Rattus norvegicus

71 known processes

Top1

topoisomerase (DNA) I

(Aliases: Ab2-086)

Top1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein complex subunit organization GO:0071822 302 0.130
reproductive process GO:0022414 372 0.116
sexual reproduction GO:0019953 148 0.104
growth GO:0040007 165 0.096
synaptic growth at neuromuscular junction GO:0051124 1 0.084
positive regulation of phosphorus metabolic process GO:0010562 262 0.081
oxoacid metabolic process GO:0043436 290 0.073
multi organism reproductive process GO:0044703 262 0.067
reproduction GO:0000003 245 0.062
receptor localization to synapse GO:0097120 2 0.062
axonogenesis GO:0007409 71 0.059
axis specification GO:0009798 4 0.057
regulation of protein modification process GO:0031399 194 0.053
regulation of phosphate metabolic process GO:0019220 349 0.053
intracellular signal transduction GO:0035556 314 0.053
cellular amino acid metabolic process GO:0006520 107 0.052
regulation of phosphorus metabolic process GO:0051174 349 0.051
cell cycle GO:0007049 101 0.051
macromolecular complex subunit organization GO:0043933 339 0.049
protein phosphorylation GO:0006468 345 0.049
response to extracellular stimulus GO:0009991 380 0.048
single organism reproductive process GO:0044702 297 0.044
cell projection morphogenesis GO:0048858 123 0.044
cellular protein localization GO:0034613 122 0.043
cellular component biogenesis GO:0044085 368 0.040
homeostatic process GO:0042592 331 0.040
positive regulation of growth GO:0045927 55 0.040
cell projection organization GO:0030030 302 0.038
regulation of catalytic activity GO:0050790 304 0.035
muscle contraction GO:0006936 88 0.035
developmental process involved in reproduction GO:0003006 159 0.034
organelle organization GO:0006996 266 0.034
carbohydrate derivative metabolic process GO:1901135 346 0.034
nucleoside triphosphate catabolic process GO:0009143 123 0.033
positive regulation of phosphorylation GO:0042327 177 0.033
organic acid metabolic process GO:0006082 292 0.033
response to alkaloid GO:0043279 132 0.032
macromolecular complex assembly GO:0065003 273 0.032
positive regulation of response to stimulus GO:0048584 285 0.032
multicellular organism reproduction GO:0032504 233 0.031
cell part morphogenesis GO:0032990 123 0.031
neuron projection development GO:0031175 273 0.031
regulation of protein phosphorylation GO:0001932 183 0.031
protein complex biogenesis GO:0070271 263 0.030
positive regulation of signaling GO:0023056 270 0.030
positive regulation of signal transduction GO:0009967 175 0.029
actin filament based process GO:0030029 86 0.029
neurological system process GO:0050877 219 0.028
purine nucleotide metabolic process GO:0006163 229 0.028
regulation of protein metabolic process GO:0051246 289 0.028
positive regulation of cell communication GO:0010647 271 0.028
cation transport GO:0006812 382 0.026
response to ethanol GO:0045471 162 0.026
gamete generation GO:0007276 124 0.026
vesicle mediated transport GO:0016192 181 0.026
regulation of growth GO:0040008 105 0.026
response to radiation GO:0009314 137 0.026
negative regulation of cellular metabolic process GO:0031324 281 0.026
regulation of molecular function GO:0065009 398 0.025
positive regulation of neurogenesis GO:0050769 165 0.025
carboxylic acid metabolic process GO:0019752 289 0.025
leukocyte activation GO:0045321 76 0.025
regulation of intracellular signal transduction GO:1902531 218 0.025
positive regulation of intracellular signal transduction GO:1902533 138 0.024
locomotor rhythm GO:0045475 1 0.024
organ regeneration GO:0031100 101 0.024
protein complex assembly GO:0006461 263 0.023
proteolysis GO:0006508 175 0.023
microtubule organizing center organization GO:0031023 1 0.023
cell morphogenesis involved in differentiation GO:0000904 119 0.023
regulation of signal transduction GO:0009966 318 0.023
negative regulation of receptor internalization GO:0002091 2 0.022
neuron projection morphogenesis GO:0048812 122 0.022
rna biosynthetic process GO:0032774 380 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
neuron differentiation GO:0030182 368 0.021
divalent metal ion transport GO:0070838 132 0.021
centrosome organization GO:0051297 1 0.021
cellular response to stress GO:0033554 269 0.021
neuron development GO:0048666 286 0.021
behavior GO:0007610 205 0.021
cytoskeleton organization GO:0007010 111 0.021
axon development GO:0061564 96 0.021
cellular amine metabolic process GO:0044106 38 0.020
multicellular organism growth GO:0035264 1 0.020
gastrulation GO:0007369 2 0.020
cellular ion homeostasis GO:0006873 184 0.020
muscle system process GO:0003012 115 0.020
carbohydrate metabolic process GO:0005975 130 0.020
chemical homeostasis GO:0048878 292 0.020
protein oligomerization GO:0051259 191 0.020
positive regulation of phosphate metabolic process GO:0045937 262 0.020
single organism behavior GO:0044708 130 0.020
meiotic cell cycle process GO:1903046 3 0.020
spindle organization GO:0007051 2 0.020
ureteric bud development GO:0001657 14 0.020
negative regulation of peptidase activity GO:0010466 38 0.019
regulation of establishment of protein localization GO:0070201 69 0.019
positive regulation of gene expression GO:0010628 244 0.019
cellular catabolic process GO:0044248 295 0.019
regulation of membrane potential GO:0042391 110 0.019
reproductive system development GO:0061458 128 0.019
positive regulation of neuron differentiation GO:0045666 126 0.019
cellular response to external stimulus GO:0071496 118 0.018
regulation of apoptotic process GO:0042981 335 0.018
positive regulation of neuron projection development GO:0010976 99 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
regulation of phosphorylation GO:0042325 248 0.018
cellular homeostasis GO:0019725 252 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
cation homeostasis GO:0055080 195 0.018
peristalsis GO:0030432 2 0.018
embryonic axis specification GO:0000578 1 0.018
neuronal ion channel clustering GO:0045161 3 0.018
anterior posterior pattern specification GO:0009952 1 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
