Caenorhabditis elegans

217 known processes

let-60 (CELE_ZK792.6)

Protein LET-60

let-60 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axonogenesis GO:0007409 102 0.964
positive regulation of locomotion GO:0040017 42 0.958
Human
cell part morphogenesis GO:0032990 152 0.950
neuron projection guidance GO:0097485 82 0.944
cell morphogenesis GO:0000902 163 0.942
Fly
cell fate commitment GO:0045165 139 0.920
positive regulation of nematode larval development GO:0061063 54 0.919
developmental process involved in reproduction GO:0003006 1165 0.902
neuron projection morphogenesis GO:0048812 114 0.881
axon guidance GO:0007411 82 0.881
response to fibroblast growth factor GO:0071774 5 0.879
positive regulation of rna biosynthetic process GO:1902680 102 0.878
Human
regulation of vulval development GO:0040028 248 0.877
cell projection morphogenesis GO:0048858 148 0.873
establishment of localization GO:0051234 1171 0.856
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.851
Fly
cell motility GO:0048870 313 0.829
Human Fly
taxis GO:0042330 128 0.810
regulation of cell migration GO:0030334 55 0.807
Human
locomotion GO:0040011 1634 0.807
post embryonic development GO:0009791 2152 0.804
regulation of nitrogen compound metabolic process GO:0051171 222 0.802
cell projection organization GO:0030030 231 0.796
embryo development ending in birth or egg hatching GO:0009792 2992 0.795
response to wounding GO:0009611 4 0.790
Human
sex differentiation GO:0007548 909 0.789
epidermis development GO:0008544 24 0.770
positive regulation of signaling GO:0023056 66 0.764
Human Mouse Fly
fibroblast growth factor receptor signaling pathway GO:0008543 5 0.749
cell surface receptor signaling pathway GO:0007166 149 0.746
organ development GO:0048513 1102 0.741
localization of cell GO:0051674 313 0.740
Human Fly
cellular response to growth factor stimulus GO:0071363 18 0.733
regulation of cell fate commitment GO:0010453 22 0.730
signaling GO:0023052 401 0.727
cellular component morphogenesis GO:0032989 318 0.726
Fly
cell morphogenesis involved in differentiation GO:0000904 112 0.723
Fly
guanosine containing compound metabolic process GO:1901068 49 0.719
positive regulation of ras protein signal transduction GO:0046579 7 0.713
Mouse
cell migration GO:0016477 306 0.709
Human Fly
chemotaxis GO:0006935 120 0.697
positive regulation of vulval development GO:0040026 52 0.696
regulation of nucleic acid templated transcription GO:1903506 165 0.689
Human
reproductive structure development GO:0048608 850 0.671
positive regulation of signal transduction GO:0009967 40 0.670
Human Mouse Fly
positive regulation of cellular process GO:0048522 332 0.669
positive regulation of transcription dna templated GO:0045893 102 0.664
Human
transport GO:0006810 1093 0.663
skin development GO:0043588 24 0.662
single organism reproductive process GO:0044702 1196 0.655
development of primary sexual characteristics GO:0045137 840 0.652
generation of neurons GO:0048699 235 0.650
Fly
regulation of cell morphogenesis GO:0022604 40 0.647
positive regulation of post embryonic development GO:0048582 54 0.644
positive regulation of cell migration GO:0030335 3 0.642
Human
tissue development GO:0009888 112 0.633
Mouse Fly
erbb signaling pathway GO:0038127 9 0.628
wnt signaling pathway GO:0016055 27 0.625
vulval development GO:0040025 333 0.619
gonad development GO:0008406 840 0.614
embryo development GO:0009790 3052 0.607
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.605
ribonucleotide catabolic process GO:0009261 75 0.598
ribonucleoside triphosphate catabolic process GO:0009203 72 0.593
cell development GO:0048468 696 0.591
skeletal muscle organ development GO:0060538 3 0.589
Mouse
regulation of nematode larval development GO:0061062 260 0.587
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.580
neuron development GO:0048666 199 0.579
Fly
positive regulation of cell communication GO:0010647 69 0.575
Human Mouse Fly
