Rattus norvegicus

0 known processes

Ttc3

tetratricopeptide repeat domain 3

Ttc3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
calcineurin nfat signaling cascade GO:0033173 3 0.299
regulation of programmed cell death GO:0043067 341 0.275
neuron apoptotic process GO:0051402 88 0.186
cellular response to oxygen containing compound GO:1901701 386 0.170
rna metabolic process GO:0016070 406 0.167
regulation of rna metabolic process GO:0051252 391 0.107
macromolecular complex assembly GO:0065003 273 0.105
brain development GO:0007420 247 0.105
synaptic vesicle priming GO:0016082 4 0.103
regulation of locomotion GO:0040012 148 0.102
response to growth factor GO:0070848 189 0.093
cell migration GO:0016477 197 0.091
regulation of apoptotic process GO:0042981 335 0.086
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.083
positive regulation of cellular component organization GO:0051130 200 0.082
cellular response to hydroperoxide GO:0071447 2 0.081
synaptic transmission GO:0007268 235 0.079
positive regulation of developmental process GO:0051094 283 0.077
neurological system process GO:0050877 219 0.075
positive regulation of multicellular organismal process GO:0051240 387 0.072
behavior GO:0007610 205 0.072
central nervous system development GO:0007417 311 0.072
protein complex biogenesis GO:0070271 263 0.071
head development GO:0060322 247 0.070
positive regulation of phosphate metabolic process GO:0045937 262 0.069
positive regulation of response to stimulus GO:0048584 285 0.068
regulation of cell differentiation GO:0045595 320 0.065
response to bacterium GO:0009617 200 0.065
positive regulation of cell differentiation GO:0045597 217 0.065
tissue development GO:0009888 252 0.064
regulation of multicellular organismal development GO:2000026 376 0.062
neuronal action potential GO:0019228 35 0.059
oxoacid metabolic process GO:0043436 290 0.059
cation transport GO:0006812 382 0.059
cell type specific apoptotic process GO:0097285 134 0.057
calcium ion transport GO:0006816 131 0.056
divalent metal ion transport GO:0070838 132 0.055
positive regulation of neurogenesis GO:0050769 165 0.055
apoptotic process GO:0006915 381 0.053
regulation of cellular component organization GO:0051128 368 0.053
regulation of nucleic acid templated transcription GO:1903506 380 0.051
cellular component movement GO:0006928 248 0.049
cytosolic calcium ion homeostasis GO:0051480 140 0.048
regulation of growth GO:0040008 105 0.048
organelle organization GO:0006996 266 0.048
positive regulation of transport GO:0051050 245 0.047
regulation of neuron death GO:1901214 115 0.046
regulation of anatomical structure size GO:0090066 135 0.044
cerebral cortex tangential migration GO:0021800 1 0.044
positive regulation of cell development GO:0010720 176 0.043
positive regulation of cellular component movement GO:0051272 102 0.042
metal ion transport GO:0030001 289 0.042
regulation of neuron apoptotic process GO:0043523 83 0.042
regulation of phosphorus metabolic process GO:0051174 349 0.042
intracellular transport GO:0046907 185 0.041
carboxylic acid metabolic process GO:0019752 289 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.041
negative regulation of cell death GO:0060548 229 0.041
ion homeostasis GO:0050801 212 0.041
negative regulation of signaling GO:0023057 157 0.040
positive regulation of signal transduction GO:0009967 175 0.040
positive regulation of biosynthetic process GO:0009891 319 0.040
mrna metabolic process GO:0016071 20 0.040
macromolecular complex subunit organization GO:0043933 339 0.039
response to wounding GO:0009611 254 0.039
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.039
positive regulation of phosphorus metabolic process GO:0010562 262 0.039
neuron death GO:0070997 127 0.039
protein complex subunit organization GO:0071822 302 0.039
cellular chemical homeostasis GO:0055082 247 0.039
regulation of cell motility GO:2000145 131 0.039
positive regulation of nucleic acid templated transcription GO:1903508 197 0.038
cellular component biogenesis GO:0044085 368 0.038
secretion GO:0046903 307 0.038
reproductive process GO:0022414 372 0.038
positive regulation of signaling GO:0023056 270 0.037
positive regulation of cytoplasmic transport GO:1903651 32 0.036
rna biosynthetic process GO:0032774 380 0.036
single organism organelle organization GO:1902589 180 0.035
response to acid chemical GO:0001101 222 0.035
positive regulation of phosphorylation GO:0042327 177 0.034
regulation of nervous system development GO:0051960 264 0.034
single organism behavior GO:0044708 130 0.034
cognition GO:0050890 92 0.033
protein phosphorylation GO:0006468 345 0.033
nucleic acid templated transcription GO:0097659 379 0.033
cell cell signaling GO:0007267 335 0.033
