Rattus norvegicus

216 known processes

Timp2

TIMP metallopeptidase inhibitor 2

(Aliases: MGC105282)

Timp2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
wound healing GO:0042060 122 0.921
Rat
regulation of cell motility GO:2000145 131 0.626
response to wounding GO:0009611 254 0.605
Rat
regulation of locomotion GO:0040012 148 0.468
regulation of cellular component movement GO:0051270 150 0.423
regulation of cell proliferation GO:0042127 359 0.383
tissue development GO:0009888 252 0.372
Rat
regulation of cellular component organization GO:0051128 368 0.369
regulation of cell migration GO:0030334 128 0.346
glial cell differentiation GO:0010001 65 0.334
regeneration GO:0031099 163 0.329
Rat
response to cytokine GO:0034097 215 0.323
cell motility GO:0048870 202 0.314
locomotion GO:0040011 237 0.310
response to corticosteroid GO:0031960 235 0.293
response to extracellular stimulus GO:0009991 380 0.277
Rat
response to metal ion GO:0010038 253 0.274
negative regulation of cell death GO:0060548 229 0.266
Rat
enzyme linked receptor protein signaling pathway GO:0007167 116 0.225
response to growth factor GO:0070848 189 0.202
gliogenesis GO:0042063 93 0.197
negative regulation of multicellular organismal process GO:0051241 203 0.194
reproductive process GO:0022414 372 0.192
Rat
vesicle mediated transport GO:0016192 181 0.190
negative regulation of apoptotic process GO:0043066 181 0.190
Rat
response to estradiol GO:0032355 164 0.189
aging GO:0007568 241 0.184
single organism reproductive process GO:0044702 297 0.181
Rat
regulation of programmed cell death GO:0043067 341 0.180
Rat
response to peptide GO:1901652 292 0.179
Rat
apoptotic process GO:0006915 381 0.178
Rat
urogenital system development GO:0001655 78 0.166
regulation of cellular protein metabolic process GO:0032268 267 0.161
response to nutrient GO:0007584 248 0.161
Rat
response to nutrient levels GO:0031667 370 0.160
Rat
response to glucocorticoid GO:0051384 223 0.158
response to inorganic substance GO:0010035 377 0.151
cellular response to endogenous stimulus GO:0071495 377 0.147
response to peptide hormone GO:0043434 278 0.146
Rat
response to estrogen GO:0043627 232 0.144
Rat
regulation of neuron differentiation GO:0045664 208 0.143
cellular response to growth factor stimulus GO:0071363 162 0.139
regulation of multicellular organismal development GO:2000026 376 0.138
response to acid chemical GO:0001101 222 0.134
Rat
central nervous system development GO:0007417 311 0.129
localization of cell GO:0051674 202 0.128
positive regulation of multicellular organismal process GO:0051240 387 0.128
neuron development GO:0048666 286 0.126
cellular component movement GO:0006928 248 0.125
positive regulation of cell migration GO:0030335 96 0.123
positive regulation of cell proliferation GO:0008284 249 0.123
regulation of protein metabolic process GO:0051246 289 0.120
cell projection organization GO:0030030 302 0.116
regulation of cell projection organization GO:0031344 175 0.111
positive regulation of cell differentiation GO:0045597 217 0.110
negative regulation of response to stimulus GO:0048585 155 0.109
positive regulation of cellular component movement GO:0051272 102 0.107
response to amino acid GO:0043200 75 0.107
Rat
response to reactive oxygen species GO:0000302 120 0.105
head development GO:0060322 247 0.103
growth GO:0040007 165 0.102
Rat
regulation of cell morphogenesis GO:0022604 77 0.102
biological adhesion GO:0022610 110 0.101
positive regulation of intracellular signal transduction GO:1902533 138 0.101
cellular component assembly GO:0022607 360 0.095
cellular response to organic cyclic compound GO:0071407 202 0.094
positive regulation of signaling GO:0023056 270 0.094
regulation of phosphate metabolic process GO:0019220 349 0.092
response to external biotic stimulus GO:0043207 221 0.091
Rat
cardiovascular system development GO:0072358 134 0.090
reproduction GO:0000003 245 0.090
Rat
positive regulation of cell projection organization GO:0031346 111 0.087
response to carbohydrate GO:0009743 183 0.086
macromolecule localization GO:0033036 252 0.085
regulation of nervous system development GO:0051960 264 0.082
cell adhesion GO:0007155 110 0.082
cellular response to oxygen containing compound GO:1901701 386 0.081
sensory organ development GO:0007423 74 0.080
