Rattus norvegicus

0 known processes

Spink8

serine peptidase inhibitor, Kazal type 8

(Aliases: RGD1307150)

Spink8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
anatomical structure morphogenesis GO:0009653 298 0.083
positive regulation of multicellular organismal process GO:0051240 387 0.083
response to temperature stimulus GO:0009266 94 0.078
response to wounding GO:0009611 254 0.078
regulation of phosphorus metabolic process GO:0051174 349 0.076
response to oxygen levels GO:0070482 265 0.071
programmed cell death GO:0012501 392 0.068
regulation of programmed cell death GO:0043067 341 0.066
cellular component biogenesis GO:0044085 368 0.062
positive regulation of cellular component organization GO:0051130 200 0.057
positive regulation of response to stimulus GO:0048584 285 0.057
biological adhesion GO:0022610 110 0.056
reproductive process GO:0022414 372 0.055
tissue development GO:0009888 252 0.055
cellular component assembly GO:0022607 360 0.055
cellular component morphogenesis GO:0032989 155 0.054
cell adhesion GO:0007155 110 0.053
reproduction GO:0000003 245 0.049
organ morphogenesis GO:0009887 75 0.048
multicellular organism reproduction GO:0032504 233 0.048
monovalent inorganic cation transport GO:0015672 172 0.048
regulation of apoptotic process GO:0042981 335 0.046
cation transport GO:0006812 382 0.046
regulation of cellular component organization GO:0051128 368 0.044
striated muscle tissue development GO:0014706 58 0.044
single organism reproductive process GO:0044702 297 0.043
multicellular organismal reproductive process GO:0048609 233 0.041
secretion GO:0046903 307 0.041
signal transduction by phosphorylation GO:0023014 144 0.040
response to peptide GO:1901652 292 0.040
positive regulation of biosynthetic process GO:0009891 319 0.039
response to inorganic substance GO:0010035 377 0.039
gland development GO:0048732 155 0.038
regulation of hormone levels GO:0010817 187 0.038
cell projection organization GO:0030030 302 0.037
single organismal cell cell adhesion GO:0016337 42 0.037
single organism biosynthetic process GO:0044711 342 0.037
macromolecular complex subunit organization GO:0043933 339 0.037
organelle organization GO:0006996 266 0.036
metal ion transport GO:0030001 289 0.036
muscle system process GO:0003012 115 0.035
transmembrane transport GO:0055085 412 0.035
cellular response to stress GO:0033554 269 0.035
positive regulation of cell proliferation GO:0008284 249 0.035
regulation of body fluid levels GO:0050878 90 0.034
intracellular signal transduction GO:0035556 314 0.034
reproductive system development GO:0061458 128 0.034
growth GO:0040007 165 0.034
positive regulation of phosphate metabolic process GO:0045937 262 0.033
anion transport GO:0006820 178 0.033
organic anion transport GO:0015711 132 0.033
secretion by cell GO:0032940 248 0.032
neuron projection development GO:0031175 273 0.032
regulation of multicellular organismal development GO:2000026 376 0.032
liver development GO:0001889 90 0.032
neuron development GO:0048666 286 0.032
positive regulation of transport GO:0051050 245 0.032
response to extracellular stimulus GO:0009991 380 0.031
organic cyclic compound catabolic process GO:1901361 175 0.031
positive regulation of secretion GO:0051047 140 0.031
nucleic acid templated transcription GO:0097659 379 0.030
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.030
regulation of anatomical structure morphogenesis GO:0022603 141 0.030
carboxylic acid transport GO:0046942 115 0.030
negative regulation of programmed cell death GO:0043069 183 0.030
positive regulation of signaling GO:0023056 270 0.029
regulation of cell proliferation GO:0042127 359 0.029
sodium ion transport GO:0006814 82 0.028
sulfur compound biosynthetic process GO:0044272 19 0.028
head development GO:0060322 247 0.028
cell growth GO:0016049 104 0.027
hormone transport GO:0009914 121 0.027
purine nucleoside metabolic process GO:0042278 169 0.027
regulation of response to external stimulus GO:0032101 106 0.027
response to peptide hormone GO:0043434 278 0.026
cation transmembrane transport GO:0098655 263 0.026
single organism cell adhesion GO:0098602 46 0.026
cell morphogenesis GO:0000902 142 0.026
protein complex subunit organization GO:0071822 302 0.026
hepaticobiliary system development GO:0061008 90 0.026
developmental process involved in reproduction GO:0003006 159 0.026
muscle tissue development GO:0060537 58 0.026
regulation of phosphate metabolic process GO:0019220 349 0.025
