Rattus norvegicus

0 known processes

Tdh

L-threonine dehydrogenase

Tdh biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of hormone levels GO:0010817 187 0.188
response to nutrient levels GO:0031667 370 0.130
organic acid metabolic process GO:0006082 292 0.124
oxoacid metabolic process GO:0043436 290 0.112
carboxylic acid metabolic process GO:0019752 289 0.111
cellular response to oxygen containing compound GO:1901701 386 0.097
circulatory system process GO:0003013 183 0.093
rna metabolic process GO:0016070 406 0.086
immune system process GO:0002376 204 0.085
positive regulation of nucleic acid templated transcription GO:1903508 197 0.082
organic hydroxy compound metabolic process GO:1901615 115 0.081
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.078
response to inorganic substance GO:0010035 377 0.074
response to acid chemical GO:0001101 222 0.074
regulation of rna metabolic process GO:0051252 391 0.073
protein complex assembly GO:0006461 263 0.072
cellular lipid metabolic process GO:0044255 208 0.071
protein complex subunit organization GO:0071822 302 0.071
cellular response to endogenous stimulus GO:0071495 377 0.069
regulation of signal transduction GO:0009966 318 0.068
cellular response to hormone stimulus GO:0032870 247 0.066
negative regulation of macromolecule metabolic process GO:0010605 260 0.065
cellular response to organic cyclic compound GO:0071407 202 0.063
small molecule biosynthetic process GO:0044283 124 0.061
response to peptide hormone GO:0043434 278 0.060
regulation of protein metabolic process GO:0051246 289 0.060
transcription from rna polymerase ii promoter GO:0006366 252 0.058
response to corticosteroid GO:0031960 235 0.057
positive regulation of phosphate metabolic process GO:0045937 262 0.057
monocarboxylic acid metabolic process GO:0032787 152 0.057
single organism biosynthetic process GO:0044711 342 0.057
nucleic acid templated transcription GO:0097659 379 0.055
regulation of molecular function GO:0065009 398 0.055
cellular ketone metabolic process GO:0042180 51 0.052
regulation of rna biosynthetic process GO:2001141 381 0.052
response to extracellular stimulus GO:0009991 380 0.052
homeostatic process GO:0042592 331 0.052
reproductive process GO:0022414 372 0.052
positive regulation of biosynthetic process GO:0009891 319 0.051
lipid metabolic process GO:0006629 283 0.051
choline transport GO:0015871 4 0.050
transcription dna templated GO:0006351 377 0.050
positive regulation of response to stimulus GO:0048584 285 0.049
lipid biosynthetic process GO:0008610 128 0.048
organic substance catabolic process GO:1901575 316 0.048
response to peptide GO:1901652 292 0.047
aging GO:0007568 241 0.047
positive regulation of rna metabolic process GO:0051254 203 0.046
positive regulation of rna biosynthetic process GO:1902680 197 0.045
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.045
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.045
proteolysis GO:0006508 175 0.045
macromolecular complex subunit organization GO:0043933 339 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
regulation of membrane potential GO:0042391 110 0.044
negative regulation of gene expression GO:0010629 199 0.044
regulation of cell proliferation GO:0042127 359 0.042
positive regulation of transcription dna templated GO:0045893 197 0.042
rna biosynthetic process GO:0032774 380 0.042
macromolecular complex assembly GO:0065003 273 0.041
cellular chemical homeostasis GO:0055082 247 0.040
regulation of phosphate metabolic process GO:0019220 349 0.040
regulation of cell differentiation GO:0045595 320 0.040
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.040
regulation of programmed cell death GO:0043067 341 0.040
cellular response to cytokine stimulus GO:0071345 127 0.039
cellular component assembly GO:0022607 360 0.039
negative regulation of metabolic process GO:0009892 331 0.039
multi organism reproductive process GO:0044703 262 0.039
single organism organelle organization GO:1902589 180 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.037
programmed cell death GO:0012501 392 0.037
negative regulation of cellular metabolic process GO:0031324 281 0.037
catabolic process GO:0009056 351 0.037
multicellular organismal reproductive process GO:0048609 233 0.036
cellular catabolic process GO:0044248 295 0.036
protein oligomerization GO:0051259 191 0.035
organophosphate metabolic process GO:0019637 370 0.034
regulation of nucleic acid templated transcription GO:1903506 380 0.034
alcohol metabolic process GO:0006066 77 0.034
regulation of cell development GO:0060284 263 0.034
cellular response to lipid GO:0071396 201 0.033
regulation of cellular ketone metabolic process GO:0010565 27 0.032
steroid metabolic process GO:0008202 73 0.032
negative regulation of cell death GO:0060548 229 0.032