carbohydrate derivative catabolic process GO:1901136 82 0.574
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.570
regulation of locomotion GO:0040012 161 0.560
Human
sexual reproduction GO:0019953 546 0.557
gastrulation GO:0007369 58 0.556
Fly
multicellular organism reproduction GO:0032504 819 0.551
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.550
Human
regulation of signaling GO:0023051 172 0.549
gamete generation GO:0007276 461 0.547
ribonucleoside triphosphate metabolic process GO:0009199 87 0.542
single organism localization GO:1902578 518 0.541
response to endogenous stimulus GO:0009719 33 0.534
negative regulation of biological process GO:0048519 567 0.532
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 34 0.531
regulation of cell fate specification GO:0042659 22 0.531
head development GO:0060322 1 0.524
positive regulation of small gtpase mediated signal transduction GO:0051057 7 0.522
Mouse
nucleotide metabolic process GO:0009117 108 0.517
axon development GO:0061564 163 0.517
multicellular organismal reproductive process GO:0048609 815 0.516
cell growth GO:0016049 44 0.515
Fly
purine containing compound catabolic process GO:0072523 75 0.513
regulation of multicellular organismal development GO:2000026 317 0.513
glycosyl compound metabolic process GO:1901657 100 0.509
reproductive system development GO:0061458 850 0.506
nucleoside triphosphate catabolic process GO:0009143 72 0.501
organonitrogen compound catabolic process GO:1901565 90 0.494
multicellular organismal reproductive behavior GO:0033057 384 0.493
positive regulation of cellular metabolic process GO:0031325 178 0.488
muscle tissue development GO:0060537 1 0.487
Mouse
cellular component movement GO:0006928 388 0.480
Human Fly
positive regulation of nucleic acid templated transcription GO:1903508 102 0.473
Human
regulation of gtp catabolic process GO:0033124 32 0.466
nucleic acid templated transcription GO:0097659 169 0.465
Human
regulation of developmental process GO:0050793 684 0.463
establishment of vesicle localization GO:0051650 23 0.461
genitalia development GO:0048806 741 0.460
response to organic substance GO:0010033 131 0.458
regulation of rna metabolic process GO:0051252 173 0.455
Human
regulation of cellular metabolic process GO:0031323 305 0.448
regulation of filopodium assembly GO:0051489 2 0.447
enzyme linked receptor protein signaling pathway GO:0007167 50 0.446
autophagy GO:0006914 29 0.443
Fly
positive regulation of intracellular signal transduction GO:1902533 24 0.440
Human Mouse Fly
nucleotide catabolic process GO:0009166 77 0.436
response to chemical GO:0042221 356 0.426
nucleobase containing compound metabolic process GO:0006139 406 0.426
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.423
Human
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.420
nucleoside triphosphate metabolic process GO:0009141 87 0.419
nucleic acid metabolic process GO:0090304 299 0.418
Human
heterocycle catabolic process GO:0046700 119 0.415
small gtpase mediated signal transduction GO:0007264 32 0.414
Human Mouse
regulation of cellular component movement GO:0051270 62 0.409
Human
positive regulation of neurogenesis GO:0050769 4 0.408
Fly
nucleobase containing compound catabolic process GO:0034655 114 0.407
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.403
catabolic process GO:0009056 318 0.400
regulation of rna biosynthetic process GO:2001141 165 0.399
Human
regulation of response to stimulus GO:0048583 243 0.399
single organism signaling GO:0044700 401 0.395
nervous system development GO:0007399 253 0.394
Fly
ras protein signal transduction GO:0007265 31 0.387
Human Mouse
male sex differentiation GO:0046661 86 0.385
protein modification process GO:0036211 207 0.380
Human
regulation of organ morphogenesis GO:2000027 4 0.376
Fly
digestive tract development GO:0048565 122 0.374
Fly
neuron differentiation GO:0030182 217 0.373
Fly
tissue morphogenesis GO:0048729 65 0.371
Mouse
behavior GO:0007610 527 0.368
