Rattus norvegicus

0 known processes

Slpi

secretory leukocyte peptidase inhibitor

Slpi biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
defense response GO:0006952 194 0.312
response to biotic stimulus GO:0009607 226 0.264
response to other organism GO:0051707 220 0.209
chemical homeostasis GO:0048878 292 0.202
response to external biotic stimulus GO:0043207 221 0.139
regulation of multicellular organismal development GO:2000026 376 0.130
locomotion GO:0040011 237 0.123
regulation of cellular extravasation GO:0002691 2 0.115
cellular component biogenesis GO:0044085 368 0.109
divalent inorganic cation homeostasis GO:0072507 165 0.108
anatomical structure morphogenesis GO:0009653 298 0.108
programmed cell death GO:0012501 392 0.104
macromolecular complex subunit organization GO:0043933 339 0.103
inflammatory response GO:0006954 150 0.102
response to nutrient GO:0007584 248 0.096
positive regulation of locomotion GO:0040017 102 0.088
cellular component movement GO:0006928 248 0.088
regulation of cell migration GO:0030334 128 0.087
regulation of locomotion GO:0040012 148 0.083
regulation of cell motility GO:2000145 131 0.082
immune response GO:0006955 104 0.081
positive regulation of cell motility GO:2000147 97 0.081
leukocyte cell cell adhesion GO:0007159 4 0.077
behavior GO:0007610 205 0.077
regulation of cellular localization GO:0060341 263 0.076
positive regulation of phosphorylation GO:0042327 177 0.075
cellular ion homeostasis GO:0006873 184 0.075
metal ion homeostasis GO:0055065 186 0.074
cell migration GO:0016477 197 0.074
intracellular signal transduction GO:0035556 314 0.072
positive regulation of multicellular organismal process GO:0051240 387 0.072
regulation of neurogenesis GO:0050767 247 0.072
taxis GO:0042330 67 0.070
positive regulation of response to stimulus GO:0048584 285 0.070
negative regulation of immune response to tumor cell GO:0002838 2 0.069
regulation of apoptotic process GO:0042981 335 0.065
ion homeostasis GO:0050801 212 0.065
cellular component assembly GO:0022607 360 0.063
cellular homeostasis GO:0019725 252 0.063
positive regulation of cellular biosynthetic process GO:0031328 295 0.062
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.062
cellular metal ion homeostasis GO:0006875 172 0.061
calcium ion homeostasis GO:0055074 162 0.060
response to radiation GO:0009314 137 0.060
innate immune response GO:0045087 35 0.059
regulation of cellular protein metabolic process GO:0032268 267 0.059
regulation of programmed cell death GO:0043067 341 0.059
organic acid metabolic process GO:0006082 292 0.059
regulation of rna metabolic process GO:0051252 391 0.057
positive regulation of cell communication GO:0010647 271 0.057
immune system process GO:0002376 204 0.056
central nervous system development GO:0007417 311 0.056
cellular response to external stimulus GO:0071496 118 0.056
cell motility GO:0048870 202 0.055
regulation of molecular function GO:0065009 398 0.054
Human
reproductive process GO:0022414 372 0.054
multicellular organismal reproductive process GO:0048609 233 0.054
regulation of cell development GO:0060284 263 0.053
vesicle mediated transport GO:0016192 181 0.053
head development GO:0060322 247 0.053
positive regulation of response to external stimulus GO:0032103 51 0.053
cellular chemical homeostasis GO:0055082 247 0.052
positive regulation of cell differentiation GO:0045597 217 0.051
regulation of lymphocyte chemotaxis GO:1901623 1 0.051
response to hypoxia GO:0001666 231 0.051
multi organism reproductive process GO:0044703 262 0.050
regulation of neuron projection development GO:0010975 161 0.050
regulation of cellular component organization GO:0051128 368 0.049
regulation of cell differentiation GO:0045595 320 0.049
cytosolic calcium ion homeostasis GO:0051480 140 0.049
mast cell migration GO:0097531 4 0.048
brain development GO:0007420 247 0.048
response to extracellular stimulus GO:0009991 380 0.048
homeostatic process GO:0042592 331 0.048
regulation of protein metabolic process GO:0051246 289 0.048
cellular lipid metabolic process GO:0044255 208 0.046
cell projection organization GO:0030030 302 0.045
rna metabolic process GO:0016070 406 0.045
intracellular transport GO:0046907 185 0.045
protein complex biogenesis GO:0070271 263 0.043
lymphocyte chemotaxis GO:0048247 3 0.043
g protein coupled receptor signaling pathway GO:0007186 242 0.043
reproduction GO:0000003 245 0.042
carboxylic acid metabolic process GO:0019752 289 0.042
metal ion transport GO:0030001 289 0.042
regulation of transcription dna templated GO:0006355 374 0.041
regulation of nervous system development GO:0051960 264 0.041
cardiovascular system development GO:0072358 134 0.041
cation homeostasis GO:0055080 195 0.041