negative regulation of protein metabolic process GO:0051248 114 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
response to cytokine GO:0034097 215 0.017
positive regulation of protein modification process GO:0031401 142 0.017
cellular component movement GO:0006928 248 0.017
regulation of immune system process GO:0002682 123 0.017
cell morphogenesis GO:0000902 142 0.017
amine metabolic process GO:0009308 38 0.017
positive regulation of molecular function GO:0044093 230 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
multicellular organismal signaling GO:0035637 44 0.016
response to nutrient levels GO:0031667 370 0.016
behavioral response to ethanol GO:0048149 1 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
muscle structure development GO:0061061 87 0.016
regulation of cellular localization GO:0060341 263 0.016
rna metabolic process GO:0016070 406 0.016
lymphocyte activation GO:0046649 43 0.016
transmembrane transport GO:0055085 412 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.015
synaptic transmission GO:0007268 235 0.015
regulation of protein transport GO:0051223 68 0.015
negative regulation of phagocytosis GO:0050765 4 0.015
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.015
regulation of nervous system development GO:0051960 264 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.015
ribose phosphate metabolic process GO:0019693 235 0.014
dna metabolic process GO:0006259 96 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
positive regulation of transport GO:0051050 245 0.014
negative regulation of cell death GO:0060548 229 0.014
cell cycle process GO:0022402 57 0.014
secretion by cell GO:0032940 248 0.014
receptor clustering GO:0043113 13 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
reproductive structure development GO:0048608 128 0.014
negative regulation of gene expression GO:0010629 199 0.014
cell cell signaling GO:0007267 335 0.013
calcium ion homeostasis GO:0055074 162 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
metal ion homeostasis GO:0055065 186 0.013
gland development GO:0048732 155 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
negative regulation of arp2 3 complex mediated actin nucleation GO:0034316 1 0.013
positive regulation of protein kinase activity GO:0045860 73 0.013
regulation of multicellular organismal development GO:2000026 376 0.013
positive regulation of developmental growth GO:0048639 29 0.013
brain development GO:0007420 247 0.013
cellular response to endogenous stimulus GO:0071495 377 0.013
negative regulation of lymphocyte activation GO:0051250 10 0.013
dendrite morphogenesis GO:0048813 43 0.013
head development GO:0060322 247 0.013
regulation of cellular component organization GO:0051128 368 0.013
purine containing compound metabolic process GO:0072521 253 0.013
cellular component assembly GO:0022607 360 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
regulation of cell proliferation GO:0042127 359 0.013
cell motility GO:0048870 202 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
regulation of kinase activity GO:0043549 117 0.013
positive regulation of biosynthetic process GO:0009891 319 0.013
regulation of protein processing GO:0070613 50 0.013
protein deubiquitination GO:0016579 4 0.013
embryonic pattern specification GO:0009880 1 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
actin cytoskeleton organization GO:0030036 73 0.012
biological adhesion GO:0022610 110 0.012
positive regulation of multicellular organismal process GO:0051240 387 0.012
organophosphate metabolic process GO:0019637 370 0.012
regulation of neurogenesis GO:0050767 247 0.012
dendritic spine organization GO:0097061 12 0.012
neurotransmitter gated ion channel clustering GO:0072578 3 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
negative regulation of endopeptidase activity GO:0010951 36 0.012
regulation of mapk cascade GO:0043408 116 0.012
potassium ion transport GO:0006813 97 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
regulation of hormone levels GO:0010817 187 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
regulation of secretion by cell GO:1903530 208 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
response to testosterone GO:0033574 55 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
sensory perception GO:0007600 101 0.011
negative regulation of proteolysis GO:0045861 41 0.011
positive regulation of synapse assembly GO:0051965 12 0.011
negative regulation of macromolecule metabolic process GO:0010605 260 0.011
deoxyribose phosphate metabolic process GO:0019692 9 0.011
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 6 0.011
transmission of nerve impulse GO:0019226 42 0.011
secretion GO:0046903 307 0.011
male gamete generation GO:0048232 99 0.011
regulation of transferase activity GO:0051338 123 0.011
cellular amino acid catabolic process GO:0009063 21 0.011
embryo development GO:0009790 49 0.011
regulation of programmed cell death GO:0043067 341 0.011
catabolic process GO:0009056 351 0.011
locomotion GO:0040011 237 0.011
cellular response to nitrogen compound GO:1901699 210 0.010
single organism biosynthetic process GO:0044711 342 0.010
regulation of neuron differentiation GO:0045664 208 0.010
neuron death GO:0070997 127 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
cellular component morphogenesis GO:0032989 155 0.010
nucleotide metabolic process GO:0009117 279 0.010
positive regulation of nervous system development GO:0051962 178 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
purine ribonucleoside metabolic process GO:0046128 168 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
positive regulation of secretion by cell GO:1903532 128 0.010
regeneration GO:0031099 163 0.010
rho protein signal transduction GO:0007266 11 0.010
positive regulation of transferase activity GO:0051347 81 0.010
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.010

Top1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org