Caenorhabditis elegans

45 known processes

age-1 (CELE_B0334.8)

Protein AGE-1

age-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.740
multicellular organism reproduction GO:0032504 819 0.712
Fly
embryo development ending in birth or egg hatching GO:0009792 2992 0.689
post embryonic development GO:0009791 2152 0.679
locomotion GO:0040011 1634 0.572
establishment of localization GO:0051234 1171 0.569
Worm
single organism organelle organization GO:1902589 501 0.559
regulation of macromolecule metabolic process GO:0060255 421 0.495
Mouse Fly
neurogenesis GO:0022008 236 0.387
Zebrafish Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.382
Fly
cell projection organization GO:0030030 231 0.348
Zebrafish Fly
single organism reproductive process GO:0044702 1196 0.333
Fly
vesicle mediated transport GO:0016192 852 0.332
Worm
nervous system development GO:0007399 253 0.329
Zebrafish Fly
endocytosis GO:0006897 819 0.281
Worm
cell development GO:0048468 696 0.277
Zebrafish Fly
positive regulation of biosynthetic process GO:0009891 109 0.267
Fly
negative regulation of biological process GO:0048519 567 0.264
Human Mouse Fly
multi organism reproductive process GO:0044703 867 0.262
Fly
apoptotic process GO:0006915 478 0.260
Human Mouse
nucleic acid metabolic process GO:0090304 299 0.244
Mouse
negative regulation of macromolecule metabolic process GO:0010605 229 0.238
negative regulation of metabolic process GO:0009892 240 0.235
Fly
multicellular organismal reproductive process GO:0048609 815 0.233
Fly
death GO:0016265 547 0.224
Human Mouse
signaling GO:0023052 401 0.221
Mouse Fly
signal transduction GO:0007165 317 0.212
Mouse Fly
regulation of primary metabolic process GO:0080090 292 0.211
Mouse Fly
regulation of gene expression epigenetic GO:0040029 163 0.197
Mouse
organelle organization GO:0006996 783 0.195
Worm
gamete generation GO:0007276 461 0.190
Fly
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.190
Fly
female gamete generation GO:0007292 254 0.184
Fly
transport GO:0006810 1093 0.181
Worm
protein modification process GO:0036211 207 0.179
Mouse
organic substance biosynthetic process GO:1901576 323 0.163
Human Mouse Worm Fly
multicellular organismal aging GO:0010259 812 0.160
regulation of cellular metabolic process GO:0031323 305 0.157
Mouse Fly
neuron projection development GO:0031175 187 0.152
Zebrafish Fly
negative regulation of developmental process GO:0051093 227 0.150
heterocycle biosynthetic process GO:0018130 187 0.143
cellular macromolecule biosynthetic process GO:0034645 247 0.140
Fly
cell death GO:0008219 547 0.139
Human Mouse
regulation of gene expression GO:0010468 366 0.136
Mouse Fly
single organism transport GO:0044765 447 0.134
Worm
cellular protein modification process GO:0006464 207 0.133
Mouse
sex differentiation GO:0007548 909 0.133
negative regulation of nematode larval development GO:0061064 208 0.132
biosynthetic process GO:0009058 323 0.131
Human Mouse Worm Fly
regulation of cellular biosynthetic process GO:0031326 189 0.130
Fly
negative regulation of gene expression GO:0010629 217 0.129
negative regulation of vulval development GO:0040027 206 0.125
cell cycle GO:0007049 526 0.123
Fly
multicellular organismal reproductive behavior GO:0033057 384 0.121
developmental process involved in reproduction GO:0003006 1165 0.120
Fly
neuron development GO:0048666 199 0.118
Zebrafish Fly
chromosome organization GO:0051276 104 0.110
taxis GO:0042330 128 0.108
regulation of metabolic process GO:0019222 478 0.104
Mouse Fly
cell cycle process GO:0022402 482 0.104
neuron projection morphogenesis GO:0048812 114 0.103
Zebrafish Fly
determination of adult lifespan GO:0008340 812 0.103
establishment of cell polarity GO:0030010 46 0.102
single organism localization GO:1902578 518 0.102
Worm
germ cell development GO:0007281 351 0.102
Fly
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.102
Zebrafish Fly
nucleobase containing compound biosynthetic process GO:0034654 184 0.101
response to organic substance GO:0010033 131 0.101
