Rattus norvegicus

50 known processes

Txnip

thioredoxin interacting protein

(Aliases: MGC94673,Vdup1)

Txnip biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to extracellular stimulus GO:0009991 380 0.193
positive regulation of response to stimulus GO:0048584 285 0.175
programmed cell death GO:0012501 392 0.175
cellular component assembly GO:0022607 360 0.163
protein complex subunit organization GO:0071822 302 0.154
apoptotic process GO:0006915 381 0.153
response to nutrient levels GO:0031667 370 0.135
regulation of programmed cell death GO:0043067 341 0.132
negative regulation of cell death GO:0060548 229 0.115
macromolecular complex subunit organization GO:0043933 339 0.110
regulation of signal transduction GO:0009966 318 0.109
cellular component movement GO:0006928 248 0.105
positive regulation of multicellular organismal process GO:0051240 387 0.103
intracellular signal transduction GO:0035556 314 0.102
negative regulation of metabolic process GO:0009892 331 0.094
Fly
response to inorganic substance GO:0010035 377 0.086
cellular response to organonitrogen compound GO:0071417 197 0.085
cellular response to oxygen containing compound GO:1901701 386 0.083
regulation of apoptotic process GO:0042981 335 0.083
macromolecular complex assembly GO:0065003 273 0.077
rna biosynthetic process GO:0032774 380 0.077
response to acid chemical GO:0001101 222 0.076
positive regulation of cell communication GO:0010647 271 0.076
response to nutrient GO:0007584 248 0.076
organic acid metabolic process GO:0006082 292 0.073
transcription dna templated GO:0006351 377 0.071
carboxylic acid metabolic process GO:0019752 289 0.070
negative regulation of cellular metabolic process GO:0031324 281 0.069
positive regulation of cell proliferation GO:0008284 249 0.068
oxoacid metabolic process GO:0043436 290 0.067
regulation of multicellular organismal development GO:2000026 376 0.067
regulation of immune system process GO:0002682 123 0.067
positive regulation of developmental process GO:0051094 283 0.066
positive regulation of transport GO:0051050 245 0.063
rna metabolic process GO:0016070 406 0.062
protein complex assembly GO:0006461 263 0.062
central nervous system development GO:0007417 311 0.062
regulation of cell differentiation GO:0045595 320 0.061
cellular amine metabolic process GO:0044106 38 0.061
negative regulation of gene expression GO:0010629 199 0.061
Fly
positive regulation of immune system process GO:0002684 90 0.061
cellular lipid metabolic process GO:0044255 208 0.060
regeneration GO:0031099 163 0.059
regulation of cell proliferation GO:0042127 359 0.057
reproductive process GO:0022414 372 0.057
cellular response to stress GO:0033554 269 0.056
response to oxidative stress GO:0006979 186 0.055
protein complex biogenesis GO:0070271 263 0.055
single organism biosynthetic process GO:0044711 342 0.054
lipid metabolic process GO:0006629 283 0.054
regulation of rna metabolic process GO:0051252 391 0.054
cellular response to nitrogen compound GO:1901699 210 0.053
negative regulation of cellular biosynthetic process GO:0031327 161 0.053
amine metabolic process GO:0009308 38 0.052
regulation of body fluid levels GO:0050878 90 0.052
biological adhesion GO:0022610 110 0.051
cellular component biogenesis GO:0044085 368 0.048
organic anion transport GO:0015711 132 0.047
small molecule biosynthetic process GO:0044283 124 0.047
cellular ketone metabolic process GO:0042180 51 0.047
localization of cell GO:0051674 202 0.046
cellular response to endogenous stimulus GO:0071495 377 0.046
response to biotic stimulus GO:0009607 226 0.046
cellular amino acid metabolic process GO:0006520 107 0.046
response to other organism GO:0051707 220 0.046
positive regulation of signaling GO:0023056 270 0.045
regulation of cellular amino acid metabolic process GO:0006521 2 0.044
response to vitamin GO:0033273 131 0.044
response to external biotic stimulus GO:0043207 221 0.044
transcription from rna polymerase ii promoter GO:0006366 252 0.043
hemostasis GO:0007599 26 0.043
defense response GO:0006952 194 0.042
positive regulation of phosphorus metabolic process GO:0010562 262 0.042
