Caenorhabditis elegans

108 known processes

nhr-49 (CELE_K10C3.6)

Protein NHR-49

nhr-49 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of nucleic acid templated transcription GO:1903508 102 0.994
rna biosynthetic process GO:0032774 169 0.990
heterocycle biosynthetic process GO:0018130 187 0.983
positive regulation of rna biosynthetic process GO:1902680 102 0.982
positive regulation of rna metabolic process GO:0051254 103 0.979
positive regulation of transcription dna templated GO:0045893 102 0.978
organic cyclic compound biosynthetic process GO:1901362 195 0.970
nucleic acid templated transcription GO:0097659 169 0.966
regulation of rna biosynthetic process GO:2001141 165 0.954
regulation of transcription dna templated GO:0006355 164 0.947
regulation of nucleic acid templated transcription GO:1903506 165 0.936
transcription dna templated GO:0006351 168 0.931
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.930
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.928
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.926
transcription from rna polymerase ii promoter GO:0006366 149 0.916
nucleobase containing compound biosynthetic process GO:0034654 184 0.915
cellular nitrogen compound biosynthetic process GO:0044271 192 0.911
positive regulation of cellular biosynthetic process GO:0031328 109 0.907
regulation of rna metabolic process GO:0051252 173 0.900
positive regulation of macromolecule metabolic process GO:0010604 149 0.876
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.872
regulation of nitrogen compound metabolic process GO:0051171 222 0.861
aromatic compound biosynthetic process GO:0019438 192 0.830
positive regulation of biosynthetic process GO:0009891 109 0.823
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.804
regulation of gene expression GO:0010468 366 0.791
regulation of cellular biosynthetic process GO:0031326 189 0.779
nucleic acid metabolic process GO:0090304 299 0.730
rna metabolic process GO:0016070 228 0.729
establishment of localization GO:0051234 1171 0.694
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.685
gene expression GO:0010467 412 0.665
positive regulation of gene expression GO:0010628 112 0.604
regulation of macromolecule metabolic process GO:0060255 421 0.596
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.592
nucleobase containing compound metabolic process GO:0006139 406 0.576
muscle tissue development GO:0060537 1 0.563
Mouse
regulation of macromolecule biosynthetic process GO:0010556 189 0.549
organic substance biosynthetic process GO:1901576 323 0.543
cellular biosynthetic process GO:0044249 315 0.532
positive regulation of metabolic process GO:0009893 187 0.526
regulation of biosynthetic process GO:0009889 189 0.475
embryo development GO:0009790 3052 0.409
monocarboxylic acid metabolic process GO:0032787 22 0.408
cellular macromolecule biosynthetic process GO:0034645 247 0.386
multicellular organism reproduction GO:0032504 819 0.380
Mouse
oxoacid metabolic process GO:0043436 47 0.379
positive regulation of cellular metabolic process GO:0031325 178 0.329
post embryonic development GO:0009791 2152 0.327
embryo development ending in birth or egg hatching GO:0009792 2992 0.298
macromolecule biosynthetic process GO:0009059 250 0.276
single organism signaling GO:0044700 401 0.267
Human Zebrafish Mouse
body morphogenesis GO:0010171 620 0.259
biosynthetic process GO:0009058 323 0.257
negative regulation of biological process GO:0048519 567 0.254
Human Zebrafish Mouse
signaling GO:0023052 401 0.242
Human Zebrafish Mouse
developmental process involved in reproduction GO:0003006 1165 0.223
Mouse
multi organism reproductive process GO:0044703 867 0.223
Mouse
cell fate commitment GO:0045165 139 0.216
Human Zebrafish
