Caenorhabditis elegans

2 known processes

klf-2 (CELE_F53F8.1)

Protein KLF-2

klf-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.389
gene expression GO:0010467 412 0.338
Mouse
developmental process involved in reproduction GO:0003006 1165 0.324
regulation of nitrogen compound metabolic process GO:0051171 222 0.317
Mouse
regulation of rna biosynthetic process GO:2001141 165 0.306
Mouse
organ development GO:0048513 1102 0.295
Zebrafish Mouse Worm
sex differentiation GO:0007548 909 0.293
nucleic acid templated transcription GO:0097659 169 0.289
Mouse
regulation of metabolic process GO:0019222 478 0.289
Mouse
post embryonic development GO:0009791 2152 0.279
Worm
transcription dna templated GO:0006351 168 0.269
Mouse
positive regulation of transcription dna templated GO:0045893 102 0.267
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 192 0.263
Mouse
locomotion GO:0040011 1634 0.260
regulation of rna metabolic process GO:0051252 173 0.249
Mouse
single organism reproductive process GO:0044702 1196 0.243
organic cyclic compound biosynthetic process GO:1901362 195 0.242
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.232
Mouse
regulation of macromolecule biosynthetic process GO:0010556 189 0.230
Mouse
regulation of gene expression GO:0010468 366 0.225
Mouse
embryo development ending in birth or egg hatching GO:0009792 2992 0.223
regulation of nucleic acid templated transcription GO:1903506 165 0.217
Mouse
transcription from rna polymerase ii promoter GO:0006366 149 0.217
Mouse
regulation of cellular metabolic process GO:0031323 305 0.205
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 102 0.201
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.201
Mouse
reproductive system development GO:0061458 850 0.200
regulation of cellular biosynthetic process GO:0031326 189 0.180
Mouse
regulation of macromolecule metabolic process GO:0060255 421 0.178
Mouse
regulation of transcription dna templated GO:0006355 164 0.177
Mouse
heterocycle biosynthetic process GO:0018130 187 0.174
Mouse
head development GO:0060322 1 0.172
nucleobase containing compound biosynthetic process GO:0034654 184 0.172
Mouse
regulation of primary metabolic process GO:0080090 292 0.170
Mouse
nucleic acid metabolic process GO:0090304 299 0.165
Mouse
positive regulation of rna metabolic process GO:0051254 103 0.164
Mouse
death GO:0016265 547 0.164
Worm
nucleobase containing compound metabolic process GO:0006139 406 0.163
Mouse
multicellular organismal reproductive process GO:0048609 815 0.161
biosynthetic process GO:0009058 323 0.159
Mouse
development of primary sexual characteristics GO:0045137 840 0.152
programmed cell death GO:0012501 500 0.151
Worm
pattern specification process GO:0007389 59 0.149
cell fate commitment GO:0045165 139 0.147
regulation of developmental process GO:0050793 684 0.143
Mouse
cell death GO:0008219 547 0.141
Worm
sexual reproduction GO:0019953 546 0.140
cellular biosynthetic process GO:0044249 315 0.139
Mouse
aromatic compound biosynthetic process GO:0019438 192 0.139
Mouse
determination of adult lifespan GO:0008340 812 0.139
cellular macromolecule biosynthetic process GO:0034645 247 0.137
Mouse
multicellular organism reproduction GO:0032504 819 0.136
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.136
Mouse
generation of neurons GO:0048699 235 0.133
Mouse
apoptotic process GO:0006915 478 0.133
Worm
positive regulation of rna biosynthetic process GO:1902680 102 0.130
Mouse
aging GO:0007568 812 0.129
cellular component morphogenesis GO:0032989 318 0.127
Mouse
genitalia development GO:0048806 741 0.127
macromolecule biosynthetic process GO:0009059 250 0.124
Mouse
cell development GO:0048468 696 0.124
Mouse
cell projection organization GO:0030030 231 0.123
