Rattus norvegicus

0 known processes

Top2b

topoisomerase (DNA) II beta

Top2b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.243
tissue development GO:0009888 252 0.241
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.232
regulation of molecular function GO:0065009 398 0.221
transcription dna templated GO:0006351 377 0.214
positive regulation of transport GO:0051050 245 0.209
protein complex assembly GO:0006461 263 0.195
positive regulation of cell communication GO:0010647 271 0.178
signal transduction by phosphorylation GO:0023014 144 0.176
regulation of multicellular organismal development GO:2000026 376 0.173
regulation of cell proliferation GO:0042127 359 0.157
macromolecular complex assembly GO:0065003 273 0.146
purine nucleoside triphosphate metabolic process GO:0009144 141 0.144
ribonucleoside triphosphate catabolic process GO:0009203 122 0.138
positive regulation of multicellular organismal process GO:0051240 387 0.135
positive regulation of cell differentiation GO:0045597 217 0.132
positive regulation of biosynthetic process GO:0009891 319 0.131
macromolecule localization GO:0033036 252 0.130
nucleobase containing small molecule metabolic process GO:0055086 316 0.123
glycosyl compound metabolic process GO:1901657 182 0.120
regulation of cellular component organization GO:0051128 368 0.117
purine ribonucleotide metabolic process GO:0009150 227 0.113
purine nucleoside triphosphate catabolic process GO:0009146 122 0.113
regulation of cell differentiation GO:0045595 320 0.112
protein phosphorylation GO:0006468 345 0.105
release of cytochrome c from mitochondria GO:0001836 8 0.104
positive regulation of phosphate metabolic process GO:0045937 262 0.104
protein complex biogenesis GO:0070271 263 0.101
regulation of cellular localization GO:0060341 263 0.101
single organism catabolic process GO:0044712 283 0.100
positive regulation of developmental process GO:0051094 283 0.099
regulation of nucleic acid templated transcription GO:1903506 380 0.097
multicellular organism growth GO:0035264 1 0.097
rna biosynthetic process GO:0032774 380 0.095
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.095
cellular nitrogen compound catabolic process GO:0044270 163 0.092
nucleic acid templated transcription GO:0097659 379 0.089
regulation of catalytic activity GO:0050790 304 0.089
carbohydrate derivative metabolic process GO:1901135 346 0.088
cellular component biogenesis GO:0044085 368 0.088
positive regulation of cellular component organization GO:0051130 200 0.087
positive regulation of response to stimulus GO:0048584 285 0.087
positive regulation of cell development GO:0010720 176 0.085
regulation of protein metabolic process GO:0051246 289 0.084
regulation of cellular amino acid metabolic process GO:0006521 2 0.084
organophosphate catabolic process GO:0046434 148 0.082
positive regulation of molecular function GO:0044093 230 0.080
glycosyl compound catabolic process GO:1901658 126 0.080
programmed cell death GO:0012501 392 0.080
regulation of phosphorus metabolic process GO:0051174 349 0.080
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.079
macromolecular complex subunit organization GO:0043933 339 0.078
cellular response to stress GO:0033554 269 0.077
apoptotic process GO:0006915 381 0.076
regulation of phosphorylation GO:0042325 248 0.076
purine ribonucleoside metabolic process GO:0046128 168 0.074
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.074
nucleoside phosphate metabolic process GO:0006753 283 0.073
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.073
oxoacid metabolic process GO:0043436 290 0.072
amine metabolic process GO:0009308 38 0.071
regulation of transcription dna templated GO:0006355 374 0.071
cellular component assembly GO:0022607 360 0.071
positive regulation of cellular biosynthetic process GO:0031328 295 0.071
regulation of rna biosynthetic process GO:2001141 381 0.071
synaptic transmission GO:0007268 235 0.070
ribose phosphate metabolic process GO:0019693 235 0.070
nucleoside catabolic process GO:0009164 126 0.070
cellular response to growth factor stimulus GO:0071363 162 0.069
negative regulation of metabolic process GO:0009892 331 0.069
head development GO:0060322 247 0.068
transcription from rna polymerase ii promoter GO:0006366 252 0.068
