Caenorhabditis elegans

59 known processes

pmk-2 (CELE_F42G8.3)

Protein PMK-2

pmk-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2152 0.273
embryo development ending in birth or egg hatching GO:0009792 2992 0.240
embryo development GO:0009790 3052 0.215
organ development GO:0048513 1102 0.211
establishment of localization GO:0051234 1171 0.174
Mouse Worm
genitalia development GO:0048806 741 0.153
locomotion GO:0040011 1634 0.132
multicellular organismal aging GO:0010259 812 0.128
Worm Fly
single organism organelle organization GO:1902589 501 0.118
Worm
single organism signaling GO:0044700 401 0.114
transport GO:0006810 1093 0.102
Mouse Worm
hermaphrodite genitalia development GO:0040035 734 0.099
regulation of multicellular organismal process GO:0051239 726 0.097
Human Mouse Fly
regulation of biological quality GO:0065008 741 0.093
Mouse Worm Fly
positive regulation of developmental growth GO:0048639 354 0.089
Fly
nucleobase containing compound metabolic process GO:0006139 406 0.087
Mouse Worm
regulation of rna metabolic process GO:0051252 173 0.086
Mouse Worm Fly
regulation of macromolecule metabolic process GO:0060255 421 0.085
Mouse Worm Fly
positive regulation of metabolic process GO:0009893 187 0.081
Human Mouse Worm Fly
organelle organization GO:0006996 783 0.081
Worm
behavior GO:0007610 527 0.079
determination of adult lifespan GO:0008340 812 0.077
Worm Fly
p38mapk cascade GO:0038066 2 0.075
Mouse Worm
vesicle mediated transport GO:0016192 852 0.073
regulation of metabolic process GO:0019222 478 0.067
Human Mouse Worm Fly
gene expression GO:0010467 412 0.067
Mouse Worm
gonad development GO:0008406 840 0.064
vulval development GO:0040025 333 0.064
positive regulation of jnk cascade GO:0046330 3 0.064
regulation of primary metabolic process GO:0080090 292 0.063
Mouse Worm Fly
macromolecule localization GO:0033036 771 0.062
Mouse Worm
sex differentiation GO:0007548 909 0.062
regulation of growth GO:0040008 409 0.062
Fly
maintenance of location GO:0051235 580 0.061
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.060
Mouse Worm Fly
lipid storage GO:0019915 565 0.060
developmental growth GO:0048589 412 0.059
Mouse Fly
regulation of gene expression GO:0010468 366 0.058
Mouse Worm Fly
programmed cell death GO:0012501 500 0.058
Worm
rna metabolic process GO:0016070 228 0.058
Mouse Worm
positive regulation of multicellular organismal process GO:0051240 417 0.058
Human Mouse Fly
cell cycle process GO:0022402 482 0.057
Mouse
cell death GO:0008219 547 0.056
Worm
cell development GO:0048468 696 0.056
Mouse Worm
lipid localization GO:0010876 573 0.055
nucleic acid metabolic process GO:0090304 299 0.055
Mouse Worm
regulation of developmental growth GO:0048638 389 0.054
Fly
regulation of cellular metabolic process GO:0031323 305 0.053
Human Mouse Worm Fly
regulation of vulval development GO:0040028 248 0.052
multicellular organism reproduction GO:0032504 819 0.052
Worm
germ cell development GO:0007281 351 0.051
Worm
macromolecule biosynthetic process GO:0009059 250 0.050
Mouse Worm
regulation of developmental process GO:0050793 684 0.050
Mouse Fly
positive regulation of developmental process GO:0051094 408 0.049
Mouse Fly
signaling GO:0023052 401 0.049
heterocycle biosynthetic process GO:0018130 187 0.048
Mouse Worm
single organism localization GO:1902578 518 0.048
Mouse Worm
death GO:0016265 547 0.047
Worm
positive regulation of multicellular organism growth GO:0040018 352 0.047
Fly
negative regulation of developmental process GO:0051093 227 0.046
protein modification process GO:0036211 207 0.046
endocytosis GO:0006897 819 0.046
gamete generation GO:0007276 461 0.046
Worm
response to external stimulus GO:0009605 289 0.045
Human Mouse Worm Fly
regulation of post embryonic development GO:0048580 260 0.045
multi organism reproductive process GO:0044703 867 0.045
Worm
organic substance biosynthetic process GO:1901576 323 0.045
Mouse Worm
positive regulation of stress activated mapk cascade GO:0032874 3 0.045