Mouse
reproductive structure development GO:0048608 850 0.123
positive regulation of cellular process GO:0048522 332 0.122
Mouse
digestive tract development GO:0048565 122 0.122
Zebrafish Mouse
regulation of multicellular organismal process GO:0051239 726 0.117
rna biosynthetic process GO:0032774 169 0.117
Mouse
rna metabolic process GO:0016070 228 0.116
Mouse
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.115
negative regulation of biological process GO:0048519 567 0.114
Mouse
multicellular organismal aging GO:0010259 812 0.113
organic substance biosynthetic process GO:1901576 323 0.113
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.113
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 250 0.110
Zebrafish Mouse
positive regulation of gene expression GO:0010628 112 0.110
Mouse
cell morphogenesis GO:0000902 163 0.109
Mouse
negative regulation of metabolic process GO:0009892 240 0.109
Mouse
regulation of biosynthetic process GO:0009889 189 0.107
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.106
Mouse
regulation of biological quality GO:0065008 741 0.105
Worm
body morphogenesis GO:0010171 620 0.104
gonad development GO:0008406 840 0.101
multi organism reproductive process GO:0044703 867 0.100
cell migration GO:0016477 306 0.097
embryonic morphogenesis GO:0048598 152 0.096
positive regulation of biosynthetic process GO:0009891 109 0.095
Mouse
oviposition GO:0018991 364 0.094
localization of cell GO:0051674 313 0.094
cell motility GO:0048870 313 0.093
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.093
Mouse
organ morphogenesis GO:0009887 67 0.093
establishment of localization GO:0051234 1171 0.092
Worm
receptor mediated endocytosis GO:0006898 715 0.091
regulation of multicellular organismal development GO:2000026 317 0.090
tube development GO:0035295 126 0.089
Zebrafish Mouse
digestive tract morphogenesis GO:0048546 76 0.088
reproductive behavior GO:0019098 387 0.088
taxis GO:0042330 128 0.088
Mouse
behavior GO:0007610 527 0.086
gastrulation GO:0007369 58 0.085
epithelial tube morphogenesis GO:0060562 1 0.085
negative regulation of gene expression GO:0010629 217 0.083
Mouse
neuron projection development GO:0031175 187 0.082
Mouse
positive regulation of metabolic process GO:0009893 187 0.082
Mouse
muscle tissue development GO:0060537 1 0.082
Mouse
macromolecule localization GO:0033036 771 0.082
Worm
neuron differentiation GO:0030182 217 0.080
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.080
Mouse
axon development GO:0061564 163 0.079
Mouse
negative regulation of transcription dna templated GO:0045892 53 0.079
Mouse
negative regulation of macromolecule metabolic process GO:0010605 229 0.077
Mouse
positive regulation of macromolecule metabolic process GO:0010604 149 0.076
Mouse
digestive system development GO:0055123 122 0.075
Zebrafish Mouse
neuron projection guidance GO:0097485 82 0.075
Mouse
multi multicellular organism process GO:0044706 390 0.074
neuron projection morphogenesis GO:0048812 114 0.074
Mouse
transport GO:0006810 1093 0.073
Worm
signal transduction GO:0007165 317 0.072
Mouse
multicellular organismal reproductive behavior GO:0033057 384 0.071
organelle organization GO:0006996 783 0.070
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.069
Mouse
mesoderm development GO:0007498 27 0.069
regulation of nematode larval development GO:0061062 260 0.068
vulval development GO:0040025 333 0.068
Worm
cell projection morphogenesis GO:0048858 148 0.067
Mouse
negative regulation of cellular process GO:0048523 239 0.067
Mouse
regulation of locomotion GO:0040012 161 0.067
positive regulation of multicellular organismal process GO:0051240 417 0.066
vesicle mediated transport GO:0016192 852 0.066
Worm
