Caenorhabditis elegans

15 known processes

mec-12 (CELE_C44B11.3)

Protein MEC-12

mec-12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transport GO:0006810 1093 0.443
Worm
multi organism reproductive process GO:0044703 867 0.374
Worm
embryo development GO:0009790 3052 0.364
Worm
sexual reproduction GO:0019953 546 0.360
Worm
regulation of multicellular organismal process GO:0051239 726 0.337
post embryonic development GO:0009791 2152 0.327
Worm
sex differentiation GO:0007548 909 0.321
multicellular organism reproduction GO:0032504 819 0.283
organ development GO:0048513 1102 0.239
cellular component movement GO:0006928 388 0.220
Worm
gonad development GO:0008406 840 0.207
hermaphrodite genitalia development GO:0040035 734 0.204
reproductive system development GO:0061458 850 0.197
reproductive structure development GO:0048608 850 0.190
developmental process involved in reproduction GO:0003006 1165 0.186
positive regulation of developmental process GO:0051094 408 0.181
neuron differentiation GO:0030182 217 0.180
development of primary sexual characteristics GO:0045137 840 0.171
multi organism reproductive behavior GO:0044705 387 0.160
response to mechanical stimulus GO:0009612 28 0.160
single organism behavior GO:0044708 83 0.159
negative regulation of biological process GO:0048519 567 0.159
vesicle mediated transport GO:0016192 852 0.149
Worm
receptor mediated endocytosis GO:0006898 715 0.146
Worm
locomotion GO:0040011 1634 0.144
organic substance catabolic process GO:1901575 294 0.144
cell development GO:0048468 696 0.137
Zebrafish
macromolecule localization GO:0033036 771 0.130
Worm
regulation of metabolic process GO:0019222 478 0.128
endocytosis GO:0006897 819 0.128
Worm
macromolecule catabolic process GO:0009057 202 0.126
response to chemical GO:0042221 356 0.125
protein catabolic process GO:0030163 162 0.124
multicellular organismal reproductive process GO:0048609 815 0.122
multi multicellular organism process GO:0044706 390 0.122
regulation of biological quality GO:0065008 741 0.118
Zebrafish Worm
microtubule based process GO:0007017 182 0.116
cellular component morphogenesis GO:0032989 318 0.113
genitalia development GO:0048806 741 0.111
oviposition GO:0018991 364 0.105
neurogenesis GO:0022008 236 0.103
Zebrafish
neuron projection development GO:0031175 187 0.098
behavior GO:0007610 527 0.098
body morphogenesis GO:0010171 620 0.097
cell motility GO:0048870 313 0.096
Worm
cell projection organization GO:0030030 231 0.096
reproductive behavior GO:0019098 387 0.093
multicellular organism growth GO:0035264 385 0.092
localization of cell GO:0051674 313 0.092
Worm
positive regulation of developmental growth GO:0048639 354 0.092
establishment of localization in cell GO:0051649 318 0.090
Worm
organelle organization GO:0006996 783 0.090
Worm
cell cycle process GO:0022402 482 0.086
Worm
multicellular organismal reproductive behavior GO:0033057 384 0.086
organelle localization GO:0051640 127 0.086
Worm
regulation of multicellular organism growth GO:0040014 373 0.085
establishment of organelle localization GO:0051656 123 0.085
Worm
protein metabolic process GO:0019538 422 0.083
regulation of developmental process GO:0050793 684 0.083
positive regulation of multicellular organism growth GO:0040018 352 0.083
regulation of gene expression GO:0010468 366 0.081
spindle organization GO:0007051 92 0.081
Worm
regulation of organelle organization GO:0033043 164 0.080
organelle fission GO:0048285 363 0.078
Worm
lipid storage GO:0019915 565 0.078
Worm
female gamete generation GO:0007292 254 0.077
establishment of localization GO:0051234 1171 0.077
Worm
cellular component assembly involved in morphogenesis GO:0010927 183 0.076