organic acid metabolic process GO:0006082 47 0.197
vesicle mediated transport GO:0016192 852 0.193
regulation of metabolic process GO:0019222 478 0.192
regulation of multicellular organismal development GO:2000026 317 0.188
Mouse
regulation of biological quality GO:0065008 741 0.184
transport GO:0006810 1093 0.180
determination of adult lifespan GO:0008340 812 0.177
wnt signaling pathway GO:0016055 27 0.174
endocytosis GO:0006897 819 0.170
sexual reproduction GO:0019953 546 0.169
Mouse
negative regulation of developmental process GO:0051093 227 0.160
neuron projection guidance GO:0097485 82 0.156
regulation of primary metabolic process GO:0080090 292 0.154
regulation of developmental process GO:0050793 684 0.153
Mouse
negative regulation of nematode larval development GO:0061064 208 0.147
multicellular organismal reproductive process GO:0048609 815 0.135
Mouse
regulation of neuron differentiation GO:0045664 40 0.131
lipid localization GO:0010876 573 0.124
positive regulation of developmental process GO:0051094 408 0.120
skeletal muscle organ development GO:0060538 3 0.110
Mouse
regulation of cell differentiation GO:0045595 81 0.110
negative regulation of macromolecule metabolic process GO:0010605 229 0.105
Human Zebrafish Mouse
macromolecule localization GO:0033036 771 0.103
regulation of cellular metabolic process GO:0031323 305 0.102
vulval development GO:0040025 333 0.099
small molecule metabolic process GO:0044281 186 0.098
cell migration GO:0016477 306 0.095
Human Mouse
cellular lipid metabolic process GO:0044255 40 0.094
organ development GO:0048513 1102 0.094
Mouse
receptor mediated endocytosis GO:0006898 715 0.094
regulation of lipid metabolic process GO:0019216 4 0.093
female gamete generation GO:0007292 254 0.091
taxis GO:0042330 128 0.091
lipid metabolic process GO:0006629 77 0.091
regulation of developmental growth GO:0048638 389 0.090
oocyte differentiation GO:0009994 45 0.089
motor neuron axon guidance GO:0008045 13 0.088
regulation of post embryonic development GO:0048580 260 0.088
behavior GO:0007610 527 0.087
cytoskeleton organization GO:0007010 339 0.082
lipid storage GO:0019915 565 0.082
aging GO:0007568 812 0.082
maintenance of location GO:0051235 580 0.081
reproductive behavior GO:0019098 387 0.080
cell development GO:0048468 696 0.080
Mouse
chemotaxis GO:0006935 120 0.077
regulation of multicellular organismal process GO:0051239 726 0.077
Human Mouse
chromatin modification GO:0016568 32 0.075
negative regulation of gene expression GO:0010629 217 0.075
Human Zebrafish Mouse
multi multicellular organism process GO:0044706 390 0.074
Mouse
regulation of filopodium assembly GO:0051489 2 0.074
oviposition GO:0018991 364 0.073
multi organism reproductive behavior GO:0044705 387 0.072
localization of cell GO:0051674 313 0.072
Human Mouse
single organism reproductive process GO:0044702 1196 0.069
Mouse
canonical wnt signaling pathway GO:0060070 3 0.069
regulation of reproductive process GO:2000241 66 0.067
Mouse
chromosome organization GO:0051276 104 0.066
regulation of cell projection organization GO:0031344 38 0.065
multicellular organismal aging GO:0010259 812 0.064
establishment of localization in cell GO:0051649 318 0.064
Mouse
oogenesis GO:0048477 229 0.064
striated muscle cell differentiation GO:0051146 158 0.063
Mouse
innate immune response GO:0045087 190 0.062
defense response GO:0006952 296 0.062
cellular catabolic process GO:0044248 199 0.061
macromolecular complex assembly GO:0065003 193 0.061
Human Mouse
regeneration GO:0031099 4 0.060
neuron projection morphogenesis GO:0048812 114 0.060
macromolecular complex subunit organization GO:0043933 320 0.059
Human Mouse
growth GO:0040007 562 0.058
Human Mouse
regulation of vulval development GO:0040028 248 0.058
