Rattus norvegicus

49 known processes

Timeless

timeless homolog (Drosophila)

(Aliases: Tim)

Timeless biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome segregation GO:0007059 2 0.318
regulation of cellular component organization GO:0051128 368 0.156
chromosome organization GO:0051276 36 0.140
negative regulation of macromolecule metabolic process GO:0010605 260 0.116
dna metabolic process GO:0006259 96 0.112
double strand break repair GO:0006302 1 0.095
nucleic acid templated transcription GO:0097659 379 0.093
single organism organelle organization GO:1902589 180 0.090
regulation of transcription dna templated GO:0006355 374 0.084
regulation of rna metabolic process GO:0051252 391 0.084
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.083
negative regulation of cellular metabolic process GO:0031324 281 0.082
negative regulation of metabolic process GO:0009892 331 0.076
organelle organization GO:0006996 266 0.075
macromolecular complex subunit organization GO:0043933 339 0.075
reproductive process GO:0022414 372 0.074
organic acid metabolic process GO:0006082 292 0.073
neuron development GO:0048666 286 0.072
negative regulation of cellular biosynthetic process GO:0031327 161 0.068
reproduction GO:0000003 245 0.067
rna metabolic process GO:0016070 406 0.067
response to extracellular stimulus GO:0009991 380 0.067
negative regulation of gene expression GO:0010629 199 0.060
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.059
cell cycle GO:0007049 101 0.059
cellular component morphogenesis GO:0032989 155 0.059
regulation of molecular function GO:0065009 398 0.058
spindle organization GO:0007051 2 0.058
negative regulation of phosphate metabolic process GO:0045936 80 0.057
cellular response to organic cyclic compound GO:0071407 202 0.056
response to corticosteroid GO:0031960 235 0.056
tissue development GO:0009888 252 0.054
regulation of cell proliferation GO:0042127 359 0.054
neurological system process GO:0050877 219 0.054
cellular response to oxygen containing compound GO:1901701 386 0.052
response to inorganic substance GO:0010035 377 0.051
oxoacid metabolic process GO:0043436 290 0.051
positive regulation of rna metabolic process GO:0051254 203 0.050
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.049
rna biosynthetic process GO:0032774 380 0.049
transcription dna templated GO:0006351 377 0.048
cellular response to stress GO:0033554 269 0.048
positive regulation of biosynthetic process GO:0009891 319 0.047
neuron differentiation GO:0030182 368 0.047
regulation of phosphorylation GO:0042325 248 0.047
negative regulation of biosynthetic process GO:0009890 168 0.047
cellular amino acid metabolic process GO:0006520 107 0.046
protein localization GO:0008104 191 0.046
single organism reproductive process GO:0044702 297 0.046
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.046
transcription from rna polymerase ii promoter GO:0006366 252 0.046
carboxylic acid metabolic process GO:0019752 289 0.045
regulation of phosphorus metabolic process GO:0051174 349 0.045
regulation of protein phosphorylation GO:0001932 183 0.044
response to peptide GO:1901652 292 0.043
tetrahydrofolate metabolic process GO:0046653 9 0.042
regulation of organelle organization GO:0033043 80 0.042
response to hypoxia GO:0001666 231 0.041
mitotic spindle organization GO:0007052 2 0.041
organophosphate metabolic process GO:0019637 370 0.040
nucleotide metabolic process GO:0009117 279 0.040
regulation of multicellular organismal development GO:2000026 376 0.040
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.040
cytoskeleton organization GO:0007010 111 0.039
cellular component biogenesis GO:0044085 368 0.038
response to nutrient levels GO:0031667 370 0.037
single organism biosynthetic process GO:0044711 342 0.037
response to metal ion GO:0010038 253 0.037
cellular catabolic process GO:0044248 295 0.036
positive regulation of gene expression GO:0010628 244 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.035
multicellular organismal reproductive process GO:0048609 233 0.035
multicellular organism reproduction GO:0032504 233 0.035
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.035
histone h3 acetylation GO:0043966 2 0.035
