Caenorhabditis elegans

141 known processes

wrn-1 (CELE_F18C5.2)

Protein WRN-1

wrn-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.537
embryo development ending in birth or egg hatching GO:0009792 2992 0.473
single organism transport GO:0044765 447 0.389
Human
vesicle mediated transport GO:0016192 852 0.315
locomotion GO:0040011 1634 0.277
response to organic substance GO:0010033 131 0.276
phosphate containing compound metabolic process GO:0006796 232 0.234
transport GO:0006810 1093 0.212
Human
developmental growth GO:0048589 412 0.204
regulation of multicellular organismal process GO:0051239 726 0.179
response to abiotic stimulus GO:0009628 152 0.143
organic substance biosynthetic process GO:1901576 323 0.138
Human Mouse
post embryonic development GO:0009791 2152 0.136
organic substance catabolic process GO:1901575 294 0.133
growth GO:0040007 562 0.133
cellular response to organic substance GO:0071310 119 0.130
positive regulation of multicellular organismal process GO:0051240 417 0.128
macromolecule localization GO:0033036 771 0.122
regulation of developmental growth GO:0048638 389 0.118
regulation of growth GO:0040008 409 0.117
cellular localization GO:0051641 360 0.110
Human
cell cycle process GO:0022402 482 0.108
programmed cell death GO:0012501 500 0.105
Human
small molecule metabolic process GO:0044281 186 0.104
heterocycle catabolic process GO:0046700 119 0.097
nucleobase containing compound catabolic process GO:0034655 114 0.097
cell death GO:0008219 547 0.094
Human
death GO:0016265 547 0.092
Human
response to chemical GO:0042221 356 0.087
single organism organelle organization GO:1902589 501 0.086
Human Mouse
mitotic cell cycle process GO:1903047 194 0.086
positive regulation of metabolic process GO:0009893 187 0.082
Human
single organism localization GO:1902578 518 0.081
Human
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.078
catabolic process GO:0009056 318 0.078
secretion by cell GO:0032940 138 0.075
purine ribonucleoside catabolic process GO:0046130 75 0.075
lipid localization GO:0010876 573 0.071
signal transduction GO:0007165 317 0.070
regulation of nitrogen compound metabolic process GO:0051171 222 0.069
purine containing compound catabolic process GO:0072523 75 0.068
establishment of localization in cell GO:0051649 318 0.068
Human
regulation of biological quality GO:0065008 741 0.067
Human Mouse
meiotic nuclear division GO:0007126 300 0.066
positive regulation of cellular process GO:0048522 332 0.066
regulation of cell morphogenesis GO:0022604 40 0.065
cellular response to chemical stimulus GO:0070887 129 0.065
positive regulation of growth GO:0045927 369 0.065
protein metabolic process GO:0019538 422 0.064
enzyme linked receptor protein signaling pathway GO:0007167 50 0.063
positive regulation of developmental process GO:0051094 408 0.063
lipid storage GO:0019915 565 0.062
protein localization GO:0008104 205 0.062
dna recombination GO:0006310 19 0.061
regulation of macromolecule metabolic process GO:0060255 421 0.059
maintenance of location GO:0051235 580 0.057
cytoskeleton organization GO:0007010 339 0.057
neurogenesis GO:0022008 236 0.054
nucleoside triphosphate metabolic process GO:0009141 87 0.054
endocytosis GO:0006897 819 0.052
organelle organization GO:0006996 783 0.052
Human Mouse
organophosphate metabolic process GO:0019637 125 0.051
neuron recognition GO:0008038 83 0.051
regulation of locomotion GO:0040012 161 0.051
biosynthetic process GO:0009058 323 0.051
Human Mouse
regulation of developmental process GO:0050793 684 0.050
regulation of multicellular organism growth GO:0040014 373 0.050
gonad development GO:0008406 840 0.050
nucleic acid metabolic process GO:0090304 299 0.049
membrane organization GO:0061024 135 0.049
cell cycle GO:0007049 526 0.049
multicellular organism growth GO:0035264 385 0.048
purine nucleotide catabolic process GO:0006195 75 0.047
single organism signaling GO:0044700 401 0.047
positive regulation of macromolecule metabolic process GO:0010604 149 0.046
determination of adult lifespan GO:0008340 812 0.046
