Caenorhabditis elegans

100 known processes

pxn-2 (CELE_K09C8.5)

Protein PXN-2

pxn-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development ending in birth or egg hatching GO:0009792 2992 0.590
Worm
embryo development GO:0009790 3052 0.580
locomotion GO:0040011 1634 0.442
post embryonic development GO:0009791 2152 0.370
Worm
transport GO:0006810 1093 0.230
Fly
axon development GO:0061564 163 0.222
single organism localization GO:1902578 518 0.178
Fly
genitalia development GO:0048806 741 0.178
regulation of developmental process GO:0050793 684 0.176
cell migration GO:0016477 306 0.171
muscle tissue development GO:0060537 1 0.157
muscle cell differentiation GO:0042692 171 0.142
development of primary sexual characteristics GO:0045137 840 0.137
growth GO:0040007 562 0.136
cell development GO:0048468 696 0.133
establishment of localization GO:0051234 1171 0.128
Fly
organelle organization GO:0006996 783 0.123
developmental process involved in reproduction GO:0003006 1165 0.120
single organism organelle organization GO:1902589 501 0.119
single organism reproductive process GO:0044702 1196 0.113
cell motility GO:0048870 313 0.112
cellular component movement GO:0006928 388 0.112
reproductive system development GO:0061458 850 0.111
regulation of multicellular organismal process GO:0051239 726 0.110
localization of cell GO:0051674 313 0.109
body morphogenesis GO:0010171 620 0.107
developmental growth GO:0048589 412 0.106
gonad development GO:0008406 840 0.105
aging GO:0007568 812 0.104
neuron differentiation GO:0030182 217 0.104
regulation of biological quality GO:0065008 741 0.103
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.098
organ development GO:0048513 1102 0.097
macromolecule localization GO:0033036 771 0.094
multicellular organismal aging GO:0010259 812 0.093
vesicle mediated transport GO:0016192 852 0.089
Fly
determination of adult lifespan GO:0008340 812 0.089
positive regulation of multicellular organism growth GO:0040018 352 0.084
regulation of developmental growth GO:0048638 389 0.083
response to chemical GO:0042221 356 0.083
regulation of multicellular organismal development GO:2000026 317 0.082
regulation of growth GO:0040008 409 0.081
positive regulation of locomotion GO:0040017 42 0.081
organelle assembly GO:0070925 214 0.080
hermaphrodite genitalia development GO:0040035 734 0.079
protein complex biogenesis GO:0070271 186 0.079
anatomical structure formation involved in morphogenesis GO:0048646 250 0.079
reproductive structure development GO:0048608 850 0.079
multicellular organism growth GO:0035264 385 0.078
endocytosis GO:0006897 819 0.078
Fly
positive regulation of developmental process GO:0051094 408 0.077
cell death GO:0008219 547 0.076
cellular component biogenesis GO:0044085 297 0.076
cell projection organization GO:0030030 231 0.076
organelle fission GO:0048285 363 0.075
negative regulation of multicellular organismal process GO:0051241 236 0.075
receptor mediated endocytosis GO:0006898 715 0.075
muscle structure development GO:0061061 191 0.075
regulation of multicellular organism growth GO:0040014 373 0.073
meiotic nuclear division GO:0007126 300 0.072
meiotic cell cycle GO:0051321 335 0.072
cellular macromolecular complex assembly GO:0034622 184 0.070
neuron projection guidance GO:0097485 82 0.069
maintenance of location GO:0051235 580 0.068
macromolecular complex subunit organization GO:0043933 320 0.068
positive regulation of multicellular organismal process GO:0051240 417 0.068
sex differentiation GO:0007548 909 0.068
axon guidance GO:0007411 82 0.067
regulation of locomotion GO:0040012 161 0.067
actin cytoskeleton organization GO:0030036 184 0.066
lipid localization GO:0010876 573 0.066
neurogenesis GO:0022008 236 0.066
protein complex subunit organization GO:0071822 280 0.066
actomyosin structure organization GO:0031032 154 0.065
myofibril assembly GO:0030239 154 0.064
cellular protein complex assembly GO:0043623 178 0.062
lipid storage GO:0019915 565 0.061
protein complex assembly GO:0006461 186 0.061
secretion GO:0046903 147 0.060
cellular component assembly involved in morphogenesis GO:0010927 183 0.059
digestive tract morphogenesis GO:0048546 76 0.058
striated muscle cell differentiation GO:0051146 158 0.058
neuron development GO:0048666 199 0.055
cellular component assembly GO:0022607 293 0.054
cellular biosynthetic process GO:0044249 315 0.053
positive regulation of growth GO:0045927 369 0.052
cytoskeleton organization GO:0007010 339 0.052
muscle cell development GO:0055001 158 0.052
single organism transport GO:0044765 447 0.050
