Rattus norvegicus

122 known processes

Txnrd1

thioredoxin reductase 1

(Aliases: MGC93353,Tr)

Txnrd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apoptotic process GO:0006915 381 0.560
programmed cell death GO:0012501 392 0.479
regulation of programmed cell death GO:0043067 341 0.407
cellular amino acid metabolic process GO:0006520 107 0.341
cellular response to external stimulus GO:0071496 118 0.299
response to nitrosative stress GO:0051409 2 0.293
negative regulation of cell death GO:0060548 229 0.276
cellular modified amino acid biosynthetic process GO:0042398 18 0.243
chromosome segregation GO:0007059 2 0.206
negative regulation of apoptotic process GO:0043066 181 0.205
cellular amino acid biosynthetic process GO:0008652 32 0.204
intracellular signal transduction GO:0035556 314 0.195
response to oxidative stress GO:0006979 186 0.190
positive regulation of biosynthetic process GO:0009891 319 0.182
positive regulation of cellular biosynthetic process GO:0031328 295 0.163
regulation of catalytic activity GO:0050790 304 0.158
mitotic spindle organization GO:0007052 2 0.158
carbohydrate metabolic process GO:0005975 130 0.149
cellular response to alkaloid GO:0071312 25 0.148
negative regulation of programmed cell death GO:0043069 183 0.146
organelle organization GO:0006996 266 0.144
organic acid metabolic process GO:0006082 292 0.138
cellular response to stress GO:0033554 269 0.131
positive regulation of multicellular organismal process GO:0051240 387 0.128
spindle organization GO:0007051 2 0.126
peptide biosynthetic process GO:0043043 3 0.126
response to oxygen levels GO:0070482 265 0.124
positive regulation of gene expression GO:0010628 244 0.115
regulation of apoptotic process GO:0042981 335 0.113
macromolecule localization GO:0033036 252 0.109
carboxylic acid metabolic process GO:0019752 289 0.107
dna metabolic process GO:0006259 96 0.107
modification dependent macromolecule catabolic process GO:0043632 14 0.102
peptidyl amino acid modification GO:0018193 126 0.102
regulation of neuron apoptotic process GO:0043523 83 0.100
response to extracellular stimulus GO:0009991 380 0.099
cell type specific apoptotic process GO:0097285 134 0.096
protein complex biogenesis GO:0070271 263 0.095
regulation of ion transport GO:0043269 245 0.094
protein complex assembly GO:0006461 263 0.091
regulation of molecular function GO:0065009 398 0.090
regulation of neuron death GO:1901214 115 0.090
protein complex subunit organization GO:0071822 302 0.088
protein ubiquitination GO:0016567 28 0.087
regulation of cellular protein metabolic process GO:0032268 267 0.086
positive regulation of response to stimulus GO:0048584 285 0.086
response to nutrient levels GO:0031667 370 0.085
positive regulation of rna metabolic process GO:0051254 203 0.083
protein targeting to nucleus GO:0044744 35 0.081
growth GO:0040007 165 0.080
catabolic process GO:0009056 351 0.080
nucleic acid templated transcription GO:0097659 379 0.080
response to decreased oxygen levels GO:0036293 237 0.079
negative regulation of neuron apoptotic process GO:0043524 45 0.076
response to nutrient GO:0007584 248 0.076
cellular response to oxidative stress GO:0034599 76 0.073
sulfur compound biosynthetic process GO:0044272 19 0.071
single organism carbohydrate metabolic process GO:0044723 118 0.071
protein localization GO:0008104 191 0.069
dendrite development GO:0016358 72 0.068
regulation of cellular response to stress GO:0080135 49 0.067
neuron death GO:0070997 127 0.066
regulation of transcription dna templated GO:0006355 374 0.066
nuclear transport GO:0051169 49 0.066
regulation of response to stress GO:0080134 126 0.065
rna biosynthetic process GO:0032774 380 0.063
single organism reproductive process GO:0044702 297 0.062
cellular response to nitrogen compound GO:1901699 210 0.062
macromolecular complex assembly GO:0065003 273 0.062
apoptotic signaling pathway GO:0097190 27 0.062
regulation of phosphorus metabolic process GO:0051174 349 0.060
positive regulation of nucleic acid templated transcription GO:1903508 197 0.060
signal transduction by phosphorylation GO:0023014 144 0.059
positive regulation of cell communication GO:0010647 271 0.059
response to ammonium ion GO:0060359 71 0.058
brain development GO:0007420 247 0.058
protein phosphorylation GO:0006468 345 0.057
single organism intracellular transport GO:1902582 166 0.055
reproductive process GO:0022414 372 0.054
response to radiation GO:0009314 137 0.052