protein phosphorylation GO:0006468 345 0.042
protein oligomerization GO:0051259 191 0.041
endocytosis GO:0006897 84 0.041
locomotion GO:0040011 237 0.041
secretion GO:0046903 307 0.040
regulation of response to stress GO:0080134 126 0.040
response to mechanical stimulus GO:0009612 134 0.040
regulation of rna biosynthetic process GO:2001141 381 0.040
regulation of protein modification process GO:0031399 194 0.040
negative regulation of cell differentiation GO:0045596 99 0.039
cell migration GO:0016477 197 0.039
vesicle mediated transport GO:0016192 181 0.039
organelle organization GO:0006996 266 0.039
immune system process GO:0002376 204 0.039
homeostatic process GO:0042592 331 0.038
negative regulation of biosynthetic process GO:0009890 168 0.038
inflammatory response GO:0006954 150 0.036
carboxylic acid biosynthetic process GO:0046394 83 0.036
regulation of phosphate metabolic process GO:0019220 349 0.036
response to molecule of bacterial origin GO:0002237 194 0.036
neuron development GO:0048666 286 0.036
regulation of protein metabolic process GO:0051246 289 0.035
mapk cascade GO:0000165 140 0.035
regulation of cellular component movement GO:0051270 150 0.035
regulation of cellular component organization GO:0051128 368 0.035
neuron differentiation GO:0030182 368 0.035
regulation of cellular localization GO:0060341 263 0.035
single organism reproductive process GO:0044702 297 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.034
regulation of phosphorylation GO:0042325 248 0.034
cellular response to organic cyclic compound GO:0071407 202 0.034
organic acid biosynthetic process GO:0016053 83 0.033
anatomical structure morphogenesis GO:0009653 298 0.033
negative regulation of response to stimulus GO:0048585 155 0.032
organophosphate metabolic process GO:0019637 370 0.032
response to glucocorticoid GO:0051384 223 0.032
nitrogen compound transport GO:0071705 229 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
negative regulation of developmental process GO:0051093 125 0.031
negative regulation of multicellular organismal process GO:0051241 203 0.031
cellular response to cytokine stimulus GO:0071345 127 0.031
multi organism reproductive process GO:0044703 262 0.031
negative regulation of programmed cell death GO:0043069 183 0.031
enzyme linked receptor protein signaling pathway GO:0007167 116 0.031
response to decreased oxygen levels GO:0036293 237 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.031
positive regulation of phosphate metabolic process GO:0045937 262 0.031
nucleic acid templated transcription GO:0097659 379 0.031
single organism organelle organization GO:1902589 180 0.030
cell projection organization GO:0030030 302 0.030
cellular response to peptide GO:1901653 133 0.030
positive regulation of cellular protein metabolic process GO:0032270 167 0.029
monocarboxylic acid metabolic process GO:0032787 152 0.029
cell activation GO:0001775 97 0.028
growth GO:0040007 165 0.028
cellular response to external stimulus GO:0071496 118 0.028
cellular response to hormone stimulus GO:0032870 247 0.027
negative regulation of rna metabolic process GO:0051253 123 0.027
positive regulation of cell differentiation GO:0045597 217 0.027
single organism intracellular transport GO:1902582 166 0.027
organonitrogen compound biosynthetic process GO:1901566 167 0.027
regulation of transcription dna templated GO:0006355 374 0.027
ion homeostasis GO:0050801 212 0.027
positive regulation of cell motility GO:2000147 97 0.026
cell type specific apoptotic process GO:0097285 134 0.026
regulation of intracellular signal transduction GO:1902531 218 0.026
positive regulation of locomotion GO:0040017 102 0.026
gliogenesis GO:0042063 93 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.026
oxidation reduction process GO:0055114 304 0.026
regulation of nucleic acid templated transcription GO:1903506 380 0.026
response to osmotic stress GO:0006970 42 0.026
positive regulation of cell death GO:0010942 184 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
neuron projection development GO:0031175 273 0.025
regulation of cell migration GO:0030334 128 0.025