lipid localization GO:0010876 573 0.075
Worm
catabolic process GO:0009056 318 0.073
embryo development ending in birth or egg hatching GO:0009792 2992 0.072
Worm
mitotic spindle organization GO:0007052 81 0.072
Worm
gamete generation GO:0007276 461 0.072
maintenance of location GO:0051235 580 0.071
Worm
positive regulation of multicellular organismal process GO:0051240 417 0.071
organic cyclic compound biosynthetic process GO:1901362 195 0.070
signaling GO:0023052 401 0.067
Zebrafish
protein modification process GO:0036211 207 0.066
negative regulation of multicellular organismal process GO:0051241 236 0.063
cell migration GO:0016477 306 0.062
Worm
molting cycle GO:0042303 281 0.062
axon development GO:0061564 163 0.061
negative regulation of developmental process GO:0051093 227 0.061
growth GO:0040007 562 0.061
cellular component biogenesis GO:0044085 297 0.059
regulation of growth GO:0040008 409 0.057
gene expression GO:0010467 412 0.057
regulation of cellular biosynthetic process GO:0031326 189 0.057
cellular localization GO:0051641 360 0.057
Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.055
generation of neurons GO:0048699 235 0.055
positive regulation of cellular process GO:0048522 332 0.055
nucleobase containing compound metabolic process GO:0006139 406 0.055
single organism transport GO:0044765 447 0.055
positive regulation of growth GO:0045927 369 0.054
multi organism behavior GO:0051705 389 0.054
single organism localization GO:1902578 518 0.054
Worm
response to external stimulus GO:0009605 289 0.052
determination of adult lifespan GO:0008340 812 0.052
Worm
positive regulation of cellular metabolic process GO:0031325 178 0.052
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.052
oogenesis GO:0048477 229 0.051
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.051
tube development GO:0035295 126 0.051
single organism reproductive process GO:0044702 1196 0.051
Worm
cytoskeleton organization GO:0007010 339 0.051
Worm
positive regulation of metabolic process GO:0009893 187 0.050
aromatic compound biosynthetic process GO:0019438 192 0.050
muscle organ morphogenesis GO:0048644 4 0.050
regulation of hydrolase activity GO:0051336 45 0.048
aging GO:0007568 812 0.048
Worm
organic substance biosynthetic process GO:1901576 323 0.048
regulation of cellular component organization GO:0051128 248 0.048
cell cycle GO:0007049 526 0.047
Worm
cellular component assembly GO:0022607 293 0.046
mechanosensory behavior GO:0007638 25 0.046
positive regulation of rna biosynthetic process GO:1902680 102 0.046
developmental growth GO:0048589 412 0.045
cellular nitrogen compound biosynthetic process GO:0044271 192 0.045
single organism organelle organization GO:1902589 501 0.045
Worm
cellular biosynthetic process GO:0044249 315 0.044
regulation of developmental growth GO:0048638 389 0.043
phosphate containing compound metabolic process GO:0006796 232 0.043
striated muscle cell development GO:0055002 157 0.043
establishment of nucleus localization GO:0040023 55 0.042
Worm
neuron development GO:0048666 199 0.042
regulation of cell communication GO:0010646 176 0.041
cellular macromolecule biosynthetic process GO:0034645 247 0.041
cell death GO:0008219 547 0.040
Worm
regulation of locomotion GO:0040012 161 0.040
regulation of macromolecule metabolic process GO:0060255 421 0.039
negative regulation of gene expression GO:0010629 217 0.039
organonitrogen compound metabolic process GO:1901564 151 0.039
response to biotic stimulus GO:0009607 101 0.039
striated muscle cell differentiation GO:0051146 158 0.038
muscle cell development GO:0055001 158 0.038