response to metal ion GO:0010038 253 0.032
multicellular organism reproduction GO:0032504 233 0.031
negative regulation of multicellular organismal process GO:0051241 203 0.031
chemical homeostasis GO:0048878 292 0.031
negative regulation of response to stimulus GO:0048585 155 0.031
single organism catabolic process GO:0044712 283 0.031
cell adhesion GO:0007155 110 0.030
response to alkaloid GO:0043279 132 0.030
regulation of system process GO:0044057 208 0.030
anion transport GO:0006820 178 0.029
blood circulation GO:0008015 183 0.029
positive regulation of signal transduction GO:0009967 175 0.029
reproduction GO:0000003 245 0.029
amine metabolic process GO:0009308 38 0.028
establishment or maintenance of transmembrane electrochemical gradient GO:0010248 1 0.028
positive regulation of cell proliferation GO:0008284 249 0.028
carbohydrate derivative metabolic process GO:1901135 346 0.028
head development GO:0060322 247 0.027
fatty acid metabolic process GO:0006631 99 0.027
cellular component biogenesis GO:0044085 368 0.027
neuron differentiation GO:0030182 368 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
negative regulation of molecular function GO:0044092 133 0.027
response to cytokine GO:0034097 215 0.027
cellular amine metabolic process GO:0044106 38 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
regulation of catalytic activity GO:0050790 304 0.027
hormone metabolic process GO:0042445 69 0.026
positive regulation of gene expression GO:0010628 244 0.026
cellular response to organonitrogen compound GO:0071417 197 0.026
response to hydrogen peroxide GO:0042542 89 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.025
immune response GO:0006955 104 0.025
regulation of transcription dna templated GO:0006355 374 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
signal transduction by phosphorylation GO:0023014 144 0.025
cation transport GO:0006812 382 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
response to nutrient GO:0007584 248 0.025
central nervous system development GO:0007417 311 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
positive regulation of cell communication GO:0010647 271 0.025
cellular response to peptide hormone stimulus GO:0071375 120 0.025
organic acid biosynthetic process GO:0016053 83 0.024
cellular hormone metabolic process GO:0034754 49 0.024
developmental process involved in reproduction GO:0003006 159 0.024
neuron development GO:0048666 286 0.024
cell motility GO:0048870 202 0.024
rhythmic process GO:0048511 156 0.024
response to monosaccharide GO:0034284 159 0.024
response to herbicide GO:0009635 16 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
nitrogen compound transport GO:0071705 229 0.024
kidney development GO:0001822 67 0.024
negative regulation of innate immune response GO:0045824 4 0.024
organelle organization GO:0006996 266 0.023
negative regulation of biosynthetic process GO:0009890 168 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
response to wounding GO:0009611 254 0.023
negative regulation of amine transport GO:0051953 24 0.023
positive regulation of secretion GO:0051047 140 0.023
cellular component movement GO:0006928 248 0.023
amide transport GO:0042886 105 0.023
terpenoid metabolic process GO:0006721 37 0.023
cellular response to stress GO:0033554 269 0.023
protein phosphorylation GO:0006468 345 0.022
gliogenesis GO:0042063 93 0.022
protein complex biogenesis GO:0070271 263 0.022
oligopeptide transport GO:0006857 4 0.022
smooth muscle cell proliferation GO:0048659 77 0.022
carboxylic acid biosynthetic process GO:0046394 83 0.022
response to estrogen GO:0043627 232 0.022
cellular response to growth factor stimulus GO:0071363 162 0.022
neuron projection development GO:0031175 273 0.022
positive regulation of intracellular signal transduction GO:1902533 138 0.021
protein homooligomerization GO:0051260 91 0.021
response to hexose GO:0009746 144 0.021
negative regulation of cell communication GO:0010648 158 0.021
tissue development GO:0009888 252 0.021
antibiotic transport GO:0042891 2 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
positive regulation of programmed cell death GO:0043068 157 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
response to glucocorticoid GO:0051384 223 0.020
positive regulation of cell death GO:0010942 184 0.020
biological adhesion GO:0022610 110 0.020
response to estradiol GO:0032355 164 0.020
apoptotic process GO:0006915 381 0.020
cell projection organization GO:0030030 302 0.020
oxidation reduction process GO:0055114 304 0.020
monocarboxylic acid biosynthetic process GO:0072330 48 0.020
single organism reproductive process GO:0044702 297 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
transmembrane transport GO:0055085 412 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