post embryonic organ development GO:0048569 336 0.065
Worm
response to chemical GO:0042221 356 0.065
Mouse
cell part morphogenesis GO:0032990 152 0.065
Mouse
neurogenesis GO:0022008 236 0.065
Mouse
lipid localization GO:0010876 573 0.065
Worm
maintenance of location GO:0051235 580 0.065
Worm
negative regulation of nucleic acid templated transcription GO:1903507 53 0.063
Mouse
lipid storage GO:0019915 565 0.062
Worm
response to external stimulus GO:0009605 289 0.062
Mouse
multi organism reproductive behavior GO:0044705 387 0.061
growth GO:0040007 562 0.061
Zebrafish
regulation of cell differentiation GO:0045595 81 0.060
Mouse
negative regulation of biosynthetic process GO:0009890 65 0.060
Mouse
axonogenesis GO:0007409 102 0.060
Mouse
nervous system development GO:0007399 253 0.059
Zebrafish Mouse
positive regulation of cellular metabolic process GO:0031325 178 0.057
Mouse
cellular component movement GO:0006928 388 0.057
Mouse
positive regulation of cellular biosynthetic process GO:0031328 109 0.057
Mouse
regulation of vulval development GO:0040028 248 0.056
muscle structure development GO:0061061 191 0.056
Mouse
multi organism behavior GO:0051705 389 0.056
endocytosis GO:0006897 819 0.056
Worm
regulation of developmental growth GO:0048638 389 0.056
negative regulation of cellular metabolic process GO:0031324 95 0.055
Mouse
muscle cell differentiation GO:0042692 171 0.053
muscle organ morphogenesis GO:0048644 4 0.052
gamete generation GO:0007276 461 0.052
developmental growth GO:0048589 412 0.051
positive regulation of growth GO:0045927 369 0.051
single organism signaling GO:0044700 401 0.051
Mouse
tissue development GO:0009888 112 0.051
Mouse
positive regulation of developmental process GO:0051094 408 0.050
Mouse
germ cell development GO:0007281 351 0.049
hermaphrodite genitalia development GO:0040035 734 0.049
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.049
regulation of growth GO:0040008 409 0.047
neuron development GO:0048666 199 0.047
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.047
Mouse
multicellular organism growth GO:0035264 385 0.047
molting cycle GO:0042303 281 0.047
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.045
negative regulation of nematode larval development GO:0061064 208 0.045
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.045
Mouse
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.044
cell morphogenesis involved in differentiation GO:0000904 112 0.044
Mouse
negative regulation of vulval development GO:0040027 206 0.044
positive regulation of developmental growth GO:0048639 354 0.043
protein metabolic process GO:0019538 422 0.042
Worm
regulation of cell migration GO:0030334 55 0.042
negative regulation of cellular biosynthetic process GO:0031327 65 0.041
Mouse
negative regulation of multicellular organismal process GO:0051241 236 0.041
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.040
Mouse
negative regulation of developmental process GO:0051093 227 0.040
male sex differentiation GO:0046661 86 0.040
positive regulation of multicellular organism growth GO:0040018 352 0.039
chemotaxis GO:0006935 120 0.039
Mouse
regulation of multicellular organism growth GO:0040014 373 0.039
mesoderm morphogenesis GO:0048332 24 0.038
system process GO:0003008 136 0.037
catabolic process GO:0009056 318 0.037
Worm
regulation of localization GO:0032879 194 0.036
regulation of cellular component organization GO:0051128 248 0.036
Mouse
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.036
Mouse
cell surface receptor signaling pathway GO:0007166 149 0.036
Mouse
regulation of post embryonic development GO:0048580 260 0.035
cytoskeleton organization GO:0007010 339 0.035
mesodermal cell fate specification GO:0007501 13 0.035
cell cycle process GO:0022402 482 0.035
