Rattus norvegicus

0 known processes

Smad4

SMAD family member 4

(Aliases: Madh4)

Smad4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron projection development GO:0031175 273 0.365
Rat
neuron development GO:0048666 286 0.269
Rat
rna metabolic process GO:0016070 406 0.264
Rat
regulation of rna metabolic process GO:0051252 391 0.204
Rat
regulation of transcription dna templated GO:0006355 374 0.191
Rat
cellular component assembly GO:0022607 360 0.187
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.181
Rat
anatomical structure morphogenesis GO:0009653 298 0.180
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.180
Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.178
Rat
single organism reproductive process GO:0044702 297 0.157
Rat
positive regulation of cellular protein metabolic process GO:0032270 167 0.153
Rat
nucleic acid templated transcription GO:0097659 379 0.145
Rat
proteolysis GO:0006508 175 0.141
Rat
regulation of signal transduction GO:0009966 318 0.141
Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.138
Rat
positive regulation of signaling GO:0023056 270 0.137
Rat
apoptotic process GO:0006915 381 0.137
Rat
rna biosynthetic process GO:0032774 380 0.132
Rat
neuron differentiation GO:0030182 368 0.129
Rat
regulation of molecular function GO:0065009 398 0.126
Rat
alternative mrna splicing via spliceosome GO:0000380 4 0.126
regulation of cell proliferation GO:0042127 359 0.124
Rat
cell projection organization GO:0030030 302 0.124
Rat
developmental process involved in reproduction GO:0003006 159 0.121
Rat
reproductive process GO:0022414 372 0.119
Rat
protein complex subunit organization GO:0071822 302 0.118
Rat
regulation of multicellular organismal development GO:2000026 376 0.113
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.110
Rat
cellular component biogenesis GO:0044085 368 0.110
Rat
positive regulation of cell death GO:0010942 184 0.108
Rat
protein phosphorylation GO:0006468 345 0.107
positive regulation of cell communication GO:0010647 271 0.107
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.106
Rat
regulation of intracellular signal transduction GO:1902531 218 0.104
positive regulation of phosphorus metabolic process GO:0010562 262 0.096
Rat
negative regulation of biosynthetic process GO:0009890 168 0.094
Rat
regulation of programmed cell death GO:0043067 341 0.092
Rat
regulation of cell development GO:0060284 263 0.091
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.089
Rat
intracellular signal transduction GO:0035556 314 0.088
Rat
positive regulation of rna metabolic process GO:0051254 203 0.086
Rat
regulation of rna biosynthetic process GO:2001141 381 0.086
Rat
negative regulation of cell proliferation GO:0008285 119 0.085
Rat
regulation of cell differentiation GO:0045595 320 0.083
Rat
cell morphogenesis involved in differentiation GO:0000904 119 0.083
Rat
positive regulation of signal transduction GO:0009967 175 0.082
Rat
regulation of cellular protein metabolic process GO:0032268 267 0.082
Rat
transcription dna templated GO:0006351 377 0.081
Rat
cellular component movement GO:0006928 248 0.081
Rat
response to hydrogen peroxide GO:0042542 89 0.078
aging GO:0007568 241 0.077
regulation of apoptotic process GO:0042981 335 0.077
Rat
organelle organization GO:0006996 266 0.077
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.076
Rat
regulation of protein metabolic process GO:0051246 289 0.076
Rat
programmed cell death GO:0012501 392 0.076
Rat
response to wounding GO:0009611 254 0.074
Rat
rhythmic process GO:0048511 156 0.073
regulation of cellular component organization GO:0051128 368 0.073
Rat
organic acid metabolic process GO:0006082 292 0.072
cell morphogenesis GO:0000902 142 0.072
Rat
regulation of phosphate metabolic process GO:0019220 349 0.072
Rat
cellular amino acid metabolic process GO:0006520 107 0.071
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.070
Rat
multi organism reproductive process GO:0044703 262 0.069
negative regulation of programmed cell death GO:0043069 183 0.068
Rat
reproduction GO:0000003 245 0.067
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.066
positive regulation of protein metabolic process GO:0051247 178 0.065
Rat
positive regulation of molecular function GO:0044093 230 0.065
Rat
response to radiation GO:0009314 137 0.064