positive regulation of cellular component biogenesis GO:0044089 55 0.052
small molecule biosynthetic process GO:0044283 124 0.052
negative regulation of muscle cell apoptotic process GO:0010656 21 0.051
aging GO:0007568 241 0.048
meiotic cell cycle process GO:1903046 3 0.048
amide biosynthetic process GO:0043604 10 0.047
regulation of phosphate metabolic process GO:0019220 349 0.047
cellular response to endogenous stimulus GO:0071495 377 0.047
cellular modified amino acid metabolic process GO:0006575 61 0.046
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.046
glutathione biosynthetic process GO:0006750 3 0.046
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 1 0.046
regulation of protein phosphorylation GO:0001932 183 0.045
ncrna metabolic process GO:0034660 8 0.045
macromolecular complex subunit organization GO:0043933 339 0.044
regulation of intracellular signal transduction GO:1902531 218 0.044
single organism organelle organization GO:1902589 180 0.044
cellular amide metabolic process GO:0043603 44 0.043
cellular protein localization GO:0034613 122 0.043
immune effector process GO:0002252 53 0.042
cellular chemical homeostasis GO:0055082 247 0.041
oxoacid metabolic process GO:0043436 290 0.041
response to alkaloid GO:0043279 132 0.041
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.041
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.040
multi organism reproductive process GO:0044703 262 0.040
multicellular organism growth GO:0035264 1 0.039
regulation of protein metabolic process GO:0051246 289 0.039
regulation of organelle organization GO:0033043 80 0.039
modification dependent protein catabolic process GO:0019941 14 0.039
meiosis i GO:0007127 2 0.039
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 1 0.038
anatomical structure morphogenesis GO:0009653 298 0.038
Mouse
homeostatic process GO:0042592 331 0.038
positive regulation of phosphorylation GO:0042327 177 0.038
carbohydrate derivative biosynthetic process GO:1901137 124 0.038
single organism cellular localization GO:1902580 102 0.037
regulation of cellular component biogenesis GO:0044087 86 0.037
regulation of rna metabolic process GO:0051252 391 0.037
peptidyl tyrosine modification GO:0018212 72 0.037
activation of cysteine type endopeptidase activity GO:0097202 4 0.037
regulation of protein modification process GO:0031399 194 0.037
proteolysis GO:0006508 175 0.037
circulatory system process GO:0003013 183 0.036
myeloid cell activation involved in immune response GO:0002275 13 0.036
actin filament depolymerization GO:0030042 3 0.036
cellular catabolic process GO:0044248 295 0.036
nucleoside monophosphate metabolic process GO:0009123 93 0.035
multicellular organism reproduction GO:0032504 233 0.035
intracellular transport GO:0046907 185 0.035
regulation of cellular component organization GO:0051128 368 0.034
neuron apoptotic process GO:0051402 88 0.034
positive regulation of developmental process GO:0051094 283 0.034
circulatory system development GO:0072359 134 0.034
purine nucleoside monophosphate metabolic process GO:0009126 84 0.033
reactive oxygen species metabolic process GO:0072593 37 0.033
transcription dna templated GO:0006351 377 0.033
response to hypoxia GO:0001666 231 0.033
sexual reproduction GO:0019953 148 0.032
negative regulation of developmental process GO:0051093 125 0.032
negative regulation of actin filament depolymerization GO:0030835 2 0.032
jak stat cascade GO:0007259 26 0.032
organic substance catabolic process GO:1901575 316 0.032
cellular response to nutrient levels GO:0031669 60 0.031
cellular response to extracellular stimulus GO:0031668 73 0.031
amine metabolic process GO:0009308 38 0.030
autophagic cell death GO:0048102 4 0.030
smooth muscle cell proliferation GO:0048659 77 0.030
regulation of cell proliferation GO:0042127 359 0.030
cellular cation homeostasis GO:0030003 180 0.030
multicellular organismal reproductive process GO:0048609 233 0.030
regulation of cellular localization GO:0060341 263 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
cellular protein complex assembly GO:0043623 44 0.030
maintenance of location GO:0051235 17 0.029
ncrna processing GO:0034470 3 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.029
positive regulation of organelle organization GO:0010638 48 0.029
head development GO:0060322 247 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.029
cytoskeleton organization GO:0007010 111 0.028