regulation of gene expression GO:0010468 366 0.045
negative regulation of macromolecule metabolic process GO:0010605 229 0.044
cell surface receptor signaling pathway GO:0007166 149 0.044
transcription dna templated GO:0006351 168 0.044
multicellular organismal aging GO:0010259 812 0.043
purine nucleoside triphosphate catabolic process GO:0009146 72 0.042
positive regulation of cellular metabolic process GO:0031325 178 0.042
generation of neurons GO:0048699 235 0.041
protein modification process GO:0036211 207 0.041
regulation of cellular component organization GO:0051128 248 0.041
phosphorus metabolic process GO:0006793 232 0.041
establishment of localization GO:0051234 1171 0.040
Human
negative regulation of metabolic process GO:0009892 240 0.039
cellular protein modification process GO:0006464 207 0.039
macromolecular complex subunit organization GO:0043933 320 0.039
purine ribonucleotide metabolic process GO:0009150 95 0.039
regulation of gene expression epigenetic GO:0040029 163 0.039
cell projection morphogenesis GO:0048858 148 0.039
signaling GO:0023052 401 0.038
regulation of metabolic process GO:0019222 478 0.038
Human
organ development GO:0048513 1102 0.038
cellular protein metabolic process GO:0044267 279 0.037
ribonucleoside triphosphate metabolic process GO:0009199 87 0.036
purine nucleotide metabolic process GO:0006163 95 0.036
dna repair GO:0006281 23 0.035
Human
secretion GO:0046903 147 0.035
organonitrogen compound metabolic process GO:1901564 151 0.035
neuron differentiation GO:0030182 217 0.034
reproductive system development GO:0061458 850 0.034
positive regulation of multicellular organism growth GO:0040018 352 0.033
cell migration GO:0016477 306 0.033
regulation of multicellular organismal development GO:2000026 317 0.032
organic cyclic compound catabolic process GO:1901361 119 0.032
purine nucleoside metabolic process GO:0042278 92 0.032
regulation of cellular metabolic process GO:0031323 305 0.032
positive regulation of developmental growth GO:0048639 354 0.032
genitalia development GO:0048806 741 0.032
nucleoside phosphate metabolic process GO:0006753 108 0.031
cell motility GO:0048870 313 0.030
chromosome organization GO:0051276 104 0.030
Human Mouse
hermaphrodite genitalia development GO:0040035 734 0.029
gene expression GO:0010467 412 0.029
positive regulation of molecular function GO:0044093 61 0.029
Human
purine nucleoside monophosphate catabolic process GO:0009128 28 0.029
negative regulation of biological process GO:0048519 567 0.028
axon development GO:0061564 163 0.028
posttranscriptional gene silencing GO:0016441 143 0.028
regulation of cellular biosynthetic process GO:0031326 189 0.028
neuron projection development GO:0031175 187 0.028
body morphogenesis GO:0010171 620 0.026
regulation of rna metabolic process GO:0051252 173 0.026
nervous system development GO:0007399 253 0.026
glycosyl compound metabolic process GO:1901657 100 0.025
rna interference GO:0016246 137 0.025
apoptotic process GO:0006915 478 0.025
Human
macromolecule modification GO:0043412 218 0.025
meiotic cell cycle GO:0051321 335 0.024
cellular macromolecule localization GO:0070727 75 0.024
cellular macromolecule biosynthetic process GO:0034645 247 0.024
Human Mouse
cellular response to inorganic substance GO:0071241 3 0.024
cell development GO:0048468 696 0.024
glycosyl compound catabolic process GO:1901658 79 0.024
purine ribonucleotide catabolic process GO:0009154 75 0.023
oxoacid metabolic process GO:0043436 47 0.023
regulation of hydrolase activity GO:0051336 45 0.023
Human
regulation of phosphorus metabolic process GO:0051174 81 0.023
carboxylic acid metabolic process GO:0019752 34 0.023
cell cell signaling GO:0007267 118 0.023
neuron development GO:0048666 199 0.023
positive regulation of catalytic activity GO:0043085 59 0.022
Human
cell projection organization GO:0030030 231 0.022
reproductive structure development GO:0048608 850 0.022
negative regulation of cellular process GO:0048523 239 0.022
response to inorganic substance GO:0010035 50 0.021