intracellular signal transduction GO:0035556 314 0.068
positive regulation of programmed cell death GO:0043068 157 0.066
positive regulation of protein phosphorylation GO:0001934 135 0.066
purine containing compound metabolic process GO:0072521 253 0.066
ribonucleotide metabolic process GO:0009259 231 0.065
positive regulation of phosphorus metabolic process GO:0010562 262 0.065
organelle organization GO:0006996 266 0.064
receptor localization to synapse GO:0097120 2 0.064
rna metabolic process GO:0016070 406 0.063
carbohydrate derivative catabolic process GO:1901136 147 0.062
regulation of signal transduction GO:0009966 318 0.062
purine ribonucleoside catabolic process GO:0046130 124 0.061
nucleoside metabolic process GO:0009116 179 0.061
ribonucleotide catabolic process GO:0009261 136 0.060
aromatic compound catabolic process GO:0019439 168 0.060
positive regulation of signal transduction GO:0009967 175 0.059
response to monosaccharide GO:0034284 159 0.059
cellular catabolic process GO:0044248 295 0.059
cell cycle checkpoint GO:0000075 2 0.059
positive regulation of rna metabolic process GO:0051254 203 0.058
nucleoside triphosphate metabolic process GO:0009141 144 0.058
immune system process GO:0002376 204 0.057
heterocycle catabolic process GO:0046700 167 0.057
positive regulation of rna biosynthetic process GO:1902680 197 0.057
purine ribonucleotide catabolic process GO:0009154 136 0.057
chromosome segregation GO:0007059 2 0.057
negative regulation of cellular metabolic process GO:0031324 281 0.056
regulation of protein phosphorylation GO:0001932 183 0.056
establishment of protein localization GO:0045184 141 0.056
positive regulation of gene expression GO:0010628 244 0.055
central nervous system development GO:0007417 311 0.054
leukocyte activation GO:0045321 76 0.054
response to decreased oxygen levels GO:0036293 237 0.054
negative regulation of macromolecule metabolic process GO:0010605 260 0.054
regulation of cellular amine metabolic process GO:0033238 8 0.054
purine nucleotide metabolic process GO:0006163 229 0.054
lens development in camera type eye GO:0002088 13 0.053
negative regulation of organ growth GO:0046621 3 0.053
purine nucleoside metabolic process GO:0042278 169 0.053
protein transport GO:0015031 132 0.053
positive regulation of signaling GO:0023056 270 0.052
nucleotide catabolic process GO:0009166 139 0.052
cytoskeleton organization GO:0007010 111 0.052
protein localization GO:0008104 191 0.052
negative regulation of cell cycle phase transition GO:1901988 4 0.052
enzyme linked receptor protein signaling pathway GO:0007167 116 0.051
cell cycle GO:0007049 101 0.051
regulation of intracellular signal transduction GO:1902531 218 0.051
negative regulation of cell proliferation GO:0008285 119 0.050
regulation of rna metabolic process GO:0051252 391 0.050
organic acid metabolic process GO:0006082 292 0.050
regulation of phosphate metabolic process GO:0019220 349 0.050
positive regulation of protein metabolic process GO:0051247 178 0.049
cellular ketone metabolic process GO:0042180 51 0.049
cellular amine metabolic process GO:0044106 38 0.048
growth GO:0040007 165 0.048
organonitrogen compound catabolic process GO:1901565 179 0.048
cellular protein localization GO:0034613 122 0.047
purine nucleotide catabolic process GO:0006195 136 0.046
regulation of apoptotic process GO:0042981 335 0.045
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.045
response to radiation GO:0009314 137 0.045
protein maturation GO:0051604 68 0.045
positive regulation of transcription dna templated GO:0045893 197 0.045
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.044
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.044
positive regulation of catalytic activity GO:0043085 184 0.043
intracellular transport GO:0046907 185 0.043
nucleobase containing compound catabolic process GO:0034655 152 0.043
protein processing GO:0016485 68 0.042
regulation of programmed cell death GO:0043067 341 0.042
organophosphate metabolic process GO:0019637 370 0.042
heart morphogenesis GO:0003007 3 0.041
positive regulation of secretion GO:0051047 140 0.041
protein complex subunit organization GO:0071822 302 0.041
purine containing compound catabolic process GO:0072523 138 0.041
response to metal ion GO:0010038 253 0.040
positive regulation of nervous system development GO:0051962 178 0.040