multi multicellular organism process GO:0044706 138 0.078
chemical homeostasis GO:0048878 292 0.077
negative regulation of programmed cell death GO:0043069 183 0.075
Rat
response to other organism GO:0051707 220 0.075
Rat
multicellular organism reproduction GO:0032504 233 0.074
Rat
positive regulation of nervous system development GO:0051962 178 0.073
sulfur compound metabolic process GO:0006790 70 0.070
positive regulation of phosphate metabolic process GO:0045937 262 0.069
positive regulation of cell communication GO:0010647 271 0.068
reproductive system development GO:0061458 128 0.066
peptide metabolic process GO:0006518 32 0.065
response to interleukin 1 GO:0070555 55 0.065
regulation of viral transcription GO:0046782 2 0.065
glial cell development GO:0021782 19 0.065
regulation of growth GO:0040008 105 0.065
cellular response to hormone stimulus GO:0032870 247 0.064
negative regulation of peptidase activity GO:0010466 38 0.062
negative regulation of cell development GO:0010721 82 0.060
positive regulation of cell motility GO:2000147 97 0.059
regulation of schwann cell migration GO:1900147 2 0.057
regulation of epithelial cell proliferation GO:0050678 49 0.056
developmental growth GO:0048589 100 0.056
Rat
neuron projection development GO:0031175 273 0.056
carboxylic acid metabolic process GO:0019752 289 0.055
secretion GO:0046903 307 0.054
organic acid metabolic process GO:0006082 292 0.053
protein complex biogenesis GO:0070271 263 0.053
negative regulation of cellular component organization GO:0051129 83 0.052
cellular component biogenesis GO:0044085 368 0.051
secretion by cell GO:0032940 248 0.051
regulation of axonogenesis GO:0050770 37 0.050
cellular homeostasis GO:0019725 252 0.048
positive regulation of neuron projection development GO:0010976 99 0.048
response to axon injury GO:0048678 59 0.048
positive regulation of locomotion GO:0040017 102 0.045
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.045
negative regulation of hemostasis GO:1900047 6 0.045
cellular response to metal ion GO:0071248 55 0.044
negative regulation of developmental process GO:0051093 125 0.044
oxoacid metabolic process GO:0043436 290 0.044
multi organism reproductive process GO:0044703 262 0.043
cellular amino acid metabolic process GO:0006520 107 0.042
single organism biosynthetic process GO:0044711 342 0.042
protein complex assembly GO:0006461 263 0.041
macromolecular complex assembly GO:0065003 273 0.041
regulation of neurogenesis GO:0050767 247 0.041
behavior GO:0007610 205 0.041
regulation of apoptotic process GO:0042981 335 0.040
Rat
response to camp GO:0051591 91 0.040
brain development GO:0007420 247 0.039
intracellular signal transduction GO:0035556 314 0.039
positive regulation of response to stimulus GO:0048584 285 0.039
response to ethanol GO:0045471 162 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.039
negative regulation of phosphate metabolic process GO:0045936 80 0.038
response to bacterium GO:0009617 200 0.038
Rat
regulation of cell differentiation GO:0045595 320 0.037
skeletal system development GO:0001501 41 0.036
Rat
homeostatic process GO:0042592 331 0.036
morphogenesis of an epithelium GO:0002009 20 0.036
cell migration GO:0016477 197 0.036
regulation of response to stress GO:0080134 126 0.036
extracellular matrix organization GO:0030198 13 0.036
protein homooligomerization GO:0051260 91 0.036
response to cadmium ion GO:0046686 35 0.035
regulation of catalytic activity GO:0050790 304 0.035
regulation of hydrolase activity GO:0051336 143 0.035
cellular response to corticosteroid stimulus GO:0071384 69 0.035
respiratory system development GO:0060541 45 0.034
cell type specific apoptotic process GO:0097285 134 0.034
monovalent inorganic cation transport GO:0015672 172 0.034
multicellular organismal catabolic process GO:0044243 2 0.034
axonogenesis GO:0007409 71 0.034
response to retinoic acid GO:0032526 63 0.034
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.034
regulation of cell growth GO:0001558 85 0.033
metal ion transport GO:0030001 289 0.033
female pregnancy GO:0007565 122 0.033
positive regulation of gene expression GO:0010628 244 0.033
astrocyte development GO:0014002 4 0.033
cellular response to cytokine stimulus GO:0071345 127 0.033