positive regulation of multicellular organism growth GO:0040018 352 0.058
gamete generation GO:0007276 461 0.058
negative regulation of vulval development GO:0040027 206 0.057
neuron differentiation GO:0030182 217 0.057
Mouse
multicellular organism growth GO:0035264 385 0.057
cellular protein metabolic process GO:0044267 279 0.057
Human Mouse
regulation of multicellular organism growth GO:0040014 373 0.056
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.055
catabolic process GO:0009056 318 0.054
Fly
positive regulation of cellular process GO:0048522 332 0.054
positive regulation of multicellular organismal process GO:0051240 417 0.054
cellular response to stress GO:0033554 162 0.051
positive regulation of growth GO:0045927 369 0.051
post embryonic organ development GO:0048569 336 0.050
negative regulation of post embryonic development GO:0048581 208 0.050
regulation of cell migration GO:0030334 55 0.048
Human
negative regulation of transcription dna templated GO:0045892 53 0.047
Human Zebrafish Mouse
response to wounding GO:0009611 4 0.046
Human
generation of neurons GO:0048699 235 0.046
Mouse
regulation of neurogenesis GO:0050767 40 0.046
negative regulation of cellular metabolic process GO:0031324 95 0.046
Human Zebrafish Mouse
cell motility GO:0048870 313 0.045
Human Mouse
regulation of nematode larval development GO:0061062 260 0.045
nervous system development GO:0007399 253 0.045
Mouse
regulation of locomotion GO:0040012 161 0.045
Human
neurogenesis GO:0022008 236 0.045
Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.045
protein catabolic process GO:0030163 162 0.044
regulation of response to stimulus GO:0048583 243 0.044
developmental growth GO:0048589 412 0.044
axonogenesis GO:0007409 102 0.044
carboxylic acid metabolic process GO:0019752 34 0.044
negative regulation of nucleic acid templated transcription GO:1903507 53 0.043
Human Zebrafish Mouse
reproductive system development GO:0061458 850 0.043
Mouse
positive regulation of developmental growth GO:0048639 354 0.043
regulation of synapse assembly GO:0051963 2 0.043
multicellular organismal reproductive behavior GO:0033057 384 0.042
muscle cell differentiation GO:0042692 171 0.042
Mouse
cellular component morphogenesis GO:0032989 318 0.042
signal transduction GO:0007165 317 0.041
Human Zebrafish Mouse
regulation of neuron projection development GO:0010975 31 0.041
histone modification GO:0016570 30 0.041
negative regulation of multicellular organismal process GO:0051241 236 0.041
Human
macromolecule catabolic process GO:0009057 202 0.041
regulation of multi organism process GO:0043900 69 0.041
protein localization GO:0008104 205 0.041
response to chemical GO:0042221 356 0.040
Human Zebrafish Mouse
posttranscriptional regulation of gene expression GO:0010608 166 0.040
Mouse
autophagy GO:0006914 29 0.040
neuron projection development GO:0031175 187 0.039
locomotion GO:0040011 1634 0.039
gene silencing GO:0016458 143 0.039
covalent chromatin modification GO:0016569 30 0.039
axon development GO:0061564 163 0.039
regulation of apoptotic signaling pathway GO:2001233 1 0.038
cellular ketone metabolic process GO:0042180 14 0.038
intracellular transport GO:0046907 77 0.037
cell death GO:0008219 547 0.037
dendrite development GO:0016358 42 0.036
single organism transport GO:0044765 447 0.036
Mouse
negative regulation of metabolic process GO:0009892 240 0.036
Human Zebrafish Mouse
multi organism behavior GO:0051705 389 0.036
axon guidance GO:0007411 82 0.035
programmed cell death GO:0012501 500 0.034
anatomical structure formation involved in morphogenesis GO:0048646 250 0.034
regulation of cell projection assembly GO:0060491 3 0.034
system process GO:0003008 136 0.033
Mouse
peptidyl amino acid modification GO:0018193 58 0.033
