Rattus norvegicus

0 known processes

Zap70

zeta-chain (TCR) associated protein kinase

(Aliases: Srk,MGC108902)

Zap70 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of metabolic process GO:0009892 331 0.100
response to tumor cell GO:0002347 4 0.097
cell activation GO:0001775 97 0.095
Human Rat
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.083
negative regulation of immune response to tumor cell GO:0002838 2 0.078
leukocyte cell cell adhesion GO:0007159 4 0.074
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.072
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.072
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 1 0.070
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 1 0.069
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.069
regulation of molecular function GO:0065009 398 0.068
negative regulation of response to tumor cell GO:0002835 2 0.063
lymphocyte activation GO:0046649 43 0.062
Human
programmed cell death GO:0012501 392 0.054
negative regulation of cellular metabolic process GO:0031324 281 0.053
leukocyte activation GO:0045321 76 0.051
Human Rat
response to biotic stimulus GO:0009607 226 0.050
neuron differentiation GO:0030182 368 0.050
immune response to tumor cell GO:0002418 3 0.049
positive regulation of cellular biosynthetic process GO:0031328 295 0.049
response to external biotic stimulus GO:0043207 221 0.048
regulation of cell proliferation GO:0042127 359 0.045
regulation of rna metabolic process GO:0051252 391 0.045
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.044
rna metabolic process GO:0016070 406 0.043
negative regulation of natural killer cell mediated immune response to tumor cell GO:0002856 1 0.043
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.043
positive regulation of transcription dna templated GO:0045893 197 0.042
response to oxidative stress GO:0006979 186 0.042
cellular response to stress GO:0033554 269 0.042
immune response GO:0006955 104 0.042
Human Rat
regulation of signal transduction GO:0009966 318 0.041
regulation of immune response to tumor cell GO:0002837 3 0.041
intracellular signal transduction GO:0035556 314 0.040
defense response GO:0006952 194 0.039
response to extracellular stimulus GO:0009991 380 0.039
transcription dna templated GO:0006351 377 0.038
regulation of catalytic activity GO:0050790 304 0.037
rna biosynthetic process GO:0032774 380 0.035
regulation of nucleic acid templated transcription GO:1903506 380 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
positive regulation of biosynthetic process GO:0009891 319 0.033
metal ion transport GO:0030001 289 0.033
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
response to radiation GO:0009314 137 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
behavior GO:0007610 205 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.030
response to other organism GO:0051707 220 0.030
regulation of transcription dna templated GO:0006355 374 0.030
immune system process GO:0002376 204 0.029
Human Rat
response to growth factor GO:0070848 189 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.029
positive regulation of molecular function GO:0044093 230 0.028
response to estrogen GO:0043627 232 0.028
homeostatic process GO:0042592 331 0.028
leukocyte mediated immunity GO:0002443 28 0.028
Rat
ion homeostasis GO:0050801 212 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.028
regulation of programmed cell death GO:0043067 341 0.027
regulation of rna biosynthetic process GO:2001141 381 0.027
positive regulation of response to stimulus GO:0048584 285 0.026
Rat
response to reactive oxygen species GO:0000302 120 0.026
epithelium development GO:0060429 96 0.026
positive regulation of cell proliferation GO:0008284 249 0.026
organic acid metabolic process GO:0006082 292 0.026
negative regulation of biosynthetic process GO:0009890 168 0.026
regulation of cellular protein metabolic process GO:0032268 267 0.025
positive regulation of nucleic acid templated transcription GO:1903508 197 0.025
response to toxic substance GO:0009636 133 0.025
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.024
t cell activation GO:0042110 29 0.024
Human
apoptotic process GO:0006915 381 0.024
positive regulation of developmental process GO:0051094 283 0.024
Human Zebrafish
positive regulation of rna metabolic process GO:0051254 203 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
single organism biosynthetic process GO:0044711 342 0.023
cation transport GO:0006812 382 0.023
negative regulation of cell death GO:0060548 229 0.023
negative regulation of innate immune response GO:0045824 4 0.023
response to nutrient GO:0007584 248 0.023
protein phosphorylation GO:0006468 345 0.023
Human Rat
negative regulation of molecular function GO:0044092 133 0.023
inflammatory response GO:0006954 150 0.022
regulation of neurogenesis GO:0050767 247 0.022
cation homeostasis GO:0055080 195 0.022
cellular amine metabolic process GO:0044106 38 0.022
reactive oxygen species biosynthetic process GO:1903409 8 0.022
