Caenorhabditis elegans

26 known processes

cls-3 (CELE_ZC84.3)

Protein CLS-3

cls-3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.541
post embryonic development GO:0009791 2152 0.525
developmental process involved in reproduction GO:0003006 1165 0.489
Fly
organ development GO:0048513 1102 0.448
Fly
hermaphrodite genitalia development GO:0040035 734 0.416
gonad development GO:0008406 840 0.383
development of primary sexual characteristics GO:0045137 840 0.382
reproductive system development GO:0061458 850 0.360
single organism reproductive process GO:0044702 1196 0.313
Fly
vulval development GO:0040025 333 0.285
locomotion GO:0040011 1634 0.264
Mouse Worm Fly
sex differentiation GO:0007548 909 0.231
embryo development ending in birth or egg hatching GO:0009792 2992 0.229
regulation of vulval development GO:0040028 248 0.222
endocytosis GO:0006897 819 0.203
regulation of nematode larval development GO:0061062 260 0.198
sexual reproduction GO:0019953 546 0.196
Fly
multicellular organismal reproductive process GO:0048609 815 0.195
Fly
genitalia development GO:0048806 741 0.188
reproductive structure development GO:0048608 850 0.176
positive regulation of developmental process GO:0051094 408 0.160
Worm
determination of adult lifespan GO:0008340 812 0.148
positive regulation of cellular process GO:0048522 332 0.147
gene expression GO:0010467 412 0.144
aging GO:0007568 812 0.139
transport GO:0006810 1093 0.132
Worm
signal transduction GO:0007165 317 0.130
Fly
receptor mediated endocytosis GO:0006898 715 0.127
nucleic acid metabolic process GO:0090304 299 0.122
regulation of gene expression GO:0010468 366 0.122
regulation of biological quality GO:0065008 741 0.120
Human Worm Fly
gamete generation GO:0007276 461 0.120
Fly
programmed cell death GO:0012501 500 0.116
cell development GO:0048468 696 0.109
Fly
multicellular organism reproduction GO:0032504 819 0.108
Fly
post embryonic organ development GO:0048569 336 0.107
defense response GO:0006952 296 0.107
regulation of multicellular organism growth GO:0040014 373 0.105
Worm
nucleobase containing compound metabolic process GO:0006139 406 0.104
regulation of multicellular organismal process GO:0051239 726 0.104
Worm
regulation of metabolic process GO:0019222 478 0.101
regulation of macromolecule metabolic process GO:0060255 421 0.099
negative regulation of vulval development GO:0040027 206 0.097
response to chemical GO:0042221 356 0.095
Fly
multicellular organism growth GO:0035264 385 0.093
Worm
negative regulation of gene expression GO:0010629 217 0.093
positive regulation of developmental growth GO:0048639 354 0.093
Worm
positive regulation of multicellular organismal process GO:0051240 417 0.092
Worm
body morphogenesis GO:0010171 620 0.091
developmental growth GO:0048589 412 0.089
Worm
vesicle mediated transport GO:0016192 852 0.086
regulation of cell cycle GO:0051726 194 0.083
Fly
biosynthetic process GO:0009058 323 0.079
cell death GO:0008219 547 0.073
multicellular organismal aging GO:0010259 812 0.073
macromolecule localization GO:0033036 771 0.072
Human Worm Fly
cellular localization GO:0051641 360 0.072
Human Worm Fly
regulation of post embryonic development GO:0048580 260 0.072
positive regulation of multicellular organism growth GO:0040018 352 0.072
Worm
aromatic compound biosynthetic process GO:0019438 192 0.071
signaling GO:0023052 401 0.068
Fly
regulation of developmental process GO:0050793 684 0.068
Worm Fly
negative regulation of multicellular organismal process GO:0051241 236 0.068
maintenance of location GO:0051235 580 0.067
Human Worm Fly
multicellular organismal reproductive behavior GO:0033057 384 0.067
regulation of gene expression epigenetic GO:0040029 163 0.066
organelle organization GO:0006996 783 0.066
establishment of localization GO:0051234 1171 0.065
Worm Fly
innate immune response GO:0045087 190 0.064
digestive system development GO:0055123 122 0.064
negative regulation of biological process GO:0048519 567 0.064
Mouse Fly
cell proliferation GO:0008283 116 0.064
localization of cell GO:0051674 313 0.063
Mouse Fly
negative regulation of developmental process GO:0051093 227 0.062
Fly
protein metabolic process GO:0019538 422 0.062
behavior GO:0007610 527 0.062
lipid localization GO:0010876 573 0.061
growth GO:0040007 562 0.060
Worm
lipid storage GO:0019915 565 0.059
negative regulation of response to stimulus GO:0048585 73 0.059
Fly
positive regulation of cellular biosynthetic process GO:0031328 109 0.059
