Caenorhabditis elegans

64 known processes

npl-4.2 (CELE_F59E12.5)

Protein NPL-4.2

npl-4.2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
establishment of localization GO:0051234 1171 0.848
locomotion GO:0040011 1634 0.783
protein catabolic process GO:0030163 162 0.776
misfolded or incompletely synthesized protein catabolic process GO:0006515 4 0.772
er associated misfolded protein catabolic process GO:0071712 4 0.744
post embryonic development GO:0009791 2152 0.742
aging GO:0007568 812 0.657
organelle organization GO:0006996 783 0.654
embryo development ending in birth or egg hatching GO:0009792 2992 0.631
ubiquitin dependent protein catabolic process GO:0006511 32 0.626
er associated ubiquitin dependent protein catabolic process GO:0030433 6 0.597
multicellular organismal aging GO:0010259 812 0.577
cellular response to misfolded protein GO:0071218 7 0.548
nucleobase containing compound metabolic process GO:0006139 406 0.524
determination of adult lifespan GO:0008340 812 0.495
catabolic process GO:0009056 318 0.492
reproductive system development GO:0061458 850 0.461
embryo development GO:0009790 3052 0.423
cellular response to chemical stimulus GO:0070887 129 0.419
cell cycle process GO:0022402 482 0.403
transport GO:0006810 1093 0.392
nucleic acid metabolic process GO:0090304 299 0.375
modification dependent macromolecule catabolic process GO:0043632 32 0.374
cellular response to stress GO:0033554 162 0.324
macromolecular complex subunit organization GO:0043933 320 0.320
modification dependent protein catabolic process GO:0019941 32 0.312
meiotic nuclear division GO:0007126 300 0.302
rna metabolic process GO:0016070 228 0.296
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 20 0.294
proteasomal protein catabolic process GO:0010498 20 0.293
proteolysis GO:0006508 61 0.291
meiotic cell cycle GO:0051321 335 0.284
cytoskeleton organization GO:0007010 339 0.262
proteolysis involved in cellular protein catabolic process GO:0051603 32 0.244
cellular catabolic process GO:0044248 199 0.244
cellular response to topologically incorrect protein GO:0035967 76 0.243
protein metabolic process GO:0019538 422 0.242
organ development GO:0048513 1102 0.236
multi organism reproductive process GO:0044703 867 0.235
single organism organelle organization GO:1902589 501 0.234
multicellular organism reproduction GO:0032504 819 0.230
cellular response to dna damage stimulus GO:0006974 41 0.230
cellular component assembly GO:0022607 293 0.224
cellular response to organic substance GO:0071310 119 0.205
rrna metabolic process GO:0016072 3 0.195
response to topologically incorrect protein GO:0035966 82 0.184
organelle fission GO:0048285 363 0.180
dna repair GO:0006281 23 0.179
organic substance catabolic process GO:1901575 294 0.164
regulation of metabolic process GO:0019222 478 0.162
sex differentiation GO:0007548 909 0.162
developmental process involved in reproduction GO:0003006 1165 0.160
receptor mediated endocytosis GO:0006898 715 0.150
cellular protein catabolic process GO:0044257 37 0.150
protein complex subunit organization GO:0071822 280 0.147
microtubule based process GO:0007017 182 0.147
gonad development GO:0008406 840 0.144
regulation of multicellular organismal process GO:0051239 726 0.142
cellular component biogenesis GO:0044085 297 0.141
cell cycle GO:0007049 526 0.136
macromolecular complex assembly GO:0065003 193 0.135
regulation of biological quality GO:0065008 741 0.135
single organism signaling GO:0044700 401 0.134
macromolecule catabolic process GO:0009057 202 0.131
macromolecule localization GO:0033036 771 0.130
germ cell development GO:0007281 351 0.129
gamete generation GO:0007276 461 0.125
signaling GO:0023052 401 0.119
multicellular organismal reproductive process GO:0048609 815 0.115
establishment of nucleus localization GO:0040023 55 0.115
ribosome biogenesis GO:0042254 4 0.115
protein complex biogenesis GO:0070271 186 0.113
pole plasm assembly GO:0007315 2 0.112
reproductive structure development GO:0048608 850 0.112
single organism reproductive process GO:0044702 1196 0.111
heterocycle biosynthetic process GO:0018130 187 0.111
cellular localization GO:0051641 360 0.110
development of primary sexual characteristics GO:0045137 840 0.107
establishment of localization in cell GO:0051649 318 0.106
regulation of localization GO:0032879 194 0.106
death GO:0016265 547 0.101
gene expression GO:0010467 412 0.100
hermaphrodite genitalia development GO:0040035 734 0.098
cellular protein metabolic process GO:0044267 279 0.098
single organism catabolic process GO:0044712 129 0.098