protein complex biogenesis GO:0070271 263 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.021
single organism reproductive process GO:0044702 297 0.021
positive regulation of phosphorus metabolic process GO:0010562 262 0.021
positive regulation of leukocyte differentiation GO:1902107 13 0.021
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
response to cytokine GO:0034097 215 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
localization of cell GO:0051674 202 0.020
Zebrafish
lipid biosynthetic process GO:0008610 128 0.020
cellular component assembly GO:0022607 360 0.020
regulation of response to tumor cell GO:0002834 3 0.020
regulation of intracellular signal transduction GO:1902531 218 0.020
response to inorganic substance GO:0010035 377 0.020
cellular component biogenesis GO:0044085 368 0.020
regulation of necroptotic process GO:0060544 2 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
multi multicellular organism process GO:0044706 138 0.019
negative regulation of rna biosynthetic process GO:1902679 118 0.019
regulation of cell killing GO:0031341 12 0.019
response to estradiol GO:0032355 164 0.019
neuron projection development GO:0031175 273 0.019
necroptotic process GO:0070266 2 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
cell morphogenesis involved in differentiation GO:0000904 119 0.018
positive regulation of gene expression GO:0010628 244 0.018
regulation of phosphorylation GO:0042325 248 0.018
ras protein signal transduction GO:0007265 29 0.018
cell projection organization GO:0030030 302 0.018
reactive nitrogen species metabolic process GO:2001057 1 0.018
oxoacid metabolic process GO:0043436 290 0.017
amine metabolic process GO:0009308 38 0.017
response to nutrient levels GO:0031667 370 0.017
negative regulation of gene expression GO:0010629 199 0.017
immune system development GO:0002520 41 0.017
Human
t cell receptor signaling pathway GO:0050852 1 0.017
metal ion homeostasis GO:0055065 186 0.017
axis specification GO:0009798 4 0.017
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.017
t cell differentiation GO:0030217 9 0.017
Human
protein complex subunit organization GO:0071822 302 0.017
carboxylic acid metabolic process GO:0019752 289 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
organophosphate metabolic process GO:0019637 370 0.017
locomotion GO:0040011 237 0.016
Zebrafish
regulation of cell development GO:0060284 263 0.016
purine containing compound metabolic process GO:0072521 253 0.016
cellular response to oxidative stress GO:0034599 76 0.016
cellular response to external stimulus GO:0071496 118 0.016
intracellular transport GO:0046907 185 0.016
Rat
cellular ion homeostasis GO:0006873 184 0.016
nucleic acid templated transcription GO:0097659 379 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
cell morphogenesis GO:0000902 142 0.016
inflammatory response to antigenic stimulus GO:0002437 18 0.016
cellular response to organic cyclic compound GO:0071407 202 0.016
proteolysis GO:0006508 175 0.016
regulation of response to stress GO:0080134 126 0.015
cellular ketone metabolic process GO:0042180 51 0.015
response to purine containing compound GO:0014074 126 0.015
regulation of cell differentiation GO:0045595 320 0.015
Human
lymphoid progenitor cell differentiation GO:0002320 2 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
cell type specific apoptotic process GO:0097285 134 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
single organism cell adhesion GO:0098602 46 0.015
transmembrane transport GO:0055085 412 0.015
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 2 0.015
regulation of protein metabolic process GO:0051246 289 0.015
cellular response to endogenous stimulus GO:0071495 377 0.015
divalent inorganic cation transport GO:0072511 134 0.015
cell migration GO:0016477 197 0.015
Zebrafish
protein complex assembly GO:0006461 263 0.015
small gtpase mediated signal transduction GO:0007264 36 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
tissue remodeling GO:0048771 40 0.014
multi organism reproductive process GO:0044703 262 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
chemical homeostasis GO:0048878 292 0.014
regulation of t cell activation GO:0050863 23 0.014
Human
regulation of metal ion transport GO:0010959 118 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
aging GO:0007568 241 0.014
single organism catabolic process GO:0044712 283 0.014
cellular amino acid metabolic process GO:0006520 107 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
cellular catabolic process GO:0044248 295 0.014
heterocycle catabolic process GO:0046700 167 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
regulation of hydrolase activity GO:0051336 143 0.013
calcium ion transport GO:0006816 131 0.013
macromolecular complex assembly GO:0065003 273 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
cell motility GO:0048870 202 0.013
Zebrafish
ribose phosphate metabolic process GO:0019693 235 0.013
