Caenorhabditis elegans

63 known processes

unc-18 (CELE_F27D9.1)

Protein UNC-18

unc-18 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sexual reproduction GO:0019953 546 0.617
Fly
transport GO:0006810 1093 0.589
embryo development ending in birth or egg hatching GO:0009792 2992 0.414
embryo development GO:0009790 3052 0.368
Fly
gamete generation GO:0007276 461 0.350
Fly
single organism reproductive process GO:0044702 1196 0.322
Fly
establishment of localization GO:0051234 1171 0.322
taxis GO:0042330 128 0.305
multicellular organismal reproductive process GO:0048609 815 0.303
Fly
multi organism reproductive process GO:0044703 867 0.280
Fly
cell projection morphogenesis GO:0048858 148 0.261
Mouse
response to chemical GO:0042221 356 0.252
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.230
Fly
regulation of macromolecule biosynthetic process GO:0010556 189 0.223
developmental process involved in reproduction GO:0003006 1165 0.216
Fly
multicellular organism reproduction GO:0032504 819 0.215
Fly
germ cell development GO:0007281 351 0.214
Fly
response to external stimulus GO:0009605 289 0.205
single organism transport GO:0044765 447 0.204
cell development GO:0048468 696 0.193
Mouse Fly
regulation of developmental process GO:0050793 684 0.192
Fly
regulation of biological quality GO:0065008 741 0.184
aging GO:0007568 812 0.170
growth GO:0040007 562 0.162
determination of adult lifespan GO:0008340 812 0.155
regulation of metabolic process GO:0019222 478 0.147
multicellular organismal aging GO:0010259 812 0.138
regulation of multicellular organismal process GO:0051239 726 0.137
Fly
cilium morphogenesis GO:0060271 33 0.134
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.130
Mouse
regulation of macromolecule metabolic process GO:0060255 421 0.126
single organism localization GO:1902578 518 0.122
cell morphogenesis involved in differentiation GO:0000904 112 0.120
Mouse
locomotion GO:0040011 1634 0.117
localization of cell GO:0051674 313 0.114
macromolecule localization GO:0033036 771 0.114
Human Fly
hermaphrodite genitalia development GO:0040035 734 0.113
dendrite development GO:0016358 42 0.109
positive regulation of developmental process GO:0051094 408 0.108
organ development GO:0048513 1102 0.101
cell morphogenesis GO:0000902 163 0.101
Mouse
regulation of nematode larval development GO:0061062 260 0.100
head development GO:0060322 1 0.100
response to osmotic stress GO:0006970 29 0.097
nervous system development GO:0007399 253 0.092
Mouse
gene expression GO:0010467 412 0.091
cellular nitrogen compound catabolic process GO:0044270 119 0.089
response to wounding GO:0009611 4 0.089
Human
vesicle mediated transport GO:0016192 852 0.086
development of primary sexual characteristics GO:0045137 840 0.085
regulation of biosynthetic process GO:0009889 189 0.085
positive regulation of signaling GO:0023056 66 0.083
post embryonic organ development GO:0048569 336 0.083
cytoskeleton dependent intracellular transport GO:0030705 19 0.081
chemotaxis GO:0006935 120 0.080
cellular catabolic process GO:0044248 199 0.079
regulation of cell communication GO:0010646 176 0.076
programmed cell death GO:0012501 500 0.076
Mouse
negative regulation of biological process GO:0048519 567 0.076
Mouse
vulval development GO:0040025 333 0.076
post embryonic development GO:0009791 2152 0.075
multicellular organism growth GO:0035264 385 0.074
lipid storage GO:0019915 565 0.074
neuron development GO:0048666 199 0.073
Mouse
positive regulation of growth GO:0045927 369 0.073
maintenance of location GO:0051235 580 0.072
establishment of localization in cell GO:0051649 318 0.072
lipid localization GO:0010876 573 0.069
generation of neurons GO:0048699 235 0.068
Mouse
female gamete generation GO:0007292 254 0.068
Fly
response to temperature stimulus GO:0009266 66 0.067
genitalia development GO:0048806 741 0.067
regulation of developmental growth GO:0048638 389 0.066
cellular protein localization GO:0034613 75 0.066
Human
macromolecule biosynthetic process GO:0009059 250 0.063
cellular component movement GO:0006928 388 0.063
regulation of growth GO:0040008 409 0.062
ribonucleoside triphosphate metabolic process GO:0009199 87 0.062
single organism behavior GO:0044708 83 0.060
sex differentiation GO:0007548 909 0.060
carbohydrate derivative catabolic process GO:1901136 82 0.059
cell cell signaling GO:0007267 118 0.059
multi organism behavior GO:0051705 389 0.059