muscle cell proliferation GO:0033002 84 0.028
nonribosomal peptide biosynthetic process GO:0019184 3 0.028
regulation of response to tumor cell GO:0002834 3 0.028
cellular metal ion homeostasis GO:0006875 172 0.028
defense response GO:0006952 194 0.028
regulation of phosphorylation GO:0042325 248 0.028
single organism catabolic process GO:0044712 283 0.027
regulation of protein complex assembly GO:0043254 33 0.027
positive regulation of cell migration GO:0030335 96 0.027
reproduction GO:0000003 245 0.027
protein localization to organelle GO:0033365 57 0.027
regulation of immune response to tumor cell GO:0002837 3 0.027
regulation of anatomical structure morphogenesis GO:0022603 141 0.027
blood circulation GO:0008015 183 0.026
cellular carbohydrate metabolic process GO:0044262 72 0.026
positive regulation of signal transduction GO:0009967 175 0.026
cellular macromolecule localization GO:0070727 122 0.026
sister chromatid segregation GO:0000819 1 0.026
reactive oxygen species biosynthetic process GO:1903409 8 0.026
regulation of protein localization GO:0032880 81 0.026
regulation of kinase activity GO:0043549 117 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.025
inflammatory response GO:0006954 150 0.025
positive regulation of catalytic activity GO:0043085 184 0.025
cellular response to hypoxia GO:0071456 51 0.025
ubiquitin dependent protein catabolic process GO:0006511 14 0.025
regulation of smooth muscle cell proliferation GO:0048660 75 0.025
developmental process involved in reproduction GO:0003006 159 0.025
g protein coupled receptor signaling pathway GO:0007186 242 0.024
positive regulation of protein phosphorylation GO:0001934 135 0.024
positive regulation of protein metabolic process GO:0051247 178 0.024
carboxylic acid biosynthetic process GO:0046394 83 0.024
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.024
positive regulation of immunoglobulin production GO:0002639 4 0.024
transmembrane transport GO:0055085 412 0.024
positive regulation of signaling GO:0023056 270 0.024
cellular response to organic cyclic compound GO:0071407 202 0.023
single organism biosynthetic process GO:0044711 342 0.023
peptidyl tyrosine phosphorylation GO:0018108 72 0.023
anterior posterior pattern specification GO:0009952 1 0.023
response to antibiotic GO:0046677 39 0.023
secretion GO:0046903 307 0.023
response to uv c GO:0010225 2 0.023
cellular homeostasis GO:0019725 252 0.023
double strand break repair GO:0006302 1 0.023
organonitrogen compound biosynthetic process GO:1901566 167 0.023
secretion by cell GO:0032940 248 0.023
negative regulation of actin filament polymerization GO:0030837 4 0.023
positive regulation of transcription dna templated GO:0045893 197 0.023
negative regulation of neuron death GO:1901215 69 0.023
protein modification by small protein conjugation or removal GO:0070647 35 0.022
positive regulation of protein modification process GO:0031401 142 0.022
motor neuron axon guidance GO:0008045 1 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
regulation of dendrite development GO:0050773 59 0.022
regulation of reactive oxygen species metabolic process GO:2000377 26 0.022
regulation of hydrolase activity GO:0051336 143 0.022
organic acid transport GO:0015849 116 0.022
striated muscle contraction GO:0006941 44 0.022
exocytosis GO:0006887 60 0.022
macromolecule catabolic process GO:0009057 58 0.022
regulation of cell motility GO:2000145 131 0.022
cellular response to oxygen levels GO:0071453 60 0.021
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.021
embryo development GO:0009790 49 0.021
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 32 0.021
cell migration GO:0016477 197 0.021
kidney mesenchyme development GO:0072074 2 0.020
embryonic pattern specification GO:0009880 1 0.020
response to osmotic stress GO:0006970 42 0.020
myoblast fusion GO:0007520 2 0.020
embryonic axis specification GO:0000578 1 0.020
cell cycle GO:0007049 101 0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 31 0.020
nucleocytoplasmic transport GO:0006913 48 0.020
cellular response to oxygen containing compound GO:1901701 386 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.019
cardiovascular system development GO:0072358 134 0.019
central nervous system development GO:0007417 311 0.019
cellular component biogenesis GO:0044085 368 0.019
organelle localization GO:0051640 55 0.019
protein deubiquitination GO:0016579 4 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
