Rattus norvegicus

0 known processes

Sox18

SRY (sex determining region Y)-box 18

Sox18 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
noradrenergic neuron differentiation GO:0003357 1 0.325
Rat
regulation of cellular protein metabolic process GO:0032268 267 0.224
negative regulation of cellular biosynthetic process GO:0031327 161 0.211
Human Rat Fly
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.197
Human Rat Fly
regulation of signal transduction GO:0009966 318 0.187
negative regulation of transcription regulatory region dna binding GO:2000678 2 0.176
Rat
transcription dna templated GO:0006351 377 0.172
Human Rat Fly
regulation of rna biosynthetic process GO:2001141 381 0.151
Human Rat Fly
negative regulation of gene expression GO:0010629 199 0.145
Human Rat Fly
transcription from rna polymerase ii promoter GO:0006366 252 0.143
Human Rat Fly
rna biosynthetic process GO:0032774 380 0.140
Human Rat Fly
regulation of protein metabolic process GO:0051246 289 0.139
regulation of canonical wnt signaling pathway GO:0060828 4 0.136
nucleic acid templated transcription GO:0097659 379 0.135
Human Rat Fly
negative regulation of macromolecule metabolic process GO:0010605 260 0.134
Human Rat Fly
negative regulation of cellular metabolic process GO:0031324 281 0.123
Human Rat Fly
negative regulation of rna biosynthetic process GO:1902679 118 0.122
Human Rat Fly
negative regulation of metabolic process GO:0009892 331 0.118
Human Rat Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.114
Human Rat Fly
positive regulation of regulatory t cell differentiation GO:0045591 2 0.109
positive regulation of gene expression GO:0010628 244 0.105
Human Rat
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.104
Human Rat Fly
negative regulation of rna metabolic process GO:0051253 123 0.102
Human Rat Fly
regulation of multicellular organismal development GO:2000026 376 0.101
regulation of apoptotic process GO:0042981 335 0.101
Fly
regulation of transcription regulatory region dna binding GO:2000677 4 0.100
Rat
regulation of rna metabolic process GO:0051252 391 0.095
Human Rat Fly
organic acid metabolic process GO:0006082 292 0.084
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.083
Human Rat
protein phosphorylation GO:0006468 345 0.079
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.079
Human Rat
angiogenesis GO:0001525 53 0.078
Human
negative regulation of biosynthetic process GO:0009890 168 0.078
Human Rat Fly
carboxylic acid metabolic process GO:0019752 289 0.077
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.076
Human Fly
positive regulation of developmental process GO:0051094 283 0.072
regulation of programmed cell death GO:0043067 341 0.070
Fly
positive regulation of biosynthetic process GO:0009891 319 0.070
Human Rat
regulation of phosphate metabolic process GO:0019220 349 0.070
gastrulation GO:0007369 2 0.070
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.069
Human Rat Fly
regulation of molecular function GO:0065009 398 0.069
Rat
regulation of transcription dna templated GO:0006355 374 0.068
Human Rat Fly
negative regulation of nucleic acid templated transcription GO:1903507 117 0.064
Human Rat Fly
negative regulation of transcription dna templated GO:0045892 116 0.063
Human Rat Fly
rna metabolic process GO:0016070 406 0.061
Human Rat Fly
tissue development GO:0009888 252 0.061
Human
oxoacid metabolic process GO:0043436 290 0.061
negative regulation of cell death GO:0060548 229 0.060
Fly
negative regulation of molecular function GO:0044092 133 0.060
Rat
positive regulation of cell differentiation GO:0045597 217 0.058
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.058
Human Rat
regulation of cell proliferation GO:0042127 359 0.057
Fly
programmed cell death GO:0012501 392 0.056
Fly
neuron differentiation GO:0030182 368 0.055
Rat
apoptotic process GO:0006915 381 0.053
Fly
regulation of cell differentiation GO:0045595 320 0.052
anatomical structure morphogenesis GO:0009653 298 0.051
Human
cell projection organization GO:0030030 302 0.050
regulation of cellular ketone metabolic process GO:0010565 27 0.050
central nervous system development GO:0007417 311 0.049
Rat
