Caenorhabditis elegans

101 known processes

dlk-1 (CELE_F33E2.2)

Protein DLK-1

dlk-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
heterocycle biosynthetic process GO:0018130 187 0.750
Human
cellular macromolecule biosynthetic process GO:0034645 247 0.722
Human
negative regulation of biological process GO:0048519 567 0.706
post embryonic development GO:0009791 2152 0.687
organic substance biosynthetic process GO:1901576 323 0.655
Human
embryo development ending in birth or egg hatching GO:0009792 2992 0.649
embryo development GO:0009790 3052 0.625
regulation of macromolecule metabolic process GO:0060255 421 0.580
single organism reproductive process GO:0044702 1196 0.577
Fly
regulation of developmental process GO:0050793 684 0.538
gene expression GO:0010467 412 0.522
Human
sex differentiation GO:0007548 909 0.511
nucleic acid templated transcription GO:0097659 169 0.502
Human
defense response GO:0006952 296 0.487
macromolecule biosynthetic process GO:0009059 250 0.484
Human
organ development GO:0048513 1102 0.478
positive regulation of cellular biosynthetic process GO:0031328 109 0.470
nucleobase containing compound biosynthetic process GO:0034654 184 0.445
Human
negative regulation of cellular process GO:0048523 239 0.435
regulation of gene expression GO:0010468 366 0.431
Human
establishment of localization GO:0051234 1171 0.417
cellular response to organic substance GO:0071310 119 0.410
programmed cell death GO:0012501 500 0.407
positive regulation of transcription dna templated GO:0045893 102 0.391
cellular biosynthetic process GO:0044249 315 0.390
Human
regulation of biosynthetic process GO:0009889 189 0.390
Human
nucleic acid metabolic process GO:0090304 299 0.381
Human
gonad development GO:0008406 840 0.367
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.366
Human
cell cycle process GO:0022402 482 0.365
organelle organization GO:0006996 783 0.358
Mouse Fly
regulation of multicellular organismal development GO:2000026 317 0.356
cell death GO:0008219 547 0.349
multicellular organismal reproductive process GO:0048609 815 0.349
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.338
multi organism reproductive process GO:0044703 867 0.334
Fly
growth GO:0040007 562 0.324
Fly
regulation of rna metabolic process GO:0051252 173 0.305
Human
regulation of cellular metabolic process GO:0031323 305 0.284
anatomical structure formation involved in morphogenesis GO:0048646 250 0.281
positive regulation of nucleic acid templated transcription GO:1903508 102 0.275
regulation of metabolic process GO:0019222 478 0.273
vesicle mediated transport GO:0016192 852 0.265
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.262
gamete generation GO:0007276 461 0.260
Fly
genitalia development GO:0048806 741 0.260
death GO:0016265 547 0.259
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.259
Human
rna biosynthetic process GO:0032774 169 0.256
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.247
regulation of response to stimulus GO:0048583 243 0.241
cellular localization GO:0051641 360 0.232
positive regulation of rna biosynthetic process GO:1902680 102 0.227
regulation of transcription dna templated GO:0006355 164 0.225
Human
biosynthetic process GO:0009058 323 0.222
Human
developmental growth GO:0048589 412 0.217
Fly
regulation of nucleic acid templated transcription GO:1903506 165 0.211
Human
macromolecular complex subunit organization GO:0043933 320 0.209
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 192 0.209
Human
head development GO:0060322 1 0.209
development of primary sexual characteristics GO:0045137 840 0.208
intracellular signal transduction GO:0035556 96 0.206
cell development GO:0048468 696 0.206
Fly
organic cyclic compound biosynthetic process GO:1901362 195 0.204
Human
positive regulation of gene expression GO:0010628 112 0.202
enzyme linked receptor protein signaling pathway GO:0007167 50 0.198
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.194
reproductive system development GO:0061458 850 0.192
multicellular organism reproduction GO:0032504 819 0.192
Fly
positive regulation of multicellular organismal process GO:0051240 417 0.186
developmental process involved in reproduction GO:0003006 1165 0.186
oviposition GO:0018991 364 0.185
response to organic substance GO:0010033 131 0.184