meiotic cell cycle process GO:1903046 170 0.090
cell death GO:0008219 547 0.089
mitotic spindle organization GO:0007052 81 0.089
organic cyclic compound catabolic process GO:1901361 119 0.088
positive regulation of cellular process GO:0048522 332 0.088
multicellular organismal reproductive behavior GO:0033057 384 0.087
genitalia development GO:0048806 741 0.086
negative regulation of biological process GO:0048519 567 0.080
protein complex assembly GO:0006461 186 0.079
single organism transport GO:0044765 447 0.077
programmed cell death GO:0012501 500 0.077
regulation of cellular metabolic process GO:0031323 305 0.077
phosphate containing compound metabolic process GO:0006796 232 0.076
cellular macromolecular complex assembly GO:0034622 184 0.073
endocytosis GO:0006897 819 0.073
protein localization GO:0008104 205 0.071
female gamete generation GO:0007292 254 0.071
regulation of macromolecule biosynthetic process GO:0010556 189 0.069
cellular macromolecule localization GO:0070727 75 0.068
response to chemical GO:0042221 356 0.067
organelle fusion GO:0048284 8 0.066
aromatic compound biosynthetic process GO:0019438 192 0.065
positive regulation of cellular metabolic process GO:0031325 178 0.065
positive regulation of growth GO:0045927 369 0.064
maintenance of location GO:0051235 580 0.064
lipid localization GO:0010876 573 0.062
cellular nitrogen compound biosynthetic process GO:0044271 192 0.061
regulation of gene expression GO:0010468 366 0.061
regulation of cellular component organization GO:0051128 248 0.061
muscle structure development GO:0061061 191 0.061
positive regulation of developmental growth GO:0048639 354 0.060
defense response GO:0006952 296 0.060
mitotic cell cycle process GO:1903047 194 0.059
cellular macromolecule catabolic process GO:0044265 73 0.057
response to organic substance GO:0010033 131 0.055
regulation of rna metabolic process GO:0051252 173 0.055
lipid storage GO:0019915 565 0.054
regulation of growth GO:0040008 409 0.054
positive regulation of metabolic process GO:0009893 187 0.052
vesicle mediated transport GO:0016192 852 0.052
nucleobase containing compound biosynthetic process GO:0034654 184 0.052
regulation of developmental process GO:0050793 684 0.051
negative regulation of gene expression GO:0010629 217 0.051
oogenesis GO:0048477 229 0.050
negative regulation of cellular process GO:0048523 239 0.050
intracellular signal transduction GO:0035556 96 0.049
regulation of gene expression epigenetic GO:0040029 163 0.049
regulation of primary metabolic process GO:0080090 292 0.048
regulation of nucleic acid templated transcription GO:1903506 165 0.048
cellular component morphogenesis GO:0032989 318 0.048
growth GO:0040007 562 0.048
chromosome organization GO:0051276 104 0.046
signal transduction GO:0007165 317 0.046
regulation of cell communication GO:0010646 176 0.045
regulation of response to stimulus GO:0048583 243 0.045
response to endoplasmic reticulum stress GO:0034976 71 0.045
rna biosynthetic process GO:0032774 169 0.045
cellular biosynthetic process GO:0044249 315 0.044
organelle assembly GO:0070925 214 0.044
cell cell signaling GO:0007267 118 0.044
developmental growth GO:0048589 412 0.043
heterocycle catabolic process GO:0046700 119 0.043
macromolecule biosynthetic process GO:0009059 250 0.043
regulation of developmental growth GO:0048638 389 0.042
cellular protein complex assembly GO:0043623 178 0.042
actin cytoskeleton organization GO:0030036 184 0.041
regulation of multicellular organism growth GO:0040014 373 0.041
response to external stimulus GO:0009605 289 0.040
cellular protein localization GO:0034613 75 0.039
cell development GO:0048468 696 0.039
small molecule metabolic process GO:0044281 186 0.039
negative regulation of metabolic process GO:0009892 240 0.038
establishment of organelle localization GO:0051656 123 0.037
sexual reproduction GO:0019953 546 0.037
transcription from rna polymerase ii promoter GO:0006366 149 0.037
single organism localization GO:1902578 518 0.036
purine ribonucleotide metabolic process GO:0009150 95 0.036
rna localization GO:0006403 3 0.036
nucleic acid templated transcription GO:0097659 169 0.036
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 1 0.035
reproductive behavior GO:0019098 387 0.035
spindle organization GO:0007051 92 0.035
nucleobase containing compound catabolic process GO:0034655 114 0.035
positive regulation of developmental process GO:0051094 408 0.034
regulation of signal transduction GO:0009966 135 0.034
regulation of catabolic process GO:0009894 57 0.034
single organism intracellular transport GO:1902582 70 0.033