regulation of nervous system development GO:0051960 264 0.049
ribonucleotide metabolic process GO:0009259 231 0.048
circulatory system development GO:0072359 134 0.047
Human
regulation of cellular component movement GO:0051270 150 0.046
formation of primary germ layer GO:0001704 1 0.046
cellular response to oxygen containing compound GO:1901701 386 0.046
regulation of protein phosphorylation GO:0001932 183 0.046
regulation of cell development GO:0060284 263 0.046
reproductive process GO:0022414 372 0.045
glial cell differentiation GO:0010001 65 0.045
Rat
regulation of catalytic activity GO:0050790 304 0.043
kidney development GO:0001822 67 0.043
Rat
negative regulation of apoptotic process GO:0043066 181 0.043
Fly
protein complex assembly GO:0006461 263 0.043
macromolecular complex assembly GO:0065003 273 0.043
positive regulation of rna metabolic process GO:0051254 203 0.042
Human Rat
positive regulation of cell death GO:0010942 184 0.042
response to extracellular stimulus GO:0009991 380 0.042
cellular response to endogenous stimulus GO:0071495 377 0.041
regulation of protein modification process GO:0031399 194 0.040
positive regulation of rna biosynthetic process GO:1902680 197 0.040
Human Rat
cellular amine metabolic process GO:0044106 38 0.040
regulation of cellular amine metabolic process GO:0033238 8 0.040
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.040
Human Rat Fly
cellular amino acid metabolic process GO:0006520 107 0.040
regulation of cellular amino acid metabolic process GO:0006521 2 0.040
localization of cell GO:0051674 202 0.039
Human
intracellular signal transduction GO:0035556 314 0.038
regulation of phosphorylation GO:0042325 248 0.038
renal system development GO:0072001 67 0.038
Rat
regulation of cellular component organization GO:0051128 368 0.037
negative regulation of cell proliferation GO:0008285 119 0.037
Fly
positive regulation of transcription dna templated GO:0045893 197 0.036
Human Rat
response to decreased oxygen levels GO:0036293 237 0.036
positive regulation of cellular protein metabolic process GO:0032270 167 0.036
cellular component biogenesis GO:0044085 368 0.036
positive regulation of multicellular organismal process GO:0051240 387 0.035
positive regulation of protein metabolic process GO:0051247 178 0.035
positive regulation of protein phosphorylation GO:0001934 135 0.035
cellular catabolic process GO:0044248 295 0.035
positive regulation of cellular biosynthetic process GO:0031328 295 0.035
Human Rat
regulation of locomotion GO:0040012 148 0.035
cellular ketone metabolic process GO:0042180 51 0.034
carbohydrate derivative metabolic process GO:1901135 346 0.034
urogenital system development GO:0001655 78 0.034
Rat
response to growth factor GO:0070848 189 0.034
vasculogenesis GO:0001570 3 0.034
cellular component assembly GO:0022607 360 0.034
negative regulation of programmed cell death GO:0043069 183 0.033
Fly
cell morphogenesis involved in differentiation GO:0000904 119 0.033
regulation of nucleic acid templated transcription GO:1903506 380 0.033
Human Rat Fly
tube development GO:0035295 89 0.032
blood vessel development GO:0001568 69 0.032
Human
neuron projection development GO:0031175 273 0.032
cell migration GO:0016477 197 0.032
Human
regeneration GO:0031099 163 0.032
regulation of membrane potential GO:0042391 110 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.029
negative regulation of cell communication GO:0010648 158 0.029
calcium ion homeostasis GO:0055074 162 0.029
regulation of neurogenesis GO:0050767 247 0.029
cellular divalent inorganic cation homeostasis GO:0072503 162 0.029
chemical homeostasis GO:0048878 292 0.029
positive regulation of cellular component organization GO:0051130 200 0.029
positive regulation of response to stimulus GO:0048584 285 0.028
negative regulation of multicellular organismal process GO:0051241 203 0.028
epithelial cell proliferation GO:0050673 54 0.028
neuron development GO:0048666 286 0.028
organ morphogenesis GO:0009887 75 0.028
regulation of neuron differentiation GO:0045664 208 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
cellular homeostasis GO:0019725 252 0.027