nucleotide metabolic process GO:0009117 279 0.040
reproduction GO:0000003 245 0.040
protein oligomerization GO:0051259 191 0.040
negative regulation of cell death GO:0060548 229 0.039
epithelial cell proliferation GO:0050673 54 0.039
cellular amino acid metabolic process GO:0006520 107 0.039
positive regulation of apoptotic process GO:0043065 154 0.038
cell cycle process GO:0022402 57 0.038
response to molecule of bacterial origin GO:0002237 194 0.038
regulation of cellular ketone metabolic process GO:0010565 27 0.038
development of primary sexual characteristics GO:0045137 107 0.037
embryonic pattern specification GO:0009880 1 0.037
ribonucleoside metabolic process GO:0009119 174 0.036
behavior GO:0007610 205 0.036
immune response GO:0006955 104 0.035
regulation of hydrolase activity GO:0051336 143 0.035
single organism organelle organization GO:1902589 180 0.035
developmental process involved in reproduction GO:0003006 159 0.035
positive regulation of intracellular signal transduction GO:1902533 138 0.035
multicellular organismal reproductive process GO:0048609 233 0.035
neuron differentiation GO:0030182 368 0.034
positive regulation of cellular protein metabolic process GO:0032270 167 0.034
anatomical structure morphogenesis GO:0009653 298 0.034
regulation of cell development GO:0060284 263 0.033
nucleoside triphosphate catabolic process GO:0009143 123 0.033
single organism reproductive process GO:0044702 297 0.033
stress activated mapk cascade GO:0051403 35 0.032
regulation of nervous system development GO:0051960 264 0.032
single organism intracellular transport GO:1902582 166 0.032
positive regulation of phosphorylation GO:0042327 177 0.032
positive regulation of retinal cell programmed cell death GO:0046670 1 0.032
dna integrity checkpoint GO:0031570 2 0.032
regulation of cellular protein metabolic process GO:0032268 267 0.032
rhythmic process GO:0048511 156 0.032
negative regulation of cell communication GO:0010648 158 0.032
organic cyclic compound catabolic process GO:1901361 175 0.031
cell migration GO:0016477 197 0.031
regulation of growth GO:0040008 105 0.031
regulation of immune system process GO:0002682 123 0.031
protein heterooligomerization GO:0051291 89 0.031
ribonucleoside catabolic process GO:0042454 126 0.031
ras protein signal transduction GO:0007265 29 0.031
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.031
regulation of peptidase activity GO:0052547 55 0.030
regulation of mapk cascade GO:0043408 116 0.030
epithelium development GO:0060429 96 0.029
regulation of kinase activity GO:0043549 117 0.029
regulation of cellular response to stress GO:0080135 49 0.029
regulation of catabolic process GO:0009894 113 0.029
positive regulation of neuron differentiation GO:0045666 126 0.029
multi organism reproductive process GO:0044703 262 0.029
response to oxygen levels GO:0070482 265 0.029
response to acid chemical GO:0001101 222 0.028
response to nutrient levels GO:0031667 370 0.028
cell projection organization GO:0030030 302 0.028
positive regulation of protein transport GO:0051222 41 0.028
response to growth factor GO:0070848 189 0.028
organelle localization GO:0051640 55 0.028
negative regulation of rna metabolic process GO:0051253 123 0.027
cellular chemical homeostasis GO:0055082 247 0.027
multicellular organism reproduction GO:0032504 233 0.027
positive regulation of protein modification process GO:0031401 142 0.027
cation homeostasis GO:0055080 195 0.027
small gtpase mediated signal transduction GO:0007264 36 0.027
regulation of anatomical structure size GO:0090066 135 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.027
nucleoside phosphate catabolic process GO:1901292 140 0.027
inorganic cation transmembrane transport GO:0098662 202 0.027
single organism cellular localization GO:1902580 102 0.026
brain development GO:0007420 247 0.026
activation of protein kinase activity GO:0032147 47 0.026
proteolysis GO:0006508 175 0.026
reproductive process GO:0022414 372 0.026
cellular calcium ion homeostasis GO:0006874 160 0.026
regulation of behavior GO:0050795 61 0.026
gamete generation GO:0007276 124 0.026
response to camp GO:0051591 91 0.025
regulation of cellular component movement GO:0051270 150 0.025
cellular ion homeostasis GO:0006873 184 0.025