regulation of cellular protein metabolic process GO:0032268 75 0.059
death GO:0016265 547 0.059
Mouse
negative regulation of vulval development GO:0040027 206 0.058
calcium mediated signaling GO:0019722 3 0.058
cellular localization GO:0051641 360 0.058
positive regulation of cell morphogenesis involved in differentiation GO:0010770 4 0.057
positive regulation of multicellular organism growth GO:0040018 352 0.057
organ morphogenesis GO:0009887 67 0.056
transcription from rna polymerase ii promoter GO:0006366 149 0.056
purine nucleoside metabolic process GO:0042278 92 0.056
regulation of signal transduction GO:0009966 135 0.054
molting cycle GO:0042303 281 0.054
ribonucleoprotein complex assembly GO:0022618 4 0.053
organelle organization GO:0006996 783 0.053
Mouse
negative regulation of post embryonic development GO:0048581 208 0.053
receptor mediated endocytosis GO:0006898 715 0.052
multi multicellular organism process GO:0044706 390 0.052
axon guidance GO:0007411 82 0.051
lipid metabolic process GO:0006629 77 0.051
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.051
regulation of cellular metabolic process GO:0031323 305 0.051
behavior GO:0007610 527 0.049
nucleobase containing compound catabolic process GO:0034655 114 0.049
detection of external stimulus GO:0009581 4 0.049
embryonic body morphogenesis GO:0010172 49 0.049
organic substance catabolic process GO:1901575 294 0.049
axonogenesis GO:0007409 102 0.049
Mouse
cellular component morphogenesis GO:0032989 318 0.048
Mouse
nucleic acid metabolic process GO:0090304 299 0.048
purine containing compound catabolic process GO:0072523 75 0.048
positive regulation of cellular process GO:0048522 332 0.046
sensory organ morphogenesis GO:0090596 2 0.046
positive regulation of metabolic process GO:0009893 187 0.046
anatomical structure formation involved in morphogenesis GO:0048646 250 0.046
carbohydrate derivative metabolic process GO:1901135 141 0.045
protein localization GO:0008104 205 0.045
Human
positive regulation of gene expression GO:0010628 112 0.045
nucleoside triphosphate metabolic process GO:0009141 87 0.045
nucleoside catabolic process GO:0009164 78 0.045
mating behavior GO:0007617 32 0.045
positive regulation of developmental growth GO:0048639 354 0.045
aromatic compound catabolic process GO:0019439 116 0.044
endocytosis GO:0006897 819 0.044
Mouse
regulation of localization GO:0032879 194 0.044
regulation of post embryonic development GO:0048580 260 0.043
response to abiotic stimulus GO:0009628 152 0.042
Fly
regulation of multicellular organism growth GO:0040014 373 0.042
cellular macromolecule localization GO:0070727 75 0.042
Human Fly
turning behavior involved in mating GO:0034607 12 0.042
positive regulation of macromolecule metabolic process GO:0010604 149 0.041
carboxylic acid metabolic process GO:0019752 34 0.041
cell migration GO:0016477 306 0.041
negative regulation of developmental process GO:0051093 227 0.041
secretion by cell GO:0032940 138 0.040
regulation of response to wounding GO:1903034 1 0.040
regulation of phosphate metabolic process GO:0019220 81 0.040
macromolecule catabolic process GO:0009057 202 0.040
regulation of protein metabolic process GO:0051246 81 0.040
negative regulation of gene expression GO:0010629 217 0.040
carbohydrate metabolic process GO:0005975 34 0.040
developmental growth GO:0048589 412 0.040
positive regulation of multicellular organismal process GO:0051240 417 0.040
microtubule based process GO:0007017 182 0.039
organic substance transport GO:0071702 113 0.039
membrane organization GO:0061024 135 0.038
Human
cell cycle GO:0007049 526 0.038
Fly
catabolic process GO:0009056 318 0.038
intracellular signal transduction GO:0035556 96 0.038
negative regulation of cellular process GO:0048523 239 0.038
Mouse
ribonucleoside metabolic process GO:0009119 98 0.037
small molecule metabolic process GO:0044281 186 0.037
negative regulation of nematode larval development GO:0061064 208 0.036
establishment of organelle localization GO:0051656 123 0.036
reproductive behavior GO:0019098 387 0.036
single organism catabolic process GO:0044712 129 0.036
regulation of gene expression GO:0010468 366 0.035
cilium assembly GO:0042384 28 0.035
regulation of transport GO:0051049 91 0.035
reproductive structure development GO:0048608 850 0.035
purine nucleoside triphosphate metabolic process GO:0009144 87 0.035