multicellular organismal macromolecule metabolic process GO:0044259 21 0.032
epithelial cell differentiation GO:0030855 71 0.032
negative regulation of neurogenesis GO:0050768 78 0.032
positive regulation of developmental process GO:0051094 283 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
regulation of response to wounding GO:1903034 69 0.031
endocrine system development GO:0035270 30 0.031
regulation of cell adhesion GO:0030155 52 0.030
protein phosphorylation GO:0006468 345 0.030
connective tissue development GO:0061448 33 0.030
Rat
positive regulation of cellular component organization GO:0051130 200 0.029
positive regulation of neurogenesis GO:0050769 165 0.028
divalent inorganic cation transport GO:0072511 134 0.028
regulation of neuron projection development GO:0010975 161 0.028
cell growth GO:0016049 104 0.028
regulation of homotypic cell cell adhesion GO:0034110 4 0.028
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.027
reproductive structure development GO:0048608 128 0.027
tube development GO:0035295 89 0.027
sexual reproduction GO:0019953 148 0.027
response to vitamin GO:0033273 131 0.027
Rat
response to radiation GO:0009314 137 0.027
programmed cell death GO:0012501 392 0.027
Rat
protein complex subunit organization GO:0071822 302 0.027
response to mechanical stimulus GO:0009612 134 0.026
Rat
cell morphogenesis involved in differentiation GO:0000904 119 0.026
intracellular transport GO:0046907 185 0.026
positive regulation of neuron differentiation GO:0045666 126 0.026
respiratory tube development GO:0030323 43 0.026
gland development GO:0048732 155 0.026
rna biosynthetic process GO:0032774 380 0.026
regulation of response to external stimulus GO:0032101 106 0.026
inorganic cation transmembrane transport GO:0098662 202 0.025
cellular ketone metabolic process GO:0042180 51 0.025
negative regulation of response to external stimulus GO:0032102 37 0.025
negative regulation of response to wounding GO:1903035 23 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
Rat
extracellular structure organization GO:0043062 13 0.025
cell cell signaling GO:0007267 335 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
regulation of hormone levels GO:0010817 187 0.024
developmental process involved in reproduction GO:0003006 159 0.024
positive regulation of dna metabolic process GO:0051054 39 0.024
positive regulation of signal transduction GO:0009967 175 0.024
epithelium development GO:0060429 96 0.024
negative regulation of cell differentiation GO:0045596 99 0.024
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
anatomical structure morphogenesis GO:0009653 298 0.024
response to organophosphorus GO:0046683 102 0.023
hormone transport GO:0009914 121 0.023
positive regulation of cell development GO:0010720 176 0.023
cellular response to reactive oxygen species GO:0034614 55 0.023
gamete generation GO:0007276 124 0.023
regulation of axon extension GO:0030516 24 0.023
response to glucose GO:0009749 136 0.023
negative regulation of neuron differentiation GO:0045665 62 0.023
positive regulation of apoptotic process GO:0043065 154 0.023
protein localization GO:0008104 191 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.023
positive regulation of protein metabolic process GO:0051247 178 0.023
response to ketone GO:1901654 182 0.022
extracellular fibril organization GO:0043206 1 0.022
ion transmembrane transport GO:0034220 365 0.022
protein oligomerization GO:0051259 191 0.022
regulation of apoptotic signaling pathway GO:2001233 13 0.022
multicellular organism growth GO:0035264 1 0.022
negative regulation of signaling GO:0023057 157 0.022
protein maturation GO:0051604 68 0.022
response to hexose GO:0009746 144 0.021
regulation of immune system process GO:0002682 123 0.021
regulation of ion transport GO:0043269 245 0.021
negative regulation of immune response GO:0050777 15 0.021
cell substrate adhesion GO:0031589 29 0.021
response to fibroblast growth factor GO:0071774 29 0.021
negative regulation of cell projection organization GO:0031345 50 0.021
macromolecular complex subunit organization GO:0043933 339 0.021
cellular response to lipid GO:0071396 201 0.021
cellular amide metabolic process GO:0043603 44 0.021
cation transmembrane transport GO:0098655 263 0.021
neuron projection extension GO:1990138 26 0.020