single organism catabolic process GO:0044712 283 0.034
response to estrogen GO:0043627 232 0.034
sister chromatid segregation GO:0000819 1 0.034
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.034
ovulation cycle process GO:0022602 50 0.034
positive regulation of cellular biosynthetic process GO:0031328 295 0.033
gastrulation GO:0007369 2 0.033
cell morphogenesis GO:0000902 142 0.033
negative regulation of rna metabolic process GO:0051253 123 0.033
protein complex subunit organization GO:0071822 302 0.033
cellular response to endogenous stimulus GO:0071495 377 0.033
positive regulation of developmental process GO:0051094 283 0.033
regulation of nucleic acid templated transcription GO:1903506 380 0.032
response to wounding GO:0009611 254 0.032
response to decreased oxygen levels GO:0036293 237 0.032
protein complex biogenesis GO:0070271 263 0.031
meiotic cell cycle process GO:1903046 3 0.031
positive regulation of transcription dna templated GO:0045893 197 0.031
positive regulation of rna biosynthetic process GO:1902680 197 0.031
programmed cell death GO:0012501 392 0.031
regulation of rna biosynthetic process GO:2001141 381 0.031
positive regulation of cell proliferation GO:0008284 249 0.031
response to glucocorticoid GO:0051384 223 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.030
cell cycle process GO:0022402 57 0.030
cellular response to nitrogen compound GO:1901699 210 0.030
negative regulation of transcription dna templated GO:0045892 116 0.030
positive regulation of phosphorylation GO:0042327 177 0.030
glycosyl compound metabolic process GO:1901657 182 0.030
response to estradiol GO:0032355 164 0.030
negative regulation of cell communication GO:0010648 158 0.029
nucleoside phosphate metabolic process GO:0006753 283 0.029
intracellular signal transduction GO:0035556 314 0.029
cellular response to dna damage stimulus GO:0006974 19 0.029
purine ribonucleotide catabolic process GO:0009154 136 0.029
positive regulation of nervous system development GO:0051962 178 0.028
carbohydrate derivative metabolic process GO:1901135 346 0.028
negative regulation of nucleic acid templated transcription GO:1903507 117 0.028
multi organism reproductive process GO:0044703 262 0.028
positive regulation of protein modification process GO:0031401 142 0.028
reactive oxygen species metabolic process GO:0072593 37 0.027
regulation of phosphate metabolic process GO:0019220 349 0.027
protein dephosphorylation GO:0006470 38 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.026
chemical homeostasis GO:0048878 292 0.026
anatomical structure morphogenesis GO:0009653 298 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
cellular component assembly GO:0022607 360 0.026
regulation of protein metabolic process GO:0051246 289 0.026
regulation of cell differentiation GO:0045595 320 0.026
nucleoside metabolic process GO:0009116 179 0.025
positive regulation of multicellular organismal process GO:0051240 387 0.025
brain development GO:0007420 247 0.025
microtubule organizing center organization GO:0031023 1 0.025
response to transition metal nanoparticle GO:1990267 122 0.025
response to acid chemical GO:0001101 222 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
negative regulation of rna biosynthetic process GO:1902679 118 0.025
cellular macromolecule localization GO:0070727 122 0.024
cellular ketone metabolic process GO:0042180 51 0.024
cell projection morphogenesis GO:0048858 123 0.024
peptidyl amino acid modification GO:0018193 126 0.024
microtubule based process GO:0007017 36 0.024
cell projection organization GO:0030030 302 0.024
metaphase plate congression GO:0051310 1 0.024
protein transport GO:0015031 132 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.023
muscle cell proliferation GO:0033002 84 0.023
organonitrogen compound biosynthetic process GO:1901566 167 0.023
regulation of cell cycle GO:0051726 73 0.023
aging GO:0007568 241 0.023
negative regulation of cellular component organization GO:0051129 83 0.023
catabolic process GO:0009056 351 0.023
macromolecule localization GO:0033036 252 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.023
alpha amino acid metabolic process GO:1901605 71 0.023