negative regulation of apoptotic process GO:0043066 181 0.032
second messenger mediated signaling GO:0019932 51 0.032
regulation of cellular localization GO:0060341 263 0.032
locomotion GO:0040011 237 0.031
cellular amine metabolic process GO:0044106 38 0.031
positive regulation of transcription dna templated GO:0045893 197 0.031
cellular component assembly GO:0022607 360 0.031
divalent inorganic cation homeostasis GO:0072507 165 0.031
positive regulation of cellular biosynthetic process GO:0031328 295 0.031
regulation of calcineurin nfat signaling cascade GO:0070884 3 0.031
response to lipopolysaccharide GO:0032496 191 0.031
cellular response to growth factor stimulus GO:0071363 162 0.031
peptidyl amino acid modification GO:0018193 126 0.031
negative regulation of programmed cell death GO:0043069 183 0.031
regulation of neurogenesis GO:0050767 247 0.031
positive regulation of nervous system development GO:0051962 178 0.030
positive regulation of rna biosynthetic process GO:1902680 197 0.030
organic acid metabolic process GO:0006082 292 0.029
regulation of signal transduction GO:0009966 318 0.029
positive regulation of gene expression GO:0010628 244 0.029
negative regulation of neuron apoptotic process GO:0043524 45 0.029
positive regulation of apoptotic process GO:0043065 154 0.029
cellular ion homeostasis GO:0006873 184 0.029
immune system process GO:0002376 204 0.029
cellular component morphogenesis GO:0032989 155 0.029
cell adhesion GO:0007155 110 0.028
response to biotic stimulus GO:0009607 226 0.028
negative regulation of rna metabolic process GO:0051253 123 0.028
sensory organ development GO:0007423 74 0.028
divalent inorganic cation transport GO:0072511 134 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.027
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.026
anatomical structure morphogenesis GO:0009653 298 0.026
positive regulation of protein phosphorylation GO:0001934 135 0.026
reproduction GO:0000003 245 0.026
programmed cell death GO:0012501 392 0.026
small gtpase mediated signal transduction GO:0007264 36 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
negative regulation of neuron death GO:1901215 69 0.025
secretion by cell GO:0032940 248 0.025
protein complex assembly GO:0006461 263 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
regulation of membrane potential GO:0042391 110 0.025
cellular response to hormone stimulus GO:0032870 247 0.025
response to carbohydrate GO:0009743 183 0.024
amine metabolic process GO:0009308 38 0.024
cellular response to endogenous stimulus GO:0071495 377 0.024
regulation of secretion GO:0051046 224 0.024
regulation of rna biosynthetic process GO:2001141 381 0.024
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.024
cellular metal ion homeostasis GO:0006875 172 0.024
localization of cell GO:0051674 202 0.023
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
multicellular organism growth GO:0035264 1 0.023
negative regulation of cell communication GO:0010648 158 0.023
regulation of cellular component movement GO:0051270 150 0.023
learning or memory GO:0007611 90 0.023
organic substance catabolic process GO:1901575 316 0.023
calcium ion homeostasis GO:0055074 162 0.023
nucleobase containing small molecule metabolic process GO:0055086 316 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
catabolic process GO:0009056 351 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
regulation of system process GO:0044057 208 0.022
regulation of hormone secretion GO:0046883 106 0.022
positive regulation of secretion by cell GO:1903532 128 0.022
response to metal ion GO:0010038 253 0.022
establishment of protein localization GO:0045184 141 0.022
cellular cation homeostasis GO:0030003 180 0.021
carbohydrate metabolic process GO:0005975 130 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.021
regulation of homeostatic process GO:0032844 101 0.021
striated muscle tissue development GO:0014706 58 0.021
negative regulation of nervous system development GO:0051961 79 0.021
regulation of calcium ion transport GO:0051924 77 0.021
immune response GO:0006955 104 0.021
negative regulation of multicellular organismal process GO:0051241 203 0.021
positive regulation of cell communication GO:0010647 271 0.020
maintenance of location GO:0051235 17 0.020
regulation of ion transport GO:0043269 245 0.020
response to oxidative stress GO:0006979 186 0.020
activation of protein kinase b activity GO:0032148 3 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
synaptic growth at neuromuscular junction GO:0051124 1 0.020
purine containing compound metabolic process GO:0072521 253 0.020
response to amine GO:0014075 46 0.020
regulation of protein metabolic process GO:0051246 289 0.019
negative regulation of developmental process GO:0051093 125 0.019