organelle localization GO:0051640 127 0.044
Worm
aging GO:0007568 812 0.044
Human Worm Fly
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.043
post embryonic organ development GO:0048569 336 0.042
Fly
stress activated protein kinase signaling cascade GO:0031098 10 0.042
Mouse Rat Worm
sensory organ morphogenesis GO:0090596 2 0.041
stress activated mapk cascade GO:0051403 10 0.041
Mouse Rat Worm
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.041
Worm
meiotic nuclear division GO:0007126 300 0.041
Worm
small molecule metabolic process GO:0044281 186 0.041
Mouse
regulation of biosynthetic process GO:0009889 189 0.040
Mouse Worm Fly
establishment of localization in cell GO:0051649 318 0.040
Mouse Worm
apoptotic process GO:0006915 478 0.040
Worm
regulation of nitrogen compound metabolic process GO:0051171 222 0.040
Mouse Worm Fly
developmental process involved in reproduction GO:0003006 1165 0.040
growth GO:0040007 562 0.040
Mouse Fly
phosphorus metabolic process GO:0006793 232 0.039
regulation of multicellular organism growth GO:0040014 373 0.039
Fly
reproductive behavior GO:0019098 387 0.039
macromolecular complex subunit organization GO:0043933 320 0.039
Worm
muscle organ morphogenesis GO:0048644 4 0.038
negative regulation of macromolecule metabolic process GO:0010605 229 0.038
reproductive system development GO:0061458 850 0.038
cellular protein complex assembly GO:0043623 178 0.037
Worm
development of primary sexual characteristics GO:0045137 840 0.037
organic cyclic compound biosynthetic process GO:1901362 195 0.037
Mouse Worm
nucleobase containing compound biosynthetic process GO:0034654 184 0.037
Mouse Worm
cellular nitrogen compound biosynthetic process GO:0044271 192 0.037
Mouse Worm
generation of neurons GO:0048699 235 0.037
response to endoplasmic reticulum stress GO:0034976 71 0.035
Worm
establishment of vesicle localization GO:0051650 23 0.035
Worm
aromatic compound biosynthetic process GO:0019438 192 0.034
Mouse Worm
cell division GO:0051301 262 0.034
regulation of nematode larval development GO:0061062 260 0.034
establishment of organelle localization GO:0051656 123 0.034
Worm
innate immune response GO:0045087 190 0.034
Worm Fly
organonitrogen compound metabolic process GO:1901564 151 0.033
receptor mediated endocytosis GO:0006898 715 0.033
reproductive structure development GO:0048608 850 0.032
anatomical structure formation involved in morphogenesis GO:0048646 250 0.032
Mouse Worm
jnk cascade GO:0007254 8 0.032
Worm
regulation of nucleic acid templated transcription GO:1903506 165 0.031
Mouse Worm Fly
single organism transport GO:0044765 447 0.031
Mouse Worm
protein metabolic process GO:0019538 422 0.031
oogenesis GO:0048477 229 0.031
Worm
protein complex subunit organization GO:0071822 280 0.029
Worm
biosynthetic process GO:0009058 323 0.029
Mouse Worm
female gamete generation GO:0007292 254 0.029
Worm
response to heat GO:0009408 50 0.028
Worm Fly
skeletal muscle organ development GO:0060538 3 0.028
Mouse
response to wounding GO:0009611 4 0.028
Mouse
muscle structure development GO:0061061 191 0.027
Human Mouse Worm
cellular component morphogenesis GO:0032989 318 0.027
Mouse Worm
multicellular organismal reproductive process GO:0048609 815 0.027
Worm
single organism reproductive process GO:0044702 1196 0.027
ribose phosphate metabolic process GO:0019693 99 0.027
negative regulation of post embryonic development GO:0048581 208 0.027
cellular response to inorganic substance GO:0071241 3 0.026
Fly
positive regulation of cellular metabolic process GO:0031325 178 0.026
Human Mouse Worm Fly
positive regulation of cellular process GO:0048522 332 0.026
Human Mouse Worm Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.026
Mouse Worm Fly
sexual reproduction GO:0019953 546 0.026
Worm
actin filament based process GO:0030029 191 0.025
Worm
defense response to gram positive bacterium GO:0050830 31 0.025
Worm
multi multicellular organism process GO:0044706 390 0.025
catabolic process GO:0009056 318 0.025