ribonucleoside metabolic process GO:0009119 98 0.021
nucleotide catabolic process GO:0009166 77 0.021
cellular protein localization GO:0034613 75 0.021
regulation of synapse assembly GO:0051963 2 0.021
organophosphate catabolic process GO:0046434 81 0.021
ribose phosphate metabolic process GO:0019693 99 0.021
posttranscriptional regulation of gene expression GO:0010608 166 0.020
organonitrogen compound catabolic process GO:1901565 90 0.020
regulation of transcription dna templated GO:0006355 164 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.020
posttranscriptional gene silencing by rna GO:0035194 143 0.020
intracellular signal transduction GO:0035556 96 0.019
nucleobase containing compound metabolic process GO:0006139 406 0.019
nucleobase containing small molecule metabolic process GO:0055086 115 0.019
meiotic cell cycle process GO:1903046 170 0.019
axonal fasciculation GO:0007413 79 0.019
cellular component morphogenesis GO:0032989 318 0.019
regulation of post embryonic development GO:0048580 260 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.019
ribonucleoside catabolic process GO:0042454 77 0.018
head development GO:0060322 1 0.018
cellular catabolic process GO:0044248 199 0.018
regulation of cell cycle process GO:0010564 145 0.018
microtubule based process GO:0007017 182 0.018
single organism reproductive process GO:0044702 1196 0.018
regulation of response to stimulus GO:0048583 243 0.018
cellular nitrogen compound biosynthetic process GO:0044271 192 0.018
Human
negative regulation of cell cycle GO:0045786 53 0.018
regulation of signal transduction GO:0009966 135 0.018
negative regulation of gene expression GO:0010629 217 0.018
response to oxygen containing compound GO:1901700 44 0.018
neuromuscular junction development GO:0007528 2 0.018
developmental process involved in reproduction GO:0003006 1165 0.018
macromolecule biosynthetic process GO:0009059 250 0.018
Human Mouse
vulval development GO:0040025 333 0.018
multicellular organismal reproductive process GO:0048609 815 0.018
nucleoside triphosphate catabolic process GO:0009143 72 0.018
carbohydrate derivative metabolic process GO:1901135 141 0.017
single organism biosynthetic process GO:0044711 91 0.017
organic acid metabolic process GO:0006082 47 0.017
chromosome segregation GO:0007059 180 0.017
cell type specific apoptotic process GO:0097285 4 0.017
regulation of localization GO:0032879 194 0.017
regulation of cell cycle GO:0051726 194 0.017
regulation of macromolecule biosynthetic process GO:0010556 189 0.017
regulation of primary metabolic process GO:0080090 292 0.016
cellular response to dna damage stimulus GO:0006974 41 0.016
Human
establishment or maintenance of cell polarity GO:0007163 63 0.016
lipid metabolic process GO:0006629 77 0.016
regulation of meiotic cell cycle GO:0051445 136 0.016
regulation of vulval development GO:0040028 248 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.016
purine containing compound metabolic process GO:0072521 95 0.016
ribonucleotide metabolic process GO:0009259 99 0.016
cellular component biogenesis GO:0044085 297 0.016
post embryonic organ development GO:0048569 336 0.016
phosphorylation GO:0016310 116 0.016
cell substrate adhesion GO:0031589 1 0.016
negative regulation of cellular metabolic process GO:0031324 95 0.015
nucleoside monophosphate metabolic process GO:0009123 46 0.015
axonogenesis GO:0007409 102 0.015
regulation of biosynthetic process GO:0009889 189 0.015
actin cytoskeleton organization GO:0030036 184 0.015
regulation of cell size GO:0008361 30 0.015
regulation of nematode larval development GO:0061062 260 0.015
gene silencing by rna GO:0031047 143 0.015
rna metabolic process GO:0016070 228 0.015
regulation of cell communication GO:0010646 176 0.015
carbohydrate derivative catabolic process GO:1901136 82 0.015
organelle fission GO:0048285 363 0.015
inductive cell migration GO:0040039 145 0.015
regulation of signaling GO:0023051 172 0.015
regulation of transposition dna mediated GO:0000337 3 0.014
aromatic compound catabolic process GO:0019439 116 0.014