posttranscriptional regulation of gene expression GO:0010608 166 0.101
Fly
regulation of multicellular organismal development GO:2000026 317 0.099
Zebrafish Fly
posttranscriptional gene silencing by rna GO:0035194 143 0.099
organ development GO:0048513 1102 0.098
Fly
body morphogenesis GO:0010171 620 0.097
cellular component assembly GO:0022607 293 0.097
Fly
oviposition GO:0018991 364 0.096
macromolecule biosynthetic process GO:0009059 250 0.096
Fly
multicellular organism growth GO:0035264 385 0.093
Mouse Fly
regulation of macromolecule biosynthetic process GO:0010556 189 0.093
Fly
macromolecule localization GO:0033036 771 0.090
Worm
gene expression GO:0010467 412 0.090
Fly
protein localization GO:0008104 205 0.090
cellular nitrogen compound biosynthetic process GO:0044271 192 0.089
cellular protein metabolic process GO:0044267 279 0.089
Mouse Fly
aromatic compound biosynthetic process GO:0019438 192 0.086
cell part morphogenesis GO:0032990 152 0.085
Zebrafish Fly
regulation of developmental process GO:0050793 684 0.085
Zebrafish Mouse Fly
sexual reproduction GO:0019953 546 0.084
Fly
regulation of nitrogen compound metabolic process GO:0051171 222 0.083
Mouse
regulation of nematode larval development GO:0061062 260 0.083
development of primary sexual characteristics GO:0045137 840 0.081
oogenesis GO:0048477 229 0.081
Fly
posttranscriptional gene silencing GO:0016441 143 0.081
genitalia development GO:0048806 741 0.080
positive regulation of rna biosynthetic process GO:1902680 102 0.080
aging GO:0007568 812 0.078
reproductive structure development GO:0048608 850 0.077
neuron differentiation GO:0030182 217 0.076
Zebrafish Fly
positive regulation of cellular biosynthetic process GO:0031328 109 0.075
Fly
multi organism behavior GO:0051705 389 0.071
protein metabolic process GO:0019538 422 0.070
Mouse Fly
phosphorus metabolic process GO:0006793 232 0.069
Human Mouse Worm Fly
immune response GO:0006955 192 0.069
nucleic acid templated transcription GO:0097659 169 0.067
rna metabolic process GO:0016070 228 0.067
cellular localization GO:0051641 360 0.066
multi organism reproductive behavior GO:0044705 387 0.065
regulation of multicellular organismal process GO:0051239 726 0.065
Zebrafish Mouse Fly
positive regulation of response to stimulus GO:0048584 55 0.065
developmental maturation GO:0021700 26 0.063
Fly
regulation of biological quality GO:0065008 741 0.061
Zebrafish Mouse Worm Fly
cellular component morphogenesis GO:0032989 318 0.060
Zebrafish Fly
regulation of biosynthetic process GO:0009889 189 0.060
Fly
regulation of response to stimulus GO:0048583 243 0.060
vulval development GO:0040025 333 0.060
regulation of cell death GO:0010941 65 0.060
Human Mouse
regulation of cell communication GO:0010646 176 0.060
Fly
reproductive behavior GO:0019098 387 0.057
lipid storage GO:0019915 565 0.057
Worm
regulation of vulval development GO:0040028 248 0.057
cellular biosynthetic process GO:0044249 315 0.054
Human Mouse Worm Fly
maintenance of location GO:0051235 580 0.054
Worm
receptor mediated endocytosis GO:0006898 715 0.053
rna interference GO:0016246 137 0.053
neuron recognition GO:0008038 83 0.052
rna biosynthetic process GO:0032774 169 0.051
negative regulation of post embryonic development GO:0048581 208 0.051
small molecule metabolic process GO:0044281 186 0.051
regulation of transcription dna templated GO:0006355 164 0.050
nucleobase containing compound metabolic process GO:0006139 406 0.050
Mouse
lipid localization GO:0010876 573 0.050
Worm
gene silencing by rna GO:0031047 143 0.048
gene silencing GO:0016458 143 0.048
regulation of rna biosynthetic process GO:2001141 165 0.048
striated muscle cell differentiation GO:0051146 158 0.048
organic cyclic compound biosynthetic process GO:1901362 195 0.047
axonogenesis GO:0007409 102 0.047
Zebrafish
organonitrogen compound metabolic process GO:1901564 151 0.047
response to chemical GO:0042221 356 0.047
cell division GO:0051301 262 0.047
Mouse
cell morphogenesis GO:0000902 163 0.046