symbiosis encompassing mutualism through parasitism GO:0044403 5 0.033
Human
regulation of intracellular signal transduction GO:1902531 77 0.033
germ cell development GO:0007281 351 0.033
regulation of nervous system development GO:0051960 41 0.031
single organism localization GO:1902578 518 0.031
Mouse
chromatin organization GO:0006325 32 0.031
response to external stimulus GO:0009605 289 0.031
Mouse
death GO:0016265 547 0.030
positive regulation of neurogenesis GO:0050769 4 0.030
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.030
response to abiotic stimulus GO:0009628 152 0.030
Mouse
small gtpase mediated signal transduction GO:0007264 32 0.030
negative regulation of rna biosynthetic process GO:1902679 53 0.030
Human Zebrafish Mouse
regulation of localization GO:0032879 194 0.030
Human Mouse
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.029
sex differentiation GO:0007548 909 0.029
Mouse
cell projection organization GO:0030030 231 0.029
ras protein signal transduction GO:0007265 31 0.029
development of primary sexual characteristics GO:0045137 840 0.029
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.028
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.028
Human Mouse
hermaphrodite genitalia development GO:0040035 734 0.028
organonitrogen compound metabolic process GO:1901564 151 0.028
Human
lamellipodium assembly GO:0030032 2 0.027
cell morphogenesis GO:0000902 163 0.027
organelle fission GO:0048285 363 0.027
protein metabolic process GO:0019538 422 0.027
Human Mouse
regulation of growth GO:0040008 409 0.026
Human
membrane organization GO:0061024 135 0.026
molting cycle GO:0042303 281 0.026
genitalia development GO:0048806 741 0.026
cuticle development GO:0042335 100 0.026
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.026
Human Zebrafish Mouse
glycosyl compound metabolic process GO:1901657 100 0.026
regulation of epithelial cell proliferation GO:0050678 1 0.025
Human
organelle localization GO:0051640 127 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
collagen and cuticulin based cuticle development GO:0040002 99 0.025
tube morphogenesis GO:0035239 79 0.024
Mouse
response to bacterium GO:0009617 86 0.024
oocyte development GO:0048599 44 0.024
cell part morphogenesis GO:0032990 152 0.024
cellular protein complex assembly GO:0043623 178 0.024
cellular component movement GO:0006928 388 0.023
Human Mouse
neuron development GO:0048666 199 0.023
Mouse
regulation of cell development GO:0060284 49 0.022
inductive cell migration GO:0040039 145 0.022
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.022
cellular protein localization GO:0034613 75 0.022
tissue morphogenesis GO:0048729 65 0.022
Mouse
chromatin remodeling GO:0006338 2 0.022
single organism catabolic process GO:0044712 129 0.021
Fly
negative regulation of cellular process GO:0048523 239 0.021
Human Zebrafish Mouse
cellular localization GO:0051641 360 0.021
Mouse
dna templated transcription elongation GO:0006354 1 0.021
negative regulation of biosynthetic process GO:0009890 65 0.021
Human Zebrafish Mouse
positive regulation of chromosome organization GO:2001252 2 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
peptidyl serine modification GO:0018209 20 0.021
energy derivation by oxidation of organic compounds GO:0015980 14 0.021
cell cycle process GO:0022402 482 0.020
muscle system process GO:0003012 43 0.020
sensory organ morphogenesis GO:0090596 2 0.020
muscle cell development GO:0055001 158 0.020
regulation of catabolic process GO:0009894 57 0.020
carbohydrate biosynthetic process GO:0016051 4 0.020
response to acid chemical GO:0001101 4 0.020
Human Zebrafish Mouse
regulation of cell motility GO:2000145 57 0.020
Human
cell proliferation GO:0008283 116 0.020
Human Mouse
immune response GO:0006955 192 0.020