protein transport GO:0015031 45 0.014
intracellular transport GO:0046907 77 0.014
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.014
chemical homeostasis GO:0048878 29 0.014
receptor mediated endocytosis GO:0006898 715 0.014
cellular nitrogen compound catabolic process GO:0044270 119 0.014
dna duplex unwinding GO:0032508 3 0.014
ribonucleotide catabolic process GO:0009261 75 0.014
single organism membrane organization GO:0044802 35 0.014
purine nucleoside triphosphate metabolic process GO:0009144 87 0.014
regulation of catalytic activity GO:0050790 78 0.014
Human
actin filament based process GO:0030029 191 0.014
cellular response to endogenous stimulus GO:0071495 32 0.014
regulation of mitotic cell cycle GO:0007346 76 0.013
cuticle development GO:0042335 100 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
response to peptide hormone GO:0043434 14 0.013
purine nucleoside catabolic process GO:0006152 75 0.013
response to bacterium GO:0009617 86 0.013
synaptic growth at neuromuscular junction GO:0051124 1 0.013
nucleotide metabolic process GO:0009117 108 0.013
cellular component assembly GO:0022607 293 0.013
organic substance transport GO:0071702 113 0.013
response to wounding GO:0009611 4 0.013
cell division GO:0051301 262 0.013
membrane invagination GO:0010324 98 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
multi organism reproductive process GO:0044703 867 0.013
g1 s transition of mitotic cell cycle GO:0000082 2 0.012
cell cycle g1 s phase transition GO:0044843 2 0.012
muscle tissue development GO:0060537 1 0.012
embryonic morphogenesis GO:0048598 152 0.012
nucleoside metabolic process GO:0009116 99 0.012
dna metabolic process GO:0006259 74 0.012
negative regulation of gene expression epigenetic GO:0045814 2 0.012
amine metabolic process GO:0009308 15 0.012
behavior GO:0007610 527 0.012
regulation of anatomical structure morphogenesis GO:0022603 51 0.012
atp metabolic process GO:0046034 42 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 34 0.012
multicellular organism reproduction GO:0032504 819 0.012
cellular biosynthetic process GO:0044249 315 0.012
Human Mouse
oocyte differentiation GO:0009994 45 0.012
regulation of phosphate metabolic process GO:0019220 81 0.012
digestive system development GO:0055123 122 0.012
cellular response to stress GO:0033554 162 0.012
Human
cell cycle g2 m phase transition GO:0044839 1 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.012
collagen and cuticulin based cuticle development GO:0040002 99 0.011
cell morphogenesis involved in differentiation GO:0000904 112 0.011
tissue development GO:0009888 112 0.011
protein oligomerization GO:0051259 4 0.011
negative regulation of developmental process GO:0051093 227 0.011
regulation of nucleic acid templated transcription GO:1903506 165 0.011
single organism catabolic process GO:0044712 129 0.011
apoptotic cell clearance GO:0043277 111 0.011
gamete generation GO:0007276 461 0.011
cell recognition GO:0008037 85 0.011
cellular amino acid metabolic process GO:0006520 15 0.011
positive regulation of cell cycle GO:0045787 55 0.011
response to metal ion GO:0010038 33 0.011
regulation of organelle organization GO:0033043 164 0.011
development of primary sexual characteristics GO:0045137 840 0.011
macromolecule catabolic process GO:0009057 202 0.011
nucleoside phosphate catabolic process GO:1901292 77 0.011
rna biosynthetic process GO:0032774 169 0.010
regulation of molecular function GO:0065009 89 0.010
Human
single organism cellular localization GO:1902580 72 0.010
localization of cell GO:0051674 313 0.010
oviposition GO:0018991 364 0.010
negative regulation of dna recombination GO:0045910 4 0.010
aromatic compound biosynthetic process GO:0019438 192 0.010
Human
cellular response to insulin stimulus GO:0032869 14 0.010
positive regulation of meiotic cell cycle GO:0051446 47 0.010

wrn-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
disease of cellular proliferation DOID:14566 0 0.026
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015