regulation of vesicle mediated transport GO:0060627 81 0.019
regulation of ion homeostasis GO:2000021 63 0.019
metal ion homeostasis GO:0055065 186 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
endoplasmic reticulum to cytosol transport GO:1903513 4 0.019
small molecule catabolic process GO:0044282 59 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
regulation of catalytic activity GO:0050790 304 0.019
response to amphetamine GO:0001975 25 0.019
spindle organization GO:0007051 2 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
muscle structure development GO:0061061 87 0.019
cellular macromolecule localization GO:0070727 122 0.018
intracellular signal transduction GO:0035556 314 0.018
organophosphate metabolic process GO:0019637 370 0.018
regulation of anatomical structure morphogenesis GO:0022603 141 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
regulation of mrna splicing via spliceosome GO:0048024 3 0.018
motor neuron axon guidance GO:0008045 1 0.018
ras protein signal transduction GO:0007265 29 0.018
neuron projection development GO:0031175 273 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.017
circulatory system process GO:0003013 183 0.017
multicellular organism reproduction GO:0032504 233 0.017
cellular homeostasis GO:0019725 252 0.017
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.017
intracellular protein transport GO:0006886 79 0.017
calcium mediated signaling GO:0019722 23 0.017
transmission of nerve impulse GO:0019226 42 0.017
regulation of cell proliferation GO:0042127 359 0.016
response to peptide GO:1901652 292 0.016
cellular response to stress GO:0033554 269 0.016
gastrulation GO:0007369 2 0.016
eye morphogenesis GO:0048592 4 0.016
positive regulation of hormone secretion GO:0046887 65 0.016
response to extracellular stimulus GO:0009991 380 0.016
response to other organism GO:0051707 220 0.016
neuron development GO:0048666 286 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
cellular response to lipid GO:0071396 201 0.016
glycerolipid metabolic process GO:0046486 67 0.016
regulation of transcription dna templated GO:0006355 374 0.016
sequestering of calcium ion GO:0051208 8 0.016
action potential GO:0001508 54 0.016
neural crest cell migration GO:0001755 1 0.016
regulation of kinase activity GO:0043549 117 0.016
response to glucose GO:0009749 136 0.015
negative regulation of secretion GO:0051048 82 0.015
defense response GO:0006952 194 0.015
macromolecule localization GO:0033036 252 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
response to nutrient levels GO:0031667 370 0.015
cellular calcium ion homeostasis GO:0006874 160 0.015
myelination GO:0042552 39 0.015
positive regulation of cell death GO:0010942 184 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
regulation of secretion by cell GO:1903530 208 0.015
dendrite development GO:0016358 72 0.015
muscle system process GO:0003012 115 0.015
cellular response to molecule of bacterial origin GO:0071219 56 0.015
negative regulation of cellular metabolic process GO:0031324 281 0.015
response to nutrient GO:0007584 248 0.015
response to temperature stimulus GO:0009266 94 0.015
single organism intracellular transport GO:1902582 166 0.015
negative regulation of metabolic process GO:0009892 331 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
response to vitamin GO:0033273 131 0.014
regulation of leukocyte differentiation GO:1902105 20 0.014
homeostatic process GO:0042592 331 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
positive regulation of peptide hormone secretion GO:0090277 50 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
cellular protein complex assembly GO:0043623 44 0.014
positive regulation of programmed cell death GO:0043068 157 0.014
meiotic cell cycle process GO:1903046 3 0.014
nitrogen compound transport GO:0071705 229 0.014
cellular lipid metabolic process GO:0044255 208 0.014
chemical homeostasis GO:0048878 292 0.014
myeloid leukocyte differentiation GO:0002573 20 0.014
phosphatidylinositol dephosphorylation GO:0046856 4 0.014
cellular ketone metabolic process GO:0042180 51 0.014
positive regulation of cellular component biogenesis GO:0044089 55 0.014
intracellular distribution of mitochondria GO:0048312 4 0.014
heterocycle catabolic process GO:0046700 167 0.014
regulation of synaptic transmission GO:0050804 141 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
response to corticosteroid GO:0031960 235 0.013
hormone transport GO:0009914 121 0.013
relaxation of muscle GO:0090075 4 0.013
innate immune response GO:0045087 35 0.013
positive regulation of defense response GO:0031349 37 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.013
cellular catabolic process GO:0044248 295 0.013