homeostatic process GO:0042592 331 0.025
circadian rhythm GO:0007623 88 0.025
ribonucleoside triphosphate metabolic process GO:0009199 141 0.025
reactive oxygen species biosynthetic process GO:1903409 8 0.025
purine nucleoside monophosphate catabolic process GO:0009128 55 0.025
positive regulation of cell proliferation GO:0008284 249 0.025
catabolic process GO:0009056 351 0.024
cellular response to hormone stimulus GO:0032870 247 0.024
regulation of protein transport GO:0051223 68 0.024
ion transmembrane transport GO:0034220 365 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.024
positive regulation of cell death GO:0010942 184 0.024
organic substance catabolic process GO:1901575 316 0.024
negative regulation of transcription dna templated GO:0045892 116 0.024
cellular macromolecule localization GO:0070727 122 0.024
response to nicotine GO:0035094 51 0.024
actin filament based process GO:0030029 86 0.024
response to tumor necrosis factor GO:0034612 56 0.023
regulation of cell cycle GO:0051726 73 0.023
response to carbohydrate GO:0009743 183 0.023
protein homooligomerization GO:0051260 91 0.023
negative regulation of biosynthetic process GO:0009890 168 0.023
lipid metabolic process GO:0006629 283 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
neurological system process GO:0050877 219 0.023
cytosolic calcium ion homeostasis GO:0051480 140 0.023
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.022
negative regulation of cellular protein metabolic process GO:0032269 106 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.022
cellular response to endogenous stimulus GO:0071495 377 0.022
developmental growth GO:0048589 100 0.022
positive regulation of cell migration GO:0030335 96 0.022
metaphase anaphase transition of cell cycle GO:0044784 1 0.022
guanosine containing compound metabolic process GO:1901068 74 0.021
response to hexose GO:0009746 144 0.021
carbohydrate metabolic process GO:0005975 130 0.021
regulation of secretion GO:0051046 224 0.021
regulation of feeding behavior GO:0060259 14 0.021
sexual reproduction GO:0019953 148 0.021
regulation of response to stress GO:0080134 126 0.021
mapk cascade GO:0000165 140 0.020
regulation of protein localization GO:0032880 81 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.020
response to hypoxia GO:0001666 231 0.020
eye morphogenesis GO:0048592 4 0.020
cellular metal ion homeostasis GO:0006875 172 0.020
response to ethanol GO:0045471 162 0.020
regulation of cellular component biogenesis GO:0044087 86 0.020
cell adhesion GO:0007155 110 0.020
cellular response to oxygen containing compound GO:1901701 386 0.020
negative regulation of rna biosynthetic process GO:1902679 118 0.020
cellular response to biotic stimulus GO:0071216 59 0.020
regulation of neurogenesis GO:0050767 247 0.019
circadian sleep wake cycle GO:0042745 23 0.019
regulation of ion transmembrane transport GO:0034765 121 0.019
regeneration GO:0031099 163 0.019
response to inorganic substance GO:0010035 377 0.019
purine nucleoside catabolic process GO:0006152 124 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
cellular response to peptide hormone stimulus GO:0071375 120 0.019
transmission of nerve impulse GO:0019226 42 0.019
tube development GO:0035295 89 0.019
mitotic cell cycle phase transition GO:0044772 20 0.019
guanosine containing compound catabolic process GO:1901069 71 0.019
regulation of membrane potential GO:0042391 110 0.019
response to cytokine GO:0034097 215 0.019
aging GO:0007568 241 0.018
neuron development GO:0048666 286 0.018
gtp metabolic process GO:0046039 72 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
negative regulation of protein phosphorylation GO:0001933 44 0.018
regulation of vesicle mediated transport GO:0060627 81 0.018
feeding behavior GO:0007631 53 0.018
response to peptide hormone GO:0043434 278 0.018
cellular component movement GO:0006928 248 0.018
cell cell signaling GO:0007267 335 0.018
negative regulation of developmental process GO:0051093 125 0.018
regulation of cell cycle process GO:0010564 31 0.018
sex differentiation GO:0007548 113 0.018
regulation of protein modification process GO:0031399 194 0.018
response to extracellular stimulus GO:0009991 380 0.018
taxis GO:0042330 67 0.017
action potential GO:0001508 54 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
