Rattus norvegicus

0 known processes

Spta1

spectrin, alpha, erythrocytic 1 (elliptocytosis 2)

(Aliases: Spna1)

Spta1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 391 0.221
lipid metabolic process GO:0006629 283 0.219
response to glucocorticoid GO:0051384 223 0.211
rna biosynthetic process GO:0032774 380 0.208
response to acid chemical GO:0001101 222 0.191
regulation of phosphorus metabolic process GO:0051174 349 0.155
nucleic acid templated transcription GO:0097659 379 0.141
regulation of rna biosynthetic process GO:2001141 381 0.140
cellular response to endogenous stimulus GO:0071495 377 0.136
negative regulation of cellular metabolic process GO:0031324 281 0.132
positive regulation of nucleic acid templated transcription GO:1903508 197 0.130
response to oxygen levels GO:0070482 265 0.129
response to inorganic substance GO:0010035 377 0.129
multi organism reproductive process GO:0044703 262 0.121
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.120
regulation of phosphate metabolic process GO:0019220 349 0.118
positive regulation of biosynthetic process GO:0009891 319 0.118
transcription from rna polymerase ii promoter GO:0006366 252 0.116
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.115
negative regulation of cell death GO:0060548 229 0.115
transcription dna templated GO:0006351 377 0.114
response to estrogen GO:0043627 232 0.109
regulation of locomotion GO:0040012 148 0.108
response to hypoxia GO:0001666 231 0.106
response to peptide GO:1901652 292 0.106
response to decreased oxygen levels GO:0036293 237 0.105
reproduction GO:0000003 245 0.105
response to metal ion GO:0010038 253 0.104
regulation of nucleic acid templated transcription GO:1903506 380 0.104
regulation of cell differentiation GO:0045595 320 0.103
homeostatic process GO:0042592 331 0.103
enzyme linked receptor protein signaling pathway GO:0007167 116 0.099
intracellular signal transduction GO:0035556 314 0.088
multicellular organism reproduction GO:0032504 233 0.087
single organism reproductive process GO:0044702 297 0.083
response to biotic stimulus GO:0009607 226 0.083
regulation of protein modification process GO:0031399 194 0.080
cell migration GO:0016477 197 0.079
positive regulation of transcription dna templated GO:0045893 197 0.079
ossification GO:0001503 70 0.078
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.076
positive regulation of rna biosynthetic process GO:1902680 197 0.075
regulation of phosphorylation GO:0042325 248 0.074
regulation of homeostatic process GO:0032844 101 0.072
protein phosphorylation GO:0006468 345 0.072
cell projection organization GO:0030030 302 0.071
response to nutrient levels GO:0031667 370 0.070
positive regulation of developmental process GO:0051094 283 0.069
cellular response to nitrogen compound GO:1901699 210 0.069
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.069
regulation of neuron differentiation GO:0045664 208 0.068
positive regulation of phosphorus metabolic process GO:0010562 262 0.067
rna metabolic process GO:0016070 406 0.067
locomotion GO:0040011 237 0.066
response to insulin GO:0032868 133 0.065
cellular response to oxygen containing compound GO:1901701 386 0.064
response to organophosphorus GO:0046683 102 0.064
regulation of transcription dna templated GO:0006355 374 0.064
reproductive process GO:0022414 372 0.063
regulation of programmed cell death GO:0043067 341 0.061
regulation of molecular function GO:0065009 398 0.060
negative regulation of programmed cell death GO:0043069 183 0.059
multicellular organismal reproductive process GO:0048609 233 0.058
neuron differentiation GO:0030182 368 0.058
response to extracellular stimulus GO:0009991 380 0.057
response to bacterium GO:0009617 200 0.057
kidney development GO:0001822 67 0.057
response to molecule of bacterial origin GO:0002237 194 0.056
apoptotic process GO:0006915 381 0.056
response to estradiol GO:0032355 164 0.056
response to corticosteroid GO:0031960 235 0.056
cellular component movement GO:0006928 248 0.056
negative regulation of transcription dna templated GO:0045892 116 0.056
positive regulation of cellular biosynthetic process GO:0031328 295 0.055
response to camp GO:0051591 91 0.055
cellular response to organic cyclic compound GO:0071407 202 0.055