positive regulation of signaling GO:0023056 270 0.040
response to wounding GO:0009611 254 0.040
amine metabolic process GO:0009308 38 0.040
single organism intracellular transport GO:1902582 166 0.040
t cell chemotaxis GO:0010818 2 0.039
lipid metabolic process GO:0006629 283 0.039
multicellular organism reproduction GO:0032504 233 0.039
positive regulation of developmental process GO:0051094 283 0.039
response to estrogen GO:0043627 232 0.039
protein phosphorylation GO:0006468 345 0.038
localization of cell GO:0051674 202 0.038
response to nutrient levels GO:0031667 370 0.038
cellular amine metabolic process GO:0044106 38 0.038
positive regulation of protein metabolic process GO:0051247 178 0.037
rna biosynthetic process GO:0032774 380 0.037
regulation of cellular component movement GO:0051270 150 0.037
developmental process involved in reproduction GO:0003006 159 0.037
regulation of anatomical structure morphogenesis GO:0022603 141 0.036
oxoacid metabolic process GO:0043436 290 0.035
single organism organelle organization GO:1902589 180 0.035
cellular response to oxygen containing compound GO:1901701 386 0.035
organic hydroxy compound metabolic process GO:1901615 115 0.035
positive regulation of programmed cell death GO:0043068 157 0.034
protein oligomerization GO:0051259 191 0.034
positive regulation of apoptotic process GO:0043065 154 0.033
biological adhesion GO:0022610 110 0.033
regulation of cell projection organization GO:0031344 175 0.033
cell activation GO:0001775 97 0.033
sequestering of calcium ion GO:0051208 8 0.033
negative regulation of response to tumor cell GO:0002835 2 0.033
cellular divalent inorganic cation homeostasis GO:0072503 162 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
cellular cation homeostasis GO:0030003 180 0.032
positive regulation of cell death GO:0010942 184 0.032
single organismal cell cell adhesion GO:0016337 42 0.032
regulation of response to external stimulus GO:0032101 106 0.032
protein complex assembly GO:0006461 263 0.032
positive regulation of neurogenesis GO:0050769 165 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
neuron differentiation GO:0030182 368 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.030
secretion by cell GO:0032940 248 0.030
cation transport GO:0006812 382 0.030
positive regulation of behavior GO:0048520 38 0.030
cellular response to cytokine stimulus GO:0071345 127 0.030
positive regulation of chemotaxis GO:0050921 23 0.029
response to ketone GO:1901654 182 0.029
positive regulation of intracellular signal transduction GO:1902533 138 0.029
neuron development GO:0048666 286 0.029
response to toxic substance GO:0009636 133 0.028
regulation of immune system process GO:0002682 123 0.028
regulation of phosphorylation GO:0042325 248 0.028
apoptotic process GO:0006915 381 0.028
gland development GO:0048732 155 0.027
negative regulation of cell death GO:0060548 229 0.027
regulation of mapk cascade GO:0043408 116 0.027
positive regulation of tumor necrosis factor production GO:0032760 8 0.027
positive regulation of phosphorus metabolic process GO:0010562 262 0.027
signal transduction by phosphorylation GO:0023014 144 0.027
positive regulation of cell projection organization GO:0031346 111 0.027
positive regulation of biosynthetic process GO:0009891 319 0.027
immune response activating signal transduction GO:0002757 15 0.027
positive regulation of cell proliferation GO:0008284 249 0.026
positive regulation of jnk cascade GO:0046330 13 0.026
macromolecule localization GO:0033036 252 0.026
maintenance of location GO:0051235 17 0.026
cell cell signaling GO:0007267 335 0.026
cellular protein localization GO:0034613 122 0.026
leukocyte activation GO:0045321 76 0.026
macromolecular complex assembly GO:0065003 273 0.026
alcohol metabolic process GO:0006066 77 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
single organism reproductive process GO:0044702 297 0.025
regulation of protein phosphorylation GO:0001932 183 0.025
regulation of cytokine biosynthetic process GO:0042035 3 0.024
epithelium development GO:0060429 96 0.024
protein transport GO:0015031 132 0.024
regulation of protein modification process GO:0031399 194 0.024
negative regulation of programmed cell death GO:0043069 183 0.024
small molecule biosynthetic process GO:0044283 124 0.024
regulation of response to stress GO:0080134 126 0.024
regulation of behavior GO:0050795 61 0.024
cellular ketone metabolic process GO:0042180 51 0.023
wound healing GO:0042060 122 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
regulation of signal transduction GO:0009966 318 0.023
regulation of ion transport GO:0043269 245 0.023
secretion GO:0046903 307 0.023