signaling GO:0023052 401 0.035
Mouse
mesodermal cell differentiation GO:0048333 15 0.034
skeletal muscle organ development GO:0060538 3 0.034
Mouse
organic substance catabolic process GO:1901575 294 0.033
Worm
defense response GO:0006952 296 0.033
Worm
cell cycle GO:0007049 526 0.033
regulation of cell motility GO:2000145 57 0.033
axon guidance GO:0007411 82 0.033
Mouse
tube morphogenesis GO:0035239 79 0.032
male anatomical structure morphogenesis GO:0090598 78 0.032
response to wounding GO:0009611 4 0.032
female gamete generation GO:0007292 254 0.032
negative regulation of post embryonic development GO:0048581 208 0.032
negative regulation of rna metabolic process GO:0051253 53 0.030
Mouse
nematode male tail tip morphogenesis GO:0045138 77 0.029
cellular protein metabolic process GO:0044267 279 0.029
macromolecular complex subunit organization GO:0043933 320 0.029
cellular component biogenesis GO:0044085 297 0.029
Mouse
single organism organelle organization GO:1902589 501 0.028
regulation of stem cell differentiation GO:2000736 1 0.028
regulation of cellular component movement GO:0051270 62 0.028
negative regulation of rna biosynthetic process GO:1902679 53 0.027
Mouse
regulation of organ morphogenesis GO:2000027 4 0.027
regulation of cell fate specification GO:0042659 22 0.027
small molecule metabolic process GO:0044281 186 0.027
regulation of signal transduction GO:0009966 135 0.027
cellular component assembly GO:0022607 293 0.027
Mouse
posttranscriptional regulation of gene expression GO:0010608 166 0.026
regionalization GO:0003002 31 0.026
protein catabolic process GO:0030163 162 0.026
Worm
single organism localization GO:1902578 518 0.026
Worm
organonitrogen compound metabolic process GO:1901564 151 0.026
regulation of cell fate commitment GO:0010453 22 0.025
striated muscle cell differentiation GO:0051146 158 0.025
regulation of response to stimulus GO:0048583 243 0.025
sensory organ morphogenesis GO:0090596 2 0.025
response to abiotic stimulus GO:0009628 152 0.025
immune response GO:0006955 192 0.025
Worm
regulation of cell communication GO:0010646 176 0.024
neuron recognition GO:0008038 83 0.024
dauer larval development GO:0040024 92 0.024
single organism transport GO:0044765 447 0.023
Worm
meiotic cell cycle GO:0051321 335 0.023
establishment of localization in cell GO:0051649 318 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
cell division GO:0051301 262 0.023
macromolecule catabolic process GO:0009057 202 0.023
Worm
striated muscle cell development GO:0055002 157 0.023
actin cytoskeleton organization GO:0030036 184 0.022
posttranscriptional gene silencing GO:0016441 143 0.022
macromolecule modification GO:0043412 218 0.021
actin filament based process GO:0030029 191 0.021
regulation of cell division GO:0051302 142 0.021
organelle assembly GO:0070925 214 0.021
oogenesis GO:0048477 229 0.021
protein complex subunit organization GO:0071822 280 0.021
pharynx development GO:0060465 51 0.021
epithelium development GO:0060429 68 0.021
Mouse
cellular macromolecular complex assembly GO:0034622 184 0.021
positive regulation of neurogenesis GO:0050769 4 0.021
negative regulation of neurogenesis GO:0050768 4 0.021
meiotic nuclear division GO:0007126 300 0.020
gene silencing by rna GO:0031047 143 0.020
embryonic body morphogenesis GO:0010172 49 0.020
protein complex biogenesis GO:0070271 186 0.020
embryonic pattern specification GO:0009880 21 0.020
regulation of cell morphogenesis GO:0022604 40 0.020
regulation of anatomical structure morphogenesis GO:0022603 51 0.020
oxoacid metabolic process GO:0043436 47 0.020
cellular protein complex assembly GO:0043623 178 0.020
macromolecular complex assembly GO:0065003 193 0.020