cellular response to steroid hormone stimulus GO:0071383 93 0.019
secretion GO:0046903 307 0.019
regulation of neurogenesis GO:0050767 247 0.019
sexual reproduction GO:0019953 148 0.019
regulation of homeostatic process GO:0032844 101 0.019
negative regulation of signaling GO:0023057 157 0.019
growth GO:0040007 165 0.019
negative regulation of cell differentiation GO:0045596 99 0.019
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.019
reproductive structure development GO:0048608 128 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
response to fatty acid GO:0070542 65 0.018
steroid biosynthetic process GO:0006694 48 0.018
purine nucleotide metabolic process GO:0006163 229 0.018
forebrain development GO:0030900 98 0.018
carbohydrate homeostasis GO:0033500 75 0.018
regulation of anatomical structure morphogenesis GO:0022603 141 0.018
response to purine containing compound GO:0014074 126 0.018
regulation of neuron projection development GO:0010975 161 0.018
tripeptide transport GO:0042939 2 0.018
response to tumor necrosis factor GO:0034612 56 0.018
regulation of cellular component organization GO:0051128 368 0.018
spermatogenesis GO:0007283 99 0.017
axon development GO:0061564 96 0.017
response to glucose GO:0009749 136 0.017
gonad development GO:0008406 104 0.017
positive regulation of signaling GO:0023056 270 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
reproductive system development GO:0061458 128 0.017
nucleotide metabolic process GO:0009117 279 0.017
response to carbohydrate GO:0009743 183 0.017
mapk cascade GO:0000165 140 0.017
inflammatory response GO:0006954 150 0.017
cytoskeleton organization GO:0007010 111 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
cellular response to peptide GO:1901653 133 0.017
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.017
muscle system process GO:0003012 115 0.016
amino acid transport GO:0006865 70 0.016
positive regulation of developmental process GO:0051094 283 0.016
response to organophosphorus GO:0046683 102 0.016
response to vitamin GO:0033273 131 0.016
response to growth factor GO:0070848 189 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
cellular component morphogenesis GO:0032989 155 0.016
sex differentiation GO:0007548 113 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
leukocyte activation GO:0045321 76 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
brain development GO:0007420 247 0.016
immune effector process GO:0002252 53 0.016
development of primary sexual characteristics GO:0045137 107 0.016
response to calcium ion GO:0051592 59 0.016
metal ion transport GO:0030001 289 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
intracellular signal transduction GO:0035556 314 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.015
peptide transport GO:0015833 97 0.015
regulation of neuron differentiation GO:0045664 208 0.015
actin cytoskeleton organization GO:0030036 73 0.015
cellular response to acid chemical GO:0071229 75 0.015
isoprenoid metabolic process GO:0006720 45 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
regulation of apoptotic process GO:0042981 335 0.015
retinal metabolic process GO:0042574 3 0.015
response to decreased oxygen levels GO:0036293 237 0.015
single organism carbohydrate metabolic process GO:0044723 118 0.015
response to biotic stimulus GO:0009607 226 0.015
cell type specific apoptotic process GO:0097285 134 0.015
response to transition metal nanoparticle GO:1990267 122 0.014
gastrulation GO:0007369 2 0.014
response to oxidative stress GO:0006979 186 0.014
membrane organization GO:0061024 94 0.014
action potential GO:0001508 54 0.014
female sex differentiation GO:0046660 59 0.014
morphogenesis of embryonic epithelium GO:0016331 3 0.014
organic hydroxy compound biosynthetic process GO:1901617 51 0.014
localization of cell GO:0051674 202 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
hormone transport GO:0009914 121 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
gamete generation GO:0007276 124 0.014
response to reactive oxygen species GO:0000302 120 0.014
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.014
epithelium development GO:0060429 96 0.014
response to external biotic stimulus GO:0043207 221 0.014
response to other organism GO:0051707 220 0.014
purine containing compound metabolic process GO:0072521 253 0.013
positive regulation of molecular function GO:0044093 230 0.013
regulation of phosphorylation GO:0042325 248 0.013
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
response to cadmium ion GO:0046686 35 0.013
negative regulation of developmental process GO:0051093 125 0.013
alditol metabolic process GO:0019400 4 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