positive regulation of multicellular organismal process GO:0051240 387 0.063
Rat
cell part morphogenesis GO:0032990 123 0.063
Rat
cellular response to growth factor stimulus GO:0071363 162 0.061
Rat
cellular response to stress GO:0033554 269 0.060
catabolic process GO:0009056 351 0.057
ossification GO:0001503 70 0.056
Rat
macromolecular complex subunit organization GO:0043933 339 0.056
Rat
negative regulation of cellular biosynthetic process GO:0031327 161 0.056
Rat
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.055
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.055
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.055
Rat
response to mechanical stimulus GO:0009612 134 0.054
positive regulation of response to stimulus GO:0048584 285 0.054
Rat
negative regulation of cell death GO:0060548 229 0.054
Rat
positive regulation of transport GO:0051050 245 0.053
protein autophosphorylation GO:0046777 66 0.053
regulation of phosphorylation GO:0042325 248 0.052
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.051
Rat
regulation of mrna splicing via spliceosome GO:0048024 3 0.051
positive regulation of cellular component organization GO:0051130 200 0.049
Rat
protein complex assembly GO:0006461 263 0.049
Rat
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.049
Rat
response to glucocorticoid GO:0051384 223 0.049
carboxylic acid metabolic process GO:0019752 289 0.049
regulation of nervous system development GO:0051960 264 0.048
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.048
cytokine production GO:0001816 61 0.048
Rat
negative regulation of gene expression GO:0010629 199 0.048
Rat
cytoskeleton organization GO:0007010 111 0.048
Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.048
Rat
positive regulation of gene expression GO:0010628 244 0.048
Rat
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.048
Rat
muscle structure development GO:0061061 87 0.047
positive regulation of apoptotic process GO:0043065 154 0.047
Rat
response to estrogen GO:0043627 232 0.046
Rat
positive regulation of cell proliferation GO:0008284 249 0.045
cellular ketone metabolic process GO:0042180 51 0.045
positive regulation of protein modification process GO:0031401 142 0.045
multicellular organismal reproductive process GO:0048609 233 0.045
biological adhesion GO:0022610 110 0.044
Rat
response to decreased oxygen levels GO:0036293 237 0.044
Rat
positive regulation of catalytic activity GO:0043085 184 0.043
Rat
positive regulation of programmed cell death GO:0043068 157 0.043
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.043
cell projection morphogenesis GO:0048858 123 0.042
Rat
protein complex biogenesis GO:0070271 263 0.042
Rat
gamete generation GO:0007276 124 0.041
positive regulation of biomineral tissue development GO:0070169 4 0.041
Rat
response to growth factor GO:0070848 189 0.041
Rat
cell motility GO:0048870 202 0.040
Rat
cellular component morphogenesis GO:0032989 155 0.040
Rat
response to inorganic substance GO:0010035 377 0.040
ion transmembrane transport GO:0034220 365 0.040
multicellular organism reproduction GO:0032504 233 0.040
negative regulation of metabolic process GO:0009892 331 0.039
Rat
cell migration GO:0016477 197 0.039
Rat
mrna processing GO:0006397 14 0.039
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.038
Rat
cellular response to organic cyclic compound GO:0071407 202 0.038
learning or memory GO:0007611 90 0.038
regulation of protein modification process GO:0031399 194 0.038
cellular response to oxygen containing compound GO:1901701 386 0.037
cell cell junction organization GO:0045216 20 0.037
Rat
response to extracellular stimulus GO:0009991 380 0.037
regulation of neurogenesis GO:0050767 247 0.036
Rat
locomotion GO:0040011 237 0.036
Rat
positive regulation of neuron differentiation GO:0045666 126 0.036
Rat
intracellular transport GO:0046907 185 0.036
male sex differentiation GO:0046661 64 0.035
Rat
reproductive system development GO:0061458 128 0.035
purine ribonucleotide metabolic process GO:0009150 227 0.035
positive regulation of biosynthetic process GO:0009891 319 0.035
Rat
cell cell signaling GO:0007267 335 0.035
macromolecular complex assembly GO:0065003 273 0.035
Rat
tissue development GO:0009888 252 0.035
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
cellular response to endogenous stimulus GO:0071495 377 0.034
Rat
nucleotide metabolic process GO:0009117 279 0.034