response to peptide GO:1901652 292 0.025
response to ethanol GO:0045471 162 0.025
positive regulation of cellular amine metabolic process GO:0033240 3 0.025
response to corticosteroid GO:0031960 235 0.024
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.024
response to metal ion GO:0010038 253 0.024
response to estrogen GO:0043627 232 0.024
peptidyl tyrosine modification GO:0018212 72 0.024
positive regulation of signal transduction GO:0009967 175 0.024
glial cell differentiation GO:0010001 65 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
Fly
regulation of cell development GO:0060284 263 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
organic acid catabolic process GO:0016054 49 0.024
cellular response to lipid GO:0071396 201 0.024
regulation of neurogenesis GO:0050767 247 0.023
wound healing GO:0042060 122 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.023
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.023
response to starvation GO:0042594 59 0.023
response to estradiol GO:0032355 164 0.023
cell adhesion GO:0007155 110 0.023
response to reactive oxygen species GO:0000302 120 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
regulation of locomotion GO:0040012 148 0.023
positive regulation of cellular component movement GO:0051272 102 0.023
organ regeneration GO:0031100 101 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.022
cognition GO:0050890 92 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.022
neurological system process GO:0050877 219 0.022
negative regulation of hemostasis GO:1900047 6 0.022
blood coagulation GO:0007596 26 0.022
cation transport GO:0006812 382 0.022
multicellular organism reproduction GO:0032504 233 0.022
cellular response to extracellular stimulus GO:0031668 73 0.022
response to radiation GO:0009314 137 0.022
lymphocyte activation GO:0046649 43 0.022
negative regulation of transport GO:0051051 136 0.021
positive regulation of cell migration GO:0030335 96 0.021
organic hydroxy compound metabolic process GO:1901615 115 0.021
response to carbohydrate GO:0009743 183 0.021
fatty acid metabolic process GO:0006631 99 0.021
regulation of nervous system development GO:0051960 264 0.021
chemical homeostasis GO:0048878 292 0.021
reproduction GO:0000003 245 0.020
response to hexose GO:0009746 144 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
rhythmic process GO:0048511 156 0.020
peptidyl amino acid modification GO:0018193 126 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
carbohydrate derivative metabolic process GO:1901135 346 0.020
cellular component morphogenesis GO:0032989 155 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
head development GO:0060322 247 0.020
leukocyte activation GO:0045321 76 0.020
single organism catabolic process GO:0044712 283 0.020
cellular response to biotic stimulus GO:0071216 59 0.019
protein homooligomerization GO:0051260 91 0.019
organic substance catabolic process GO:1901575 316 0.019
carboxylic acid transport GO:0046942 115 0.019
regulation of secretion by cell GO:1903530 208 0.019
response to lipopolysaccharide GO:0032496 191 0.019
amide transport GO:0042886 105 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.019
transmembrane transport GO:0055085 412 0.019
circulatory system process GO:0003013 183 0.019
regulation of neuron differentiation GO:0045664 208 0.019
multi multicellular organism process GO:0044706 138 0.019
hormone secretion GO:0046879 115 0.019
cell motility GO:0048870 202 0.018
positive regulation of cellular component organization GO:0051130 200 0.018
cellular catabolic process GO:0044248 295 0.018
regulation of system process GO:0044057 208 0.018
negative regulation of immune system process GO:0002683 39 0.018
response to bacterium GO:0009617 200 0.018
positive regulation of molecular function GO:0044093 230 0.017
response to peptide hormone GO:0043434 278 0.017
secretion by cell GO:0032940 248 0.017
regulation of hormone levels GO:0010817 187 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.017
catabolic process GO:0009056 351 0.017
signal release GO:0023061 145 0.017
anion transport GO:0006820 178 0.017