Mouse
mesodermal cell differentiation GO:0048333 15 0.367
motor neuron axon guidance GO:0008045 13 0.364
regulation of cell motility GO:2000145 57 0.364
Human
nucleoside phosphate catabolic process GO:1901292 77 0.363
positive regulation of biosynthetic process GO:0009891 109 0.362
Human
hermaphrodite genitalia development GO:0040035 734 0.358
response to growth factor GO:0070848 18 0.354
neurogenesis GO:0022008 236 0.353
Fly
meiotic cell cycle GO:0051321 335 0.352
organelle organization GO:0006996 783 0.351
Human Mouse
neuron projection development GO:0031175 187 0.351
regulation of macromolecule biosynthetic process GO:0010556 189 0.348
Human
purine nucleotide catabolic process GO:0006195 75 0.346
post embryonic organ development GO:0048569 336 0.343
regulation of primary metabolic process GO:0080090 292 0.343
positive regulation of purine nucleotide catabolic process GO:0033123 28 0.338
regulation of cellular component organization GO:0051128 248 0.336
organic cyclic compound biosynthetic process GO:1901362 195 0.334
Human
regulation of signal transduction GO:0009966 135 0.334
positive regulation of response to stimulus GO:0048584 55 0.334
Human Mouse Fly
meiotic nuclear division GO:0007126 300 0.333
pattern specification process GO:0007389 59 0.332
Fly
negative regulation of cellular process GO:0048523 239 0.330
Human Mouse Fly
programmed cell death GO:0012501 500 0.329
Mouse Fly
anterior posterior axis specification GO:0009948 17 0.326
protein complex subunit organization GO:0071822 280 0.319
embryonic pattern specification GO:0009880 21 0.319
protein metabolic process GO:0019538 422 0.319
Human
epidermal growth factor receptor signaling pathway GO:0007173 9 0.315
positive regulation of neuron differentiation GO:0045666 4 0.314
Fly
regulation of transcription dna templated GO:0006355 164 0.311
Human
positive regulation of cell morphogenesis involved in differentiation GO:0010770 4 0.310
male anatomical structure morphogenesis GO:0090598 78 0.309
membrane organization GO:0061024 135 0.308
response to external stimulus GO:0009605 289 0.291
Fly
sensory organ morphogenesis GO:0090596 2 0.289
Fly
regulation of multicellular organismal process GO:0051239 726 0.289
rna metabolic process GO:0016070 228 0.287
Human
macromolecule catabolic process GO:0009057 202 0.285
regulation of meiosis GO:0040020 94 0.284
positive regulation of ras gtpase activity GO:0032320 19 0.282
purine ribonucleoside metabolic process GO:0046128 92 0.281
oviposition GO:0018991 364 0.280
signal transduction GO:0007165 317 0.277
purine nucleoside triphosphate metabolic process GO:0009144 87 0.276
regulation of cell communication GO:0010646 176 0.276
cellular protein metabolic process GO:0044267 279 0.276
Human
regulation of cell differentiation GO:0045595 81 0.275
nucleoside phosphate metabolic process GO:0006753 108 0.273
vesicle mediated transport GO:0016192 852 0.272
single organism transport GO:0044765 447 0.271
reproductive behavior GO:0019098 387 0.270
cellular response to organic substance GO:0071310 119 0.270
regulation of neuron differentiation GO:0045664 40 0.270
Fly
establishment of localization in cell GO:0051649 318 0.270
regulation of molecular function GO:0065009 89 0.270
ribonucleoside catabolic process GO:0042454 77 0.269
rho protein signal transduction GO:0007266 2 0.267
purine nucleoside metabolic process GO:0042278 92 0.266
macromolecule biosynthetic process GO:0009059 250 0.266
Human
cellular response to endogenous stimulus GO:0071495 32 0.266
cellular macromolecule biosynthetic process GO:0034645 247 0.265
Human
positive regulation of cell cycle GO:0045787 55 0.263
positive regulation of metabolic process GO:0009893 187 0.259
regionalization GO:0003002 31 0.259
Fly
anterior posterior pattern specification GO:0009952 27 0.259
regulation of nucleoside metabolic process GO:0009118 37 0.257
organophosphate catabolic process GO:0046434 81 0.257
ribonucleotide metabolic process GO:0009259 99 0.251