transport GO:0006810 1093 0.184
multi organism reproductive behavior GO:0044705 387 0.184
cell cycle GO:0007049 526 0.183
protein metabolic process GO:0019538 422 0.183
protein complex subunit organization GO:0071822 280 0.178
positive regulation of developmental growth GO:0048639 354 0.176
locomotion GO:0040011 1634 0.174
receptor mediated endocytosis GO:0006898 715 0.172
nucleobase containing compound metabolic process GO:0006139 406 0.169
Human
reproductive structure development GO:0048608 850 0.168
regulation of cellular component size GO:0032535 40 0.165
aromatic compound biosynthetic process GO:0019438 192 0.164
Human
regulation of multicellular organismal process GO:0051239 726 0.163
cell projection morphogenesis GO:0048858 148 0.159
Fly
positive regulation of multicellular organism growth GO:0040018 352 0.158
cellular component assembly GO:0022607 293 0.154
regulation of rna biosynthetic process GO:2001141 165 0.153
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.150
cell proliferation GO:0008283 116 0.149
establishment of localization in cell GO:0051649 318 0.146
multicellular organism growth GO:0035264 385 0.145
apoptotic process GO:0006915 478 0.145
endocytosis GO:0006897 819 0.145
regulation of biological quality GO:0065008 741 0.145
cell morphogenesis GO:0000902 163 0.143
Fly
multi organism behavior GO:0051705 389 0.142
regulation of growth GO:0040008 409 0.139
positive regulation of epithelial cell proliferation GO:0050679 1 0.138
positive regulation of developmental process GO:0051094 408 0.138
regulation of nitrogen compound metabolic process GO:0051171 222 0.138
Human
positive regulation of rna metabolic process GO:0051254 103 0.134
signal transduction GO:0007165 317 0.134
positive regulation of metabolic process GO:0009893 187 0.133
regulation of response to stress GO:0080134 28 0.133
response to oxygen containing compound GO:1901700 44 0.132
neurogenesis GO:0022008 236 0.128
Fly
negative regulation of metabolic process GO:0009892 240 0.128
macromolecule modification GO:0043412 218 0.126
behavior GO:0007610 527 0.126
neurotransmitter secretion GO:0007269 26 0.125
phosphorus metabolic process GO:0006793 232 0.118
hermaphrodite genitalia development GO:0040035 734 0.118
regulation of cellular biosynthetic process GO:0031326 189 0.117
Human
innate immune response GO:0045087 190 0.117
cellular protein metabolic process GO:0044267 279 0.116
regulation of primary metabolic process GO:0080090 292 0.109
muscle tissue development GO:0060537 1 0.108
single organism behavior GO:0044708 83 0.107
tube development GO:0035295 126 0.107
cellular response to stress GO:0033554 162 0.107
Human Fly
cellular response to endogenous stimulus GO:0071495 32 0.107
cellular component morphogenesis GO:0032989 318 0.106
Fly
multi multicellular organism process GO:0044706 390 0.105
reproductive behavior GO:0019098 387 0.105
single organism organelle organization GO:1902589 501 0.097
Mouse
digestive system development GO:0055123 122 0.096
cellular component biogenesis GO:0044085 297 0.096
mapk cascade GO:0000165 31 0.094
dauer larval development GO:0040024 92 0.094
cell division GO:0051301 262 0.092
regulation of macromolecule biosynthetic process GO:0010556 189 0.092
Human
macromolecule localization GO:0033036 771 0.089
regulation of multicellular organism growth GO:0040014 373 0.089
neuron development GO:0048666 199 0.087
Fly
rna metabolic process GO:0016070 228 0.087
Human
cell surface receptor signaling pathway GO:0007166 149 0.084
positive regulation of cellular metabolic process GO:0031325 178 0.083
protein localization GO:0008104 205 0.083
dna metabolic process GO:0006259 74 0.083
immune response GO:0006955 192 0.082
negative regulation of biosynthetic process GO:0009890 65 0.080
positive regulation of growth GO:0045927 369 0.077
regulation of organelle organization GO:0033043 164 0.076
response to endogenous stimulus GO:0009719 33 0.076
cell morphogenesis involved in differentiation GO:0000904 112 0.076
Fly
cell motility GO:0048870 313 0.075
negative regulation of response to stimulus GO:0048585 73 0.075
organelle fission GO:0048285 363 0.075
positive regulation of biosynthetic process GO:0009891 109 0.075
regulation of cell differentiation GO:0045595 81 0.075
bmp signaling pathway GO:0030509 3 0.074