response to external stimulus GO:0009605 289 0.058
Fly
macromolecule biosynthetic process GO:0009059 250 0.057
meiotic cell cycle GO:0051321 335 0.056
negative regulation of nematode larval development GO:0061064 208 0.056
negative regulation of metabolic process GO:0009892 240 0.055
negative regulation of cellular metabolic process GO:0031324 95 0.055
negative regulation of macromolecule metabolic process GO:0010605 229 0.054
apoptotic process GO:0006915 478 0.054
cell cycle process GO:0022402 482 0.053
regulation of growth GO:0040008 409 0.053
Worm
positive regulation of growth GO:0045927 369 0.052
Worm
death GO:0016265 547 0.052
multi organism behavior GO:0051705 389 0.051
female gamete generation GO:0007292 254 0.050
Fly
organic substance biosynthetic process GO:1901576 323 0.049
cellular protein metabolic process GO:0044267 279 0.049
regulation of cell cycle process GO:0010564 145 0.049
Fly
cellular macromolecule biosynthetic process GO:0034645 247 0.048
protein complex subunit organization GO:0071822 280 0.047
Human Mouse Worm Fly
cell motility GO:0048870 313 0.047
Mouse Fly
single organism localization GO:1902578 518 0.046
Human Worm Fly
catabolic process GO:0009056 318 0.046
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.045
generation of neurons GO:0048699 235 0.043
Fly
cell surface receptor signaling pathway GO:0007166 149 0.043
oviposition GO:0018991 364 0.043
neuron differentiation GO:0030182 217 0.043
Fly
cell migration GO:0016477 306 0.042
Mouse Fly
regulation of nucleic acid templated transcription GO:1903506 165 0.041
head development GO:0060322 1 0.041
regulation of developmental growth GO:0048638 389 0.040
Worm
macromolecular complex subunit organization GO:0043933 320 0.040
Human Mouse Worm Fly
cellular biosynthetic process GO:0044249 315 0.040
immune response GO:0006955 192 0.040
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.040
intracellular signal transduction GO:0035556 96 0.039
Fly
mitotic cell cycle process GO:1903047 194 0.039
phosphate containing compound metabolic process GO:0006796 232 0.038
single organism organelle organization GO:1902589 501 0.038
meiotic nuclear division GO:0007126 300 0.038
regulation of multicellular organismal development GO:2000026 317 0.038
positive regulation of biosynthetic process GO:0009891 109 0.037
rna metabolic process GO:0016070 228 0.037
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.036
Fly
glycosyl compound metabolic process GO:1901657 100 0.036
germ cell development GO:0007281 351 0.035
Fly
posttranscriptional regulation of gene expression GO:0010608 166 0.034
organelle fission GO:0048285 363 0.034
transcription dna templated GO:0006351 168 0.034
multi multicellular organism process GO:0044706 390 0.034
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.033
cellular response to stress GO:0033554 162 0.033
reproductive behavior GO:0019098 387 0.033
negative regulation of post embryonic development GO:0048581 208 0.033
response to biotic stimulus GO:0009607 101 0.033
cell cycle GO:0007049 526 0.032
organelle assembly GO:0070925 214 0.032
Fly
striated muscle cell differentiation GO:0051146 158 0.032
neurogenesis GO:0022008 236 0.032
Fly
nucleic acid templated transcription GO:0097659 169 0.031
negative regulation of cellular process GO:0048523 239 0.031
Mouse Fly
posttranscriptional gene silencing GO:0016441 143 0.031
cellular component assembly GO:0022607 293 0.031
Human Fly
gene silencing by rna GO:0031047 143 0.031
protein complex biogenesis GO:0070271 186 0.031
Human Fly
phosphorus metabolic process GO:0006793 232 0.031
multi organism reproductive behavior GO:0044705 387 0.030
rna biosynthetic process GO:0032774 169 0.030
ribosome biogenesis GO:0042254 4 0.029
regulation of primary metabolic process GO:0080090 292 0.029
establishment of localization in cell GO:0051649 318 0.029
Worm Fly
rna interference GO:0016246 137 0.029
cellular component movement GO:0006928 388 0.029
Mouse Fly
regulation of signal transduction GO:0009966 135 0.029
Fly
nucleoside triphosphate catabolic process GO:0009143 72 0.029
regulation of cellular metabolic process GO:0031323 305 0.028
anatomical structure formation involved in morphogenesis GO:0048646 250 0.028
Fly
molting cycle GO:0042303 281 0.028
regulation of response to stimulus GO:0048583 243 0.028
Fly
epithelial cell proliferation GO:0050673 1 0.028
regulation of cellular biosynthetic process GO:0031326 189 0.028
protein modification process GO:0036211 207 0.027