positive regulation of multicellular organism growth GO:0040018 352 0.033
single fertilization GO:0007338 61 0.033
negative regulation of cellular metabolic process GO:0031324 95 0.032
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.032
oocyte construction GO:0007308 2 0.031
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.031
pronuclear migration GO:0035046 51 0.031
striated muscle cell development GO:0055002 157 0.031
body morphogenesis GO:0010171 620 0.030
vulval development GO:0040025 333 0.030
negative regulation of rna metabolic process GO:0051253 53 0.029
regulation of nitrogen compound metabolic process GO:0051171 222 0.029
positive regulation of macromolecule metabolic process GO:0010604 149 0.029
negative regulation of macromolecule metabolic process GO:0010605 229 0.029
immune response GO:0006955 192 0.029
oocyte axis specification GO:0007309 2 0.029
cellular macromolecule biosynthetic process GO:0034645 247 0.029
regulation of organelle organization GO:0033043 164 0.028
negative regulation of cellular biosynthetic process GO:0031327 65 0.028
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.027
organic substance transport GO:0071702 113 0.027
organonitrogen compound metabolic process GO:1901564 151 0.027
regulation of apoptotic signaling pathway GO:2001233 1 0.027
centrosomal and pronuclear rotation GO:0035047 6 0.026
phosphorus metabolic process GO:0006793 232 0.026
nuclear migration GO:0007097 54 0.026
regulation of cellular catabolic process GO:0031329 51 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.026
chromosome segregation GO:0007059 180 0.026
regulation of transcription dna templated GO:0006355 164 0.025
homeostatic process GO:0042592 51 0.025
cell type specific apoptotic process GO:0097285 4 0.025
protein localization to organelle GO:0033365 37 0.025
chromatin modification GO:0016568 32 0.024
aromatic compound catabolic process GO:0019439 116 0.024
nucleus localization GO:0051647 55 0.024
protein oligomerization GO:0051259 4 0.024
muscle cell development GO:0055001 158 0.024
meiotic chromosome segregation GO:0045132 139 0.024
actin filament based process GO:0030029 191 0.024
neurotransmitter secretion GO:0007269 26 0.024
positive regulation of multicellular organismal process GO:0051240 417 0.024
ribonucleotide metabolic process GO:0009259 99 0.024
regulation of signaling GO:0023051 172 0.024
response to abiotic stimulus GO:0009628 152 0.023
fertilization GO:0009566 63 0.023
oxidation reduction process GO:0055114 59 0.023
macromolecule modification GO:0043412 218 0.023
response to external biotic stimulus GO:0043207 101 0.023
transcription dna templated GO:0006351 168 0.023
purine nucleoside triphosphate metabolic process GO:0009144 87 0.023
negative regulation of rna biosynthetic process GO:1902679 53 0.023
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.022
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.022
dna metabolic process GO:0006259 74 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.022
regulation of macromolecule metabolic process GO:0060255 421 0.021
multi organism reproductive behavior GO:0044705 387 0.021
biosynthetic process GO:0009058 323 0.021
gene silencing by rna GO:0031047 143 0.021
nervous system development GO:0007399 253 0.021
oocyte differentiation GO:0009994 45 0.021
actomyosin structure organization GO:0031032 154 0.021
negative regulation of developmental process GO:0051093 227 0.020
cellular protein modification process GO:0006464 207 0.020
myosin filament organization GO:0031033 138 0.020
behavior GO:0007610 527 0.020
mrna metabolic process GO:0016071 31 0.020
protein dna complex assembly GO:0065004 7 0.020
head development GO:0060322 1 0.020
rna processing GO:0006396 34 0.020
multicellular organism growth GO:0035264 385 0.019
striated muscle cell differentiation GO:0051146 158 0.019
anterior posterior pattern specification GO:0009952 27 0.019
regulation of intracellular signal transduction GO:1902531 77 0.018
negative regulation of vulval development GO:0040027 206 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.018
embryonic pattern specification GO:0009880 21 0.018
muscle cell differentiation GO:0042692 171 0.018
myofibril assembly GO:0030239 154 0.018
secretion by cell GO:0032940 138 0.018
striated muscle myosin thick filament assembly GO:0071688 138 0.018
regulation of multicellular organismal development GO:2000026 317 0.018
cellular component assembly involved in morphogenesis GO:0010927 183 0.018
negative regulation of nucleic acid templated transcription GO:1903507 53 0.018
rna interference GO:0016246 137 0.018