sensory organ development GO:0007423 74 0.025
behavior GO:0007610 205 0.025
sexual reproduction GO:0019953 148 0.025
homeostatic process GO:0042592 331 0.025
ribose phosphate metabolic process GO:0019693 235 0.025
organophosphate metabolic process GO:0019637 370 0.025
regulation of catalytic activity GO:0050790 304 0.024
hepatocyte proliferation GO:0072574 3 0.024
brain development GO:0007420 247 0.024
positive regulation of cell communication GO:0010647 271 0.024
regulation of cell development GO:0060284 263 0.024
response to estrogen GO:0043627 232 0.023
negative regulation of cell death GO:0060548 229 0.023
response to mechanical stimulus GO:0009612 134 0.023
organic acid biosynthetic process GO:0016053 83 0.022
regulation of establishment of planar polarity GO:0090175 2 0.022
purine containing compound catabolic process GO:0072523 138 0.022
response to hypoxia GO:0001666 231 0.022
anterior posterior pattern specification GO:0009952 1 0.022
cellular chemical homeostasis GO:0055082 247 0.022
positive regulation of signal transduction GO:0009967 175 0.022
response to decreased oxygen levels GO:0036293 237 0.022
carboxylic acid metabolic process GO:0019752 289 0.022
response to heat GO:0009408 60 0.021
epithelium development GO:0060429 96 0.021
neuron differentiation GO:0030182 368 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
muscle filament sliding GO:0030049 2 0.021
cation homeostasis GO:0055080 195 0.021
oxoacid metabolic process GO:0043436 290 0.021
carbohydrate derivative catabolic process GO:1901136 147 0.020
fibrinolysis GO:0042730 2 0.020
epithelial cell proliferation GO:0050673 54 0.020
protein phosphorylation GO:0006468 345 0.020
regulation of response to stress GO:0080134 126 0.020
macromolecular complex assembly GO:0065003 273 0.020
muscle structure development GO:0061061 87 0.020
actin filament based process GO:0030029 86 0.020
rhythmic process GO:0048511 156 0.020
regulation of rna metabolic process GO:0051252 391 0.020
acrosome assembly GO:0001675 3 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
regulation of neuron projection development GO:0010975 161 0.020
negative regulation of developmental process GO:0051093 125 0.020
response to nutrient levels GO:0031667 370 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
response to carbohydrate GO:0009743 183 0.020
organic acid metabolic process GO:0006082 292 0.020
potassium ion transport GO:0006813 97 0.020
catabolic process GO:0009056 351 0.020
central nervous system development GO:0007417 311 0.020
intestinal absorption GO:0050892 3 0.020
positive regulation of cell differentiation GO:0045597 217 0.019
positive regulation of intracellular signal transduction GO:1902533 138 0.019
regulation of epithelial cell proliferation GO:0050678 49 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
regulation of transcription dna templated GO:0006355 374 0.019
single organism carbohydrate metabolic process GO:0044723 118 0.019
immune system process GO:0002376 204 0.019
monocarboxylic acid metabolic process GO:0032787 152 0.019
inorganic cation transmembrane transport GO:0098662 202 0.019
negative regulation of signaling GO:0023057 157 0.019
organonitrogen compound catabolic process GO:1901565 179 0.019
epithelial cell differentiation GO:0030855 71 0.019
regulation of secretion by cell GO:1903530 208 0.018
regulation of response to wounding GO:1903034 69 0.018
macromolecule localization GO:0033036 252 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
protein complex assembly GO:0006461 263 0.018
apoptotic process GO:0006915 381 0.018
cell cycle GO:0007049 101 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
spermatogenesis GO:0007283 99 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
chemical homeostasis GO:0048878 292 0.018
regulation of secretion GO:0051046 224 0.018
cellular homeostasis GO:0019725 252 0.018
organic substance catabolic process GO:1901575 316 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
nitrogen compound transport GO:0071705 229 0.018
cytoskeleton organization GO:0007010 111 0.017
negative regulation of wound healing GO:0061045 8 0.017
liver morphogenesis GO:0072576 3 0.017
positive regulation of secretion by cell GO:1903532 128 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
response to nutrient GO:0007584 248 0.017
positive regulation of gene expression GO:0010628 244 0.017
cell cell signaling GO:0007267 335 0.017