immune response GO:0006955 192 0.025
Worm Fly
cell part morphogenesis GO:0032990 152 0.025
negative regulation of multicellular organismal process GO:0051241 236 0.025
protein complex biogenesis GO:0070271 186 0.025
Worm
regulation of cell cycle process GO:0010564 145 0.025
multicellular organism growth GO:0035264 385 0.025
Fly
positive regulation of rna metabolic process GO:0051254 103 0.025
Mouse Worm
organelle fission GO:0048285 363 0.024
Worm
nucleic acid templated transcription GO:0097659 169 0.024
Mouse Worm
carbohydrate derivative metabolic process GO:1901135 141 0.024
neuron projection development GO:0031175 187 0.024
nucleotide metabolic process GO:0009117 108 0.024
negative regulation of vulval development GO:0040027 206 0.024
regulation of multicellular organismal development GO:2000026 317 0.024
Mouse Fly
phosphate containing compound metabolic process GO:0006796 232 0.023
body morphogenesis GO:0010171 620 0.023
negative regulation of gene expression GO:0010629 217 0.023
cytoskeleton organization GO:0007010 339 0.022
Worm
response to temperature stimulus GO:0009266 66 0.022
Worm Fly
striated muscle cell differentiation GO:0051146 158 0.022
Mouse Worm
cellular localization GO:0051641 360 0.022
Mouse Worm
peptidyl amino acid modification GO:0018193 58 0.022
Human Mouse Worm
dna metabolic process GO:0006259 74 0.022
regulation of gene expression epigenetic GO:0040029 163 0.021
neuromuscular junction development GO:0007528 2 0.021
actin cytoskeleton organization GO:0030036 184 0.021
Worm
nervous system development GO:0007399 253 0.021
cell morphogenesis GO:0000902 163 0.021
Mouse
positive regulation of biosynthetic process GO:0009891 109 0.021
Mouse Worm
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.021
signal transduction GO:0007165 317 0.020
synaptic vesicle transport GO:0048489 21 0.020
negative regulation of biological process GO:0048519 567 0.020
Mouse Rat Fly
negative regulation of nematode larval development GO:0061064 208 0.020
neuron projection morphogenesis GO:0048812 114 0.020
regulation of bmp signaling pathway GO:0030510 3 0.020
Fly
muscle cell development GO:0055001 158 0.020
Mouse Worm
posttranscriptional regulation of gene expression GO:0010608 166 0.019
response to chemical GO:0042221 356 0.019
Human Mouse Rat Worm Fly
defense response to other organism GO:0098542 100 0.019
Worm Fly
macromolecule catabolic process GO:0009057 202 0.019
oviposition GO:0018991 364 0.019
defense response to gram negative bacterium GO:0050829 64 0.019
Worm
regulation of macromolecule biosynthetic process GO:0010556 189 0.019
Mouse Worm Fly
regulation of transcription dna templated GO:0006355 164 0.019
Mouse Worm Fly
positive regulation of rna biosynthetic process GO:1902680 102 0.019
Mouse Worm
nucleobase containing compound catabolic process GO:0034655 114 0.019
defense response GO:0006952 296 0.019
Worm Fly
cell type specific apoptotic process GO:0097285 4 0.019
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.019
nucleobase containing small molecule metabolic process GO:0055086 115 0.019
nucleoside phosphate metabolic process GO:0006753 108 0.019
positive regulation of growth GO:0045927 369 0.019
Fly
cellular biosynthetic process GO:0044249 315 0.019
Mouse Worm
regulation of phosphorus metabolic process GO:0051174 81 0.019
Fly
microtubule based process GO:0007017 182 0.019
cell morphogenesis involved in differentiation GO:0000904 112 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.018
Mouse Worm
peptidyl serine modification GO:0018209 20 0.018
Human Mouse Worm
regulation of cell differentiation GO:0045595 81 0.018
Mouse
cellular component movement GO:0006928 388 0.018
Worm
cellular component assembly GO:0022607 293 0.018
Worm
posttranscriptional gene silencing GO:0016441 143 0.018
head development GO:0060322 1 0.018
gene silencing by rna GO:0031047 143 0.018
cellular component biogenesis GO:0044085 297 0.018
Worm
regulation of cellular amine metabolic process GO:0033238 0 0.017