negative regulation of macromolecule metabolic process GO:0010605 229 0.074
macromolecular complex assembly GO:0065003 193 0.073
sexual reproduction GO:0019953 546 0.073
Fly
multicellular organismal reproductive behavior GO:0033057 384 0.072
maintenance of location GO:0051235 580 0.071
cellular protein modification process GO:0006464 207 0.071
regulation of cellular component organization GO:0051128 248 0.071
body morphogenesis GO:0010171 620 0.070
phosphate containing compound metabolic process GO:0006796 232 0.069
regulation of epithelial cell proliferation GO:0050678 1 0.069
nervous system development GO:0007399 253 0.067
Fly
phosphorylation GO:0016310 116 0.067
multicellular organismal aging GO:0010259 812 0.067
cellular response to chemical stimulus GO:0070887 129 0.066
epithelial cell proliferation GO:0050673 1 0.065
regulation of signal transduction GO:0009966 135 0.065
determination of adult lifespan GO:0008340 812 0.064
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.064
cytoskeleton organization GO:0007010 339 0.064
neuron projection morphogenesis GO:0048812 114 0.064
Fly
protein modification process GO:0036211 207 0.063
generation of neurons GO:0048699 235 0.063
Fly
post embryonic organ development GO:0048569 336 0.062
signaling GO:0023052 401 0.061
lipid localization GO:0010876 573 0.060
negative regulation of cell communication GO:0010648 61 0.060
single organism transport GO:0044765 447 0.060
lipid storage GO:0019915 565 0.059
regulation of meiotic cell cycle GO:0051445 136 0.059
regulation of developmental growth GO:0048638 389 0.059
transcription from rna polymerase ii promoter GO:0006366 149 0.059
secretion by cell GO:0032940 138 0.058
single organism signaling GO:0044700 401 0.058
digestive tract development GO:0048565 122 0.057
cellular component movement GO:0006928 388 0.056
axon development GO:0061564 163 0.055
Fly
negative regulation of gene expression GO:0010629 217 0.055
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.054
Fly
vulval development GO:0040025 333 0.054
negative regulation of cellular metabolic process GO:0031324 95 0.054
protein phosphorylation GO:0006468 85 0.053
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 16 0.053
regulation of anatomical structure size GO:0090066 46 0.053
cellular response to abiotic stimulus GO:0071214 4 0.053
tissue development GO:0009888 112 0.052
regulation of cell size GO:0008361 30 0.052
response to chemical GO:0042221 356 0.051
regulation of signaling GO:0023051 172 0.050
positive regulation of cell projection organization GO:0031346 4 0.049
negative regulation of cellular biosynthetic process GO:0031327 65 0.048
regulation of cell proliferation GO:0042127 105 0.048
positive regulation of neurogenesis GO:0050769 4 0.048
adult locomotory behavior GO:0008344 1 0.048
cellular response to transforming growth factor beta stimulus GO:0071560 13 0.047
positive regulation of macromolecule metabolic process GO:0010604 149 0.046
neuron projection development GO:0031175 187 0.046
Fly
regulation of phosphate metabolic process GO:0019220 81 0.045
stem cell proliferation GO:0072089 9 0.045
cellular macromolecular complex assembly GO:0034622 184 0.044
positive regulation of cellular process GO:0048522 332 0.043
single organism localization GO:1902578 518 0.043
negative regulation of signal transduction GO:0009968 60 0.042
protein complex biogenesis GO:0070271 186 0.042
pattern specification process GO:0007389 59 0.041
regulation of anatomical structure morphogenesis GO:0022603 51 0.041
synaptic growth at neuromuscular junction GO:0051124 1 0.040
neurotransmitter transport GO:0006836 32 0.040
small molecule metabolic process GO:0044281 186 0.039
neuromuscular junction development GO:0007528 2 0.039
response to external stimulus GO:0009605 289 0.038
spicule insertion GO:0034609 2 0.038
regulation of cell death GO:0010941 65 0.038
meiotic cell cycle GO:0051321 335 0.038
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.037
mitotic cell cycle process GO:1903047 194 0.037
negative regulation of nucleic acid templated transcription GO:1903507 53 0.037
posttranscriptional regulation of gene expression GO:0010608 166 0.036
intraspecies interaction between organisms GO:0051703 3 0.036
regulation of cell communication GO:0010646 176 0.035