regulation of post embryonic development GO:0048580 260 0.251
regulation of meiotic cell cycle GO:0051445 136 0.251
gtp catabolic process GO:0006184 46 0.248
actin filament based process GO:0030029 191 0.248
Human Mouse
regulation of cellular biosynthetic process GO:0031326 189 0.246
Human
developmental growth involved in morphogenesis GO:0060560 37 0.243
purine ribonucleotide catabolic process GO:0009154 75 0.238
vesicle localization GO:0051648 24 0.231
regulation of cell projection organization GO:0031344 38 0.230
positive regulation of molecular function GO:0044093 61 0.229
regulation of response to wounding GO:1903034 1 0.229
Human
regulation of cell cycle GO:0051726 194 0.227
Human
inductive cell migration GO:0040039 145 0.226
glycosyl compound catabolic process GO:1901658 79 0.224
secretion by cell GO:0032940 138 0.223
regulation of gtpase activity GO:0043087 30 0.221
regulation of cell projection assembly GO:0060491 3 0.216
Human
positive regulation of gene expression GO:0010628 112 0.216
Human Mouse
regulation of anatomical structure morphogenesis GO:0022603 51 0.216
Fly
aging GO:0007568 812 0.215
Human Mouse Worm
aromatic compound biosynthetic process GO:0019438 192 0.214
Human
cell type specific apoptotic process GO:0097285 4 0.213
Mouse
filopodium assembly GO:0046847 2 0.212
regeneration GO:0031099 4 0.208
regulation of metabolic process GO:0019222 478 0.208
regulation of ras gtpase activity GO:0032318 21 0.206
germ cell development GO:0007281 351 0.204
protein catabolic process GO:0030163 162 0.204
cell cycle GO:0007049 526 0.203
Human
regulation of cell adhesion GO:0030155 6 0.202
system process GO:0003008 136 0.201
Mouse
organic substance catabolic process GO:1901575 294 0.200
positive regulation of catalytic activity GO:0043085 59 0.199
memory GO:0007613 3 0.197
purine nucleoside triphosphate catabolic process GO:0009146 72 0.197
body morphogenesis GO:0010171 620 0.196
mesoderm morphogenesis GO:0048332 24 0.195
digestive tract morphogenesis GO:0048546 76 0.195
Fly
gene expression GO:0010467 412 0.193
Human Mouse
rna biosynthetic process GO:0032774 169 0.192
Human
epidermal cell differentiation GO:0009913 7 0.191
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.191
Human
cellular biosynthetic process GO:0044249 315 0.189
Human
cellular nitrogen compound biosynthetic process GO:0044271 192 0.189
Human
regulation of biosynthetic process GO:0009889 189 0.187
Human
regulation of ras protein signal transduction GO:0046578 41 0.187
positive regulation of gtpase activity GO:0043547 28 0.186
multi organism behavior GO:0051705 389 0.184
positive regulation of rna metabolic process GO:0051254 103 0.182
Human
carbohydrate derivative metabolic process GO:1901135 141 0.181
determination of adult lifespan GO:0008340 812 0.181
Worm
cell substrate adhesion GO:0031589 1 0.180
endocytosis GO:0006897 819 0.180
cell cycle process GO:0022402 482 0.180
Human
regulation of organelle organization GO:0033043 164 0.179
Human
single organism organelle organization GO:1902589 501 0.176
Human Mouse
protein localization GO:0008104 205 0.175
Worm Fly
multi organism reproductive behavior GO:0044705 387 0.175
multi multicellular organism process GO:0044706 390 0.174
cell projection assembly GO:0030031 35 0.174
Human
cellular protein localization GO:0034613 75 0.173
Worm Fly
nucleobase containing compound biosynthetic process GO:0034654 184 0.172
Human
positive regulation of epithelial cell proliferation GO:0050679 1 0.172
Human
ribose phosphate metabolic process GO:0019693 99 0.172
cell division GO:0051301 262 0.171
neural precursor cell proliferation GO:0061351 9 0.170
biosynthetic process GO:0009058 323 0.169
Human
apoptotic process GO:0006915 478 0.167
Mouse Fly
multi organism reproductive process GO:0044703 867 0.166
tube morphogenesis GO:0035239 79 0.165
Mouse Fly
axis specification GO:0009798 23 0.165
Fly
regulation of canonical wnt signaling pathway GO:0060828 1 0.164