response to external biotic stimulus GO:0043207 221 0.013
response to monosaccharide GO:0034284 159 0.013
response to ethanol GO:0045471 162 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
regulation of postsynaptic membrane potential GO:0060078 25 0.013
regulation of axon extension GO:0030516 24 0.013
cation homeostasis GO:0055080 195 0.013
response to estrogen GO:0043627 232 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
purine ribonucleotide biosynthetic process GO:0009152 81 0.013
oxidation reduction process GO:0055114 304 0.013
regulation of response to stress GO:0080134 126 0.012
peptide secretion GO:0002790 86 0.012
regulation of response to external stimulus GO:0032101 106 0.012
regulation of phosphorylation GO:0042325 248 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
regulation of metal ion transport GO:0010959 118 0.012
cellular response to drug GO:0035690 30 0.012
positive regulation of locomotion GO:0040017 102 0.012
positive regulation of secretion GO:0051047 140 0.012
response to hypoxia GO:0001666 231 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
negative regulation of signal transduction GO:0009968 83 0.012
cell projection organization GO:0030030 302 0.012
cellular protein localization GO:0034613 122 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
regulation of phospholipase activity GO:0010517 12 0.012
positive regulation of immune system process GO:0002684 90 0.012
taxis GO:0042330 67 0.012
regulation of hormone levels GO:0010817 187 0.012
response to cytokine GO:0034097 215 0.012
transmembrane transport GO:0055085 412 0.012
sequestering of metal ion GO:0051238 9 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
insulin secretion GO:0030073 69 0.012
multicellular organismal signaling GO:0035637 44 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
glandular epithelial cell differentiation GO:0002067 4 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
regulation of immune system process GO:0002682 123 0.012
regulation of cell projection organization GO:0031344 175 0.012
regulation of muscle system process GO:0090257 79 0.011
regulation of cellular component size GO:0032535 51 0.011
response to mineralocorticoid GO:0051385 49 0.011
male gamete generation GO:0048232 99 0.011
growth GO:0040007 165 0.011
embryo development GO:0009790 49 0.011
peptide metabolic process GO:0006518 32 0.011
embryonic skeletal system development GO:0048706 3 0.011
regulation of neuron differentiation GO:0045664 208 0.011
heart contraction GO:0060047 57 0.011
regeneration GO:0031099 163 0.011
peptidyl tyrosine phosphorylation GO:0018108 72 0.011
skeletal muscle organ development GO:0060538 33 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
synaptic vesicle exocytosis GO:0016079 15 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
positive regulation of intracellular transport GO:0032388 39 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
immune system development GO:0002520 41 0.011
protein localization GO:0008104 191 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
female meiotic division GO:0007143 4 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
regulation of developmental growth GO:0048638 45 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
activation of immune response GO:0002253 26 0.011
signal release GO:0023061 145 0.011
cellular glucose homeostasis GO:0001678 66 0.011
actin nucleation GO:0045010 2 0.011
single organism biosynthetic process GO:0044711 342 0.011
regulation of release of sequestered calcium ion into cytosol GO:0051279 18 0.011
calcium ion transport into cytosol GO:0060402 38 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
telencephalon development GO:0021537 62 0.011
regulation of behavior GO:0050795 61 0.010
regulation of defense response GO:0031347 68 0.010
macromolecule methylation GO:0043414 16 0.010
response to glucocorticoid GO:0051384 223 0.010
negative regulation of hormone secretion GO:0046888 46 0.010
parasympathetic nervous system development GO:0048486 1 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
aromatic compound catabolic process GO:0019439 168 0.010
cell motility GO:0048870 202 0.010
aging GO:0007568 241 0.010
regulation of transferase activity GO:0051338 123 0.010
single organism carbohydrate metabolic process GO:0044723 118 0.010
regulation of protein complex assembly GO:0043254 33 0.010

Ttc3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.066
nervous system disease DOID:863 0 0.066
brain disease DOID:936 0 0.035
central nervous system disease DOID:331 0 0.035
epilepsy syndrome DOID:1826 0 0.035
neurodegenerative disease DOID:1289 0 0.016
synucleinopathy DOID:0050890 0 0.016
parkinson s disease DOID:14330 0 0.016