regulation of carbohydrate metabolic process GO:0006109 41 0.019
regulation of cytoskeleton organization GO:0051493 49 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
positive regulation of molecular function GO:0044093 230 0.019
positive regulation of cell death GO:0010942 184 0.018
multicellular organismal signaling GO:0035637 44 0.018
purine ribonucleoside biosynthetic process GO:0046129 21 0.018
gamete generation GO:0007276 124 0.018
vesicle mediated transport GO:0016192 181 0.018
protein modification by small protein conjugation GO:0032446 31 0.018
protein processing GO:0016485 68 0.018
regulation of developmental growth GO:0048638 45 0.018
neuromuscular process GO:0050905 2 0.018
glutathione metabolic process GO:0006749 15 0.018
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 3 0.018
negative regulation of gene expression GO:0010629 199 0.018
positive regulation of cellular component organization GO:0051130 200 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
regulation of membrane potential GO:0042391 110 0.018
cellular ion homeostasis GO:0006873 184 0.018
negative regulation of molecular function GO:0044092 133 0.017
response to carbohydrate GO:0009743 183 0.017
chemical homeostasis GO:0048878 292 0.017
developmental growth GO:0048589 100 0.017
cell projection morphogenesis GO:0048858 123 0.017
lipid localization GO:0010876 62 0.017
regulation of stem cell differentiation GO:2000736 2 0.017
protein transport GO:0015031 132 0.017
ion homeostasis GO:0050801 212 0.017
lipid storage GO:0019915 1 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
cation homeostasis GO:0055080 195 0.017
positive regulation of catabolic process GO:0009896 78 0.017
epithelium development GO:0060429 96 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.017
small gtpase mediated signal transduction GO:0007264 36 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
membrane organization GO:0061024 94 0.016
axis specification GO:0009798 4 0.016
actin filament based process GO:0030029 86 0.016
dephosphorylation GO:0016311 98 0.016
response to growth factor GO:0070848 189 0.016
regulation of metal ion transport GO:0010959 118 0.016
cytoskeleton dependent cytokinesis GO:0061640 2 0.016
ras protein signal transduction GO:0007265 29 0.016
response to estrogen GO:0043627 232 0.016
regulation of anatomical structure size GO:0090066 135 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.015
response to isoquinoline alkaloid GO:0014072 28 0.015
response to inorganic substance GO:0010035 377 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
endoplasmic reticulum unfolded protein response GO:0030968 2 0.015
mitotic sister chromatid segregation GO:0000070 1 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
neuron projection development GO:0031175 273 0.015
microtubule based process GO:0007017 36 0.015
transmission of nerve impulse GO:0019226 42 0.015
leukocyte activation involved in immune response GO:0002366 16 0.015
muscle system process GO:0003012 115 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.015
alternative mrna splicing via spliceosome GO:0000380 4 0.015
neurological system process GO:0050877 219 0.015
localization of cell GO:0051674 202 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
rna metabolic process GO:0016070 406 0.014
chromosome localization GO:0050000 1 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
chromosome organization GO:0051276 36 0.014
positive regulation of adherens junction organization GO:1903393 2 0.014
cation transport GO:0006812 382 0.014
organic anion transport GO:0015711 132 0.014
cellular component assembly GO:0022607 360 0.014
microtubule cytoskeleton organization GO:0000226 25 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
cellular response to steroid hormone stimulus GO:0071383 93 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
intracellular protein transport GO:0006886 79 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
positive regulation of protein kinase activity GO:0045860 73 0.014
positive regulation of jnk cascade GO:0046330 13 0.014
regulation of intracellular transport GO:0032386 65 0.014
protein oligomerization GO:0051259 191 0.014
phospholipid metabolic process GO:0006644 61 0.014
regulation of locomotion GO:0040012 148 0.013
epithelial cell differentiation GO:0030855 71 0.013
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 2 0.013