vesicle mediated transport GO:0016192 181 0.034
positive regulation of phosphorylation GO:0042327 177 0.034
epithelium development GO:0060429 96 0.034
homeostatic process GO:0042592 331 0.033
response to reactive oxygen species GO:0000302 120 0.033
negative regulation of response to stimulus GO:0048585 155 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
protein oligomerization GO:0051259 191 0.033
positive regulation of cellular amine metabolic process GO:0033240 3 0.033
signal transduction by phosphorylation GO:0023014 144 0.033
Rat
oxoacid metabolic process GO:0043436 290 0.033
positive regulation of transcription dna templated GO:0045893 197 0.033
Rat
negative regulation of apoptotic process GO:0043066 181 0.033
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.032
response to nutrient levels GO:0031667 370 0.032
positive regulation of intracellular signal transduction GO:1902533 138 0.032
cell adhesion GO:0007155 110 0.032
Rat
synaptic growth at neuromuscular junction GO:0051124 1 0.032
sex differentiation GO:0007548 113 0.031
Rat
negative regulation of signal transduction GO:0009968 83 0.031
regulation of protein phosphorylation GO:0001932 183 0.031
regulation of catalytic activity GO:0050790 304 0.031
Rat
response to hypoxia GO:0001666 231 0.031
Rat
cellular response to oxidative stress GO:0034599 76 0.031
positive regulation of cell differentiation GO:0045597 217 0.030
Rat
endocytosis GO:0006897 84 0.030
digestive tract development GO:0048565 39 0.030
bmp signaling pathway GO:0030509 4 0.030
Rat
regulation of cellular component movement GO:0051270 150 0.030
Rat
response to biotic stimulus GO:0009607 226 0.030
amine metabolic process GO:0009308 38 0.029
anterior posterior pattern specification GO:0009952 1 0.029
negative regulation of transcription dna templated GO:0045892 116 0.029
Rat
cellular response to reactive oxygen species GO:0034614 55 0.029
positive regulation of protein phosphorylation GO:0001934 135 0.029
embryonic pattern specification GO:0009880 1 0.028
negative regulation of cell communication GO:0010648 158 0.028
response to estradiol GO:0032355 164 0.027
single organism catabolic process GO:0044712 283 0.027
single organism behavior GO:0044708 130 0.027
organ morphogenesis GO:0009887 75 0.027
positive regulation of neuron projection development GO:0010976 99 0.027
Rat
axis specification GO:0009798 4 0.027
reactive oxygen species biosynthetic process GO:1903409 8 0.026
protein heterooligomerization GO:0051291 89 0.026
peptidyl amino acid modification GO:0018193 126 0.026
immune system process GO:0002376 204 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
cognition GO:0050890 92 0.026
defense response GO:0006952 194 0.026
lipid metabolic process GO:0006629 283 0.026
response to antibiotic GO:0046677 39 0.025
positive regulation of secretion GO:0051047 140 0.025
multicellular organism growth GO:0035264 1 0.025
cellular response to cytokine stimulus GO:0071345 127 0.025
transmembrane transport GO:0055085 412 0.025
response to oxidative stress GO:0006979 186 0.025
regulation of catabolic process GO:0009894 113 0.025
response to toxic substance GO:0009636 133 0.025
sexual reproduction GO:0019953 148 0.025
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.025
axon development GO:0061564 96 0.024
response to light stimulus GO:0009416 52 0.024
female sex differentiation GO:0046660 59 0.024
cellular response to steroid hormone stimulus GO:0071383 93 0.024
cell cycle GO:0007049 101 0.024
negative regulation of intracellular signal transduction GO:1902532 38 0.024
positive regulation of cell development GO:0010720 176 0.024
Rat
behavior GO:0007610 205 0.024
Rat
tube development GO:0035295 89 0.024
single organism organelle organization GO:1902589 180 0.024
Rat
regulation of response to stress GO:0080134 126 0.024
meiotic cell cycle process GO:1903046 3 0.024
regulation of cellular localization GO:0060341 263 0.023
positive regulation of developmental process GO:0051094 283 0.023
Rat
embryo development GO:0009790 49 0.023
negative regulation of signaling GO:0023057 157 0.023
negative regulation of rna metabolic process GO:0051253 123 0.023
Rat
cell substrate adhesion GO:0031589 29 0.023
Rat
protein modification by small protein conjugation or removal GO:0070647 35 0.022
female gonad development GO:0008585 53 0.022