cell type specific apoptotic process GO:0097285 4 0.027
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.027
organonitrogen compound metabolic process GO:1901564 151 0.027
oogenesis GO:0048477 229 0.027
Fly
multi organism reproductive process GO:0044703 867 0.027
Fly
regulation of biosynthetic process GO:0009889 189 0.027
response to other organism GO:0051707 101 0.026
gene silencing GO:0016458 143 0.026
negative regulation of transcription dna templated GO:0045892 53 0.026
response to abiotic stimulus GO:0009628 152 0.026
regulation of macromolecule biosynthetic process GO:0010556 189 0.026
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.026
regulation of intracellular signal transduction GO:1902531 77 0.025
Fly
positive regulation of vulval development GO:0040026 52 0.025
actomyosin structure organization GO:0031032 154 0.024
cytoskeleton organization GO:0007010 339 0.024
Human Mouse Worm Fly
single organism cellular localization GO:1902580 72 0.024
Fly
regulation of transcription dna templated GO:0006355 164 0.024
regulation of signaling GO:0023051 172 0.024
Fly
regulation of rna metabolic process GO:0051252 173 0.024
regulation of epithelial cell proliferation GO:0050678 1 0.023
cellular component biogenesis GO:0044085 297 0.023
Human Fly
cellular nitrogen compound biosynthetic process GO:0044271 192 0.023
nucleobase containing compound biosynthetic process GO:0034654 184 0.023
posttranscriptional gene silencing by rna GO:0035194 143 0.022
response to wounding GO:0009611 4 0.022
negative regulation of rna metabolic process GO:0051253 53 0.022
protein complex assembly GO:0006461 186 0.022
Human Fly
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.022
enzyme linked receptor protein signaling pathway GO:0007167 50 0.022
cellular component morphogenesis GO:0032989 318 0.021
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.021
regulation of cell proliferation GO:0042127 105 0.021
muscle cell differentiation GO:0042692 171 0.021
negative regulation of gene expression epigenetic GO:0045814 2 0.021
regeneration GO:0031099 4 0.020
muscle structure development GO:0061061 191 0.020
organic cyclic compound catabolic process GO:1901361 119 0.020
regulation of cell division GO:0051302 142 0.020
Fly
negative regulation of nucleic acid templated transcription GO:1903507 53 0.020
regulation of apoptotic signaling pathway GO:2001233 1 0.020
transcription from rna polymerase ii promoter GO:0006366 149 0.020
regulation of localization GO:0032879 194 0.020
phosphorylation GO:0016310 116 0.019
defense response to bacterium GO:0042742 86 0.019
protein localization GO:0008104 205 0.019
Human Worm Fly
rrna metabolic process GO:0016072 3 0.019
positive regulation of rna metabolic process GO:0051254 103 0.019
negative regulation of cellular biosynthetic process GO:0031327 65 0.018
aromatic compound catabolic process GO:0019439 116 0.018
mechanosensory behavior GO:0007638 25 0.018
regulation of nucleocytoplasmic transport GO:0046822 3 0.018
canonical wnt signaling pathway GO:0060070 3 0.018
regulation of rna biosynthetic process GO:2001141 165 0.018
striated muscle myosin thick filament assembly GO:0071688 138 0.018
cell projection organization GO:0030030 231 0.018
Fly
negative regulation of signal transduction GO:0009968 60 0.018
Fly
single organism transport GO:0044765 447 0.018
chemotaxis GO:0006935 120 0.017
Fly
cellular catabolic process GO:0044248 199 0.017
macromolecule catabolic process GO:0009057 202 0.017
response to external biotic stimulus GO:0043207 101 0.017
positive regulation of rna biosynthetic process GO:1902680 102 0.017
muscle cell development GO:0055001 158 0.017
macromolecular complex assembly GO:0065003 193 0.017
Human Fly
collagen and cuticulin based cuticle development GO:0040002 99 0.017
positive regulation of neurogenesis GO:0050769 4 0.016
inductive cell migration GO:0040039 145 0.016
negative regulation of biosynthetic process GO:0009890 65 0.016
positive regulation of transcription from rna polymerase ii promoter in response to osmotic stress GO:0061393 1 0.016
taxis GO:0042330 128 0.015
Fly
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.015
heterocycle catabolic process GO:0046700 119 0.015
organic cyclic compound biosynthetic process GO:1901362 195 0.015
myosin filament assembly GO:0031034 138 0.015
actin filament based process GO:0030029 191 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 16 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.015