chromosome organization GO:0051276 104 0.035
Mouse
aromatic compound catabolic process GO:0019439 116 0.035
germ cell development GO:0007281 351 0.035
protein complex assembly GO:0006461 186 0.034
localization of cell GO:0051674 313 0.034
epithelium development GO:0060429 68 0.034
regulation of nematode larval development GO:0061062 260 0.033
regulation of intracellular signal transduction GO:1902531 77 0.033
nucleobase containing small molecule metabolic process GO:0055086 115 0.032
negative regulation of rna metabolic process GO:0051253 53 0.032
nucleoside phosphate metabolic process GO:0006753 108 0.032
negative regulation of cellular protein metabolic process GO:0032269 27 0.032
aging GO:0007568 812 0.032
regulation of vulval development GO:0040028 248 0.032
negative regulation of signaling GO:0023057 61 0.031
organ morphogenesis GO:0009887 67 0.031
system process GO:0003008 136 0.031
sterol transport GO:0015918 4 0.031
regulation of mapk cascade GO:0043408 23 0.030
organic acid metabolic process GO:0006082 47 0.030
regulation of nuclear division GO:0051783 115 0.030
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.029
homeostatic process GO:0042592 51 0.028
negative regulation of vulval development GO:0040027 206 0.027
axon guidance GO:0007411 82 0.027
cell fate commitment GO:0045165 139 0.027
transcription dna templated GO:0006351 168 0.027
Human
lipid metabolic process GO:0006629 77 0.027
cell type specific apoptotic process GO:0097285 4 0.027
skeletal muscle organ development GO:0060538 3 0.026
synapse organization GO:0050808 24 0.026
synaptic transmission GO:0007268 106 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.026
negative regulation of nematode larval development GO:0061064 208 0.026
regulation of cell cycle process GO:0010564 145 0.025
negative regulation of transcription dna templated GO:0045892 53 0.025
molting cycle GO:0042303 281 0.024
g protein coupled receptor signaling pathway GO:0007186 46 0.024
adult behavior GO:0030534 3 0.024
cellular response to growth factor stimulus GO:0071363 18 0.024
stress activated mapk cascade GO:0051403 10 0.024
Human
negative regulation of rna biosynthetic process GO:1902679 53 0.023
regulation of nervous system development GO:0051960 41 0.023
carbohydrate derivative metabolic process GO:1901135 141 0.023
organic substance catabolic process GO:1901575 294 0.022
actomyosin structure organization GO:0031032 154 0.022
regulation of neurotransmitter levels GO:0001505 36 0.022
stem cell differentiation GO:0048863 7 0.021
cell migration GO:0016477 306 0.021
regulation of post embryonic development GO:0048580 260 0.021
positive regulation of proteasomal protein catabolic process GO:1901800 1 0.021
regulation of programmed cell death GO:0043067 50 0.021
single organism carbohydrate metabolic process GO:0044723 29 0.021
tube morphogenesis GO:0035239 79 0.020
stress activated protein kinase signaling cascade GO:0031098 10 0.020
Human
regulation of nucleocytoplasmic transport GO:0046822 3 0.020
organonitrogen compound metabolic process GO:1901564 151 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.020
regulation of cell cycle GO:0051726 194 0.020
nuclear migration GO:0007097 54 0.019
response to transforming growth factor beta GO:0071559 13 0.019
regulation of phosphorus metabolic process GO:0051174 81 0.019
regulation of bmp signaling pathway GO:0030510 3 0.019
regulation of lipid metabolic process GO:0019216 4 0.019
regulation of cell development GO:0060284 49 0.019
cellular macromolecule localization GO:0070727 75 0.019
positive regulation of neuron differentiation GO:0045666 4 0.019
regulation of catalytic activity GO:0050790 78 0.019
organ growth GO:0035265 5 0.018
muscle structure development GO:0061061 191 0.018
purine nucleotide metabolic process GO:0006163 95 0.018
positive regulation of neuron projection development GO:0010976 4 0.018
taxis GO:0042330 128 0.018
response to other organism GO:0051707 101 0.018
cellular response to dna damage stimulus GO:0006974 41 0.018
regulation of cellular protein metabolic process GO:0032268 75 0.018
negative regulation of bmp signaling pathway GO:0030514 1 0.018
meiotic nuclear division GO:0007126 300 0.018
cellular catabolic process GO:0044248 199 0.017