single organism nuclear import GO:1902593 35 0.013
nucleotide metabolic process GO:0009117 279 0.013
response to ionizing radiation GO:0010212 59 0.013
smad protein complex assembly GO:0007183 1 0.013
cellular macromolecular complex assembly GO:0034622 58 0.013
cellular response to dna damage stimulus GO:0006974 19 0.013
cellular response to hydrogen peroxide GO:0070301 42 0.013
vesicle organization GO:0016050 29 0.013
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 3 0.013
purine nucleoside monophosphate biosynthetic process GO:0009127 20 0.013
regulation of catabolic process GO:0009894 113 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.013
regulation of glucocorticoid biosynthetic process GO:0031946 1 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
tissue homeostasis GO:0001894 28 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
positive regulation of protein import into nucleus translocation GO:0033160 7 0.012
cellular component morphogenesis GO:0032989 155 0.012
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.012
cellular component movement GO:0006928 248 0.012
insulin receptor signaling pathway GO:0008286 24 0.012
immune response GO:0006955 104 0.012
cytoplasmic transport GO:0016482 115 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
cellular ketone metabolic process GO:0042180 51 0.012
male gamete generation GO:0048232 99 0.012
regulation of endopeptidase activity GO:0052548 51 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
arp2 3 complex mediated actin nucleation GO:0034314 2 0.012
regulation of actin filament depolymerization GO:0030834 2 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.012
regulation of secretion by cell GO:1903530 208 0.012
rna catabolic process GO:0006401 3 0.012
establishment of chromosome localization GO:0051303 1 0.012
steroid biosynthetic process GO:0006694 48 0.012
response to morphine GO:0043278 27 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
regulation of system process GO:0044057 208 0.012
regulation of cellular amino acid metabolic process GO:0006521 2 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.012
cell part morphogenesis GO:0032990 123 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
behavior GO:0007610 205 0.011
response to gonadotropin GO:0034698 34 0.011
anatomical structure homeostasis GO:0060249 29 0.011
heterocycle catabolic process GO:0046700 167 0.011
purine containing compound metabolic process GO:0072521 253 0.011
positive regulation of humoral immune response GO:0002922 2 0.011
cellular amine metabolic process GO:0044106 38 0.011
protein homooligomerization GO:0051260 91 0.011
cell cell signaling GO:0007267 335 0.011
metal ion homeostasis GO:0055065 186 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.011
positive regulation of alkaline phosphatase activity GO:0010694 2 0.011
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.011
spermatogenesis GO:0007283 99 0.011
cellular response to nutrient GO:0031670 30 0.011
positive regulation of developmental growth GO:0048639 29 0.011
negative regulation of cell communication GO:0010648 158 0.011
microtubule anchoring GO:0034453 1 0.011
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.011
regulation of cell differentiation GO:0045595 320 0.011
protein localization to nucleus GO:0034504 39 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
syncytium formation by plasma membrane fusion GO:0000768 3 0.011
negative regulation of peptidase activity GO:0010466 38 0.011
synaptic transmission GO:0007268 235 0.011
positive regulation of natural killer cell mediated immunity GO:0002717 2 0.011
wound healing GO:0042060 122 0.010
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.010
response to axon injury GO:0048678 59 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 4 0.010
vitamin d metabolic process GO:0042359 4 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.010
cellular macromolecule catabolic process GO:0044265 29 0.010
single organism membrane organization GO:0044802 74 0.010
regulation of neuron differentiation GO:0045664 208 0.010
positive regulation of transcription factor import into nucleus GO:0042993 4 0.010
muscle contraction GO:0006936 88 0.010

Txnrd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.081
nervous system disease DOID:863 0 0.081
central nervous system disease DOID:331 0 0.026
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010