regulation of proteolysis GO:0030162 66 0.017
peptidyl threonine phosphorylation GO:0018107 7 0.017
immune effector process GO:0002252 53 0.017
regulation of neuron differentiation GO:0045664 208 0.017
regulation of synaptic transmission GO:0050804 141 0.017
positive regulation of immune system process GO:0002684 90 0.017
positive regulation of secretion by cell GO:1903532 128 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
camera type eye development GO:0043010 48 0.017
biological adhesion GO:0022610 110 0.017
cytoskeleton dependent cytokinesis GO:0061640 2 0.017
positive regulation of cellular component biogenesis GO:0044089 55 0.017
cellular response to peptide GO:1901653 133 0.017
negative regulation of signaling GO:0023057 157 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
organonitrogen compound biosynthetic process GO:1901566 167 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
cellular response to nitrogen compound GO:1901699 210 0.016
regulation of cytokine production GO:0001817 56 0.016
establishment of organelle localization GO:0051656 37 0.016
regulation of transmembrane transport GO:0034762 122 0.016
anterior posterior pattern specification GO:0009952 1 0.016
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.016
metal ion homeostasis GO:0055065 186 0.016
neuronal action potential GO:0019228 35 0.016
muscle contraction GO:0006936 88 0.016
synapse organization GO:0050808 46 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
mitotic cell cycle GO:0000278 49 0.016
cell cycle phase transition GO:0044770 21 0.016
secretion GO:0046903 307 0.016
response to nutrient GO:0007584 248 0.016
neuron fate commitment GO:0048663 4 0.016
regulation of transferase activity GO:0051338 123 0.016
chromosome organization GO:0051276 36 0.016
peptidyl amino acid modification GO:0018193 126 0.016
organ morphogenesis GO:0009887 75 0.016
regulation of ras protein signal transduction GO:0046578 45 0.016
regulation of system process GO:0044057 208 0.016
cation transport GO:0006812 382 0.016
muscle cell differentiation GO:0042692 52 0.016
neuron neuron synaptic transmission GO:0007270 60 0.015
rhythmic behavior GO:0007622 24 0.015
response to lipopolysaccharide GO:0032496 191 0.015
negative regulation of phosphate metabolic process GO:0045936 80 0.015
pseudopodium assembly GO:0031269 3 0.015
response to glucose GO:0009749 136 0.015
positive regulation of mapk cascade GO:0043410 92 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
female sex differentiation GO:0046660 59 0.015
negative regulation of phosphorus metabolic process GO:0010563 80 0.015
secretion by cell GO:0032940 248 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
regulation of establishment of protein localization GO:0070201 69 0.015
protein autophosphorylation GO:0046777 66 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
response to external biotic stimulus GO:0043207 221 0.015
gtp catabolic process GO:0006184 71 0.015
chemical homeostasis GO:0048878 292 0.015
ovulation cycle GO:0042698 67 0.015
response to temperature stimulus GO:0009266 94 0.015
regulation of protein complex assembly GO:0043254 33 0.015
t cell activation GO:0042110 29 0.014
multicellular organismal signaling GO:0035637 44 0.014
positive regulation of mitochondrion organization GO:0010822 4 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
single organism biosynthetic process GO:0044711 342 0.014
cell activation GO:0001775 97 0.014
mitotic cell cycle process GO:1903047 35 0.014
cell part morphogenesis GO:0032990 123 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
response to alkaloid GO:0043279 132 0.014
response to wounding GO:0009611 254 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.014
positive regulation of endocytosis GO:0045807 28 0.014
mitotic cell cycle checkpoint GO:0007093 1 0.014
centrosome organization GO:0051297 1 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
development of primary female sexual characteristics GO:0046545 56 0.014
locomotion GO:0040011 237 0.014
response to other organism GO:0051707 220 0.014
cellular protein complex assembly GO:0043623 44 0.014
dna damage checkpoint GO:0000077 2 0.014
spermatogenesis GO:0007283 99 0.014
tube formation GO:0035148 3 0.014
response to retinoic acid GO:0032526 63 0.014