small molecule metabolic process GO:0044281 186 0.163
receptor mediated endocytosis GO:0006898 715 0.160
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.160
Human
epithelium development GO:0060429 68 0.159
Mouse Fly
purine containing compound metabolic process GO:0072521 95 0.159
canonical wnt signaling pathway GO:0060070 3 0.158
regulation of axonogenesis GO:0050770 24 0.155
negative regulation of multicellular organismal process GO:0051241 236 0.155
female gamete generation GO:0007292 254 0.154
tube development GO:0035295 126 0.154
Mouse Fly
embryonic morphogenesis GO:0048598 152 0.153
Zebrafish Fly
defense response GO:0006952 296 0.150
cellular response to fibroblast growth factor stimulus GO:0044344 5 0.149
negative regulation of macromolecule metabolic process GO:0010605 229 0.149
Human
regulation of gene expression GO:0010468 366 0.149
Human Mouse
establishment of organelle localization GO:0051656 123 0.148
transcription dna templated GO:0006351 168 0.146
Human
positive regulation of macromolecule metabolic process GO:0010604 149 0.146
Human Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 29 0.144
tube formation GO:0035148 2 0.144
stem cell division GO:0017145 18 0.144
cellular component biogenesis GO:0044085 297 0.143
Human
secretion GO:0046903 147 0.143
phosphate containing compound metabolic process GO:0006796 232 0.142
negative regulation of nematode larval development GO:0061064 208 0.142
cell adhesion GO:0007155 21 0.141
nucleobase containing small molecule metabolic process GO:0055086 115 0.141
growth GO:0040007 562 0.141
Fly
organonitrogen compound metabolic process GO:1901564 151 0.141
positive regulation of cell projection organization GO:0031346 4 0.140
Human
regulation of cell division GO:0051302 142 0.139
nucleoside metabolic process GO:0009116 99 0.138
organophosphate metabolic process GO:0019637 125 0.134
transcription from rna polymerase ii promoter GO:0006366 149 0.132
Human
organelle localization GO:0051640 127 0.131
positive regulation of phosphate metabolic process GO:0045937 56 0.131
regulation of biological quality GO:0065008 741 0.131
Mouse Fly
oogenesis GO:0048477 229 0.129
cell death GO:0008219 547 0.129
Mouse Fly
macromolecule localization GO:0033036 771 0.128
Worm Fly
regulation of anatomical structure size GO:0090066 46 0.126
Fly
single organism catabolic process GO:0044712 129 0.126
cellular localization GO:0051641 360 0.126
macromolecular complex subunit organization GO:0043933 320 0.126
digestive system development GO:0055123 122 0.124
Fly
cellular response to stress GO:0033554 162 0.123
Human Fly
negative regulation of neurogenesis GO:0050768 4 0.123
cellular response to chemical stimulus GO:0070887 129 0.122
epithelial tube morphogenesis GO:0060562 1 0.122
Mouse
axon extension GO:0048675 37 0.121
aromatic compound catabolic process GO:0019439 116 0.119
single organism nuclear import GO:1902593 6 0.119
Fly
heterocycle biosynthetic process GO:0018130 187 0.118
Human
organelle fission GO:0048285 363 0.118
ribonucleoside metabolic process GO:0009119 98 0.117
multicellular organismal aging GO:0010259 812 0.117
Worm
developmental cell growth GO:0048588 39 0.116
Fly
purine ribonucleoside catabolic process GO:0046130 75 0.116
biological adhesion GO:0022610 21 0.115
positive regulation of nucleotide metabolic process GO:0045981 28 0.114
cognition GO:0050890 27 0.114
Mouse
cellular response to abiotic stimulus GO:0071214 4 0.114
dauer larval development GO:0040024 92 0.113
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.113
regulation of cell cycle process GO:0010564 145 0.113
Human
hyperosmotic response GO:0006972 19 0.112
regulation of neurogenesis GO:0050767 40 0.111
Fly
negative regulation of vulval development GO:0040027 206 0.111
cellular component assembly GO:0022607 293 0.110
Human
developmental growth GO:0048589 412 0.110
Fly
mesodermal cell fate specification GO:0007501 13 0.107
regulation of neuron projection development GO:0010975 31 0.106