positive regulation of catalytic activity GO:0043085 184 0.054
cellular component biogenesis GO:0044085 368 0.053
chemical homeostasis GO:0048878 292 0.052
response to external biotic stimulus GO:0043207 221 0.052
negative regulation of apoptotic process GO:0043066 181 0.051
positive regulation of molecular function GO:0044093 230 0.050
anatomical structure morphogenesis GO:0009653 298 0.050
single organism biosynthetic process GO:0044711 342 0.050
regulation of cellular protein metabolic process GO:0032268 267 0.049
cellular response to organonitrogen compound GO:0071417 197 0.049
cellular response to lipid GO:0071396 201 0.049
regulation of cell development GO:0060284 263 0.049
renal system development GO:0072001 67 0.048
tube development GO:0035295 89 0.047
response to other organism GO:0051707 220 0.047
negative regulation of gene expression GO:0010629 199 0.047
urogenital system development GO:0001655 78 0.047
circulatory system process GO:0003013 183 0.047
positive regulation of gene expression GO:0010628 244 0.047
positive regulation of protein metabolic process GO:0051247 178 0.046
cellular response to peptide hormone stimulus GO:0071375 120 0.046
localization of cell GO:0051674 202 0.046
positive regulation of multicellular organismal process GO:0051240 387 0.046
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.046
carboxylic acid metabolic process GO:0019752 289 0.045
regulation of cellular ketone metabolic process GO:0010565 27 0.045
positive regulation of protein phosphorylation GO:0001934 135 0.044
cardiovascular system development GO:0072358 134 0.044
regulation of intracellular signal transduction GO:1902531 218 0.044
intracellular transport GO:0046907 185 0.043
response to nutrient GO:0007584 248 0.043
regulation of protein phosphorylation GO:0001932 183 0.042
response to peptide hormone GO:0043434 278 0.042
response to purine containing compound GO:0014074 126 0.041
negative regulation of metabolic process GO:0009892 331 0.040
positive regulation of phosphate metabolic process GO:0045937 262 0.040
ion homeostasis GO:0050801 212 0.039
positive regulation of phosphorylation GO:0042327 177 0.039
tissue development GO:0009888 252 0.038
programmed cell death GO:0012501 392 0.038
cellular lipid metabolic process GO:0044255 208 0.038
negative regulation of nucleic acid templated transcription GO:1903507 117 0.038
negative regulation of cell differentiation GO:0045596 99 0.037
cell morphogenesis GO:0000902 142 0.037
negative regulation of rna metabolic process GO:0051253 123 0.037
regulation of system process GO:0044057 208 0.037
immune system process GO:0002376 204 0.037
negative regulation of rna biosynthetic process GO:1902679 118 0.036
regulation of catalytic activity GO:0050790 304 0.036
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.036
organelle organization GO:0006996 266 0.035
regulation of cellular amine metabolic process GO:0033238 8 0.035
cellular response to hormone stimulus GO:0032870 247 0.035
central nervous system development GO:0007417 311 0.035
nuclear transport GO:0051169 49 0.034
hematopoietic or lymphoid organ development GO:0048534 36 0.034
regulation of nervous system development GO:0051960 264 0.034
metal ion homeostasis GO:0055065 186 0.033
maintenance of location GO:0051235 17 0.033
neuron projection development GO:0031175 273 0.033
positive regulation of cell differentiation GO:0045597 217 0.033
regulation of ossification GO:0030278 32 0.032
regulation of multicellular organismal development GO:2000026 376 0.032
cellular component morphogenesis GO:0032989 155 0.032
carboxylic acid transport GO:0046942 115 0.032
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.032
regulation of signal transduction GO:0009966 318 0.032
regulation of protein metabolic process GO:0051246 289 0.032
cellular homeostasis GO:0019725 252 0.031
regulation of anatomical structure size GO:0090066 135 0.031
bmp signaling pathway GO:0030509 4 0.030
carboxylic acid biosynthetic process GO:0046394 83 0.030
response to ethanol GO:0045471 162 0.030
proteolysis GO:0006508 175 0.030
positive regulation of cellular protein metabolic process GO:0032270 167 0.030
cellular response to stress GO:0033554 269 0.030