actin cytoskeleton organization GO:0030036 73 0.023
sequestering of metal ion GO:0051238 9 0.023
negative regulation of response to stimulus GO:0048585 155 0.023
leukocyte migration GO:0050900 38 0.023
response to decreased oxygen levels GO:0036293 237 0.023
actin filament based process GO:0030029 86 0.022
regulation of tumor necrosis factor production GO:0032680 13 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 8 0.022
blood vessel development GO:0001568 69 0.022
regulation of catalytic activity GO:0050790 304 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
anterior posterior pattern specification GO:0009952 1 0.022
multi multicellular organism process GO:0044706 138 0.021
negative regulation of apoptotic process GO:0043066 181 0.021
positive regulation of phosphate metabolic process GO:0045937 262 0.021
response to mechanical stimulus GO:0009612 134 0.021
cell adhesion GO:0007155 110 0.021
organophosphate metabolic process GO:0019637 370 0.021
positive regulation of nervous system development GO:0051962 178 0.021
positive regulation of protein phosphorylation GO:0001934 135 0.021
establishment of protein localization GO:0045184 141 0.020
tumor necrosis factor superfamily cytokine production GO:0071706 13 0.020
organelle organization GO:0006996 266 0.020
positive regulation of cell development GO:0010720 176 0.020
regulation of secretion GO:0051046 224 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
cellular calcium ion homeostasis GO:0006874 160 0.020
monocarboxylic acid biosynthetic process GO:0072330 48 0.020
chemotaxis GO:0006935 66 0.020
regulation of neuron differentiation GO:0045664 208 0.020
neurological system process GO:0050877 219 0.020
gamete generation GO:0007276 124 0.020
protein complex subunit organization GO:0071822 302 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.020
cell part morphogenesis GO:0032990 123 0.019
circulatory system development GO:0072359 134 0.019
positive regulation of neuron projection development GO:0010976 99 0.019
neuron death GO:0070997 127 0.019
protein localization GO:0008104 191 0.019
fatty acid derivative metabolic process GO:1901568 38 0.019
response to transition metal nanoparticle GO:1990267 122 0.019
response to tumor cell GO:0002347 4 0.019
response to cytokine GO:0034097 215 0.018
regulation of chemotaxis GO:0050920 29 0.018
positive regulation of protein modification process GO:0031401 142 0.018
positive regulation of transport GO:0051050 245 0.018
positive regulation of immune system process GO:0002684 90 0.018
icosanoid metabolic process GO:0006690 38 0.018
negative regulation of innate immune response GO:0045824 4 0.018
regulation of metal ion transport GO:0010959 118 0.018
positive regulation of secretion GO:0051047 140 0.018
regulation of cytokine production GO:0001817 56 0.018
organic acid biosynthetic process GO:0016053 83 0.018
regulation of dna metabolic process GO:0051052 60 0.018
response to inorganic substance GO:0010035 377 0.018
regulation of t cell migration GO:2000404 1 0.018
axis specification GO:0009798 4 0.018
response to bacterium GO:0009617 200 0.018
mast cell chemotaxis GO:0002551 4 0.018
reactive nitrogen species metabolic process GO:2001057 1 0.017
blood vessel morphogenesis GO:0048514 58 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
positive regulation of cell migration GO:0030335 96 0.017
response to molecule of fungal origin GO:0002238 3 0.017
cell projection morphogenesis GO:0048858 123 0.017
tissue development GO:0009888 252 0.017
single organism cellular localization GO:1902580 102 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
divalent inorganic cation transport GO:0072511 134 0.017
single organism biosynthetic process GO:0044711 342 0.017
regulation of secretion by cell GO:1903530 208 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
leukocyte aggregation GO:0070486 1 0.017
response to vitamin GO:0033273 131 0.016
embryonic pattern specification GO:0009880 1 0.016
single organism behavior GO:0044708 130 0.016
regulation of phosphate metabolic process GO:0019220 349 0.016
leukocyte mediated immunity GO:0002443 28 0.016
lymphocyte migration GO:0072676 3 0.016
intracellular protein transport GO:0006886 79 0.016
positive regulation of cellular component movement GO:0051272 102 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
positive regulation of immune response GO:0050778 42 0.015
regulation of neutrophil migration GO:1902622 6 0.015
cellular response to molecule of bacterial origin GO:0071219 56 0.015
positive regulation of mapk cascade GO:0043410 92 0.015
cytokine production GO:0001816 61 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
positive regulation of molecular function GO:0044093 230 0.015