regulation of epithelial to mesenchymal transition GO:0010717 2 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
tissue regeneration GO:0042246 36 0.020
Rat
circulatory system development GO:0072359 134 0.020
regulation of peptidase activity GO:0052547 55 0.020
coagulation GO:0050817 28 0.020
organ morphogenesis GO:0009887 75 0.020
cation transport GO:0006812 382 0.020
organelle organization GO:0006996 266 0.020
epithelial cell proliferation GO:0050673 54 0.020
neurological system process GO:0050877 219 0.020
cellular response to steroid hormone stimulus GO:0071383 93 0.020
receptor internalization GO:0031623 14 0.020
regulation of secretion by cell GO:1903530 208 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.019
cellular component morphogenesis GO:0032989 155 0.019
negative regulation of neuron apoptotic process GO:0043524 45 0.019
cellular amine metabolic process GO:0044106 38 0.019
response to hydrogen peroxide GO:0042542 89 0.019
cellular response to inorganic substance GO:0071241 65 0.019
cellular protein localization GO:0034613 122 0.019
regulation of phosphorus metabolic process GO:0051174 349 0.019
single organism intracellular transport GO:1902582 166 0.019
positive regulation of cell death GO:0010942 184 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.018
kidney development GO:0001822 67 0.018
axon extension GO:0048675 26 0.018
apoptotic signaling pathway GO:0097190 27 0.018
blood coagulation GO:0007596 26 0.018
negative regulation of proteolysis GO:0045861 41 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.017
response to purine containing compound GO:0014074 126 0.017
regulation of lipid metabolic process GO:0019216 68 0.017
positive regulation of endothelial cell migration GO:0010595 4 0.017
cytoplasmic transport GO:0016482 115 0.017
response to transition metal nanoparticle GO:1990267 122 0.017
cellular response to glucocorticoid stimulus GO:0071385 68 0.017
negative regulation of gene expression GO:0010629 199 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.017
cell activation GO:0001775 97 0.016
Rat
tissue morphogenesis GO:0048729 22 0.016
regulation of cell development GO:0060284 263 0.016
neuron differentiation GO:0030182 368 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
response to folic acid GO:0051593 14 0.016
Rat
cellular response to external stimulus GO:0071496 118 0.016
immune system process GO:0002376 204 0.016
positive regulation of protein modification process GO:0031401 142 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
positive regulation of protein phosphorylation GO:0001934 135 0.016
positive regulation of cellular biosynthetic process GO:0031328 295 0.016
muscle cell apoptotic process GO:0010657 30 0.016
developmental growth involved in morphogenesis GO:0060560 33 0.016
endocytosis GO:0006897 84 0.016
reactive oxygen species metabolic process GO:0072593 37 0.016
synaptic transmission GO:0007268 235 0.015
neuron death GO:0070997 127 0.015
response to monosaccharide GO:0034284 159 0.015
cell part morphogenesis GO:0032990 123 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
positive regulation of cell growth GO:0030307 44 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
negative regulation of wound healing GO:0061045 8 0.015
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
regulation of molecular function GO:0065009 398 0.015
positive regulation of transport GO:0051050 245 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
cellular macromolecular complex assembly GO:0034622 58 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
regulation of phosphorylation GO:0042325 248 0.015
lung development GO:0030324 43 0.015
steroid metabolic process GO:0008202 73 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
response to corticosterone GO:0051412 40 0.014
negative regulation of endopeptidase activity GO:0010951 36 0.014
cation homeostasis GO:0055080 195 0.014
regulation of body fluid levels GO:0050878 90 0.014
calcium ion transport GO:0006816 131 0.014
cellular catabolic process GO:0044248 295 0.014
striated muscle tissue development GO:0014706 58 0.014
response to insulin GO:0032868 133 0.014
bone development GO:0060348 25 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