cellular response to glucocorticoid stimulus GO:0071385 68 0.030
epithelium development GO:0060429 96 0.030
negative regulation of biosynthetic process GO:0009890 168 0.029
multicellular organismal signaling GO:0035637 44 0.029
regulation of cellular component organization GO:0051128 368 0.029
oxoacid metabolic process GO:0043436 290 0.029
gamete generation GO:0007276 124 0.028
positive regulation of signaling GO:0023056 270 0.028
neuronal action potential GO:0019228 35 0.028
cell morphogenesis involved in differentiation GO:0000904 119 0.028
response to cytokine GO:0034097 215 0.028
organonitrogen compound biosynthetic process GO:1901566 167 0.028
neuron development GO:0048666 286 0.028
negative regulation of cellular biosynthetic process GO:0031327 161 0.027
organ regeneration GO:0031100 101 0.027
cellular ketone metabolic process GO:0042180 51 0.027
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
positive regulation of rna metabolic process GO:0051254 203 0.026
epithelial cell proliferation GO:0050673 54 0.026
organic acid metabolic process GO:0006082 292 0.026
embryo development GO:0009790 49 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.025
regulation of ion transport GO:0043269 245 0.025
regulation of neurogenesis GO:0050767 247 0.024
immune system development GO:0002520 41 0.024
osteoblast differentiation GO:0001649 26 0.024
hemopoiesis GO:0030097 34 0.024
cell motility GO:0048870 202 0.024
positive regulation of signal transduction GO:0009967 175 0.023
anion transport GO:0006820 178 0.023
regulation of blood pressure GO:0008217 83 0.023
response to lipopolysaccharide GO:0032496 191 0.023
organophosphate metabolic process GO:0019637 370 0.023
cellular response to corticosteroid stimulus GO:0071384 69 0.023
regulation of cell motility GO:2000145 131 0.023
negative regulation of multicellular organismal process GO:0051241 203 0.023
negative regulation of cell proliferation GO:0008285 119 0.023
regulation of blood circulation GO:1903522 110 0.023
positive regulation of cell communication GO:0010647 271 0.023
cation transport GO:0006812 382 0.023
regulation of apoptotic process GO:0042981 335 0.023
positive regulation of protein modification process GO:0031401 142 0.022
regulation of immune system process GO:0002682 123 0.022
regulation of growth GO:0040008 105 0.022
nitrogen compound transport GO:0071705 229 0.022
response to mineralocorticoid GO:0051385 49 0.022
carbohydrate derivative metabolic process GO:1901135 346 0.022
cellular macromolecule localization GO:0070727 122 0.022
regeneration GO:0031099 163 0.022
defense response GO:0006952 194 0.021
macromolecular complex subunit organization GO:0043933 339 0.021
sexual reproduction GO:0019953 148 0.021
positive regulation of cellular component movement GO:0051272 102 0.021
leukocyte differentiation GO:0002521 30 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
cellular amine metabolic process GO:0044106 38 0.020
cellular chemical homeostasis GO:0055082 247 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
heart morphogenesis GO:0003007 3 0.020
intracellular protein transport GO:0006886 79 0.020
negative regulation of developmental process GO:0051093 125 0.020
cellular amino acid metabolic process GO:0006520 107 0.020
cardiac muscle cell contraction GO:0086003 10 0.020
cellular response to steroid hormone stimulus GO:0071383 93 0.020
transmission of nerve impulse GO:0019226 42 0.019
positive regulation of nervous system development GO:0051962 178 0.019
positive regulation of cell motility GO:2000147 97 0.019
lipid biosynthetic process GO:0008610 128 0.019
regulation of lipid metabolic process GO:0019216 68 0.019
vascular process in circulatory system GO:0003018 96 0.019
single organism intracellular transport GO:1902582 166 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
response to mechanical stimulus GO:0009612 134 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.018
response to starvation GO:0042594 59 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.018
anterior posterior pattern specification GO:0009952 1 0.018
regulation of cell projection organization GO:0031344 175 0.018
cellular response to external stimulus GO:0071496 118 0.018
response to oxidative stress GO:0006979 186 0.018