cellular catabolic process GO:0044248 295 0.022
negative regulation of nucleic acid templated transcription GO:1903507 117 0.022
Rat
cellular amine metabolic process GO:0044106 38 0.022
ribonucleoside metabolic process GO:0009119 174 0.022
kidney development GO:0001822 67 0.022
Rat
protein maturation GO:0051604 68 0.022
Rat
urogenital system development GO:0001655 78 0.022
Rat
peptidyl tyrosine phosphorylation GO:0018108 72 0.021
cellular chemical homeostasis GO:0055082 247 0.021
positive regulation of nervous system development GO:0051962 178 0.021
Rat
response to vitamin GO:0033273 131 0.021
regulation of kinase activity GO:0043549 117 0.021
mrna 3 end processing GO:0031124 1 0.021
regulation of transforming growth factor beta3 production GO:0032910 2 0.021
Rat
locomotor rhythm GO:0045475 1 0.021
response to cytokine GO:0034097 215 0.021
regulation of neuron projection development GO:0010975 161 0.021
Rat
development of primary female sexual characteristics GO:0046545 56 0.021
head development GO:0060322 247 0.021
neuron projection morphogenesis GO:0048812 122 0.021
Rat
wound healing GO:0042060 122 0.021
Rat
dendrite development GO:0016358 72 0.021
Rat
positive regulation of cellular component movement GO:0051272 102 0.021
Rat
regulation of cellular response to stress GO:0080135 49 0.021
regeneration GO:0031099 163 0.020
positive regulation of mapk cascade GO:0043410 92 0.020
peptidyl tyrosine modification GO:0018212 72 0.020
protein processing GO:0016485 68 0.020
Rat
regulation of hydrolase activity GO:0051336 143 0.020
Rat
positive regulation of neurogenesis GO:0050769 165 0.020
Rat
cellular response to lipid GO:0071396 201 0.020
purine containing compound metabolic process GO:0072521 253 0.020
protein ubiquitination GO:0016567 28 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.019
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 1 0.019
Rat
response to corticosteroid GO:0031960 235 0.019
regulation of mesenchymal cell proliferation GO:0010464 4 0.019
reactive nitrogen species metabolic process GO:2001057 1 0.019
regulation of metal ion transport GO:0010959 118 0.019
reproductive structure development GO:0048608 128 0.019
dendrite morphogenesis GO:0048813 43 0.019
Rat
cellular protein localization GO:0034613 122 0.019
regulation of neuron differentiation GO:0045664 208 0.019
Rat
vasculature development GO:0001944 70 0.019
organic substance catabolic process GO:1901575 316 0.019
regulation of locomotion GO:0040012 148 0.019
Rat
single organism cellular localization GO:1902580 102 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
circulatory system process GO:0003013 183 0.019
regulation of ion transmembrane transport GO:0034765 121 0.019
embryonic axis specification GO:0000578 1 0.018
neurological system process GO:0050877 219 0.018
negative regulation of developmental process GO:0051093 125 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
circadian rhythm GO:0007623 88 0.018
single organism biosynthetic process GO:0044711 342 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.018
response to oxygen levels GO:0070482 265 0.018
Rat
cell type specific apoptotic process GO:0097285 134 0.018
Rat
cellular response to peptide hormone stimulus GO:0071375 120 0.018
regulation of growth GO:0040008 105 0.018
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.018
Rat
cellular response to tumor necrosis factor GO:0071356 46 0.017
metal ion transport GO:0030001 289 0.017
response to other organism GO:0051707 220 0.017
protein modification by small protein conjugation GO:0032446 31 0.017
spindle organization GO:0007051 2 0.017
regulation of cytokine production GO:0001817 56 0.017
Rat
positive regulation of cell projection organization GO:0031346 111 0.017
Rat
muscle cell differentiation GO:0042692 52 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
positive regulation of transforming growth factor beta3 production GO:0032916 2 0.017
Rat
negative regulation of transport GO:0051051 136 0.017
hormone secretion GO:0046879 115 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
response to transforming growth factor beta GO:0071559 46 0.017
Rat
ovulation cycle GO:0042698 67 0.017
cell growth GO:0016049 104 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
cellular macromolecule localization GO:0070727 122 0.016
germ cell migration GO:0008354 1 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.016