Fly
generation of neurons GO:0048699 235 0.050
striated muscle myosin thick filament assembly GO:0071688 138 0.049
skeletal muscle organ development GO:0060538 3 0.049
behavior GO:0007610 527 0.048
cell projection morphogenesis GO:0048858 148 0.047
tube morphogenesis GO:0035239 79 0.046
nucleobase containing compound metabolic process GO:0006139 406 0.046
cellular component morphogenesis GO:0032989 318 0.046
myosin filament assembly GO:0031034 138 0.044
establishment of localization in cell GO:0051649 318 0.043
actin filament based process GO:0030029 191 0.042
striated muscle cell development GO:0055002 157 0.042
sexual reproduction GO:0019953 546 0.042
macromolecule biosynthetic process GO:0009059 250 0.042
multi organism reproductive process GO:0044703 867 0.042
positive regulation of developmental growth GO:0048639 354 0.041
basement membrane organization GO:0071711 3 0.041
muscle attachment GO:0016203 3 0.039
organ morphogenesis GO:0009887 67 0.039
protein localization GO:0008104 205 0.038
signaling GO:0023052 401 0.037
muscle organ morphogenesis GO:0048644 4 0.037
inductive cell migration GO:0040039 145 0.037
system process GO:0003008 136 0.037
cell part morphogenesis GO:0032990 152 0.037
signal transduction GO:0007165 317 0.036
response to external stimulus GO:0009605 289 0.036
multicellular organismal reproductive process GO:0048609 815 0.035
tissue development GO:0009888 112 0.035
nervous system development GO:0007399 253 0.033
chemotaxis GO:0006935 120 0.033
cell substrate adhesion GO:0031589 1 0.033
response to wounding GO:0009611 4 0.033
cell recognition GO:0008037 85 0.032
programmed cell death GO:0012501 500 0.032
biosynthetic process GO:0009058 323 0.032
regulation of localization GO:0032879 194 0.032
small molecule metabolic process GO:0044281 186 0.031
phosphorus metabolic process GO:0006793 232 0.031
apoptotic process GO:0006915 478 0.031
cellular macromolecule biosynthetic process GO:0034645 247 0.031
oviposition GO:0018991 364 0.031
cellular localization GO:0051641 360 0.031
secretion by cell GO:0032940 138 0.030
regulation of cellular component organization GO:0051128 248 0.030
macromolecular complex assembly GO:0065003 193 0.029
transcription dna templated GO:0006351 168 0.029
microtubule based process GO:0007017 182 0.029
regulation of striated muscle contraction GO:0006942 4 0.028
organic substance catabolic process GO:1901575 294 0.028
regulation of macromolecule metabolic process GO:0060255 421 0.028
negative regulation of developmental process GO:0051093 227 0.028
neuron projection morphogenesis GO:0048812 114 0.028
death GO:0016265 547 0.028
myosin filament organization GO:0031033 138 0.028
vulval development GO:0040025 333 0.027
nucleobase containing small molecule metabolic process GO:0055086 115 0.027
embryonic morphogenesis GO:0048598 152 0.027
cellular protein metabolic process GO:0044267 279 0.027
Worm
single organism signaling GO:0044700 401 0.027
neuron projection development GO:0031175 187 0.026
digestive tract development GO:0048565 122 0.026
single organism catabolic process GO:0044712 129 0.025
Human
negative regulation of biological process GO:0048519 567 0.025
protein metabolic process GO:0019538 422 0.025
Worm
epithelial tube morphogenesis GO:0060562 1 0.025
reproductive behavior GO:0019098 387 0.025
heterocycle biosynthetic process GO:0018130 187 0.025
aromatic compound biosynthetic process GO:0019438 192 0.025
ion transmembrane transport GO:0034220 91 0.025
taxis GO:0042330 128 0.024
cell division GO:0051301 262 0.024
regulation of rna biosynthetic process GO:2001141 165 0.024
organonitrogen compound metabolic process GO:1901564 151 0.024
regulation of cell cycle process GO:0010564 145 0.023
cell cycle GO:0007049 526 0.023
organic substance biosynthetic process GO:1901576 323 0.023
cellular catabolic process GO:0044248 199 0.023
Human
muscle organ development GO:0007517 26 0.023
response to acid chemical GO:0001101 4 0.023
heterocycle catabolic process GO:0046700 119 0.023
axonal defasciculation GO:0007414 1 0.023
nucleic acid templated transcription GO:0097659 169 0.022
gene expression GO:0010467 412 0.022
neuromuscular junction development GO:0007528 2 0.022
regulation of nuclear division GO:0051783 115 0.022
post embryonic organ development GO:0048569 336 0.022
digestive system development GO:0055123 122 0.022
cell morphogenesis involved in differentiation GO:0000904 112 0.022
muscle system process GO:0003012 43 0.022
positive regulation of cellular process GO:0048522 332 0.022