negative regulation of molecular function GO:0044092 133 0.014
negative regulation of protein processing GO:0010955 47 0.014
receptor metabolic process GO:0043112 18 0.014
muscle tissue development GO:0060537 58 0.014
negative regulation of neuron projection development GO:0010977 46 0.014
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
Rat
organonitrogen compound catabolic process GO:1901565 179 0.013
erk1 and erk2 cascade GO:0070371 48 0.013
response to hypoxia GO:0001666 231 0.013
rhythmic process GO:0048511 156 0.013
Rat
actin cytoskeleton organization GO:0030036 73 0.013
single organism cell adhesion GO:0098602 46 0.013
response to oxygen levels GO:0070482 265 0.013
mapk cascade GO:0000165 140 0.013
male gamete generation GO:0048232 99 0.013
regulation of secretion GO:0051046 224 0.013
establishment of vesicle localization GO:0051650 31 0.013
cortical actin cytoskeleton organization GO:0030866 2 0.013
regulation of bmp signaling pathway GO:0030510 2 0.013
negative regulation of neuron death GO:1901215 69 0.013
cranial suture morphogenesis GO:0060363 4 0.013
single organismal cell cell adhesion GO:0016337 42 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
regulation of cellular component size GO:0032535 51 0.012
dna metabolic process GO:0006259 96 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
cellular potassium ion transport GO:0071804 72 0.012
regulation of erythrocyte aggregation GO:0034118 1 0.012
regulation of system process GO:0044057 208 0.012
regulation of nucleocytoplasmic transport GO:0046822 28 0.012
membrane fusion GO:0061025 26 0.012
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.012
amide transport GO:0042886 105 0.012
cell morphogenesis GO:0000902 142 0.012
peptidyl amino acid modification GO:0018193 126 0.012
response to ionizing radiation GO:0010212 59 0.012
positive regulation of axon extension GO:0045773 14 0.011
hormone metabolic process GO:0042445 69 0.011
regulation of rna biosynthetic process GO:2001141 381 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 7 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
regulation of wound healing GO:0061041 14 0.011
response to decreased oxygen levels GO:0036293 237 0.011
lipid localization GO:0010876 62 0.011
response to vitamin d GO:0033280 34 0.011
regulation of embryonic development GO:0045995 2 0.011
regulation of epithelial cell migration GO:0010632 17 0.011
response to lead ion GO:0010288 33 0.011
negative regulation of immune system process GO:0002683 39 0.011
collagen fibril organization GO:0030199 1 0.011
response to alkaloid GO:0043279 132 0.011
receptor mediated endocytosis GO:0006898 42 0.011
regulation of fatty acid metabolic process GO:0019217 18 0.011
cell recognition GO:0008037 11 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
regulation of protein kinase activity GO:0045859 105 0.011
regulation of protein localization GO:0032880 81 0.011
positive regulation of growth GO:0045927 55 0.011
development of primary sexual characteristics GO:0045137 107 0.011
neuronal action potential GO:0019228 35 0.010
regulation of anatomical structure size GO:0090066 135 0.010
negative regulation of rna biosynthetic process GO:1902679 118 0.010
telencephalon development GO:0021537 62 0.010
amine metabolic process GO:0009308 38 0.010
positive regulation of lipid metabolic process GO:0045834 33 0.010
hemostasis GO:0007599 26 0.010
nucleocytoplasmic transport GO:0006913 48 0.010
craniofacial suture morphogenesis GO:0097094 4 0.010
forebrain development GO:0030900 98 0.010
cellular protein complex assembly GO:0043623 44 0.010
maternal process involved in female pregnancy GO:0060135 38 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
positive regulation of phosphorylation GO:0042327 177 0.010

Timp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.053
musculoskeletal system disease DOID:17 0 0.053
connective tissue disease DOID:65 0 0.053
nervous system disease DOID:863 0 0.037
retinal disease DOID:5679 0 0.025
retinal degeneration DOID:8466 0 0.025
sensory system disease DOID:0050155 0 0.025
eye and adnexa disease DOID:1492 0 0.025
eye disease DOID:5614 0 0.025
bone development disease DOID:0080006 0 0.015
bone disease DOID:0080001 0 0.015
osteochondrodysplasia DOID:2256 0 0.011
osteogenesis imperfecta DOID:12347 0 0.011