hormone transport GO:0009914 121 0.017
positive regulation of nervous system development GO:0051962 178 0.017
signal transduction by phosphorylation GO:0023014 144 0.017
glycerolipid metabolic process GO:0046486 67 0.017
cell cycle GO:0007049 101 0.017
ion transmembrane transport GO:0034220 365 0.017
cytoskeleton organization GO:0007010 111 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
response to camp GO:0051591 91 0.017
coagulation GO:0050817 28 0.017
cation homeostasis GO:0055080 195 0.017
regulation of cell projection organization GO:0031344 175 0.016
cellular amino acid biosynthetic process GO:0008652 32 0.016
positive regulation of programmed cell death GO:0043068 157 0.016
insulin secretion GO:0030073 69 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
alcohol metabolic process GO:0006066 77 0.016
developmental process involved in reproduction GO:0003006 159 0.016
aging GO:0007568 241 0.016
peptide transport GO:0015833 97 0.016
regulation of hormone secretion GO:0046883 106 0.016
regulation of membrane potential GO:0042391 110 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
regulation of neuron projection development GO:0010975 161 0.016
hepaticobiliary system development GO:0061008 90 0.016
peptidyl tyrosine phosphorylation GO:0018108 72 0.016
regulation of peptide transport GO:0090087 87 0.016
peptide secretion GO:0002790 86 0.015
response to cytokine GO:0034097 215 0.015
peptide hormone secretion GO:0030072 84 0.015
positive regulation of secretion GO:0051047 140 0.015
regulation of anatomical structure size GO:0090066 135 0.015
positive regulation of protein modification process GO:0031401 142 0.015
regulation of secretion GO:0051046 224 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
regulation of blood vessel size GO:0050880 89 0.015
brain development GO:0007420 247 0.015
response to wounding GO:0009611 254 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
actin cytoskeleton organization GO:0030036 73 0.015
single organism behavior GO:0044708 130 0.015
tissue regeneration GO:0042246 36 0.015
regulation of tolerance induction to nonself antigen GO:0002655 1 0.015
cellular response to oxidative stress GO:0034599 76 0.015
ras protein signal transduction GO:0007265 29 0.015
calcium ion homeostasis GO:0055074 162 0.015
response to oxygen levels GO:0070482 265 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
cellular homeostasis GO:0019725 252 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
regulation of peptide secretion GO:0002791 82 0.014
response to monosaccharide GO:0034284 159 0.014
response to retinoic acid GO:0032526 63 0.014
actin filament based process GO:0030029 86 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
regulation of molecular function GO:0065009 398 0.014
urogenital system development GO:0001655 78 0.014
metal ion homeostasis GO:0055065 186 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
cellular response to abiotic stimulus GO:0071214 85 0.013
cellular response to corticosteroid stimulus GO:0071384 69 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
lipid biosynthetic process GO:0008610 128 0.013
regulation of catalytic activity GO:0050790 304 0.013
cellular response to metal ion GO:0071248 55 0.013
t cell activation GO:0042110 29 0.013
response to hypoxia GO:0001666 231 0.013
cell morphogenesis GO:0000902 142 0.013
glucan metabolic process GO:0044042 23 0.013
regulation of ion transport GO:0043269 245 0.013
regulation of phosphorus metabolic process GO:0051174 349 0.013
cytosolic calcium ion homeostasis GO:0051480 140 0.013
lipid transport GO:0006869 61 0.013
organic acid transport GO:0015849 116 0.013
phospholipid metabolic process GO:0006644 61 0.013
cellular response to alcohol GO:0097306 87 0.013
regulation of defense response GO:0031347 68 0.013
cellular response to nutrient levels GO:0031669 60 0.013
positive regulation of biosynthetic process GO:0009891 319 0.013
glycogen metabolic process GO:0005977 23 0.013
cellular response to iron ion starvation GO:0010106 1 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
response to hydrogen peroxide GO:0042542 89 0.013