sexual reproduction GO:0019953 148 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
positive regulation of phosphate metabolic process GO:0045937 262 0.023
cellular response to organonitrogen compound GO:0071417 197 0.022
regulation of apoptotic process GO:0042981 335 0.022
actin filament based process GO:0030029 86 0.022
regulation of protein modification process GO:0031399 194 0.022
mitotic cell cycle GO:0000278 49 0.022
response to oxygen levels GO:0070482 265 0.022
ras protein signal transduction GO:0007265 29 0.021
response to external biotic stimulus GO:0043207 221 0.021
secretion GO:0046903 307 0.021
establishment of chromosome localization GO:0051303 1 0.021
dna replication GO:0006260 37 0.021
single organism cellular localization GO:1902580 102 0.021
central nervous system development GO:0007417 311 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
regulation of neuron projection development GO:0010975 161 0.021
apoptotic process GO:0006915 381 0.021
chromatin assembly or disassembly GO:0006333 1 0.021
amine metabolic process GO:0009308 38 0.020
folic acid containing compound metabolic process GO:0006760 10 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.020
positive regulation of cell death GO:0010942 184 0.020
mitotic sister chromatid segregation GO:0000070 1 0.020
response to reactive oxygen species GO:0000302 120 0.020
carbohydrate derivative biosynthetic process GO:1901137 124 0.020
cellular protein localization GO:0034613 122 0.020
organic substance catabolic process GO:1901575 316 0.020
regulation of neuron differentiation GO:0045664 208 0.020
protein complex assembly GO:0006461 263 0.019
gland development GO:0048732 155 0.019
centrosome organization GO:0051297 1 0.019
histone modification GO:0016570 30 0.019
regulation of cell development GO:0060284 263 0.019
regulation of kinase activity GO:0043549 117 0.019
response to ethanol GO:0045471 162 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
protein phosphorylation GO:0006468 345 0.019
ovulation cycle GO:0042698 67 0.019
neuron projection development GO:0031175 273 0.019
dephosphorylation GO:0016311 98 0.019
nucleoside triphosphate metabolic process GO:0009141 144 0.019
cell cell signaling GO:0007267 335 0.019
regulation of transferase activity GO:0051338 123 0.019
cell morphogenesis involved in differentiation GO:0000904 119 0.019
negative regulation of protein metabolic process GO:0051248 114 0.019
cellular response to external stimulus GO:0071496 118 0.019
coenzyme metabolic process GO:0006732 86 0.019
centrosome cycle GO:0007098 1 0.019
regulation of programmed cell death GO:0043067 341 0.018
regulation of cytoskeleton organization GO:0051493 49 0.018
establishment of organelle localization GO:0051656 37 0.018
regulation of protein kinase activity GO:0045859 105 0.018
organelle fission GO:0048285 25 0.018
ribonucleoside metabolic process GO:0009119 174 0.018
cell fate determination GO:0001709 2 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
cytoskeleton dependent cytokinesis GO:0061640 2 0.018
positive regulation of programmed cell death GO:0043068 157 0.018
sensory perception GO:0007600 101 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
jak stat cascade GO:0007259 26 0.018
regulation of cell morphogenesis GO:0022604 77 0.018
cellular amine metabolic process GO:0044106 38 0.018
regulation of nervous system development GO:0051960 264 0.018
purine containing compound metabolic process GO:0072521 253 0.018
hepaticobiliary system development GO:0061008 90 0.018
positive regulation of transport GO:0051050 245 0.018
purine ribonucleotide metabolic process GO:0009150 227 0.018
rhythmic process GO:0048511 156 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
regulation of catalytic activity GO:0050790 304 0.017
negative regulation of phosphorus metabolic process GO:0010563 80 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
nucleotide biosynthetic process GO:0009165 98 0.017
cellular response to abiotic stimulus GO:0071214 85 0.017
ion homeostasis GO:0050801 212 0.017
regulation of proteasomal protein catabolic process GO:0061136 4 0.017
regulation of dna metabolic process GO:0051052 60 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