cell type specific apoptotic process GO:0097285 134 0.017
ion transmembrane transport GO:0034220 365 0.017
response to monosaccharide GO:0034284 159 0.017
heart morphogenesis GO:0003007 3 0.017
signal release GO:0023061 145 0.017
ion homeostasis GO:0050801 212 0.017
regulation of neuron differentiation GO:0045664 208 0.017
calcium ion homeostasis GO:0055074 162 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
negative regulation of metabolic process GO:0009892 331 0.016
aromatic compound catabolic process GO:0019439 168 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
regulation of nervous system development GO:0051960 264 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
developmental growth GO:0048589 100 0.016
rna metabolic process GO:0016070 406 0.016
development of primary sexual characteristics GO:0045137 107 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
multi organism reproductive process GO:0044703 262 0.016
cellular protein complex assembly GO:0043623 44 0.016
response to tumor necrosis factor GO:0034612 56 0.016
wound healing GO:0042060 122 0.016
proteolysis GO:0006508 175 0.016
regulation of molecular function GO:0065009 398 0.016
ras protein signal transduction GO:0007265 29 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
regulation of fibrinolysis GO:0051917 2 0.016
coenzyme metabolic process GO:0006732 86 0.015
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.015
regeneration GO:0031099 163 0.015
regulation of cell projection organization GO:0031344 175 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
gamete generation GO:0007276 124 0.015
regulation of cell adhesion GO:0030155 52 0.015
gastrulation GO:0007369 2 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
regulation of protein metabolic process GO:0051246 289 0.015
cellular ion homeostasis GO:0006873 184 0.015
purine containing compound metabolic process GO:0072521 253 0.014
nucleoside phosphate catabolic process GO:1901292 140 0.014
positive regulation of nervous system development GO:0051962 178 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
amide transport GO:0042886 105 0.014
regulation of cell growth GO:0001558 85 0.014
nucleotide metabolic process GO:0009117 279 0.014
lipid biosynthetic process GO:0008610 128 0.014
alcohol metabolic process GO:0006066 77 0.014
positive regulation of ion transport GO:0043270 94 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
carboxylic acid biosynthetic process GO:0046394 83 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
positive regulation of blood coagulation GO:0030194 4 0.014
embryonic appendage morphogenesis GO:0035113 4 0.014
acetyl coa metabolic process GO:0006084 17 0.014
regulation of cell differentiation GO:0045595 320 0.013
response to insulin GO:0032868 133 0.013
cardiac muscle tissue morphogenesis GO:0055008 1 0.013
establishment of tissue polarity GO:0007164 2 0.013
regulation of neurogenesis GO:0050767 247 0.013
peptide transport GO:0015833 97 0.013
smooth muscle contraction GO:0006939 37 0.013
protein localization GO:0008104 191 0.013
coagulation GO:0050817 28 0.013
male gamete generation GO:0048232 99 0.013
single organism organelle organization GO:1902589 180 0.013
action potential GO:0001508 54 0.013
digestion GO:0007586 26 0.013
axis specification GO:0009798 4 0.013
sodium ion transmembrane transport GO:0035725 67 0.013
inflammatory response GO:0006954 150 0.013
cell motility GO:0048870 202 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.013
cell part morphogenesis GO:0032990 123 0.013
fractalkine metabolic process GO:0050756 3 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
cellular response to low density lipoprotein particle stimulus GO:0071404 3 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.013
cellular response to lipid GO:0071396 201 0.012
cardiovascular system development GO:0072358 134 0.012
amine metabolic process GO:0009308 38 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
ovulation cycle GO:0042698 67 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
positive regulation of developmental process GO:0051094 283 0.012
localization of cell GO:0051674 202 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
chromosome segregation GO:0007059 2 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
regulation of ion transport GO:0043269 245 0.012
positive regulation of cell death GO:0010942 184 0.012
organ regeneration GO:0031100 101 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