response to bacterium GO:0009617 86 0.037
nucleobase containing compound biosynthetic process GO:0034654 184 0.037
system process GO:0003008 136 0.037
Zebrafish
cellular catabolic process GO:0044248 199 0.036
nuclear migration GO:0007097 54 0.036
Worm
single organism signaling GO:0044700 401 0.036
Zebrafish
macromolecular complex assembly GO:0065003 193 0.036
post embryonic organ development GO:0048569 336 0.036
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.035
nervous system development GO:0007399 253 0.035
Zebrafish
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.034
organic cyclic compound catabolic process GO:1901361 119 0.034
response to abiotic stimulus GO:0009628 152 0.033
eating behavior GO:0042755 59 0.033
regulation of nematode larval development GO:0061062 260 0.033
biosynthetic process GO:0009058 323 0.032
regulation of response to stimulus GO:0048583 243 0.032
regulation of macromolecule biosynthetic process GO:0010556 189 0.032
inductive cell migration GO:0040039 145 0.032
Worm
organelle assembly GO:0070925 214 0.032
striated muscle myosin thick filament assembly GO:0071688 138 0.031
response to other organism GO:0051707 101 0.031
aromatic compound catabolic process GO:0019439 116 0.030
positive regulation of cellular biosynthetic process GO:0031328 109 0.030
cellular protein metabolic process GO:0044267 279 0.030
muscle cell differentiation GO:0042692 171 0.030
regulation of gene expression epigenetic GO:0040029 163 0.030
head development GO:0060322 1 0.029
actin filament based process GO:0030029 191 0.029
regulation of cytoskeleton organization GO:0051493 41 0.029
regulation of rna biosynthetic process GO:2001141 165 0.029
anatomical structure formation involved in morphogenesis GO:0048646 250 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.029
germ cell development GO:0007281 351 0.029
cellular macromolecular complex assembly GO:0034622 184 0.029
protein complex assembly GO:0006461 186 0.028
regulation of signal transduction GO:0009966 135 0.027
protein complex subunit organization GO:0071822 280 0.027
Worm
mitotic nuclear division GO:0007067 89 0.027
Worm
small molecule metabolic process GO:0044281 186 0.027
cell morphogenesis GO:0000902 163 0.027
secretion by cell GO:0032940 138 0.027
muscle structure development GO:0061061 191 0.027
signal transduction GO:0007165 317 0.027
regulation of cell differentiation GO:0045595 81 0.027
multicellular organismal aging GO:0010259 812 0.026
Worm
macromolecule modification GO:0043412 218 0.026
cellular protein modification process GO:0006464 207 0.026
regulation of nitrogen compound metabolic process GO:0051171 222 0.026
locomotory behavior GO:0007626 40 0.026
nucleic acid metabolic process GO:0090304 299 0.026
myosin filament assembly GO:0031034 138 0.025
myosin filament organization GO:0031033 138 0.025
chromosome segregation GO:0007059 180 0.025
organonitrogen compound catabolic process GO:1901565 90 0.025
negative regulation of metabolic process GO:0009892 240 0.025
positive regulation of nucleic acid templated transcription GO:1903508 102 0.025
regulation of post embryonic development GO:0048580 260 0.025
cell projection morphogenesis GO:0048858 148 0.024
regulation of localization GO:0032879 194 0.024
regulation of cell cycle GO:0051726 194 0.024
Worm
myofibril assembly GO:0030239 154 0.024
regulation of cell motility GO:2000145 57 0.024
regulation of actin filament based process GO:0032970 22 0.024
spindle localization GO:0051653 51 0.023
Worm
cell division GO:0051301 262 0.023
Worm
defense response to other organism GO:0098542 100 0.023
cellular protein complex assembly GO:0043623 178 0.022