anion transport GO:0006820 178 0.017
response to alkaloid GO:0043279 132 0.017
asymmetric protein localization GO:0008105 2 0.017
response to molecule of bacterial origin GO:0002237 194 0.017
response to oxidative stress GO:0006979 186 0.017
positive regulation of neuron projection development GO:0010976 99 0.016
cellular component movement GO:0006928 248 0.016
muscle structure development GO:0061061 87 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
sensory organ development GO:0007423 74 0.016
organophosphate catabolic process GO:0046434 148 0.016
tube development GO:0035295 89 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
response to toxic substance GO:0009636 133 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
response to ketone GO:1901654 182 0.016
response to peptide hormone GO:0043434 278 0.016
synaptic transmission GO:0007268 235 0.016
dicarboxylic acid metabolic process GO:0043648 42 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
response to camp GO:0051591 91 0.016
pyrimidine nucleotide biosynthetic process GO:0006221 9 0.016
biological adhesion GO:0022610 110 0.015
b cell differentiation GO:0030183 2 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
response to growth factor GO:0070848 189 0.015
regulation of cell projection organization GO:0031344 175 0.015
regulation of response to stress GO:0080134 126 0.015
regulation of reactive oxygen species metabolic process GO:2000377 26 0.015
response to hydrogen peroxide GO:0042542 89 0.015
regulation of membrane potential GO:0042391 110 0.015
response to nutrient GO:0007584 248 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
regeneration GO:0031099 163 0.015
ribonucleoside triphosphate catabolic process GO:0009203 122 0.015
positive regulation of secretion GO:0051047 140 0.015
glycosyl compound catabolic process GO:1901658 126 0.015
response to mechanical stimulus GO:0009612 134 0.015
intracellular transport GO:0046907 185 0.015
nucleoside phosphate biosynthetic process GO:1901293 102 0.015
response to vitamin GO:0033273 131 0.015
regulation of signal transduction GO:0009966 318 0.015
covalent chromatin modification GO:0016569 30 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
regulation of neurogenesis GO:0050767 247 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
positive regulation of molecular function GO:0044093 230 0.014
multicellular organism growth GO:0035264 1 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
auditory receptor cell differentiation GO:0042491 2 0.014
cell cycle checkpoint GO:0000075 2 0.014
development of primary female sexual characteristics GO:0046545 56 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
chromatin modification GO:0016568 33 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
formation of primary germ layer GO:0001704 1 0.014
response to cytokine GO:0034097 215 0.014
nucleosome organization GO:0034728 1 0.014
spermatogenesis GO:0007283 99 0.014
mitotic cell cycle process GO:1903047 35 0.014
liver development GO:0001889 90 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
cardiovascular system development GO:0072358 134 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
response to radiation GO:0009314 137 0.013
proteolysis GO:0006508 175 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
regulation of dendrite development GO:0050773 59 0.013
homeostatic process GO:0042592 331 0.013
inflammatory response GO:0006954 150 0.013
negative regulation of signal transduction GO:0009968 83 0.013
regulation of hormone levels GO:0010817 187 0.013
antral ovarian follicle growth GO:0001547 3 0.013
positive regulation of catabolic process GO:0009896 78 0.013
response to purine containing compound GO:0014074 126 0.013
cellular response to peptide GO:1901653 133 0.013
dna recombination GO:0006310 3 0.013
single organism carbohydrate metabolic process GO:0044723 118 0.013
nucleoside monophosphate metabolic process GO:0009123 93 0.013
female pregnancy GO:0007565 122 0.013
defense response GO:0006952 194 0.013
negative regulation of protein phosphorylation GO:0001933 44 0.013
negative regulation of chromosome organization GO:2001251 1 0.013
pteridine containing compound metabolic process GO:0042558 14 0.013