neuron projection morphogenesis GO:0048812 114 0.035
Mouse
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.035
cellular protein metabolic process GO:0044267 279 0.034
inductive cell migration GO:0040039 145 0.034
vesicle localization GO:0051648 24 0.034
neuron projection development GO:0031175 187 0.033
Mouse
ribonucleotide catabolic process GO:0009261 75 0.033
neuron projection extension GO:1990138 37 0.033
posttranscriptional regulation of gene expression GO:0010608 166 0.033
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.033
protein metabolic process GO:0019538 422 0.033
cell part morphogenesis GO:0032990 152 0.032
Mouse
nucleoside metabolic process GO:0009116 99 0.032
regulation of response to stimulus GO:0048583 243 0.031
sensory perception GO:0007600 27 0.031
ribonucleoside catabolic process GO:0042454 77 0.031
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.031
rna interference GO:0016246 137 0.031
positive regulation of cell migration GO:0030335 3 0.030
regulation of gene expression epigenetic GO:0040029 163 0.030
neuron differentiation GO:0030182 217 0.030
Mouse
oxoacid metabolic process GO:0043436 47 0.030
purine ribonucleoside metabolic process GO:0046128 92 0.030
neurogenesis GO:0022008 236 0.029
Mouse
biosynthetic process GO:0009058 323 0.029
multicellular organismal reproductive behavior GO:0033057 384 0.029
cell motility GO:0048870 313 0.029
nucleobase containing small molecule metabolic process GO:0055086 115 0.029
ras protein signal transduction GO:0007265 31 0.029
establishment of vesicle localization GO:0051650 23 0.029
muscle structure development GO:0061061 191 0.028
gonad development GO:0008406 840 0.028
establishment of protein localization to membrane GO:0090150 3 0.028
phosphate containing compound metabolic process GO:0006796 232 0.028
signal transduction GO:0007165 317 0.028
regulation of signaling GO:0023051 172 0.027
nucleotide catabolic process GO:0009166 77 0.027
positive regulation of cellular catabolic process GO:0031331 35 0.027
translation GO:0006412 37 0.027
positive regulation of phosphorylation GO:0042327 27 0.027
apoptotic process GO:0006915 478 0.027
Mouse
cellular macromolecule biosynthetic process GO:0034645 247 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.027
ribonucleoside triphosphate catabolic process GO:0009203 72 0.026
axon extension GO:0048675 37 0.026
gtp metabolic process GO:0046039 46 0.026
posttranscriptional gene silencing by rna GO:0035194 143 0.026
axon development GO:0061564 163 0.025
Mouse
regulation of translation GO:0006417 19 0.025
divalent inorganic cation transport GO:0072511 17 0.025
signaling GO:0023052 401 0.025
response to heat GO:0009408 50 0.025
microtubule based movement GO:0007018 33 0.024
phosphorylation GO:0016310 116 0.024
rna metabolic process GO:0016070 228 0.024
purine ribonucleotide metabolic process GO:0009150 95 0.024
response to inorganic substance GO:0010035 50 0.024
cellular response to stress GO:0033554 162 0.024
phosphorus metabolic process GO:0006793 232 0.024
regulation of behavior GO:0050795 97 0.024
organic substance biosynthetic process GO:1901576 323 0.024
purine ribonucleoside catabolic process GO:0046130 75 0.024
glycosyl compound metabolic process GO:1901657 100 0.024
protein modification process GO:0036211 207 0.024
single organism carbohydrate metabolic process GO:0044723 29 0.024
cellular response to organic substance GO:0071310 119 0.023
cellular protein modification process GO:0006464 207 0.023
activation of jun kinase activity GO:0007257 3 0.023
positive regulation of phosphorus metabolic process GO:0010562 56 0.023
cell type specific apoptotic process GO:0097285 4 0.023
Mouse
single organism intracellular transport GO:1902582 70 0.023
small gtpase mediated signal transduction GO:0007264 32 0.023
organophosphate metabolic process GO:0019637 125 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.023
cell cycle process GO:0022402 482 0.022
Fly
positive regulation of mapk cascade GO:0043410 14 0.022
regulation of cellular ketone metabolic process GO:0010565 3 0.022
regulation of phosphorus metabolic process GO:0051174 81 0.022
cell substrate adhesion GO:0031589 1 0.022
neuromuscular junction development GO:0007528 2 0.022
positive regulation of gtpase activity GO:0043547 28 0.022
cellular amine metabolic process GO:0044106 15 0.022
positive regulation of neuron differentiation GO:0045666 4 0.022