negative regulation of cellular biosynthetic process GO:0031327 65 0.019
Human Zebrafish Mouse
response to external biotic stimulus GO:0043207 101 0.019
cell cell signaling GO:0007267 118 0.019
Mouse
regulation of behavior GO:0050795 97 0.019
epithelial cell proliferation GO:0050673 1 0.019
Human
amine metabolic process GO:0009308 15 0.019
response to other organism GO:0051707 101 0.019
striated muscle cell development GO:0055002 157 0.019
negative regulation of rna metabolic process GO:0051253 53 0.019
Human Zebrafish Mouse
regulation of protein metabolic process GO:0051246 81 0.019
Human Mouse
tube development GO:0035295 126 0.018
Mouse
cellular component biogenesis GO:0044085 297 0.018
Human Mouse
positive regulation of signal transduction GO:0009967 40 0.018
internal peptidyl lysine acetylation GO:0018393 3 0.018
regulation of cellular response to stress GO:0080135 19 0.018
filopodium assembly GO:0046847 2 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 32 0.018
engulfment of apoptotic cell GO:0043652 94 0.018
gonad development GO:0008406 840 0.018
cellular amine metabolic process GO:0044106 15 0.017
regulation of response to wounding GO:1903034 1 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.017
Human Zebrafish Mouse
regulation of canonical wnt signaling pathway GO:0060828 1 0.017
cellular response to abiotic stimulus GO:0071214 4 0.017
intracellular receptor signaling pathway GO:0030522 2 0.017
Human Zebrafish Mouse
regulation of cell adhesion GO:0030155 6 0.017
regulation of cell communication GO:0010646 176 0.017
Mouse
regulation of gene expression epigenetic GO:0040029 163 0.017
protein complex biogenesis GO:0070271 186 0.017
Human Mouse
actin filament based process GO:0030029 191 0.017
enzyme linked receptor protein signaling pathway GO:0007167 50 0.017
Mouse
cellular component assembly GO:0022607 293 0.017
Human Mouse
protein complex subunit organization GO:0071822 280 0.017
Human Mouse
regulation of fibroblast growth factor receptor signaling pathway GO:0040036 2 0.016
cell morphogenesis involved in differentiation GO:0000904 112 0.016
protein modification process GO:0036211 207 0.016
Human
muscle contraction GO:0006936 43 0.016
negative regulation of locomotion GO:0040013 21 0.016
Human
positive regulation of post embryonic development GO:0048582 54 0.016
interspecies interaction between organisms GO:0044419 5 0.016
Human
muscle structure development GO:0061061 191 0.016
Mouse
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 2 0.016
membrane invagination GO:0010324 98 0.016
reproductive structure development GO:0048608 850 0.016
Mouse
regulation of lipid biosynthetic process GO:0046890 1 0.016
positive regulation of cell migration GO:0030335 3 0.016
myosin filament organization GO:0031033 138 0.016
apoptotic cell clearance GO:0043277 111 0.015
regulation of oviposition GO:0046662 43 0.015
regulation of cellular component movement GO:0051270 62 0.015
Human
apoptotic process GO:0006915 478 0.015
proteolysis GO:0006508 61 0.015
positive regulation of transcription from rna polymerase ii promoter involved in defense response to gram negative bacterium GO:1902097 4 0.015
defense response to bacterium GO:0042742 86 0.015
spindle organization GO:0007051 92 0.015
cell surface receptor signaling pathway GO:0007166 149 0.015
Mouse
myofibril assembly GO:0030239 154 0.015
tissue development GO:0009888 112 0.015
Human Zebrafish Mouse
single organism organelle organization GO:1902589 501 0.015
regulation of response to stress GO:0080134 28 0.014
phagocytosis engulfment GO:0006911 98 0.014
posttranscriptional gene silencing by rna GO:0035194 143 0.014
phosphate containing compound metabolic process GO:0006796 232 0.014
Human
negative regulation of neurogenesis GO:0050768 4 0.014