Zebrafish Fly
cellular response to organic substance GO:0071310 119 0.046
regulation of signal transduction GO:0009966 135 0.045
Fly
behavior GO:0007610 527 0.045
cell surface receptor signaling pathway GO:0007166 149 0.045
Mouse Fly
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.045
Fly
macromolecule modification GO:0043412 218 0.045
Mouse
membrane organization GO:0061024 135 0.044
Worm
positive regulation of multicellular organismal process GO:0051240 417 0.043
Fly
axon development GO:0061564 163 0.043
Zebrafish
cytoskeleton organization GO:0007010 339 0.043
response to external stimulus GO:0009605 289 0.043
growth GO:0040007 562 0.042
Zebrafish Mouse Fly
lipid metabolic process GO:0006629 77 0.042
Human Mouse Worm Fly
developmental growth GO:0048589 412 0.042
Zebrafish Mouse Fly
cellular response to nitrogen compound GO:1901699 24 0.041
response to abiotic stimulus GO:0009628 152 0.040
Worm
negative regulation of cellular process GO:0048523 239 0.040
Human Mouse Fly
tissue development GO:0009888 112 0.040
establishment or maintenance of cell polarity GO:0007163 63 0.040
ribose phosphate metabolic process GO:0019693 99 0.038
dendrite development GO:0016358 42 0.038
Fly
cellular component biogenesis GO:0044085 297 0.038
Fly
negative regulation of cellular metabolic process GO:0031324 95 0.037
Fly
programmed cell death GO:0012501 500 0.037
Human Mouse
catabolic process GO:0009056 318 0.037
Fly
multi multicellular organism process GO:0044706 390 0.037
positive regulation of growth GO:0045927 369 0.037
Fly
generation of neurons GO:0048699 235 0.036
Zebrafish Fly
hermaphrodite genitalia development GO:0040035 734 0.035
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.035
Mouse
regulation of post embryonic development GO:0048580 260 0.035
regulation of rna metabolic process GO:0051252 173 0.035
regulation of growth GO:0040008 409 0.034
Zebrafish Mouse Fly
muscle tissue development GO:0060537 1 0.033
head development GO:0060322 1 0.033
establishment of organelle localization GO:0051656 123 0.033
regulation of developmental growth GO:0048638 389 0.033
Zebrafish Mouse Fly
positive regulation of developmental growth GO:0048639 354 0.033
Fly
intracellular signal transduction GO:0035556 96 0.033
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.033
protein complex biogenesis GO:0070271 186 0.032
regulation of behavior GO:0050795 97 0.032
anatomical structure formation involved in morphogenesis GO:0048646 250 0.032
positive regulation of signaling GO:0023056 66 0.031
muscle structure development GO:0061061 191 0.031
nucleobase containing compound catabolic process GO:0034655 114 0.031
macromolecular complex subunit organization GO:0043933 320 0.031
protein complex subunit organization GO:0071822 280 0.030
negative regulation of multicellular organismal process GO:0051241 236 0.030
phagocytosis GO:0006909 115 0.029
Worm
cellular response to chemical stimulus GO:0070887 129 0.029
histone modification GO:0016570 30 0.029
glycosyl compound metabolic process GO:1901657 100 0.028
microtubule based process GO:0007017 182 0.028
transcription dna templated GO:0006351 168 0.028
regulation of intracellular signal transduction GO:1902531 77 0.028
regulation of signaling GO:0023051 172 0.028
Fly
positive regulation of cellular metabolic process GO:0031325 178 0.027
Mouse Fly
carbohydrate derivative metabolic process GO:1901135 141 0.027
cell motility GO:0048870 313 0.027
regulation of multi organism process GO:0043900 69 0.027
single organism signaling GO:0044700 401 0.027
Mouse Fly
chemotaxis GO:0006935 120 0.026
cell projection morphogenesis GO:0048858 148 0.026
Zebrafish Fly
positive regulation of multicellular organism growth GO:0040018 352 0.025
positive regulation of macromolecule metabolic process GO:0010604 149 0.025
Mouse Fly
reproductive system development GO:0061458 850 0.025
nucleoside triphosphate metabolic process GO:0009141 87 0.025
cellular ketone metabolic process GO:0042180 14 0.024
regulation of protein metabolic process GO:0051246 81 0.024