positive regulation of cell proliferation GO:0008284 249 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.026
organelle organization GO:0006996 266 0.026
regulation of anatomical structure morphogenesis GO:0022603 141 0.026
homeostatic process GO:0042592 331 0.026
amine metabolic process GO:0009308 38 0.026
brain development GO:0007420 247 0.026
cell cell signaling GO:0007267 335 0.026
anatomical structure formation involved in morphogenesis GO:0048646 83 0.025
Human
organophosphate metabolic process GO:0019637 370 0.025
ribonucleoside metabolic process GO:0009119 174 0.025
regulation of anatomical structure size GO:0090066 135 0.025
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.025
protein complex biogenesis GO:0070271 263 0.025
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.025
negative regulation of response to stimulus GO:0048585 155 0.025
sensory organ development GO:0007423 74 0.024
Fly
organ regeneration GO:0031100 101 0.024
actin filament based process GO:0030029 86 0.024
positive regulation of nucleic acid templated transcription GO:1903508 197 0.024
Human Rat
single organism organelle organization GO:1902589 180 0.024
blood vessel morphogenesis GO:0048514 58 0.024
Human
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
enzyme linked receptor protein signaling pathway GO:0007167 116 0.023
positive regulation of neurogenesis GO:0050769 165 0.023
catabolic process GO:0009056 351 0.023
cellular response to organic cyclic compound GO:0071407 202 0.023
response to corticosteroid GO:0031960 235 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.022
Human Rat
gliogenesis GO:0042063 93 0.022
Rat
immune system process GO:0002376 204 0.022
regulation of catabolic process GO:0009894 113 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.022
macromolecule localization GO:0033036 252 0.022
macromolecular complex subunit organization GO:0043933 339 0.021
response to oxygen levels GO:0070482 265 0.021
locomotion GO:0040011 237 0.021
Human
axis specification GO:0009798 4 0.021
cellular chemical homeostasis GO:0055082 247 0.021
cellular response to stress GO:0033554 269 0.021
cell projection morphogenesis GO:0048858 123 0.021
cell part morphogenesis GO:0032990 123 0.021
response to monosaccharide GO:0034284 159 0.021
negative regulation of protein metabolic process GO:0051248 114 0.021
positive regulation of cell development GO:0010720 176 0.021
multicellular organismal reproductive process GO:0048609 233 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
positive regulation of protein modification process GO:0031401 142 0.020
head development GO:0060322 247 0.020
positive regulation of apoptotic process GO:0043065 154 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
single organism catabolic process GO:0044712 283 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
positive regulation of molecular function GO:0044093 230 0.020
cell motility GO:0048870 202 0.020
Human
regulation of kinase activity GO:0043549 117 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
regulation of cell motility GO:2000145 131 0.020
regulation of alpha beta t cell activation GO:0046634 2 0.019
multi multicellular organism process GO:0044706 138 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
nucleoside metabolic process GO:0009116 179 0.019
metal ion homeostasis GO:0055065 186 0.019
ras protein signal transduction GO:0007265 29 0.019
peptidyl amino acid modification GO:0018193 126 0.019
cellular response to lipid GO:0071396 201 0.019
regulation of neuron projection development GO:0010975 161 0.019
carbohydrate derivative catabolic process GO:1901136 147 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
cellular component movement GO:0006928 248 0.019
Human
cellular macromolecule localization GO:0070727 122 0.019
single organism reproductive process GO:0044702 297 0.019
purine containing compound catabolic process GO:0072523 138 0.019
cellular cation homeostasis GO:0030003 180 0.018
growth GO:0040007 165 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
positive regulation of transport GO:0051050 245 0.018
cell morphogenesis GO:0000902 142 0.018
regulation of epithelial cell proliferation GO:0050678 49 0.018