regulation of cell cycle phase transition GO:1901987 12 0.016
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
ubiquitin dependent protein catabolic process GO:0006511 14 0.016
regulation of mapk cascade GO:0043408 116 0.016
ribose phosphate biosynthetic process GO:0046390 87 0.016
central nervous system development GO:0007417 311 0.016
response to nutrient GO:0007584 248 0.016
regulation of smooth muscle cell proliferation GO:0048660 75 0.016
response to peptide hormone GO:0043434 278 0.016
maintenance of location GO:0051235 17 0.016
smad protein complex assembly GO:0007183 1 0.016
Rat
regulation of transmembrane transport GO:0034762 122 0.016
neuronal action potential GO:0019228 35 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
Rat
smooth muscle cell proliferation GO:0048659 77 0.016
cellular macromolecule catabolic process GO:0044265 29 0.016
modification dependent protein catabolic process GO:0019941 14 0.016
neuron projection guidance GO:0097485 24 0.015
regulation of protein kinase activity GO:0045859 105 0.015
cation transport GO:0006812 382 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
memory GO:0007613 54 0.015
anion transport GO:0006820 178 0.015
reactive oxygen species metabolic process GO:0072593 37 0.015
circulatory system development GO:0072359 134 0.015
organophosphate metabolic process GO:0019637 370 0.015
regulation of cell motility GO:2000145 131 0.015
Rat
ion homeostasis GO:0050801 212 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
ras protein signal transduction GO:0007265 29 0.015
regulation of cell growth GO:0001558 85 0.015
metal ion homeostasis GO:0055065 186 0.015
b cell differentiation GO:0030183 2 0.015
muscle cell proliferation GO:0033002 84 0.015
regulation of cell cycle g2 m phase transition GO:1902749 4 0.015
cell cycle g1 s phase transition GO:0044843 13 0.015
sodium ion transport GO:0006814 82 0.015
gonad development GO:0008406 104 0.015
intracellular protein transport GO:0006886 79 0.015
positive regulation of response to external stimulus GO:0032103 51 0.014
Rat
cellular response to organonitrogen compound GO:0071417 197 0.014
asymmetric protein localization GO:0008105 2 0.014
regulation of peptidase activity GO:0052547 55 0.014
Rat
g protein coupled receptor signaling pathway GO:0007186 242 0.014
regulation of cell migration GO:0030334 128 0.014
Rat
chemotaxis GO:0006935 66 0.014
Rat
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.014
leukocyte activation GO:0045321 76 0.014
negative regulation of cell cycle phase transition GO:1901988 4 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
Rat
cellular protein catabolic process GO:0044257 19 0.014
chemical homeostasis GO:0048878 292 0.014
regulation of g2 m transition of mitotic cell cycle GO:0010389 4 0.014
developmental growth GO:0048589 100 0.014
calcium ion homeostasis GO:0055074 162 0.014
regulation of secretion by cell GO:1903530 208 0.014
regulation of hormone levels GO:0010817 187 0.014
developmental maturation GO:0021700 25 0.014
single organism intracellular transport GO:1902582 166 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
Rat
purine nucleotide metabolic process GO:0006163 229 0.014
cell activation GO:0001775 97 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
Rat
regulation of nucleotide metabolic process GO:0006140 117 0.014
positive regulation of transferase activity GO:0051347 81 0.014
regulation of cell cycle GO:0051726 73 0.014
osteoblast differentiation GO:0001649 26 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
Rat
cellular calcium ion homeostasis GO:0006874 160 0.014
response to peptide GO:1901652 292 0.014
regulation of cellular catabolic process GO:0031329 101 0.013
positive regulation of response to wounding GO:1903036 34 0.013
nucleoside metabolic process GO:0009116 179 0.013
regulation of proteasomal protein catabolic process GO:0061136 4 0.013
regulation of ion transport GO:0043269 245 0.013
response to external biotic stimulus GO:0043207 221 0.013
nitrogen compound transport GO:0071705 229 0.013
mapk cascade GO:0000165 140 0.013
Rat
leukocyte cell cell adhesion GO:0007159 4 0.013
endothelial cell apoptotic process GO:0072577 3 0.013
protein catabolic process GO:0030163 30 0.013
digestive system development GO:0055123 41 0.013
cellular response to peptide GO:1901653 133 0.013