cellular response to dna damage stimulus GO:0006974 19 0.014
lymphocyte activation involved in immune response GO:0002285 3 0.014
response to organophosphorus GO:0046683 102 0.014
regulation of cellular catabolic process GO:0031329 101 0.013
cell morphogenesis GO:0000902 142 0.013
cell motility GO:0048870 202 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
negative regulation of epithelial cell proliferation GO:0050680 16 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
protein localization to nucleus GO:0034504 39 0.013
cellular homeostasis GO:0019725 252 0.013
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 4 0.013
defense response GO:0006952 194 0.013
apoptotic mitochondrial changes GO:0008637 10 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
ion homeostasis GO:0050801 212 0.013
atp catabolic process GO:0006200 54 0.013
protein polymerization GO:0051258 22 0.013
positive regulation of cell motility GO:2000147 97 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.013
endomembrane system organization GO:0010256 48 0.013
atp metabolic process GO:0046034 72 0.013
regulation of cell projection organization GO:0031344 175 0.013
cognition GO:0050890 92 0.013
cellular response to lipid GO:0071396 201 0.013
transmembrane transport GO:0055085 412 0.013
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
cytokine production GO:0001816 61 0.013
calcium ion homeostasis GO:0055074 162 0.013
cellular cation homeostasis GO:0030003 180 0.013
regulation of circadian sleep wake cycle GO:0042749 18 0.013
mitotic sister chromatid separation GO:0051306 1 0.013
positive regulation of hydrolase activity GO:0051345 86 0.012
lymphocyte activation GO:0046649 43 0.012
kidney development GO:0001822 67 0.012
positive regulation of interleukin 1 secretion GO:0050716 3 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
positive regulation of dna metabolic process GO:0051054 39 0.012
stem cell maintenance GO:0019827 6 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
regulation of organelle organization GO:0033043 80 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
axis specification GO:0009798 4 0.012
muscle structure development GO:0061061 87 0.012
metal ion transport GO:0030001 289 0.012
response to oxidative stress GO:0006979 186 0.012
protein targeting GO:0006605 61 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
negative regulation of molecular function GO:0044092 133 0.012
positive regulation of catabolic process GO:0009896 78 0.012
cytoplasmic transport GO:0016482 115 0.012
regulation of gtp catabolic process GO:0033124 58 0.012
positive regulation of pseudopodium assembly GO:0031274 1 0.012
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
regulation of endocytosis GO:0030100 42 0.012
regulation of transporter activity GO:0032409 50 0.012
gonad development GO:0008406 104 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
positive regulation of organelle organization GO:0010638 48 0.012
dna metabolic process GO:0006259 96 0.012
anion transport GO:0006820 178 0.011
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
memory GO:0007613 54 0.011
sensory organ development GO:0007423 74 0.011
regulation of small gtpase mediated signal transduction GO:0051056 48 0.011
neuron projection morphogenesis GO:0048812 122 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
glycoprotein metabolic process GO:0009100 24 0.011
male gamete generation GO:0048232 99 0.011
neuronal ion channel clustering GO:0045161 3 0.011
sodium ion transport GO:0006814 82 0.011
neuron projection development GO:0031175 273 0.011
regulation of metal ion transport GO:0010959 118 0.011
negative regulation of signal transduction GO:0009968 83 0.011
regulation of developmental growth GO:0048638 45 0.011
cellular response to tumor necrosis factor GO:0071356 46 0.011
vasculature development GO:0001944 70 0.011
forebrain development GO:0030900 98 0.011

Top2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
colon carcinoma DOID:1520 0 0.016
large intestine cancer DOID:5672 0 0.016
colon cancer DOID:219 0 0.016
gastrointestinal system cancer DOID:3119 0 0.016
intestinal cancer DOID:10155 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
colorectal cancer DOID:9256 0 0.016
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012