0.013
regulation of peptide transport GO:0090087 87 0.013
growth GO:0040007 165 0.013
retinoid metabolic process GO:0001523 24 0.013
catabolic process GO:0009056 351 0.013
epithelial cell differentiation GO:0030855 71 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
olfactory behavior GO:0042048 2 0.013
phenol containing compound biosynthetic process GO:0046189 9 0.013
regulation of leukocyte proliferation GO:0070663 26 0.013
thyroid gland development GO:0030878 1 0.013
regulation of phosphate metabolic process GO:0019220 349 0.013
regulation of molecular function GO:0065009 398 0.013
hormone secretion GO:0046879 115 0.013
mononuclear cell migration GO:0071674 3 0.013
steroid metabolic process GO:0008202 73 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
response to glucose GO:0009749 136 0.012
carboxylic acid biosynthetic process GO:0046394 83 0.012
regulation of cellular component movement GO:0051270 150 0.012
regulation of cell projection organization GO:0031344 175 0.012
development of primary male sexual characteristics GO:0046546 59 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
immune system process GO:0002376 204 0.012
negative regulation of transport GO:0051051 136 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
response to transforming growth factor beta GO:0071559 46 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
positive regulation of cell motility GO:2000147 97 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
response to monosaccharide GO:0034284 159 0.012
cellular catabolic process GO:0044248 295 0.012
cell morphogenesis GO:0000902 142 0.012
mesonephros development GO:0001823 14 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
negative regulation of kidney development GO:0090185 2 0.012
cellular hormone metabolic process GO:0034754 49 0.012
carbohydrate metabolic process GO:0005975 130 0.012
sulfur compound metabolic process GO:0006790 70 0.012
dorsal ventral axon guidance GO:0033563 1 0.012
positive regulation of protein kinase activity GO:0045860 73 0.012
regulation of membrane potential GO:0042391 110 0.011
antral ovarian follicle growth GO:0001547 3 0.011
gastrulation GO:0007369 2 0.011
positive regulation of peptide secretion GO:0002793 52 0.011
regulation of phosphorus metabolic process GO:0051174 349 0.011
actin filament based process GO:0030029 86 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
positive regulation of cell communication GO:0010647 271 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
positive regulation of lymphocyte activation GO:0051251 25 0.011
regulation of growth GO:0040008 105 0.011
cognition GO:0050890 92 0.011
locomotion GO:0040011 237 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
negative regulation of developmental process GO:0051093 125 0.011
regulation of blood circulation GO:1903522 110 0.011
macromolecule localization GO:0033036 252 0.011
nucleoside phosphate metabolic process GO:0006753 283 0.011
nucleobase containing small molecule metabolic process GO:0055086 316 0.011
tongue development GO:0043586 8 0.011
signal release GO:0023061 145 0.011
jak stat cascade GO:0007259 26 0.010
lipid transport GO:0006869 61 0.010
positive regulation of leukocyte proliferation GO:0070665 20 0.010
regulation of lipid biosynthetic process GO:0046890 38 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
regulation of cellular component biogenesis GO:0044087 86 0.010
nucleotide catabolic process GO:0009166 139 0.010
axon development GO:0061564 96 0.010
response to oxygen levels GO:0070482 265 0.010
cell cell signaling GO:0007267 335 0.010
multicellular organismal homeostasis GO:0048871 49 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
negative regulation of secretion GO:0051048 82 0.010
regulation of cell motility GO:2000145 131 0.010
regulation of catalytic activity GO:0050790 304 0.010

Slc6a4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
connective tissue disease DOID:65 0 0.014
musculoskeletal system disease DOID:17 0 0.014
disease of anatomical entity DOID:7 0 0.014
urinary system disease DOID:18 0 0.011
kidney disease DOID:557 0 0.011
renal tubular transport disease DOID:447 0 0.011