innate immune response GO:0045087 35 0.018
response to retinoic acid GO:0032526 63 0.018
negative regulation of macromolecule metabolic process GO:0010605 260 0.018
response to toxic substance GO:0009636 133 0.017
spermatogenesis GO:0007283 99 0.017
response to growth factor GO:0070848 189 0.017
monocarboxylic acid metabolic process GO:0032787 152 0.017
steroid metabolic process GO:0008202 73 0.017
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
negative regulation of molecular function GO:0044092 133 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.017
response to amphetamine GO:0001975 25 0.017
regulation of neuron projection development GO:0010975 161 0.017
positive regulation of immune system process GO:0002684 90 0.017
regulation of hormone levels GO:0010817 187 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.017
fatty acid metabolic process GO:0006631 99 0.017
cellular carbohydrate metabolic process GO:0044262 72 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
regulation of body fluid levels GO:0050878 90 0.016
regulation of osteoblast differentiation GO:0045667 14 0.016
macromolecular complex assembly GO:0065003 273 0.016
axon ensheathment GO:0008366 40 0.016
cellular response to peptide GO:1901653 133 0.016
amine metabolic process GO:0009308 38 0.016
male gamete generation GO:0048232 99 0.016
cell type specific apoptotic process GO:0097285 134 0.016
regulation of epithelial cell proliferation GO:0050678 49 0.016
epithelial cell differentiation GO:0030855 71 0.016
negative regulation of signal transduction GO:0009968 83 0.016
organic acid transport GO:0015849 116 0.015
regulation of membrane potential GO:0042391 110 0.015
aging GO:0007568 241 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
response to ketone GO:1901654 182 0.015
regulation of kinase activity GO:0043549 117 0.015
transmembrane transport GO:0055085 412 0.015
positive regulation of locomotion GO:0040017 102 0.015
cell cell signaling GO:0007267 335 0.015
cellular response to acid chemical GO:0071229 75 0.015
cellular response to camp GO:0071320 26 0.015
developmental growth GO:0048589 100 0.015
dephosphorylation GO:0016311 98 0.015
response to amino acid GO:0043200 75 0.015
small molecule biosynthetic process GO:0044283 124 0.015
salivary gland morphogenesis GO:0007435 1 0.015
cardiac chamber development GO:0003205 1 0.015
cellular response to drug GO:0035690 30 0.014
regulation of organ formation GO:0003156 2 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
cell part morphogenesis GO:0032990 123 0.014
cation homeostasis GO:0055080 195 0.014
nucleocytoplasmic transport GO:0006913 48 0.014
cellular response to biotic stimulus GO:0071216 59 0.014
negative regulation of neurogenesis GO:0050768 78 0.014
grooming behavior GO:0007625 4 0.014
response to activity GO:0014823 73 0.014
regulation of ion homeostasis GO:2000021 63 0.014
gliogenesis GO:0042063 93 0.014
regulation of transferase activity GO:0051338 123 0.014
positive regulation of ion transport GO:0043270 94 0.014
behavior GO:0007610 205 0.014
nucleoside metabolic process GO:0009116 179 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
cell projection morphogenesis GO:0048858 123 0.014
cyclic nucleotide biosynthetic process GO:0009190 63 0.014
regulation of tube size GO:0035150 89 0.014
regulation of anion transport GO:0044070 43 0.014
protein localization GO:0008104 191 0.014
regulation of cell migration GO:0030334 128 0.013
embryonic pattern specification GO:0009880 1 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
biological adhesion GO:0022610 110 0.013
gland development GO:0048732 155 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
cyclic purine nucleotide metabolic process GO:0052652 62 0.013
tissue remodeling GO:0048771 40 0.013
blood circulation GO:0008015 183 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
positive regulation of kinase activity GO:0033674 77 0.013
response to vitamin GO:0033273 131 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
embryonic axis specification GO:0000578 1 0.013
lipid transport GO:0006869 61 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
response to hexose GO:0009746 144 0.013
regulation of bmp signaling pathway GO:0030510 2 0.013