neuron development GO:0048666 286 0.013
regulation of nervous system development GO:0051960 264 0.013
cell chemotaxis GO:0060326 31 0.013
cell killing GO:0001906 13 0.013
cellular component movement GO:0006928 248 0.013
Zebrafish
positive regulation of multicellular organismal process GO:0051240 387 0.013
Human Zebrafish
response to hydrogen peroxide GO:0042542 89 0.013
spindle organization GO:0007051 2 0.013
regulation of apoptotic process GO:0042981 335 0.013
establishment of protein localization GO:0045184 141 0.013
cellular component morphogenesis GO:0032989 155 0.013
response to peptide hormone GO:0043434 278 0.013
chemosensory behavior GO:0007635 2 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
cytoplasmic transport GO:0016482 115 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
reproductive structure development GO:0048608 128 0.013
macromolecule localization GO:0033036 252 0.013
reproductive process GO:0022414 372 0.013
olfactory behavior GO:0042048 2 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
tube formation GO:0035148 3 0.013
response to wounding GO:0009611 254 0.012
catabolic process GO:0009056 351 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.012
chemotaxis GO:0006935 66 0.012
nucleotide metabolic process GO:0009117 279 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
regulation of homeostatic process GO:0032844 101 0.012
olfactory learning GO:0008355 1 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
cell cycle GO:0007049 101 0.012
cell projection morphogenesis GO:0048858 123 0.012
carbohydrate derivative metabolic process GO:1901135 346 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
lymphocyte migration GO:0072676 3 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
regulation of phosphate metabolic process GO:0019220 349 0.012
nucleoside metabolic process GO:0009116 179 0.012
negative regulation of leukocyte apoptotic process GO:2000107 4 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
regulation of neuron death GO:1901214 115 0.012
cellular response to molecule of fungal origin GO:0071226 1 0.012
lipid metabolic process GO:0006629 283 0.012
positive regulation of necroptotic process GO:0060545 2 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
growth GO:0040007 165 0.012
taxis GO:0042330 67 0.012
sequestering of metal ion GO:0051238 9 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.011
cellular response to oxygen containing compound GO:1901701 386 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
mapk cascade GO:0000165 140 0.011
regulation of cellular component movement GO:0051270 150 0.011
Zebrafish
positive regulation of protein metabolic process GO:0051247 178 0.011
dna metabolic process GO:0006259 96 0.011
antigen receptor mediated signaling pathway GO:0050851 1 0.011
negative regulation of neuron death GO:1901215 69 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
chromosome segregation GO:0007059 2 0.011
rho protein signal transduction GO:0007266 11 0.011
biological adhesion GO:0022610 110 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
Human
negative regulation of transcription dna templated GO:0045892 116 0.011
anatomical structure morphogenesis GO:0009653 298 0.011
Zebrafish
cellular response to extracellular stimulus GO:0031668 73 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
reproduction GO:0000003 245 0.011
regulation of interferon gamma production GO:0032649 3 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
nitrogen compound transport GO:0071705 229 0.011
positive regulation of natural killer cell mediated immunity GO:0002717 2 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
response to lipopolysaccharide GO:0032496 191 0.011
salivary gland development GO:0007431 3 0.011
positive regulation of protein modification process GO:0031401 142 0.011
protein oligomerization GO:0051259 191 0.011
regeneration GO:0031099 163 0.011
gastrulation GO:0007369 2 0.011
mast cell migration GO:0097531 4 0.011
gland development GO:0048732 155 0.011
cardiovascular system development GO:0072358 134 0.011
Zebrafish
regulation of cellular component organization GO:0051128 368 0.010
epithelial cell differentiation GO:0030855 71 0.010
lipid storage GO:0019915 1 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
head development GO:0060322 247 0.010
tube development GO:0035295 89 0.010
positive regulation of cell death GO:0010942 184 0.010
alpha beta t cell differentiation GO:0046632 2 0.010
organic cyclic compound catabolic process GO:1901361 175 0.010
cell adhesion GO:0007155 110 0.010
cellular lipid metabolic process GO:0044255 208 0.010
leukocyte migration GO:0050900 38 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
positive regulation of signaling GO:0023056 270 0.010

Zap70 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
musculoskeletal system disease DOID:17 0 0.019
connective tissue disease DOID:65 0 0.019
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011