negative regulation of neuron differentiation GO:0045665 62 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
organic acid transport GO:0015849 116 0.013
organic anion transport GO:0015711 132 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
cellular response to oxidative stress GO:0034599 76 0.013
response to insulin GO:0032868 133 0.012
cation transmembrane transport GO:0098655 263 0.012
hormone secretion GO:0046879 115 0.012
sodium independent organic anion transport GO:0043252 2 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
epithelial cell differentiation GO:0030855 71 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
intracellular transport GO:0046907 185 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
monosaccharide metabolic process GO:0005996 61 0.012
embryonic appendage morphogenesis GO:0035113 4 0.012
stress activated protein kinase signaling cascade GO:0031098 37 0.012
negative regulation of signal transduction GO:0009968 83 0.012
positive regulation of protein modification process GO:0031401 142 0.012
response to molecule of fungal origin GO:0002238 3 0.012
carbohydrate metabolic process GO:0005975 130 0.012
response to hypoxia GO:0001666 231 0.012
male gamete generation GO:0048232 99 0.012
leukocyte cell cell adhesion GO:0007159 4 0.012
regulation of immune response GO:0050776 55 0.012
b cell mediated immunity GO:0019724 4 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
peptidyl amino acid modification GO:0018193 126 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
toxin transport GO:1901998 3 0.012
regulation of hydrolase activity GO:0051336 143 0.012
defense response GO:0006952 194 0.012
regulation of defense response GO:0031347 68 0.012
regulation of leukocyte activation GO:0002694 45 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
positive regulation of cell differentiation GO:0045597 217 0.011
regulation of response to stress GO:0080134 126 0.011
metal ion homeostasis GO:0055065 186 0.011
regulation of isotype switching GO:0045191 1 0.011
axis specification GO:0009798 4 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 2 0.011
single organism intracellular transport GO:1902582 166 0.011
positive regulation of hormone secretion GO:0046887 65 0.011
cofactor metabolic process GO:0051186 95 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
regulation of fat cell differentiation GO:0045598 3 0.011
immunoglobulin mediated immune response GO:0016064 4 0.011
regulation of protein modification process GO:0031399 194 0.011
locomotion GO:0040011 237 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
regulation of nervous system development GO:0051960 264 0.011
regulation of immune response to tumor cell GO:0002837 3 0.011
peptide secretion GO:0002790 86 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
response to ethanol GO:0045471 162 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
drug transmembrane transport GO:0006855 13 0.011
cation homeostasis GO:0055080 195 0.011
response to toxic substance GO:0009636 133 0.011
developmental growth GO:0048589 100 0.011
glutathione transport GO:0034635 2 0.011
regulation of immune system process GO:0002682 123 0.011
negative regulation of proteolysis GO:0045861 41 0.011
negative regulation of cell development GO:0010721 82 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.011
regulation of anatomical structure size GO:0090066 135 0.011
cell migration GO:0016477 197 0.010
cytokine production GO:0001816 61 0.010
positive regulation of nervous system development GO:0051962 178 0.010
protein maturation GO:0051604 68 0.010
response to transforming growth factor beta GO:0071559 46 0.010
regulation of blood circulation GO:1903522 110 0.010
cell cycle checkpoint GO:0000075 2 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
male gonad development GO:0008584 59 0.010
quaternary ammonium group transport GO:0015697 6 0.010
regulation of proteolysis GO:0030162 66 0.010
small molecule catabolic process GO:0044282 59 0.010
development of primary female sexual characteristics GO:0046545 56 0.010
response to temperature stimulus GO:0009266 94 0.010
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.010
positive regulation of transport GO:0051050 245 0.010
response to tumor cell GO:0002347 4 0.010
regulation of mapk cascade GO:0043408 116 0.010

Tdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 0 0.023
disease of metabolism DOID:0014667 0 0.023
disease of anatomical entity DOID:7 0 0.020
urinary system disease DOID:18 0 0.020
nervous system disease DOID:863 0 0.020
central nervous system disease DOID:331 0 0.011
musculoskeletal system disease DOID:17 0 0.010
essential hypertension DOID:10825 0 0.010
cardiovascular system disease DOID:1287 0 0.010
vascular disease DOID:178 0 0.010
artery disease DOID:0050828 0 0.010
hypertension DOID:10763 0 0.010