proteolysis GO:0006508 175 0.018
lipid metabolic process GO:0006629 283 0.018
regulation of stem cell differentiation GO:2000736 2 0.018
female pregnancy GO:0007565 122 0.018
multi organism reproductive process GO:0044703 262 0.017
digestive system development GO:0055123 41 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
cellular component morphogenesis GO:0032989 155 0.017
regulation of cell projection organization GO:0031344 175 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
cytosolic calcium ion homeostasis GO:0051480 140 0.017
embryo development GO:0009790 49 0.017
purine nucleotide catabolic process GO:0006195 136 0.017
nucleoside catabolic process GO:0009164 126 0.017
positive regulation of signal transduction GO:0009967 175 0.017
multicellular organism reproduction GO:0032504 233 0.017
response to hypoxia GO:0001666 231 0.017
regulation of cellular localization GO:0060341 263 0.017
nucleotide metabolic process GO:0009117 279 0.017
nucleotide catabolic process GO:0009166 139 0.017
cellular ion homeostasis GO:0006873 184 0.017
heart morphogenesis GO:0003007 3 0.016
bmp signaling pathway GO:0030509 4 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
organic substance catabolic process GO:1901575 316 0.016
regulation of fat cell differentiation GO:0045598 3 0.016
neuron apoptotic process GO:0051402 88 0.016
synaptic transmission GO:0007268 235 0.016
vesicle mediated transport GO:0016192 181 0.016
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.016
positive regulation of nervous system development GO:0051962 178 0.016
single organism membrane organization GO:0044802 74 0.016
protein oligomerization GO:0051259 191 0.016
single organism intracellular transport GO:1902582 166 0.016
positive regulation of signaling GO:0023056 270 0.016
positive regulation of locomotion GO:0040017 102 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
erythrocyte differentiation GO:0030218 1 0.016
ossification GO:0001503 70 0.016
reproduction GO:0000003 245 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
cardiovascular system development GO:0072358 134 0.016
Human
protein complex subunit organization GO:0071822 302 0.016
t cell homeostasis GO:0043029 2 0.015
negative regulation of osteoblast differentiation GO:0045668 2 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
response to nutrient GO:0007584 248 0.015
single organism biosynthetic process GO:0044711 342 0.015
cellular calcium ion homeostasis GO:0006874 160 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
response to radiation GO:0009314 137 0.015
cation homeostasis GO:0055080 195 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
purine containing compound metabolic process GO:0072521 253 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
regulation of cell migration GO:0030334 128 0.014
biological adhesion GO:0022610 110 0.014
aromatic compound catabolic process GO:0019439 168 0.014
negative regulation of cell development GO:0010721 82 0.014
vasculature development GO:0001944 70 0.014
Human
negative regulation of signaling GO:0023057 157 0.014
response to ketone GO:1901654 182 0.014
positive regulation of cell communication GO:0010647 271 0.014
cell cell signaling involved in cell fate commitment GO:0045168 2 0.014
digestive tract development GO:0048565 39 0.014
neuron fate commitment GO:0048663 4 0.014
ameboidal type cell migration GO:0001667 26 0.014
Human
regulation of transferase activity GO:0051338 123 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
response to mechanical stimulus GO:0009612 134 0.013
regulation of regulatory t cell differentiation GO:0045589 2 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
neurological system process GO:0050877 219 0.013
regulation of immune system process GO:0002682 123 0.013
embryonic axis specification GO:0000578 1 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
regulation of actin filament based process GO:0032970 42 0.013
neuron projection morphogenesis GO:0048812 122 0.013
positive regulation of cellular component movement GO:0051272 102 0.013
cytoskeleton organization GO:0007010 111 0.013
guanosine containing compound catabolic process GO:1901069 71 0.013