chemotaxis GO:0006935 120 0.017
single organism behavior GO:0044708 83 0.017
negative regulation of metabolic process GO:0009892 240 0.017
regulation of organelle organization GO:0033043 164 0.017
actomyosin structure organization GO:0031032 154 0.017
Worm
positive regulation of epithelial cell proliferation GO:0050679 1 0.017
cell fate commitment GO:0045165 139 0.017
cellular macromolecule biosynthetic process GO:0034645 247 0.017
Mouse Worm
striated muscle cell development GO:0055002 157 0.017
Mouse Worm
posttranscriptional gene silencing by rna GO:0035194 143 0.017
positive regulation of transcription from rna polymerase ii promoter in response to osmotic stress GO:0061393 1 0.017
muscle cell differentiation GO:0042692 171 0.017
Human Mouse Worm
striated muscle myosin thick filament assembly GO:0071688 138 0.017
Worm
cellular protein metabolic process GO:0044267 279 0.017
ribonucleotide metabolic process GO:0009259 99 0.017
regulation of molecular function GO:0065009 89 0.016
protein catabolic process GO:0030163 162 0.016
epithelial tube morphogenesis GO:0060562 1 0.016
purine ribonucleotide metabolic process GO:0009150 95 0.016
positive regulation of cellular biosynthetic process GO:0031328 109 0.016
Mouse Worm
protein complex assembly GO:0006461 186 0.016
Worm
regulation of cell communication GO:0010646 176 0.016
Mouse Fly
regulation of response to stimulus GO:0048583 243 0.016
Mouse Fly
multicellular organismal reproductive behavior GO:0033057 384 0.016
neuron differentiation GO:0030182 217 0.016
intracellular transport GO:0046907 77 0.016
Mouse
cell cycle GO:0007049 526 0.016
Mouse Rat Worm
myosin filament organization GO:0031033 138 0.016
Worm
cellular protein modification process GO:0006464 207 0.016
regulation of purine nucleotide metabolic process GO:1900542 37 0.016
macromolecular complex assembly GO:0065003 193 0.015
Worm
protein phosphorylation GO:0006468 85 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.015
bmp signaling pathway GO:0030509 3 0.015
Fly
apoptotic cell clearance GO:0043277 111 0.015
organophosphate metabolic process GO:0019637 125 0.015
positive regulation of neuron projection development GO:0010976 4 0.015
purine nucleotide metabolic process GO:0006163 95 0.015
macromolecule modification GO:0043412 218 0.015
cellular response to chemical stimulus GO:0070887 129 0.015
Human Mouse Fly
response to organic substance GO:0010033 131 0.015
Human Mouse Rat Fly
vesicle localization GO:0051648 24 0.015
Worm
positive regulation of transcription from rna polymerase ii promoter involved in defense response to gram negative bacterium GO:1902097 4 0.015
Worm
regulation of signaling GO:0023051 172 0.014
Mouse Fly
neurogenesis GO:0022008 236 0.014
multi organism behavior GO:0051705 389 0.014
cell projection morphogenesis GO:0048858 148 0.014
multi organism reproductive behavior GO:0044705 387 0.014
response to mechanical stimulus GO:0009612 28 0.014
phagocytosis GO:0006909 115 0.014
positive regulation of molecular function GO:0044093 61 0.014
regulation of rna biosynthetic process GO:2001141 165 0.014
Mouse Worm Fly
axon development GO:0061564 163 0.014
regulation of signal transduction GO:0009966 135 0.014
Mouse Fly
axonogenesis GO:0007409 102 0.014
negative regulation of response to stimulus GO:0048585 73 0.014
Mouse Fly
single organism intracellular transport GO:1902582 70 0.014
Mouse
establishment of mitotic spindle orientation GO:0000132 28 0.014
cellular response to metal ion GO:0071248 3 0.013
Fly
regulation of cellular ketone metabolic process GO:0010565 3 0.013
establishment of spindle orientation GO:0051294 34 0.013
regulation of localization GO:0032879 194 0.013
Mouse Worm
cellular response to stress GO:0033554 162 0.013
Human Mouse Rat Worm Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.013
Mouse Worm
secretion by cell GO:0032940 138 0.013
response to external biotic stimulus GO:0043207 101 0.013
Human Mouse Worm Fly
myosin filament assembly GO:0031034 138 0.013