purine nucleotide catabolic process GO:0006195 75 0.022
organonitrogen compound metabolic process GO:1901564 151 0.022
epithelium development GO:0060429 68 0.022
positive regulation of protein kinase activity GO:0045860 18 0.021
cellular biosynthetic process GO:0044249 315 0.021
glycosyl compound catabolic process GO:1901658 79 0.021
multi organism reproductive behavior GO:0044705 387 0.021
nucleus localization GO:0051647 55 0.021
cellular amino acid metabolic process GO:0006520 15 0.021
regulation of primary metabolic process GO:0080090 292 0.021
organonitrogen compound catabolic process GO:1901565 90 0.021
protein localization to membrane GO:0072657 11 0.021
Human
heterocycle biosynthetic process GO:0018130 187 0.021
positive regulation of cellular metabolic process GO:0031325 178 0.021
protein complex subunit organization GO:0071822 280 0.020
neuron projection guidance GO:0097485 82 0.020
positive regulation of catalytic activity GO:0043085 59 0.020
regulation of cellular localization GO:0060341 42 0.020
single organism signaling GO:0044700 401 0.020
organic acid metabolic process GO:0006082 47 0.020
regulation of cellular biosynthetic process GO:0031326 189 0.020
regulation of cellular catabolic process GO:0031329 51 0.020
organelle assembly GO:0070925 214 0.020
regionalization GO:0003002 31 0.020
Fly
gene silencing by rna GO:0031047 143 0.019
positive regulation of jnk cascade GO:0046330 3 0.019
intracellular transport GO:0046907 77 0.019
heterocycle catabolic process GO:0046700 119 0.019
purine nucleotide metabolic process GO:0006163 95 0.019
oogenesis GO:0048477 229 0.019
Fly
cell projection organization GO:0030030 231 0.019
Mouse
macromolecule modification GO:0043412 218 0.019
regulation of nitrogen compound metabolic process GO:0051171 222 0.019
positive regulation of stress activated mapk cascade GO:0032874 3 0.019
regulation of cell cycle GO:0051726 194 0.019
cell proliferation GO:0008283 116 0.019
single organism cellular localization GO:1902580 72 0.018
Human Fly
macromolecular complex assembly GO:0065003 193 0.018
organic cyclic compound catabolic process GO:1901361 119 0.018
embryonic morphogenesis GO:0048598 152 0.018
segmentation GO:0035282 7 0.018
Fly
mating GO:0007618 34 0.018
gene silencing GO:0016458 143 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
regulation of rna metabolic process GO:0051252 173 0.018
positive regulation of signal transduction GO:0009967 40 0.018
defense response to bacterium GO:0042742 86 0.017
dauer larval development GO:0040024 92 0.017
organelle localization GO:0051640 127 0.017
axon extension involved in axon guidance GO:0048846 13 0.017
tissue morphogenesis GO:0048729 65 0.017
cell matrix adhesion GO:0007160 1 0.017
synaptic vesicle localization GO:0097479 22 0.017
regulation of organ morphogenesis GO:2000027 4 0.017
nucleoside phosphate metabolic process GO:0006753 108 0.017
organophosphate catabolic process GO:0046434 81 0.017
regulation of cell proliferation GO:0042127 105 0.017
cellular response to abiotic stimulus GO:0071214 4 0.017
negative regulation of metabolic process GO:0009892 240 0.017
homeostatic process GO:0042592 51 0.016
macromolecular complex subunit organization GO:0043933 320 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
regulation of mapk cascade GO:0043408 23 0.016
cellular lipid metabolic process GO:0044255 40 0.016
positive regulation of phosphate metabolic process GO:0045937 56 0.016
oviposition GO:0018991 364 0.016
cellular component assembly GO:0022607 293 0.016
Fly
regulation of cell cycle process GO:0010564 145 0.016
guanosine containing compound catabolic process GO:1901069 48 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.016
cellular nitrogen compound biosynthetic process GO:0044271 192 0.016
regulation of phosphorylation GO:0042325 45 0.016
amine metabolic process GO:0009308 15 0.016
positive regulation of transport GO:0051050 32 0.016
protein complex assembly GO:0006461 186 0.016
positive regulation of catabolic process GO:0009896 38 0.016
synaptic vesicle transport GO:0048489 21 0.015
pigmentation GO:0043473 2 0.015
nucleotide metabolic process GO:0009117 108 0.015
chemosensory behavior GO:0007635 33 0.015
cellular macromolecule catabolic process GO:0044265 73 0.015
developmental cell growth GO:0048588 39 0.015
dephosphorylation GO:0016311 17 0.015
integrin mediated signaling pathway GO:0007229 1 0.015