positive regulation of gene expression GO:0010628 244 0.013
response to growth factor GO:0070848 189 0.013
defense response to gram positive bacterium GO:0050830 2 0.013
regulation of mapk cascade GO:0043408 116 0.013
response to fatty acid GO:0070542 65 0.012
metal ion transport GO:0030001 289 0.012
positive regulation of ion transport GO:0043270 94 0.012
regulation of immune response GO:0050776 55 0.012
regulation of transferase activity GO:0051338 123 0.012
liver development GO:0001889 90 0.012
response to cadmium ion GO:0046686 35 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
gland development GO:0048732 155 0.012
female pregnancy GO:0007565 122 0.012
tube development GO:0035295 89 0.012
blood circulation GO:0008015 183 0.012
kidney development GO:0001822 67 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
positive regulation of transferase activity GO:0051347 81 0.012
cellular glucan metabolic process GO:0006073 23 0.012
negative regulation of transcription dna templated GO:0045892 116 0.012
cell cell signaling GO:0007267 335 0.012
response to insulin GO:0032868 133 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
unsaturated fatty acid metabolic process GO:0033559 39 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
response to hyperoxia GO:0055093 45 0.011
regulation of peptide hormone secretion GO:0090276 80 0.011
alpha amino acid metabolic process GO:1901605 71 0.011
positive regulation of cell development GO:0010720 176 0.011
response to amino acid GO:0043200 75 0.011
organic hydroxy compound transport GO:0015850 77 0.011
carboxylic acid catabolic process GO:0046395 49 0.011
coenzyme metabolic process GO:0006732 86 0.011
intracellular transport GO:0046907 185 0.011
vascular process in circulatory system GO:0003018 96 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.011
cytokinetic process GO:0032506 1 0.011
positive regulation of tolerance induction GO:0002645 1 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
regulation of muscle system process GO:0090257 79 0.011
pinocytosis GO:0006907 1 0.011
glucose homeostasis GO:0042593 75 0.011
regulation of leukocyte activation GO:0002694 45 0.011
regulation of cell adhesion GO:0030155 52 0.011
protein transport GO:0015031 132 0.011
renal system development GO:0072001 67 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
energy reserve metabolic process GO:0006112 25 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
negative regulation of cell communication GO:0010648 158 0.011
muscle contraction GO:0006936 88 0.011
cardiovascular system development GO:0072358 134 0.011
innate immune response GO:0045087 35 0.011
regulation of tube size GO:0035150 89 0.011
cellular response to starvation GO:0009267 27 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
cellular cation homeostasis GO:0030003 180 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
regulation of catabolic process GO:0009894 113 0.010
muscle system process GO:0003012 115 0.010
membrane organization GO:0061024 94 0.010
oligodendrocyte differentiation GO:0048709 32 0.010
macromolecule localization GO:0033036 252 0.010
cellular polysaccharide metabolic process GO:0044264 23 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
negative regulation of secretion GO:0051048 82 0.010
regulation of response to wounding GO:1903034 69 0.010
negative regulation of signaling GO:0023057 157 0.010
positive regulation of protein kinase activity GO:0045860 73 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
g protein coupled receptor signaling pathway GO:0007186 242 0.010
cellular response to molecule of bacterial origin GO:0071219 56 0.010
response to increased oxygen levels GO:0036296 45 0.010
response to glucose GO:0009749 136 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
regulation of homeostatic process GO:0032844 101 0.010
cellular ion homeostasis GO:0006873 184 0.010
negative regulation of innate immune response GO:0045824 4 0.010
positive regulation of smooth muscle cell migration GO:0014911 27 0.010

Txnip disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.011