regulation of neurogenesis GO:0050767 40 0.020
regulation of lipid metabolic process GO:0019216 4 0.019
muscle cell development GO:0055001 158 0.019
cellular component assembly involved in morphogenesis GO:0010927 183 0.019
synaptic target recognition GO:0008039 3 0.019
gene silencing GO:0016458 143 0.019
axonal fasciculation GO:0007413 79 0.019
organic acid metabolic process GO:0006082 47 0.019
cell recognition GO:0008037 85 0.019
posttranscriptional gene silencing by rna GO:0035194 143 0.019
protein complex assembly GO:0006461 186 0.019
cell type specific apoptotic process GO:0097285 4 0.019
regeneration GO:0031099 4 0.018
cellular response to stress GO:0033554 162 0.018
cellular localization GO:0051641 360 0.018
adult behavior GO:0030534 3 0.018
tissue morphogenesis GO:0048729 65 0.018
carboxylic acid metabolic process GO:0019752 34 0.018
regulation of cytoplasmic transport GO:1903649 3 0.018
cell proliferation GO:0008283 116 0.018
striated muscle myosin thick filament assembly GO:0071688 138 0.018
regulation of cell development GO:0060284 49 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 29 0.018
organelle fission GO:0048285 363 0.017
regulation of cell proliferation GO:0042127 105 0.017
regulation of cell death GO:0010941 65 0.017
positive regulation of neuron differentiation GO:0045666 4 0.017
regulation of cell cycle GO:0051726 194 0.017
myosin filament organization GO:0031033 138 0.017
establishment of cell polarity GO:0030010 46 0.017
regulation of epithelial cell proliferation GO:0050678 1 0.017
intracellular receptor signaling pathway GO:0030522 2 0.017
epithelial cell proliferation GO:0050673 1 0.016
inductive cell migration GO:0040039 145 0.016
regulation of signaling GO:0023051 172 0.016
cellular ketone metabolic process GO:0042180 14 0.016
mitotic cell cycle process GO:1903047 194 0.016
regulation of gastrulation GO:0010470 4 0.016
response to acid chemical GO:0001101 4 0.016
regulation of apoptotic signaling pathway GO:2001233 1 0.016
development of primary male sexual characteristics GO:0046546 4 0.016
myosin filament assembly GO:0031034 138 0.016
establishment or maintenance of cell polarity GO:0007163 63 0.016
phosphorus metabolic process GO:0006793 232 0.015
response to temperature stimulus GO:0009266 66 0.015
actomyosin structure organization GO:0031032 154 0.015
dendrite development GO:0016358 42 0.015
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.015
microtubule based process GO:0007017 182 0.015
positive regulation of vulval development GO:0040026 52 0.015
phosphate containing compound metabolic process GO:0006796 232 0.015
protein localization GO:0008104 205 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
regulation of gene expression epigenetic GO:0040029 163 0.015
neurological system process GO:0050877 53 0.015
intracellular signal transduction GO:0035556 96 0.014
canonical wnt signaling pathway GO:0060070 3 0.014
cellular response to chemical stimulus GO:0070887 129 0.014
Mouse
protein modification process GO:0036211 207 0.014
regulation of hormone secretion GO:0046883 2 0.014
pigmentation GO:0043473 2 0.014
rna interference GO:0016246 137 0.014
regulation of protein metabolic process GO:0051246 81 0.014
response to other organism GO:0051707 101 0.014
regulation of response to wounding GO:1903034 1 0.014
secretion GO:0046903 147 0.014
response to organic substance GO:0010033 131 0.014
Mouse
cellular amino acid metabolic process GO:0006520 15 0.014
regulation of neuron projection development GO:0010975 31 0.014
myofibril assembly GO:0030239 154 0.014
regulation of organelle organization GO:0033043 164 0.013
neuron projection extension GO:1990138 37 0.013
response to external biotic stimulus GO:0043207 101 0.013
amine metabolic process GO:0009308 15 0.013