maintenance of protein location in cell GO:0032507 7 0.013
head development GO:0060322 247 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
male gamete generation GO:0048232 99 0.013
cellular cation homeostasis GO:0030003 180 0.012
response to organophosphorus GO:0046683 102 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
purine containing compound catabolic process GO:0072523 138 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
response to light stimulus GO:0009416 52 0.012
organic anion transport GO:0015711 132 0.012
cofactor metabolic process GO:0051186 95 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
organ regeneration GO:0031100 101 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
regulation of chromosome segregation GO:0051983 1 0.012
organelle localization GO:0051640 55 0.012
chromatin organization GO:0006325 34 0.012
nucleotide catabolic process GO:0009166 139 0.012
cellular chemical homeostasis GO:0055082 247 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
cation transport GO:0006812 382 0.012
heterocycle catabolic process GO:0046700 167 0.012
response to other organism GO:0051707 220 0.012
negative regulation of developmental process GO:0051093 125 0.012
macromolecular complex assembly GO:0065003 273 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
actin cytoskeleton organization GO:0030036 73 0.012
developmental process involved in reproduction GO:0003006 159 0.012
pyrimidine containing compound metabolic process GO:0072527 20 0.012
signal transduction by phosphorylation GO:0023014 144 0.011
response to amino acid GO:0043200 75 0.011
anterior posterior pattern specification GO:0009952 1 0.011
single organism intracellular transport GO:1902582 166 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
positive regulation of cell development GO:0010720 176 0.011
cellular response to acid chemical GO:0071229 75 0.011
regulation of cell cycle arrest GO:0071156 2 0.011
epithelium development GO:0060429 96 0.011
cilium morphogenesis GO:0060271 2 0.011
wound healing GO:0042060 122 0.011
microtubule anchoring GO:0034453 1 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
aromatic compound catabolic process GO:0019439 168 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
metal ion homeostasis GO:0055065 186 0.011
regulation of cellular localization GO:0060341 263 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
dna packaging GO:0006323 4 0.011
mechanoreceptor differentiation GO:0042490 2 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
eye morphogenesis GO:0048592 4 0.011
digestive system development GO:0055123 41 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
hormone transport GO:0009914 121 0.011
single organism behavior GO:0044708 130 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
cytoplasmic transport GO:0016482 115 0.011
neuron fate commitment GO:0048663 4 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
gamete generation GO:0007276 124 0.010
cell adhesion GO:0007155 110 0.010
activation of cysteine type endopeptidase activity GO:0097202 4 0.010
cell cycle dna replication GO:0044786 1 0.010
negative regulation of molecular function GO:0044092 133 0.010
organic acid transport GO:0015849 116 0.010
regulation of growth GO:0040008 105 0.010
embryonic pattern specification GO:0009880 1 0.010
cellular ion homeostasis GO:0006873 184 0.010
carbohydrate metabolic process GO:0005975 130 0.010
positive regulation of dna metabolic process GO:0051054 39 0.010
purine nucleotide metabolic process GO:0006163 229 0.010
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
negative regulation of cell cycle phase transition GO:1901988 4 0.010
neuron projection morphogenesis GO:0048812 122 0.010
negative regulation of apoptotic process GO:0043066 181 0.010
histone methylation GO:0016571 3 0.010
regulation of protein serine threonine kinase activity GO:0071900 64 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
ion transmembrane transport GO:0034220 365 0.010

Timeless disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.016
nervous system disease DOID:863 0 0.015
disease of anatomical entity DOID:7 0 0.015
organ system cancer DOID:0050686 0 0.012