intracellular transport GO:0046907 185 0.013
metal ion transport GO:0030001 289 0.013
regulation of neuron death GO:1901214 115 0.013
ion homeostasis GO:0050801 212 0.013
regulation of growth GO:0040008 105 0.013
negative regulation of protein phosphorylation GO:0001933 44 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
positive regulation of alpha beta t cell activation GO:0046635 2 0.013
membrane organization GO:0061024 94 0.013
regulation of cellular component biogenesis GO:0044087 86 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
negative regulation of signal transduction GO:0009968 83 0.013
small gtpase mediated signal transduction GO:0007264 36 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
endocytosis GO:0006897 84 0.012
anterior posterior pattern specification GO:0009952 1 0.012
sex differentiation GO:0007548 113 0.012
response to estrogen GO:0043627 232 0.012
morphogenesis of embryonic epithelium GO:0016331 3 0.012
gamete generation GO:0007276 124 0.012
cellular response to external stimulus GO:0071496 118 0.012
epithelium development GO:0060429 96 0.012
Human
negative regulation of neurogenesis GO:0050768 78 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
protein localization GO:0008104 191 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
heterocycle catabolic process GO:0046700 167 0.012
negative regulation of developmental process GO:0051093 125 0.012
peptidyl tyrosine phosphorylation GO:0018108 72 0.012
transmembrane transport GO:0055085 412 0.012
regulation of hydrolase activity GO:0051336 143 0.012
male gamete generation GO:0048232 99 0.012
adult locomotory behavior GO:0008344 4 0.012
male sex differentiation GO:0046661 64 0.012
behavior GO:0007610 205 0.011
response to wounding GO:0009611 254 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
eye morphogenesis GO:0048592 4 0.011
spermatogenesis GO:0007283 99 0.011
sexual reproduction GO:0019953 148 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
negative regulation of nervous system development GO:0051961 79 0.011
second messenger mediated signaling GO:0019932 51 0.011
rho protein signal transduction GO:0007266 11 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
embryonic pattern specification GO:0009880 1 0.011
erythrocyte homeostasis GO:0034101 2 0.011
positive regulation of endothelial cell migration GO:0010595 4 0.011
ion transmembrane transport GO:0034220 365 0.011
regulation of system process GO:0044057 208 0.011
neural crest cell differentiation GO:0014033 2 0.011
regulation of secretion by cell GO:1903530 208 0.011
cellular response to alcohol GO:0097306 87 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
regulation of endocytosis GO:0030100 42 0.011
response to glucocorticoid GO:0051384 223 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
cellular protein localization GO:0034613 122 0.011
negative regulation of innate immune response GO:0045824 4 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
immunoglobulin mediated immune response GO:0016064 4 0.011
regulation of vesicle mediated transport GO:0060627 81 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
reproductive system development GO:0061458 128 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
positive regulation of humoral immune response GO:0002922 2 0.010
regulation of embryonic development GO:0045995 2 0.010
regulation of tube size GO:0035150 89 0.010
glial cell development GO:0021782 19 0.010
Rat
response to hexose GO:0009746 144 0.010
regulation of axonogenesis GO:0050770 37 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
nitrogen compound transport GO:0071705 229 0.010
positive regulation of phagocytosis engulfment GO:0060100 4 0.010
response to vitamin GO:0033273 131 0.010
regulation of synaptic transmission GO:0050804 141 0.010
skeletal system development GO:0001501 41 0.010
response to carbohydrate GO:0009743 183 0.010
forebrain development GO:0030900 98 0.010
reproductive structure development GO:0048608 128 0.010

Sox18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.014
disease of anatomical entity DOID:7 0 0.014
central nervous system disease DOID:331 0 0.010