detection of external stimulus GO:0009581 4 0.013
cellular response to abiotic stimulus GO:0071214 4 0.013
lipid metabolic process GO:0006629 77 0.013
Worm
single organism catabolic process GO:0044712 129 0.013
excretion GO:0007588 49 0.013
regulation of nuclear division GO:0051783 115 0.013
collagen and cuticulin based cuticle development GO:0040002 99 0.013
cellular catabolic process GO:0044248 199 0.013
single organism behavior GO:0044708 83 0.013
establishment of organelle localization GO:0051656 123 0.013
neuromuscular junction development GO:0007528 2 0.013
regulation of nervous system development GO:0051960 41 0.013
regulation of molecular function GO:0065009 89 0.012
translation GO:0006412 37 0.012
positive regulation of nematode larval development GO:0061063 54 0.012
regulation of meiotic cell cycle GO:0051445 136 0.012
regulation of development heterochronic GO:0040034 18 0.012
chromatin remodeling GO:0006338 2 0.012
membrane organization GO:0061024 135 0.012
cellular protein modification process GO:0006464 207 0.012
adult locomotory behavior GO:0008344 1 0.012
ribonucleoprotein complex assembly GO:0022618 4 0.012
mechanosensory behavior GO:0007638 25 0.012
regulation of nucleocytoplasmic transport GO:0046822 3 0.012
organic substance transport GO:0071702 113 0.012
positive regulation of epithelial cell proliferation GO:0050679 1 0.012
response to biotic stimulus GO:0009607 101 0.012
positive regulation of intracellular transport GO:0032388 2 0.012
chromosome segregation GO:0007059 180 0.012
regulation of meiosis GO:0040020 94 0.012
organelle localization GO:0051640 127 0.012
regulation of reproductive process GO:2000241 66 0.012
establishment of mitotic spindle orientation GO:0000132 28 0.012
cuticle development GO:0042335 100 0.012
negative regulation of neuron differentiation GO:0045665 4 0.012
cellular nitrogen compound catabolic process GO:0044270 119 0.011
hormone transport GO:0009914 2 0.011
positive regulation of molecular function GO:0044093 61 0.011
meiotic cell cycle process GO:1903046 170 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of protein transport GO:0051222 4 0.011
developmental growth involved in morphogenesis GO:0060560 37 0.011
cellular amine metabolic process GO:0044106 15 0.011
organic cyclic compound catabolic process GO:1901361 119 0.011
heterocycle catabolic process GO:0046700 119 0.011
positive regulation of cell migration GO:0030335 3 0.011
protein oligomerization GO:0051259 4 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
olfactory behavior GO:0042048 27 0.011
fertilization GO:0009566 63 0.011
negative regulation of cell communication GO:0010648 61 0.011
regulation of anatomical structure size GO:0090066 46 0.011
single organism biosynthetic process GO:0044711 91 0.011
phagocytosis GO:0006909 115 0.011
Worm
cytokinesis GO:0000910 80 0.011
regulation of axonogenesis GO:0050770 24 0.011
regulation of cell cycle process GO:0010564 145 0.011
regulation of cell projection organization GO:0031344 38 0.011
Mouse
neuron apoptotic process GO:0051402 4 0.010
regulation of epithelial cell differentiation GO:0030856 4 0.010
regulation of cellular protein metabolic process GO:0032268 75 0.010
rho protein signal transduction GO:0007266 2 0.010
single organism membrane fusion GO:0044801 13 0.010
regulation of neuron differentiation GO:0045664 40 0.010
regulation of bmp signaling pathway GO:0030510 3 0.010
rna localization GO:0006403 3 0.010
peptide hormone secretion GO:0030072 2 0.010
response to bacterium GO:0009617 86 0.010
negative regulation of response to external stimulus GO:0032102 3 0.010

klf-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.012
disease of cellular proliferation DOID:14566 0 0.010