cellular nitrogen compound catabolic process GO:0044270 119 0.022
death GO:0016265 547 0.022
Worm
negative regulation of cellular process GO:0048523 239 0.022
pronuclear migration GO:0035046 51 0.022
Worm
protein localization GO:0008104 205 0.022
Worm
phosphorus metabolic process GO:0006793 232 0.022
cell morphogenesis involved in differentiation GO:0000904 112 0.022
meiotic cell cycle GO:0051321 335 0.021
regulation of multicellular organismal development GO:2000026 317 0.021
transcription dna templated GO:0006351 168 0.021
positive regulation of rna metabolic process GO:0051254 103 0.021
single organism cellular localization GO:1902580 72 0.021
Worm
regulation of cellular metabolic process GO:0031323 305 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.021
nuclear pore distribution GO:0031081 2 0.020
cell part morphogenesis GO:0032990 152 0.020
meiotic cell cycle process GO:1903046 170 0.020
protein complex biogenesis GO:0070271 186 0.020
posttranscriptional regulation of gene expression GO:0010608 166 0.020
chemotaxis GO:0006935 120 0.020
epithelial tube morphogenesis GO:0060562 1 0.020
taxis GO:0042330 128 0.020
chemosensory behavior GO:0007635 33 0.019
nucleobase containing compound catabolic process GO:0034655 114 0.019
gene silencing GO:0016458 143 0.019
programmed cell death GO:0012501 500 0.019
Worm
heterocycle catabolic process GO:0046700 119 0.019
rna metabolic process GO:0016070 228 0.018
membrane organization GO:0061024 135 0.018
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.018
positive regulation of biosynthetic process GO:0009891 109 0.018
regulation of primary metabolic process GO:0080090 292 0.018
meiotic nuclear division GO:0007126 300 0.017
neuron recognition GO:0008038 83 0.017
response to external biotic stimulus GO:0043207 101 0.017
positive regulation of gene expression GO:0010628 112 0.017
regulation of nucleotide catabolic process GO:0030811 35 0.017
nucleic acid templated transcription GO:0097659 169 0.017
secretion GO:0046903 147 0.017
regulation of protein localization GO:0032880 50 0.017
regulation of reproductive process GO:2000241 66 0.017
actomyosin structure organization GO:0031032 154 0.017
purine ribonucleotide metabolic process GO:0009150 95 0.017
actin cytoskeleton organization GO:0030036 184 0.016
negative regulation of nematode larval development GO:0061064 208 0.016
regulation of cell division GO:0051302 142 0.016
Worm
macromolecular complex subunit organization GO:0043933 320 0.016
Worm
regulation of apoptotic signaling pathway GO:2001233 1 0.016
synaptic vesicle endocytosis GO:0048488 3 0.016
regulation of rna metabolic process GO:0051252 173 0.016
regulation of mitotic cell cycle GO:0007346 76 0.016
regulation of cellular component movement GO:0051270 62 0.016
defense response to bacterium GO:0042742 86 0.016
fertilization GO:0009566 63 0.016
Worm
negative regulation of macromolecule metabolic process GO:0010605 229 0.015
regulation of atp catabolic process GO:1903289 3 0.015
mitotic cell cycle process GO:1903047 194 0.015
Worm
establishment or maintenance of cell polarity GO:0007163 63 0.015
Worm
feeding behavior GO:0007631 70 0.015
carboxylic acid metabolic process GO:0019752 34 0.015
skeletal muscle organ development GO:0060538 3 0.015
negative regulation of gene expression epigenetic GO:0045814 2 0.015
tissue development GO:0009888 112 0.014
male anatomical structure morphogenesis GO:0090598 78 0.014
neuron projection morphogenesis GO:0048812 114 0.014
regulation of feeding behavior GO:0060259 38 0.014
mitotic nuclear envelope reassembly GO:0007084 3 0.014
response to organic substance GO:0010033 131 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.014