neuron death GO:0070997 127 0.013
cellular response to fluid shear stress GO:0071498 4 0.013
regulation of cell adhesion GO:0030155 52 0.013
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
Rat
cellular homeostasis GO:0019725 252 0.013
regulation of cell substrate adhesion GO:0010810 18 0.013
Rat
hormone transport GO:0009914 121 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
Rat
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.013
cellular response to hormone stimulus GO:0032870 247 0.013
spermatogenesis GO:0007283 99 0.013
cell junction assembly GO:0034329 18 0.013
Rat
muscle organ development GO:0007517 50 0.012
response to bacterium GO:0009617 200 0.012
mitotic cell cycle phase transition GO:0044772 20 0.012
response to ethanol GO:0045471 162 0.012
axonogenesis GO:0007409 71 0.012
rho protein signal transduction GO:0007266 11 0.012
lipid transport GO:0006869 61 0.012
forebrain development GO:0030900 98 0.012
macromolecule localization GO:0033036 252 0.012
ovulation cycle process GO:0022602 50 0.012
protein homooligomerization GO:0051260 91 0.012
regulation of secretion GO:0051046 224 0.012
secretion by cell GO:0032940 248 0.012
multi multicellular organism process GO:0044706 138 0.012
response to tumor necrosis factor GO:0034612 56 0.012
response to glucose GO:0009749 136 0.012
cell cycle checkpoint GO:0000075 2 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
brain development GO:0007420 247 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.011
Rat
purine ribonucleotide biosynthetic process GO:0009152 81 0.011
adherens junction assembly GO:0034333 10 0.011
Rat
negative regulation of catalytic activity GO:0043086 103 0.011
regulation of response to external stimulus GO:0032101 106 0.011
Rat
response to monosaccharide GO:0034284 159 0.011
response to acid chemical GO:0001101 222 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
protein localization GO:0008104 191 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
syncytium formation by plasma membrane fusion GO:0000768 3 0.011
negative regulation of protein maturation GO:1903318 47 0.011
regulation of endopeptidase activity GO:0052548 51 0.011
Rat
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
regulation of cell cycle process GO:0010564 31 0.011
regulation of anatomical structure size GO:0090066 135 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
regulation of muscle cell apoptotic process GO:0010660 26 0.011
Rat
positive regulation of secretion by cell GO:1903532 128 0.011
regulation of defense response GO:0031347 68 0.011
inflammatory response GO:0006954 150 0.011
regulation of rna splicing GO:0043484 6 0.011
lipid biosynthetic process GO:0008610 128 0.011
gliogenesis GO:0042063 93 0.011
secretion GO:0046903 307 0.011
cellular lipid metabolic process GO:0044255 208 0.011
regulation of cell projection organization GO:0031344 175 0.011
Rat
rna localization GO:0006403 4 0.010
positive regulation of kinase activity GO:0033674 77 0.010
muscle tissue development GO:0060537 58 0.010
hair follicle development GO:0001942 2 0.010
endomembrane system organization GO:0010256 48 0.010
protein localization to organelle GO:0033365 57 0.010
monovalent inorganic cation transport GO:0015672 172 0.010
positive regulation of protein kinase activity GO:0045860 73 0.010
chromosome segregation GO:0007059 2 0.010
myoblast fusion GO:0007520 2 0.010
cytoplasmic transport GO:0016482 115 0.010
insulin like growth factor receptor signaling pathway GO:0048009 3 0.010
regulation of vesicle mediated transport GO:0060627 81 0.010
cellular response to external stimulus GO:0071496 118 0.010
negative regulation of nervous system development GO:0051961 79 0.010
eye morphogenesis GO:0048592 4 0.010
ribonucleotide metabolic process GO:0009259 231 0.010
regulation of protein localization GO:0032880 81 0.010
modification dependent macromolecule catabolic process GO:0043632 14 0.010
regulation of embryonic development GO:0045995 2 0.010
enzyme linked receptor protein signaling pathway GO:0007167 116 0.010
Rat
regulation of response to wounding GO:1903034 69 0.010
response to fluid shear stress GO:0034405 16 0.010
cation homeostasis GO:0055080 195 0.010
positive regulation of ion transport GO:0043270 94 0.010
growth GO:0040007 165 0.010

Smad4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.013