Worm
cell cell signaling GO:0007267 118 0.013
Worm Fly
purine containing compound metabolic process GO:0072521 95 0.013
synaptic transmission GO:0007268 106 0.013
Worm Fly
cellular response to abiotic stimulus GO:0071214 4 0.013
Human
response to biotic stimulus GO:0009607 101 0.013
Human Mouse Worm Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.013
Mouse Worm
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 2 0.013
regulation of canonical wnt signaling pathway GO:0060828 1 0.013
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 87 0.013
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.013
cell substrate adhesion GO:0031589 1 0.013
rna interference GO:0016246 137 0.012
mapk cascade GO:0000165 31 0.012
organic substance catabolic process GO:1901575 294 0.012
oxoacid metabolic process GO:0043436 47 0.012
Mouse
localization of cell GO:0051674 313 0.012
cell surface receptor signaling pathway GO:0007166 149 0.012
Human Mouse Fly
molting cycle GO:0042303 281 0.012
Fly
negative regulation of neuron differentiation GO:0045665 4 0.012
cell proliferation GO:0008283 116 0.012
tube development GO:0035295 126 0.012
phagocytosis engulfment GO:0006911 98 0.012
regulation of neurogenesis GO:0050767 40 0.012
transcription from rna polymerase ii promoter GO:0006366 149 0.012
Mouse Worm
regulation of dna replication GO:0006275 5 0.012
carboxylic acid metabolic process GO:0019752 34 0.011
Mouse
neuron development GO:0048666 199 0.011
signal transduction by phosphorylation GO:0023014 31 0.011
regulation of ras protein signal transduction GO:0046578 41 0.011
positive regulation of organ growth GO:0046622 4 0.011
negative regulation of cellular process GO:0048523 239 0.011
Mouse Rat
canonical wnt signaling pathway GO:0060070 3 0.011
Mouse
negative regulation of neurogenesis GO:0050768 4 0.011
gene silencing GO:0016458 143 0.011
amine metabolic process GO:0009308 15 0.011
membrane invagination GO:0010324 98 0.011
positive regulation of neurogenesis GO:0050769 4 0.011
rna localization GO:0006403 3 0.011
regulation of epithelial cell proliferation GO:0050678 1 0.011
cell migration GO:0016477 306 0.011
regulation of apoptotic signaling pathway GO:2001233 1 0.011
muscle tissue development GO:0060537 1 0.011
Mouse
negative regulation of organ growth GO:0046621 1 0.011
glycosyl compound catabolic process GO:1901658 79 0.011
heterocycle catabolic process GO:0046700 119 0.011
regulation of protein stability GO:0031647 3 0.011
transcription dna templated GO:0006351 168 0.011
Mouse Worm
engulfment of apoptotic cell GO:0043652 94 0.010
positive regulation of intracellular transport GO:0032388 2 0.010
Mouse
regulation of organ morphogenesis GO:2000027 4 0.010
establishment of synaptic vesicle localization GO:0097480 21 0.010
positive regulation of neuron differentiation GO:0045666 4 0.010
regulation of cellular component organization GO:0051128 248 0.010
Mouse Worm Fly
g1 s transition of mitotic cell cycle GO:0000082 2 0.010
neurological system process GO:0050877 53 0.010
regulation of cellular biosynthetic process GO:0031326 189 0.010
Mouse Worm Fly
purine nucleoside metabolic process GO:0042278 92 0.010
ribonucleoside triphosphate catabolic process GO:0009203 72 0.010
regulation of cytoplasmic transport GO:1903649 3 0.010
Mouse
cellular macromolecular complex assembly GO:0034622 184 0.010
Worm
oocyte development GO:0048599 44 0.010
Worm
neuron projection guidance GO:0097485 82 0.010
positive regulation of macromolecule metabolic process GO:0010604 149 0.010
Mouse Worm Fly
nucleoside triphosphate metabolic process GO:0009141 87 0.010
positive regulation of phosphorus metabolic process GO:0010562 56 0.010
Fly
protein localization GO:0008104 205 0.010
Mouse Worm
regulation of lipid metabolic process GO:0019216 4 0.010
inductive cell migration GO:0040039 145 0.010

pmk-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
organ system cancer DOID:0050686 0 0.016
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.010