lipid catabolic process GO:0016042 46 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
cofactor metabolic process GO:0051186 95 0.013
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.013
cellular response to insulin stimulus GO:0032869 81 0.012
positive regulation of cell development GO:0010720 176 0.012
regulation of cell proliferation GO:0042127 359 0.012
macromolecule localization GO:0033036 252 0.012
cellular response to hypoxia GO:0071456 51 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
hormone transport GO:0009914 121 0.012
cellular hormone metabolic process GO:0034754 49 0.012
carbohydrate metabolic process GO:0005975 130 0.012
protein complex biogenesis GO:0070271 263 0.012
endoplasmic reticulum to cytosol transport GO:1903513 4 0.012
ion transmembrane transport GO:0034220 365 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
negative regulation of cell development GO:0010721 82 0.012
cellular response to alkaloid GO:0071312 25 0.012
cellular amide metabolic process GO:0043603 44 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
regulation of nucleotide biosynthetic process GO:0030808 47 0.012
nucleotide metabolic process GO:0009117 279 0.012
protein targeting GO:0006605 61 0.012
positive regulation of homeostatic process GO:0032846 49 0.012
axis specification GO:0009798 4 0.012
developmental process involved in reproduction GO:0003006 159 0.012
ras protein signal transduction GO:0007265 29 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
oxidation reduction process GO:0055114 304 0.011
cellular component assembly GO:0022607 360 0.011
positive regulation of blood circulation GO:1903524 65 0.011
brain development GO:0007420 247 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
growth GO:0040007 165 0.011
organ morphogenesis GO:0009887 75 0.011
cellular protein localization GO:0034613 122 0.011
myeloid cell differentiation GO:0030099 22 0.011
cellular response to oxidative stress GO:0034599 76 0.011
neurological system process GO:0050877 219 0.011
response to ph GO:0009268 27 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
b cell differentiation GO:0030183 2 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
positive regulation of cell migration GO:0030335 96 0.011
heart development GO:0007507 72 0.011
positive regulation of growth GO:0045927 55 0.011
sequestering of calcium ion GO:0051208 8 0.011
metanephric comma shaped body morphogenesis GO:0072278 2 0.011
molting cycle GO:0042303 3 0.011
response to electrical stimulus GO:0051602 56 0.011
negative regulation of transport GO:0051051 136 0.011
protein homotrimerization GO:0070207 15 0.011
establishment of protein localization GO:0045184 141 0.011
connective tissue development GO:0061448 33 0.011
response to amine GO:0014075 46 0.011
response to corticosterone GO:0051412 40 0.011
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.011
regulation of muscle system process GO:0090257 79 0.011
positive regulation of neuron projection development GO:0010976 99 0.010
anion transmembrane transport GO:0098656 77 0.010
response to muscle stretch GO:0035994 2 0.010
protein localization to nucleus GO:0034504 39 0.010
cellular protein complex assembly GO:0043623 44 0.010
aromatic amino acid family metabolic process GO:0009072 9 0.010
purine containing compound biosynthetic process GO:0072522 85 0.010
response to fatty acid GO:0070542 65 0.010
protein import GO:0017038 37 0.010
response to monosaccharide GO:0034284 159 0.010
generation of precursor metabolites and energy GO:0006091 62 0.010
metanephric s shaped body morphogenesis GO:0072284 2 0.010
negative regulation of muscle organ development GO:0048635 8 0.010
regulation of organic acid transport GO:0032890 35 0.010
myelination GO:0042552 39 0.010
regulation of neuron death GO:1901214 115 0.010
regulation of stem cell differentiation GO:2000736 2 0.010

Spta1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
kidney disease DOID:557 0 0.025
disease of anatomical entity DOID:7 0 0.025
urinary system disease DOID:18 0 0.025
muscle tissue disease DOID:66 0 0.019
musculoskeletal system disease DOID:17 0 0.019
muscular disease DOID:0080000 0 0.019
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.013
disease of metabolism DOID:0014667 0 0.012