regulation of cellular protein metabolic process GO:0032268 267 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
response to lipopolysaccharide GO:0032496 191 0.012
epithelial cell proliferation involved in liver morphogenesis GO:0072575 3 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
gonad development GO:0008406 104 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
regulation of peptide secretion GO:0002791 82 0.012
regulation of cellular localization GO:0060341 263 0.012
cellular response to oxygen levels GO:0071453 60 0.012
response to ethanol GO:0045471 162 0.012
regulation of homotypic cell cell adhesion GO:0034110 4 0.012
regulation of growth GO:0040008 105 0.012
blood coagulation GO:0007596 26 0.012
response to bacterium GO:0009617 200 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
metal ion homeostasis GO:0055065 186 0.012
hepatocyte differentiation GO:0070365 8 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
regulation of rna biosynthetic process GO:2001141 381 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
regulation of hormone secretion GO:0046883 106 0.012
nucleoside metabolic process GO:0009116 179 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
cellular calcium ion homeostasis GO:0006874 160 0.011
transcription dna templated GO:0006351 377 0.011
circulatory system development GO:0072359 134 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
limb morphogenesis GO:0035108 4 0.011
response to fatty acid GO:0070542 65 0.011
regulation of signal transduction GO:0009966 318 0.011
response to hexose GO:0009746 144 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
regulation of muscle system process GO:0090257 79 0.011
cellular response to oxygen containing compound GO:1901701 386 0.011
meiotic cell cycle process GO:1903046 3 0.011
regulation of muscle contraction GO:0006937 53 0.011
heart process GO:0003015 57 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
hormone metabolic process GO:0042445 69 0.011
carbohydrate derivative metabolic process GO:1901135 346 0.011
positive regulation of transferase activity GO:0051347 81 0.011
response to ketone GO:1901654 182 0.011
nucleoside catabolic process GO:0009164 126 0.011
negative regulation of fibrinolysis GO:0051918 2 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
cellular amine metabolic process GO:0044106 38 0.011
cellular catabolic process GO:0044248 295 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
response to growth factor GO:0070848 189 0.011
heterocycle catabolic process GO:0046700 167 0.011
response to other organism GO:0051707 220 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
hemostasis GO:0007599 26 0.011
dicarboxylic acid metabolic process GO:0043648 42 0.011
cellular cation homeostasis GO:0030003 180 0.011
respiratory system development GO:0060541 45 0.011
actin cytoskeleton organization GO:0030036 73 0.011
positive regulation of renin secretion into blood stream GO:1900135 1 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
response to cytokine GO:0034097 215 0.010
regulation of behavior GO:0050795 61 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.010
potassium ion transmembrane transport GO:0071805 71 0.010
response to glucose GO:0009749 136 0.010
carbohydrate metabolic process GO:0005975 130 0.010
axon development GO:0061564 96 0.010
positive regulation of kinase activity GO:0033674 77 0.010
locomotion GO:0040011 237 0.010
single organism catabolic process GO:0044712 283 0.010
regulation of protein kinase activity GO:0045859 105 0.010
positive regulation of cell development GO:0010720 176 0.010
small molecule biosynthetic process GO:0044283 124 0.010
mapk cascade GO:0000165 140 0.010
nucleotide catabolic process GO:0009166 139 0.010
positive regulation of peptide hormone secretion GO:0090277 50 0.010
rho protein signal transduction GO:0007266 11 0.010
peptide hormone secretion GO:0030072 84 0.010

Spink8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
musculoskeletal system disease DOID:17 0 0.036
muscular disease DOID:0080000 0 0.015
nervous system disease DOID:863 0 0.015
cardiovascular system disease DOID:1287 0 0.014
myopathy DOID:423 0 0.013
heart disease DOID:114 0 0.013
cardiomyopathy DOID:0050700 0 0.013
intrinsic cardiomyopathy DOID:0060036 0 0.013
muscle tissue disease DOID:66 0 0.013
central nervous system disease DOID:331 0 0.011
disease of metabolism DOID:0014667 0 0.011