Mouse Fly
muscle cell differentiation GO:0042692 171 0.024
defense response GO:0006952 296 0.024
regulation of nucleocytoplasmic transport GO:0046822 3 0.024
dna metabolic process GO:0006259 74 0.024
Mouse
engulfment of apoptotic cell GO:0043652 94 0.023
adult behavior GO:0030534 3 0.023
ion transmembrane transport GO:0034220 91 0.023
organelle localization GO:0051640 127 0.023
regulation of localization GO:0032879 194 0.023
Worm
gonad development GO:0008406 840 0.023
organic acid metabolic process GO:0006082 47 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.023
cell morphogenesis involved in differentiation GO:0000904 112 0.022
Zebrafish Fly
regulation of synaptic plasticity GO:0048167 1 0.022
Fly
regulation of nucleic acid templated transcription GO:1903506 165 0.022
organophosphate catabolic process GO:0046434 81 0.022
membrane invagination GO:0010324 98 0.022
Worm
protein complex assembly GO:0006461 186 0.022
internal peptidyl lysine acetylation GO:0018393 3 0.022
actin filament based process GO:0030029 191 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.022
negative regulation of cellular biosynthetic process GO:0031327 65 0.021
phagocytosis engulfment GO:0006911 98 0.021
Worm
transcription from rna polymerase ii promoter GO:0006366 149 0.021
regulation of kinase activity GO:0043549 29 0.021
Mouse
actin cytoskeleton organization GO:0030036 184 0.021
apoptotic cell clearance GO:0043277 111 0.021
Worm
positive regulation of nucleic acid templated transcription GO:1903508 102 0.021
dna repair GO:0006281 23 0.020
cellular component movement GO:0006928 388 0.020
axonal fasciculation GO:0007413 79 0.020
regulation of neuron differentiation GO:0045664 40 0.020
Zebrafish Fly
phosphate containing compound metabolic process GO:0006796 232 0.020
Human Mouse Worm Fly
mitotic sister chromatid segregation GO:0000070 38 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.020
mitotic cell cycle process GO:1903047 194 0.020
single organism biosynthetic process GO:0044711 91 0.020
Human Mouse Worm Fly
sister chromatid segregation GO:0000819 46 0.020
phosphorylation GO:0016310 116 0.019
Human Mouse Fly
single organism behavior GO:0044708 83 0.019
purine ribonucleotide metabolic process GO:0009150 95 0.019
cellular response to stress GO:0033554 162 0.019
Fly
system process GO:0003008 136 0.019
cellular protein complex assembly GO:0043623 178 0.019
oxoacid metabolic process GO:0043436 47 0.019
small gtpase mediated signal transduction GO:0007264 32 0.019
nucleotide metabolic process GO:0009117 108 0.018
regulation of small gtpase mediated signal transduction GO:0051056 41 0.018
protein oligomerization GO:0051259 4 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.018
positive regulation of signal transduction GO:0009967 40 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.018
macromolecular complex assembly GO:0065003 193 0.018
sensory organ morphogenesis GO:0090596 2 0.018
single organism catabolic process GO:0044712 129 0.017
negative regulation of rna metabolic process GO:0051253 53 0.017
response to peptide hormone GO:0043434 14 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.017
protein phosphorylation GO:0006468 85 0.017
Mouse
regulation of phosphate metabolic process GO:0019220 81 0.016
Mouse
purine nucleoside metabolic process GO:0042278 92 0.016
positive regulation of nucleoside metabolic process GO:0045979 28 0.016
cellular response to dna damage stimulus GO:0006974 41 0.016
covalent chromatin modification GO:0016569 30 0.016
axon guidance GO:0007411 82 0.016
regulation of phosphorus metabolic process GO:0051174 81 0.016
Mouse
regulation of protein serine threonine kinase activity GO:0071900 18 0.016
purine containing compound metabolic process GO:0072521 95 0.016
localization of cell GO:0051674 313 0.016
negative regulation of neurogenesis GO:0050768 4 0.016
positive regulation of developmental process GO:0051094 408 0.016
Fly
meiotic nuclear division GO:0007126 300 0.016
organelle fission GO:0048285 363 0.015