protein modification process GO:0036211 207 0.017
response to biotic stimulus GO:0009607 101 0.017
organic cyclic compound biosynthetic process GO:1901362 195 0.017
regulation of cell death GO:0010941 65 0.017
positive regulation of chromosome organization GO:2001252 2 0.017
myosin filament assembly GO:0031034 138 0.016
positive regulation of rna biosynthetic process GO:1902680 102 0.016
anatomical structure formation involved in morphogenesis GO:0048646 250 0.016
response to other organism GO:0051707 101 0.016
negative regulation of signaling GO:0023057 61 0.016
positive regulation of transcription dna templated GO:0045893 102 0.016
collagen and cuticulin based cuticle development GO:0040002 99 0.016
regulation of cell division GO:0051302 142 0.016
negative regulation of gene expression epigenetic GO:0045814 2 0.016
cell division GO:0051301 262 0.016
multi multicellular organism process GO:0044706 390 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.015
molting cycle GO:0042303 281 0.015
phosphorylation GO:0016310 116 0.015
multi organism behavior GO:0051705 389 0.015
rna catabolic process GO:0006401 21 0.015
histone modification GO:0016570 30 0.015
negative regulation of programmed cell death GO:0043069 19 0.014
generation of neurons GO:0048699 235 0.014
regulation of protein localization GO:0032880 50 0.014
posttranscriptional regulation of gene expression GO:0010608 166 0.014
nucleobase containing small molecule metabolic process GO:0055086 115 0.014
covalent chromatin modification GO:0016569 30 0.014
cell proliferation GO:0008283 116 0.014
organophosphate metabolic process GO:0019637 125 0.014
male gamete generation GO:0048232 41 0.014
protein transport GO:0015031 45 0.014
organonitrogen compound catabolic process GO:1901565 90 0.014
regulation of meiotic cell cycle GO:0051445 136 0.014
response to bacterium GO:0009617 86 0.014
protein modification by small protein conjugation or removal GO:0070647 40 0.014
nucleoside triphosphate metabolic process GO:0009141 87 0.014
defense response to bacterium GO:0042742 86 0.013
cellular ketone metabolic process GO:0042180 14 0.013
rrna processing GO:0006364 3 0.013
protein refolding GO:0042026 1 0.013
intracellular receptor signaling pathway GO:0030522 2 0.013
positive regulation of catabolic process GO:0009896 38 0.013
regulation of nuclear division GO:0051783 115 0.013
negative regulation of response to stimulus GO:0048585 73 0.013
regulation of protein catabolic process GO:0042176 13 0.013
nucleotide metabolic process GO:0009117 108 0.013
intracellular transport GO:0046907 77 0.013
nucleoside phosphate metabolic process GO:0006753 108 0.013
regulation of rna biosynthetic process GO:2001141 165 0.013
membrane organization GO:0061024 135 0.012
mitotic nuclear division GO:0007067 89 0.012
double strand break repair GO:0006302 5 0.012
regulation of apoptotic process GO:0042981 36 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.012
gene silencing GO:0016458 143 0.012
negative regulation of neurogenesis GO:0050768 4 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
posttranscriptional gene silencing by rna GO:0035194 143 0.012
sister chromatid segregation GO:0000819 46 0.012
amine metabolic process GO:0009308 15 0.012
oviposition GO:0018991 364 0.012
regulation of cellular localization GO:0060341 42 0.011
negative regulation of cellular component organization GO:0051129 33 0.011
chromatin organization GO:0006325 32 0.011
oxoacid metabolic process GO:0043436 47 0.011
golgi vesicle transport GO:0048193 3 0.011
cellular response to nutrient levels GO:0031669 13 0.011
negative regulation of multicellular organismal process GO:0051241 236 0.011
regulation of chromatin modification GO:1903308 2 0.011
establishment of protein localization GO:0045184 50 0.011
regulation of meiosis GO:0040020 94 0.011
carboxylic acid metabolic process GO:0019752 34 0.011
regulation of cell proliferation GO:0042127 105 0.011
neuron apoptotic process GO:0051402 4 0.011
positive regulation of cellular component organization GO:0051130 34 0.011
nucleoside metabolic process GO:0009116 99 0.011
ribonucleoprotein complex assembly GO:0022618 4 0.011
neuromuscular junction development GO:0007528 2 0.011
purine nucleoside metabolic process GO:0042278 92 0.010
apoptotic process GO:0006915 478 0.010
negative regulation of nematode larval development GO:0061064 208 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 43 0.010
regulation of cell cycle process GO:0010564 145 0.010
macromolecular complex disassembly GO:0032984 20 0.010

npl-4.2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012