regulation of cytoplasmic transport GO:1903649 3 0.015
striated muscle cell development GO:0055002 157 0.015
cellular response to chemical stimulus GO:0070887 129 0.015
negative regulation of signaling GO:0023057 61 0.015
Fly
cellular component assembly involved in morphogenesis GO:0010927 183 0.015
single organism signaling GO:0044700 401 0.015
Fly
defense response to gram negative bacterium GO:0050829 64 0.015
system process GO:0003008 136 0.014
purine nucleotide metabolic process GO:0006163 95 0.014
myofibril assembly GO:0030239 154 0.014
macromolecule modification GO:0043412 218 0.014
axonal fasciculation GO:0007413 79 0.014
actin cytoskeleton organization GO:0030036 184 0.014
adult behavior GO:0030534 3 0.014
regulation of nuclear division GO:0051783 115 0.014
Fly
organelle localization GO:0051640 127 0.014
Worm Fly
regulation of phosphate metabolic process GO:0019220 81 0.014
cellular macromolecular complex assembly GO:0034622 184 0.013
Human
myosin filament organization GO:0031033 138 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.013
cell division GO:0051301 262 0.013
Worm Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.013
nucleoside triphosphate metabolic process GO:0009141 87 0.013
regulation of nitrogen compound metabolic process GO:0051171 222 0.013
positive regulation of gene expression GO:0010628 112 0.013
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.013
defense response to other organism GO:0098542 100 0.013
purine ribonucleoside metabolic process GO:0046128 92 0.013
dna metabolic process GO:0006259 74 0.013
ribose phosphate metabolic process GO:0019693 99 0.013
cellular protein localization GO:0034613 75 0.013
Human Worm Fly
negative regulation of cell communication GO:0010648 61 0.013
Fly
cellular protein modification process GO:0006464 207 0.013
regulation of cell differentiation GO:0045595 81 0.012
Fly
single organism behavior GO:0044708 83 0.012
sensory organ morphogenesis GO:0090596 2 0.012
dauer larval development GO:0040024 92 0.012
nucleoside phosphate metabolic process GO:0006753 108 0.012
microtubule based process GO:0007017 182 0.012
Human Mouse Worm Fly
ras protein signal transduction GO:0007265 31 0.012
Fly
establishment of organelle localization GO:0051656 123 0.012
Worm Fly
intracellular transport GO:0046907 77 0.012
Worm
response to topologically incorrect protein GO:0035966 82 0.012
organic substance transport GO:0071702 113 0.012
regulation of meiotic cell cycle GO:0051445 136 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.012
homeostatic process GO:0042592 51 0.012
cellular protein complex assembly GO:0043623 178 0.012
Human
regulation of cell communication GO:0010646 176 0.012
Fly
carboxylic acid metabolic process GO:0019752 34 0.011
cell cycle g1 s phase transition GO:0044843 2 0.011
protein oligomerization GO:0051259 4 0.011
digestive tract development GO:0048565 122 0.011
response to endoplasmic reticulum stress GO:0034976 71 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.011
nucleobase containing compound catabolic process GO:0034655 114 0.011
g1 s transition of mitotic cell cycle GO:0000082 2 0.011
small gtpase mediated signal transduction GO:0007264 32 0.011
Fly
phagocytosis GO:0006909 115 0.011
cellular response to dna damage stimulus GO:0006974 41 0.011
dna repair GO:0006281 23 0.011
positive regulation of post embryonic development GO:0048582 54 0.011
regulation of protein import into nucleus GO:0042306 3 0.011
regulation of protein targeting GO:1903533 3 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.011
nervous system development GO:0007399 253 0.011
Fly
regulation of canonical wnt signaling pathway GO:0060828 1 0.011
positive regulation of nucleic acid templated transcription GO:1903508 102 0.011
response to inorganic substance GO:0010035 50 0.010
membrane organization GO:0061024 135 0.010
axonogenesis GO:0007409 102 0.010
Fly
muscle tissue development GO:0060537 1 0.010
cellular nitrogen compound catabolic process GO:0044270 119 0.010
heterocycle biosynthetic process GO:0018130 187 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.010
neuron projection development GO:0031175 187 0.010
Fly
cellular response to organic substance GO:0071310 119 0.010
regulation of cellular localization GO:0060341 42 0.010
response to acid chemical GO:0001101 4 0.010
regulation of muscle cell differentiation GO:0051147 1 0.010

cls-3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.013
disease of anatomical entity DOID:7 0 0.010