protein catabolic process GO:0030163 162 0.021
negative regulation of cellular component organization GO:0051129 33 0.021
organic substance transport GO:0071702 113 0.021
organic cyclic compound catabolic process GO:1901361 119 0.021
chromosome organization GO:0051276 104 0.021
regulation of meiosis GO:0040020 94 0.021
ion transport GO:0006811 113 0.021
regulation of nitrogen compound metabolic process GO:0051171 222 0.020
regulation of cell division GO:0051302 142 0.020
germ cell development GO:0007281 351 0.020
phosphate containing compound metabolic process GO:0006796 232 0.020
multi multicellular organism process GO:0044706 390 0.020
regulation of post embryonic development GO:0048580 260 0.020
negative regulation of cellular process GO:0048523 239 0.020
regulation of meiotic cell cycle GO:0051445 136 0.020
axonal fasciculation GO:0007413 79 0.020
regulation of gene expression epigenetic GO:0040029 163 0.020
nucleic acid metabolic process GO:0090304 299 0.020
cell surface receptor signaling pathway GO:0007166 149 0.019
chromosome segregation GO:0007059 180 0.019
posttranscriptional regulation of gene expression GO:0010608 166 0.019
regulation of gene expression GO:0010468 366 0.019
head development GO:0060322 1 0.019
molting cycle GO:0042303 281 0.019
Worm
transcription from rna polymerase ii promoter GO:0006366 149 0.019
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.019
Worm
nucleobase containing compound biosynthetic process GO:0034654 184 0.019
negative regulation of nematode larval development GO:0061064 208 0.019
cell cycle process GO:0022402 482 0.019
axonogenesis GO:0007409 102 0.019
regulation of nematode larval development GO:0061062 260 0.019
regulation of organelle organization GO:0033043 164 0.019
gene silencing GO:0016458 143 0.018
multicellular organism reproduction GO:0032504 819 0.018
carbohydrate derivative metabolic process GO:1901135 141 0.018
negative regulation of post embryonic development GO:0048581 208 0.018
positive regulation of cell migration GO:0030335 3 0.018
organic acid metabolic process GO:0006082 47 0.018
gamete generation GO:0007276 461 0.018
protein phosphorylation GO:0006468 85 0.017
gastrulation GO:0007369 58 0.017
cilium assembly GO:0042384 28 0.017
response to abiotic stimulus GO:0009628 152 0.017
developmental growth involved in morphogenesis GO:0060560 37 0.017
regulation of vulval development GO:0040028 248 0.017
protein oligomerization GO:0051259 4 0.017
nucleoside phosphate metabolic process GO:0006753 108 0.017
cellular nitrogen compound biosynthetic process GO:0044271 192 0.017
catabolic process GO:0009056 318 0.016
Human
excretion GO:0007588 49 0.016
regulation of cellular metabolic process GO:0031323 305 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.016
synapse organization GO:0050808 24 0.016
cellular nitrogen compound catabolic process GO:0044270 119 0.016
regulation of cell communication GO:0010646 176 0.016
multicellular organismal reproductive behavior GO:0033057 384 0.016
tissue morphogenesis GO:0048729 65 0.016
negative regulation of metabolic process GO:0009892 240 0.016
cilium organization GO:0044782 32 0.016
regulation of metabolic process GO:0019222 478 0.016
carboxylic acid metabolic process GO:0019752 34 0.016
cellular protein modification process GO:0006464 207 0.016
Worm
regulation of cell proliferation GO:0042127 105 0.015
neuron projection extension GO:1990138 37 0.015
regulation of anatomical structure size GO:0090066 46 0.015
ribonucleoside metabolic process GO:0009119 98 0.015
neuron recognition GO:0008038 83 0.015
cell cell signaling GO:0007267 118 0.015
organic cyclic compound biosynthetic process GO:1901362 195 0.015
purine nucleotide metabolic process GO:0006163 95 0.015
embryonic body morphogenesis GO:0010172 49 0.015
organonitrogen compound catabolic process GO:1901565 90 0.015
synaptic transmission GO:0007268 106 0.015
epithelium development GO:0060429 68 0.015
nucleobase containing compound catabolic process GO:0034655 114 0.014
oxoacid metabolic process GO:0043436 47 0.014
sensory organ morphogenesis GO:0090596 2 0.014
cell proliferation GO:0008283 116 0.014
regulation of cellular component movement GO:0051270 62 0.014
axon extension GO:0048675 37 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
negative regulation of gene expression epigenetic GO:0045814 2 0.014
multi organism reproductive behavior GO:0044705 387 0.014
macromolecule modification GO:0043412 218 0.014
Worm
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.014
regulation of biosynthetic process GO:0009889 189 0.014