response to corticosteroid GO:0031960 235 0.015
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 13 0.015
endocytosis GO:0006897 84 0.015
regulation of hormone levels GO:0010817 187 0.015
phospholipid metabolic process GO:0006644 61 0.015
cellular response to lipoteichoic acid GO:0071223 1 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.014
positive regulation of leukocyte migration GO:0002687 21 0.014
sexual reproduction GO:0019953 148 0.014
vasculature development GO:0001944 70 0.014
defense response to gram positive bacterium GO:0050830 2 0.014
neuron projection development GO:0031175 273 0.014
regulation of intracellular transport GO:0032386 65 0.014
p38mapk cascade GO:0038066 1 0.014
response to glucocorticoid GO:0051384 223 0.014
response to lipopolysaccharide GO:0032496 191 0.014
female pregnancy GO:0007565 122 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
response to monosaccharide GO:0034284 159 0.014
immune response to tumor cell GO:0002418 3 0.014
defense response to gram negative bacterium GO:0050829 3 0.014
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 1 0.014
regulation of cell proliferation GO:0042127 359 0.014
multicellular organismal homeostasis GO:0048871 49 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
positive regulation of lymphocyte migration GO:2000403 1 0.013
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
fatty acid metabolic process GO:0006631 99 0.013
positive regulation of leukocyte chemotaxis GO:0002690 10 0.013
single organism cell adhesion GO:0098602 46 0.013
peptidyl amino acid modification GO:0018193 126 0.013
t cell migration GO:0072678 2 0.013
regulation of t cell chemotaxis GO:0010819 1 0.013
response to amphetamine GO:0001975 25 0.013
cellular response to nutrient levels GO:0031669 60 0.013
positive regulation of t cell migration GO:2000406 1 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
calcium ion transport into cytosol GO:0060402 38 0.013
mapk cascade GO:0000165 140 0.013
regulation of immune response to tumor cell GO:0002837 3 0.012
response to reactive oxygen species GO:0000302 120 0.012
muscle cell differentiation GO:0042692 52 0.012
cytoskeleton organization GO:0007010 111 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.012
oxidation reduction process GO:0055114 304 0.012
cellular macromolecule localization GO:0070727 122 0.012
response to growth factor GO:0070848 189 0.012
positive regulation of transcription factor import into nucleus GO:0042993 4 0.012
cellular response to oxidative stress GO:0034599 76 0.012
lipid storage GO:0019915 1 0.012
negative regulation of natural killer cell mediated immune response to tumor cell GO:0002856 1 0.012
neutrophil chemotaxis GO:0030593 11 0.012
muscle contraction GO:0006936 88 0.012
purine containing compound metabolic process GO:0072521 253 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
female gamete generation GO:0007292 25 0.011
divalent metal ion transport GO:0070838 132 0.011
response to activity GO:0014823 73 0.011
response to camp GO:0051591 91 0.011
tumor necrosis factor production GO:0032640 13 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
cellular response to mechanical stimulus GO:0071260 48 0.011
response to oxygen levels GO:0070482 265 0.011
regulation of lymphocyte migration GO:2000401 1 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
response to estradiol GO:0032355 164 0.011
salivary gland development GO:0007431 3 0.011
hormone secretion GO:0046879 115 0.011
gliogenesis GO:0042063 93 0.011
rhythmic process GO:0048511 156 0.011
cytoplasmic transport GO:0016482 115 0.011
lipid biosynthetic process GO:0008610 128 0.011
regulation of hydrolase activity GO:0051336 143 0.011
positive regulation of signal transduction GO:0009967 175 0.011
neuron projection morphogenesis GO:0048812 122 0.011
response to carbohydrate GO:0009743 183 0.011
positive regulation of gene expression GO:0010628 244 0.011
regulation of platelet activation GO:0010543 2 0.010
cellular response to drug GO:0035690 30 0.010
organelle localization GO:0051640 55 0.010
regulation of defense response GO:0031347 68 0.010
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
protein homooligomerization GO:0051260 91 0.010
calcium ion transport GO:0006816 131 0.010
cellular response to interleukin 1 GO:0071347 37 0.010
insulin like growth factor receptor signaling pathway GO:0048009 3 0.010
cytokine biosynthetic process GO:0042089 3 0.010
positive regulation of rna metabolic process GO:0051254 203 0.010
regulation of nucleic acid templated transcription GO:1903506 380 0.010
glial cell differentiation GO:0010001 65 0.010

Slpi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.019