response to ionizing radiation GO:0010212 16 0.015
Worm
organonitrogen compound biosynthetic process GO:1901566 44 0.015
regulation of cell differentiation GO:0045595 81 0.015
Zebrafish Fly
cell type specific apoptotic process GO:0097285 4 0.015
Mouse
meiotic cell cycle GO:0051321 335 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
post embryonic organ development GO:0048569 336 0.015
regulation of cellular protein metabolic process GO:0032268 75 0.014
Mouse Fly
intracellular transport GO:0046907 77 0.014
single organism intracellular transport GO:1902582 70 0.014
regulation of apoptotic signaling pathway GO:2001233 1 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.014
regulation of apoptotic process GO:0042981 36 0.014
Human Mouse
regulation of cell proliferation GO:0042127 105 0.014
Fly
striated muscle cell development GO:0055002 157 0.014
ribonucleoside triphosphate metabolic process GO:0009199 87 0.014
gtp metabolic process GO:0046039 46 0.014
regulation of multicellular organism growth GO:0040014 373 0.014
Mouse Fly
purine nucleotide catabolic process GO:0006195 75 0.014
organic substance catabolic process GO:1901575 294 0.014
lipid modification GO:0030258 4 0.014
Human Mouse Fly
response to insulin GO:0032868 14 0.014
cellular response to organonitrogen compound GO:0071417 14 0.014
regulation of reproductive process GO:2000241 66 0.014
cell cell signaling GO:0007267 118 0.013
Fly
glycosyl compound catabolic process GO:1901658 79 0.013
heterocycle catabolic process GO:0046700 119 0.013
cellular response to abiotic stimulus GO:0071214 4 0.013
positive regulation of cell death GO:0010942 38 0.013
regulation of transport GO:0051049 91 0.013
Worm
innate immune response GO:0045087 190 0.013
negative regulation of cell communication GO:0010648 61 0.013
Fly
establishment of localization in cell GO:0051649 318 0.013
dna recombination GO:0006310 19 0.013
transmembrane transport GO:0055085 110 0.012
oocyte differentiation GO:0009994 45 0.012
developmental cell growth GO:0048588 39 0.012
Zebrafish
regulation of programmed cell death GO:0043067 50 0.012
Human Mouse
organophosphate metabolic process GO:0019637 125 0.012
Human Mouse Worm Fly
cell recognition GO:0008037 85 0.012
carboxylic acid metabolic process GO:0019752 34 0.012
nucleotide catabolic process GO:0009166 77 0.012
regulation of meiotic cell cycle GO:0051445 136 0.012
regulation of pharyngeal pumping GO:0043051 36 0.012
signal transduction by phosphorylation GO:0023014 31 0.011
regulation of lipid metabolic process GO:0019216 4 0.011
nucleobase containing small molecule metabolic process GO:0055086 115 0.011
ras protein signal transduction GO:0007265 31 0.011
mitotic nuclear division GO:0007067 89 0.011
positive regulation of neurogenesis GO:0050769 4 0.011
single organism membrane organization GO:0044802 35 0.011
response to nitrogen compound GO:1901698 25 0.011
male sex differentiation GO:0046661 86 0.011
adult locomotory behavior GO:0008344 1 0.011
positive regulation of rna metabolic process GO:0051254 103 0.011
negative regulation of dna recombination GO:0045910 4 0.011
response to oxygen containing compound GO:1901700 44 0.010
negative regulation of signaling GO:0023057 61 0.010
Fly
chromatin modification GO:0016568 32 0.010
regulation of neuron projection development GO:0010975 31 0.010
Zebrafish Fly
regulation of organelle organization GO:0033043 164 0.010
single organism carbohydrate metabolic process GO:0044723 29 0.010
Mouse
behavioral response to ethanol GO:0048149 1 0.010
carbohydrate derivative catabolic process GO:1901136 82 0.010
cellular macromolecule localization GO:0070727 75 0.010
myosin filament assembly GO:0031034 138 0.010

age-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 0 0.020
developmental disorder of mental health DOID:0060037 0 0.020
cancer DOID:162 0 0.020
Human
disease of cellular proliferation DOID:14566 0 0.020
Human
organ system cancer DOID:0050686 0 0.014
Human
disease of anatomical entity DOID:7 0 0.011
Human