anion transport GO:0006820 30 0.014
nucleoside metabolic process GO:0009116 99 0.014
purine nucleotide catabolic process GO:0006195 75 0.013
cell morphogenesis GO:0000902 163 0.013
tube development GO:0035295 126 0.013
posttranscriptional gene silencing by rna GO:0035194 143 0.013
regulation of cell differentiation GO:0045595 81 0.013
pharyngeal pumping GO:0043050 58 0.013
ribonucleotide metabolic process GO:0009259 99 0.013
regulation of transcription dna templated GO:0006355 164 0.013
purine ribonucleoside metabolic process GO:0046128 92 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.013
transmembrane transport GO:0055085 110 0.013
regulation of nucleic acid templated transcription GO:1903506 165 0.013
carbohydrate derivative catabolic process GO:1901136 82 0.013
amine catabolic process GO:0009310 1 0.013
calcium mediated signaling GO:0019722 3 0.013
membrane organization GO:0061024 135 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
rna interference GO:0016246 137 0.013
nucleotide metabolic process GO:0009117 108 0.013
glycosyl compound metabolic process GO:1901657 100 0.012
rna localization GO:0006403 3 0.012
organic acid biosynthetic process GO:0016053 21 0.012
organophosphate metabolic process GO:0019637 125 0.012
purine ribonucleoside catabolic process GO:0046130 75 0.012
cellular homeostasis GO:0019725 22 0.012
cellular response to stress GO:0033554 162 0.012
negative regulation of vulval development GO:0040027 206 0.012
negative regulation of macromolecule metabolic process GO:0010605 229 0.012
regulation of cell migration GO:0030334 55 0.012
rna biosynthetic process GO:0032774 169 0.012
gene silencing by rna GO:0031047 143 0.012
regulation of cell motility GO:2000145 57 0.012
defense response GO:0006952 296 0.012
cell fate commitment GO:0045165 139 0.012
single organism biosynthetic process GO:0044711 91 0.012
cellular amine metabolic process GO:0044106 15 0.012
mitotic sister chromatid segregation GO:0000070 38 0.012
regulation of apoptotic signaling pathway GO:2001233 1 0.012
purine nucleoside metabolic process GO:0042278 92 0.012
adult locomotory behavior GO:0008344 1 0.012
anion transmembrane transport GO:0098656 21 0.012
cell matrix adhesion GO:0007160 1 0.012
fertilization GO:0009566 63 0.012
cellular amino acid metabolic process GO:0006520 15 0.012
chemosensory behavior GO:0007635 33 0.012
positive regulation of striated muscle contraction GO:0045989 2 0.012
adult behavior GO:0030534 3 0.012
eating behavior GO:0042755 59 0.011
mitotic nuclear division GO:0007067 89 0.011
muscle fiber development GO:0048747 2 0.011
negative regulation of signal transduction GO:0009968 60 0.011
organelle localization GO:0051640 127 0.011
regulation of synapse assembly GO:0051963 2 0.011
regulation of cell cycle GO:0051726 194 0.011
purine containing compound metabolic process GO:0072521 95 0.011
regulation of ion transport GO:0043269 39 0.011
negative regulation of signaling GO:0023057 61 0.011
developmental cell growth GO:0048588 39 0.011
regulation of signal transduction GO:0009966 135 0.011
regulation of cellular biosynthetic process GO:0031326 189 0.011
cilium morphogenesis GO:0060271 33 0.011
cgmp metabolic process GO:0046068 2 0.011
protein modification process GO:0036211 207 0.011
Worm
posttranscriptional gene silencing GO:0016441 143 0.011
multi organism behavior GO:0051705 389 0.011
bmp signaling pathway GO:0030509 3 0.010
ribose phosphate metabolic process GO:0019693 99 0.010
cellular response to chemical stimulus GO:0070887 129 0.010
Human
regulation of muscle system process GO:0090257 20 0.010
feeding behavior GO:0007631 70 0.010
meiotic chromosome segregation GO:0045132 139 0.010
cell type specific apoptotic process GO:0097285 4 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
establishment or maintenance of cell polarity GO:0007163 63 0.010
amine metabolic process GO:0009308 15 0.010
establishment of protein localization to membrane GO:0090150 3 0.010
muscle contraction GO:0006936 43 0.010

pxn-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
myopathy DOID:423 0 0.044
muscular disease DOID:0080000 0 0.044
musculoskeletal system disease DOID:17 0 0.044
muscle tissue disease DOID:66 0 0.044
congenital muscular dystrophy DOID:0050557 0 0.025
muscular dystrophy DOID:9884 0 0.025
heart disease DOID:114 0 0.017
cardiomyopathy DOID:0050700 0 0.017
intrinsic cardiomyopathy DOID:0060036 0 0.017
cardiovascular system disease DOID:1287 0 0.017
dilated cardiomyopathy DOID:12930 0 0.016
nervous system disease DOID:863 0 0.014