regulation of cell fate commitment GO:0010453 22 0.017
locomotory behavior GO:0007626 40 0.017
nucleotide metabolic process GO:0009117 108 0.017
cell substrate adhesion GO:0031589 1 0.016
single organism biosynthetic process GO:0044711 91 0.016
oxoacid metabolic process GO:0043436 47 0.016
response to growth factor GO:0070848 18 0.016
regulation of organ morphogenesis GO:2000027 4 0.016
sensory organ morphogenesis GO:0090596 2 0.016
positive regulation of catalytic activity GO:0043085 59 0.016
carboxylic acid metabolic process GO:0019752 34 0.015
regulation of cellular response to stress GO:0080135 19 0.015
negative regulation of post embryonic development GO:0048581 208 0.015
embryonic morphogenesis GO:0048598 152 0.015
organophosphate metabolic process GO:0019637 125 0.015
transforming growth factor beta receptor signaling pathway GO:0007179 13 0.015
regulation of meiosis GO:0040020 94 0.015
response to fungus GO:0009620 20 0.015
regulation of transport GO:0051049 91 0.014
epithelial tube morphogenesis GO:0060562 1 0.014
regulation of neurotransmitter secretion GO:0046928 16 0.014
response to abiotic stimulus GO:0009628 152 0.014
cell cell signaling GO:0007267 118 0.014
regulation of molecular function GO:0065009 89 0.014
carbohydrate derivative biosynthetic process GO:1901137 46 0.014
oogenesis GO:0048477 229 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
canonical wnt signaling pathway GO:0060070 3 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
actin filament based process GO:0030029 191 0.013
chemical homeostasis GO:0048878 29 0.013
response to external biotic stimulus GO:0043207 101 0.013
organelle localization GO:0051640 127 0.013
regulation of cellular catabolic process GO:0031329 51 0.013
muscle system process GO:0003012 43 0.013
regulation of cell division GO:0051302 142 0.013
rho protein signal transduction GO:0007266 2 0.013
chromatin remodeling GO:0006338 2 0.012
posttranscriptional gene silencing by rna GO:0035194 143 0.012
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.012
signal transduction by phosphorylation GO:0023014 31 0.012
macromolecule catabolic process GO:0009057 202 0.012
regulation of hydrolase activity GO:0051336 45 0.012
regulation of apoptotic process GO:0042981 36 0.012
positive regulation of cell differentiation GO:0045597 8 0.012
negative regulation of apoptotic process GO:0043066 17 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
cellular protein complex assembly GO:0043623 178 0.012
regulation of protein metabolic process GO:0051246 81 0.012
glycosyl compound metabolic process GO:1901657 100 0.012
negative regulation of developmental process GO:0051093 227 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.011
purine ribonucleotide metabolic process GO:0009150 95 0.011
female gamete generation GO:0007292 254 0.011
rna interference GO:0016246 137 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.011
negative regulation of response to external stimulus GO:0032102 3 0.011
spermatogenesis GO:0007283 41 0.011
Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
long term memory GO:0007616 2 0.011
regulation of localization GO:0032879 194 0.011
jnk cascade GO:0007254 8 0.011
Human
cellular nitrogen compound catabolic process GO:0044270 119 0.011
regulation of protein stability GO:0031647 3 0.011
striated muscle myosin thick filament assembly GO:0071688 138 0.011
response to wounding GO:0009611 4 0.011
Fly
gene silencing by rna GO:0031047 143 0.011
regulation of synapse assembly GO:0051963 2 0.011
regulation of mitotic cell cycle GO:0007346 76 0.011
regulation of catabolic process GO:0009894 57 0.010
regulation of cell morphogenesis GO:0022604 40 0.010
specification of axis polarity GO:0065001 13 0.010
nematode male tail tip morphogenesis GO:0045138 77 0.010
secretion GO:0046903 147 0.010
mitotic nuclear division GO:0007067 89 0.010
response to uv c GO:0010225 3 0.010
cellular amino acid metabolic process GO:0006520 15 0.010

dlk-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.042
cancer DOID:162 0 0.042
disease of cellular proliferation DOID:14566 0 0.042
organ system cancer DOID:0050686 0 0.042
disease of anatomical entity DOID:7 0 0.038
disease of metabolism DOID:0014667 0 0.019
large intestine cancer DOID:5672 0 0.017
intestinal cancer DOID:10155 0 0.017