mating GO:0007618 34 0.013
regulation of cell cycle process GO:0010564 145 0.013
Worm
organic substance transport GO:0071702 113 0.013
defense response GO:0006952 296 0.013
glycosyl compound metabolic process GO:1901657 100 0.013
axonal fasciculation GO:0007413 79 0.013
regulation of signaling GO:0023051 172 0.013
regulation of epithelial cell differentiation GO:0030856 4 0.013
apoptotic process GO:0006915 478 0.013
Worm
establishment of mitotic spindle localization GO:0040001 41 0.013
Worm
regulation of pharyngeal pumping GO:0043051 36 0.012
regulation of multi organism process GO:0043900 69 0.012
mating behavior GO:0007617 32 0.012
posttranscriptional gene silencing GO:0016441 143 0.012
regulation of cell migration GO:0030334 55 0.012
posttranscriptional gene silencing by rna GO:0035194 143 0.012
response to wounding GO:0009611 4 0.012
cell recognition GO:0008037 85 0.012
regulation of purine nucleotide catabolic process GO:0033121 35 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.012
cell fate commitment GO:0045165 139 0.012
positive regulation of transcription dna templated GO:0045893 102 0.012
adult locomotory behavior GO:0008344 1 0.012
regulation of cellular localization GO:0060341 42 0.012
lamellipodium assembly GO:0030032 2 0.011
single organism catabolic process GO:0044712 129 0.011
establishment of vesicle localization GO:0051650 23 0.011
adult behavior GO:0030534 3 0.011
tube morphogenesis GO:0035239 79 0.011
nucleoside metabolic process GO:0009116 99 0.011
axonogenesis GO:0007409 102 0.011
regulation of catalytic activity GO:0050790 78 0.011
purine nucleotide catabolic process GO:0006195 75 0.011
carbohydrate derivative metabolic process GO:1901135 141 0.011
negative regulation of vulval development GO:0040027 206 0.011
heterocycle biosynthetic process GO:0018130 187 0.011
nucleobase containing small molecule metabolic process GO:0055086 115 0.011
transcription from rna polymerase ii promoter GO:0006366 149 0.011
inactivation of mapkkk activity GO:0051390 2 0.011
negative regulation of cation channel activity GO:2001258 2 0.011
detection of external stimulus GO:0009581 4 0.011
digestive system development GO:0055123 122 0.011
purine nucleoside triphosphate catabolic process GO:0009146 72 0.011
regulation of nucleic acid templated transcription GO:1903506 165 0.010
regulation of phosphate metabolic process GO:0019220 81 0.010
single organism intracellular transport GO:1902582 70 0.010
organic acid metabolic process GO:0006082 47 0.010
purine nucleoside metabolic process GO:0042278 92 0.010
positive regulation of protein transport GO:0051222 4 0.010

mec-12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.053
muscular disease DOID:0080000 0 0.053
heart disease DOID:114 0 0.053
cardiomyopathy DOID:0050700 0 0.053
disease of anatomical entity DOID:7 0 0.053
cardiovascular system disease DOID:1287 0 0.053
musculoskeletal system disease DOID:17 0 0.053
muscle tissue disease DOID:66 0 0.053
dilated cardiomyopathy DOID:12930 0 0.029
intrinsic cardiomyopathy DOID:0060036 0 0.029
congenital muscular dystrophy DOID:0050557 0 0.022
muscular dystrophy DOID:9884 0 0.022
lipodystrophy DOID:811 0 0.021
skin disease DOID:37 0 0.021
integumentary system disease DOID:16 0 0.021
familial partial lipodystrophy DOID:0050440 0 0.021
neuromuscular disease DOID:440 0 0.020
charcot marie tooth disease type 2 DOID:0050539 0 0.020
charcot marie tooth disease DOID:10595 0 0.020
nervous system disease DOID:863 0 0.020
neuropathy DOID:870 0 0.020
progeria DOID:3911 0 0.015
hypertrophic cardiomyopathy DOID:11984 0 0.014
limb girdle muscular dystrophy DOID:11724 0 0.011