regulation of protein targeting GO:1903533 3 0.015
positive regulation of response to stimulus GO:0048584 55 0.015
regulation of synapse organization GO:0050807 9 0.015
gtp catabolic process GO:0006184 46 0.015
adult locomotory behavior GO:0008344 1 0.014
regulation of cellular component organization GO:0051128 248 0.014
Fly
epithelial tube morphogenesis GO:0060562 1 0.014
synaptic growth at neuromuscular junction GO:0051124 1 0.014
cellular response to hormone stimulus GO:0032870 14 0.014
engulfment of apoptotic cell GO:0043652 94 0.014
negative regulation of multicellular organismal process GO:0051241 236 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.014
posttranscriptional gene silencing GO:0016441 143 0.014
nucleobase containing compound metabolic process GO:0006139 406 0.014
cell death GO:0008219 547 0.014
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.014
detection of abiotic stimulus GO:0009582 4 0.014
response to metal ion GO:0010038 33 0.013
cellular macromolecular complex assembly GO:0034622 184 0.013
positive regulation of biosynthetic process GO:0009891 109 0.013
positive regulation of molecular function GO:0044093 61 0.013
establishment of cell polarity GO:0030010 46 0.013
nematode male tail tip morphogenesis GO:0045138 77 0.013
protein catabolic process GO:0030163 162 0.013
pattern specification process GO:0007389 59 0.013
Fly
cell fate commitment GO:0045165 139 0.013
organelle fission GO:0048285 363 0.013
nucleoside triphosphate catabolic process GO:0009143 72 0.013
regeneration GO:0031099 4 0.013
regulation of rna biosynthetic process GO:2001141 165 0.013
glycoprotein metabolic process GO:0009100 29 0.012
body morphogenesis GO:0010171 620 0.012
spindle localization GO:0051653 51 0.012
response to endogenous stimulus GO:0009719 33 0.012
ion transport GO:0006811 113 0.012
protein localization to organelle GO:0033365 37 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 12 0.012
secretion GO:0046903 147 0.012
single organism organelle organization GO:1902589 501 0.012
Mouse
positive regulation of rna metabolic process GO:0051254 103 0.012
regulation of synapse assembly GO:0051963 2 0.012
regulation of cell morphogenesis GO:0022604 40 0.012
p38mapk cascade GO:0038066 2 0.012
protein complex biogenesis GO:0070271 186 0.012
cell projection assembly GO:0030031 35 0.012
enzyme linked receptor protein signaling pathway GO:0007167 50 0.011
plasma membrane fusion GO:0045026 5 0.011
cell growth GO:0016049 44 0.011
establishment of synaptic vesicle localization GO:0097480 21 0.011
purine nucleoside catabolic process GO:0006152 75 0.011
tube morphogenesis GO:0035239 79 0.011
response to external biotic stimulus GO:0043207 101 0.011
purine nucleoside triphosphate catabolic process GO:0009146 72 0.011
immune response GO:0006955 192 0.011
cellular component biogenesis GO:0044085 297 0.011
Fly
peptidyl tyrosine phosphorylation GO:0018108 2 0.011
neuron projection extension involved in neuron projection guidance GO:1902284 13 0.011
negative regulation of cellular metabolic process GO:0031324 95 0.011
regulation of bmp signaling pathway GO:0030510 3 0.011
regulation of response to stress GO:0080134 28 0.011
microtubule based transport GO:0010970 19 0.011
bmp signaling pathway GO:0030509 3 0.011
regulation of hormone secretion GO:0046883 2 0.011
regulation of cellular response to stress GO:0080135 19 0.011
regulation of gtpase activity GO:0043087 30 0.011
locomotory behavior GO:0007626 40 0.011
monosaccharide metabolic process GO:0005996 2 0.010
negative regulation of macromolecule metabolic process GO:0010605 229 0.010
membrane invagination GO:0010324 98 0.010
peptidyl amino acid modification GO:0018193 58 0.010
positive regulation of cell projection organization GO:0031346 4 0.010
cytoskeleton organization GO:0007010 339 0.010
digestive tract development GO:0048565 122 0.010
single organism membrane organization GO:0044802 35 0.010
Human
regulation of purine nucleotide catabolic process GO:0033121 35 0.010
response to oxidative stress GO:0006979 42 0.010
phagocytosis engulfment GO:0006911 98 0.010
ribose phosphate metabolic process GO:0019693 99 0.010
positive regulation of stem cell differentiation GO:2000738 1 0.010
ubiquitin dependent protein catabolic process GO:0006511 32 0.010
actin cytoskeleton reorganization GO:0031532 4 0.010

unc-18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org