response to mechanical stimulus GO:0009612 28 0.014
cellular amino acid metabolic process GO:0006520 15 0.014
Human
regulation of dna templated transcription in response to stress GO:0043620 3 0.014
phosphorylation GO:0016310 116 0.014
Human
response to oxidative stress GO:0006979 42 0.013
cellular macromolecule catabolic process GO:0044265 73 0.013
cellular component assembly involved in morphogenesis GO:0010927 183 0.013
positive regulation of vulval development GO:0040026 52 0.013
actin filament bundle assembly GO:0051017 3 0.013
regulation of histone modification GO:0031056 1 0.013
fatty acid metabolic process GO:0006631 16 0.013
dauer larval development GO:0040024 92 0.013
male sex differentiation GO:0046661 86 0.013
regulation of cell proliferation GO:0042127 105 0.013
Human
regulation of signaling GO:0023051 172 0.013
Mouse
myosin filament assembly GO:0031034 138 0.013
protein complex assembly GO:0006461 186 0.013
Human Mouse
synaptic growth at neuromuscular junction GO:0051124 1 0.012
transmembrane transport GO:0055085 110 0.012
defense response to other organism GO:0098542 100 0.012
epithelial tube morphogenesis GO:0060562 1 0.012
microtubule based process GO:0007017 182 0.012
cell cycle GO:0007049 526 0.012
Human
digestive system development GO:0055123 122 0.012
Mouse
regulation of signal transduction GO:0009966 135 0.012
positive regulation of cellular component organization GO:0051130 34 0.012
regulation of transport GO:0051049 91 0.012
Mouse
gene silencing by rna GO:0031047 143 0.012
striated muscle myosin thick filament assembly GO:0071688 138 0.012
bmp signaling pathway GO:0030509 3 0.012
negative regulation of response to external stimulus GO:0032102 3 0.012
pigmentation GO:0043473 2 0.011
regulation of nucleocytoplasmic transport GO:0046822 3 0.011
regulation of lamellipodium assembly GO:0010591 1 0.011
muscle organ morphogenesis GO:0048644 4 0.011
Mouse
rna interference GO:0016246 137 0.011
regulation of molecular function GO:0065009 89 0.011
Human
establishment of protein localization to membrane GO:0090150 3 0.011
actomyosin structure organization GO:0031032 154 0.011
organic substance catabolic process GO:1901575 294 0.011
Fly
positive regulation of epithelial cell proliferation GO:0050679 1 0.011
positive regulation of organelle organization GO:0010638 18 0.011
g protein coupled receptor signaling pathway GO:0007186 46 0.011
regulation of protein stability GO:0031647 3 0.011
negative regulation of response to stimulus GO:0048585 73 0.011
cellular macromolecule localization GO:0070727 75 0.011
single organism biosynthetic process GO:0044711 91 0.011
lamellipodium organization GO:0097581 2 0.011
posttranscriptional gene silencing GO:0016441 143 0.011
somatic muscle development GO:0007525 1 0.011
cellular response to chemical stimulus GO:0070887 129 0.011
Human Mouse
notch signaling pathway GO:0007219 22 0.010
response to biotic stimulus GO:0009607 101 0.010
regulation of muscle contraction GO:0006937 20 0.010
peptidyl serine phosphorylation GO:0018105 20 0.010
regulation of chromatin modification GO:1903308 2 0.010
biological adhesion GO:0022610 21 0.010
axonal fasciculation GO:0007413 79 0.010
locomotory behavior GO:0007626 40 0.010
cellular macromolecular complex assembly GO:0034622 184 0.010
ubiquitin dependent protein catabolic process GO:0006511 32 0.010
secondary metabolic process GO:0019748 3 0.010
synaptic transmission GO:0007268 106 0.010
modification of morphology or physiology of other organism GO:0035821 2 0.010
Human
protein localization to organelle GO:0033365 37 0.010

nhr-49 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.026
disease of anatomical entity DOID:7 0 0.018
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011