cytoskeleton organization GO:0007010 339 0.105
Human Mouse
nematode male tail tip morphogenesis GO:0045138 77 0.105
molting cycle GO:0042303 281 0.105
negative regulation of response to stimulus GO:0048585 73 0.105
Fly
macromolecule modification GO:0043412 218 0.104
Human
single organism behavior GO:0044708 83 0.104
Mouse
purine nucleoside catabolic process GO:0006152 75 0.103
gtp metabolic process GO:0046039 46 0.101
neuron projection extension involved in neuron projection guidance GO:1902284 13 0.101
phosphorus metabolic process GO:0006793 232 0.100
guanosine containing compound catabolic process GO:1901069 48 0.099
cilium morphogenesis GO:0060271 33 0.099
cellular catabolic process GO:0044248 199 0.098
endodermal cell differentiation GO:0035987 18 0.096
regulation of bmp signaling pathway GO:0030510 3 0.096
oocyte axis specification GO:0007309 2 0.095
Fly
actin filament organization GO:0007015 21 0.095
regulation of response to stress GO:0080134 28 0.094
Human Fly
muscle organ morphogenesis GO:0048644 4 0.092
regulation of nuclear division GO:0051783 115 0.092
cellular nitrogen compound catabolic process GO:0044270 119 0.091
nucleoside catabolic process GO:0009164 78 0.090
anatomical structure formation involved in morphogenesis GO:0048646 250 0.090
Fly
axon extension involved in axon guidance GO:0048846 13 0.090
positive regulation of phosphorus metabolic process GO:0010562 56 0.089
positive regulation of hydrolase activity GO:0051345 38 0.089
cell proliferation GO:0008283 116 0.089
Human Mouse Fly
positive regulation of growth GO:0045927 369 0.088
regulation of gastrulation GO:0010470 4 0.088
death GO:0016265 547 0.088
Mouse Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.087
oocyte construction GO:0007308 2 0.087
Fly
cellular response to hormone stimulus GO:0032870 14 0.085
positive regulation of nucleotide catabolic process GO:0030813 28 0.085
organic substance biosynthetic process GO:1901576 323 0.085
Human
muscle structure development GO:0061061 191 0.084
intracellular signal transduction GO:0035556 96 0.083
Human Mouse Fly
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.083
regulation of catabolic process GO:0009894 57 0.082
regulation of nucleotide metabolic process GO:0006140 37 0.082
regulation of intracellular signal transduction GO:1902531 77 0.082
regulation of cellular component biogenesis GO:0044087 26 0.081
Human
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.080
regulation of mapk cascade GO:0043408 23 0.079
Human Fly
cellular protein modification process GO:0006464 207 0.079
Human
protein phosphorylation GO:0006468 85 0.077
Human
negative regulation of transcription dna templated GO:0045892 53 0.077
regulation of wnt signaling pathway GO:0030111 9 0.075
positive regulation of cell differentiation GO:0045597 8 0.075
Fly
establishment or maintenance of cell polarity GO:0007163 63 0.074
Fly
phosphorylation GO:0016310 116 0.073
Human Fly
regulation of localization GO:0032879 194 0.073
Human Worm
synaptic transmission GO:0007268 106 0.073
Mouse
negative regulation of developmental process GO:0051093 227 0.073
regulation of phosphorus metabolic process GO:0051174 81 0.072
maintenance of location GO:0051235 580 0.071
positive regulation of phosphorylation GO:0042327 27 0.071
Human Fly
regulation of apoptotic process GO:0042981 36 0.071
Mouse Fly
cellular macromolecule localization GO:0070727 75 0.069
Worm Fly
embryonic body morphogenesis GO:0010172 49 0.069
positive regulation of developmental growth GO:0048639 354 0.069
regulation of mesoderm development GO:2000380 2 0.069
epithelial cell differentiation GO:0030855 17 0.068
Fly
positive regulation of developmental process GO:0051094 408 0.067
macromolecular complex assembly GO:0065003 193 0.067
mitotic nuclear division GO:0007067 89 0.066
regulation of cell proliferation GO:0042127 105 0.066
Human Mouse Fly
bmp signaling pathway GO:0030509 3 0.066
signal transduction by phosphorylation GO:0023014 31 0.066
Human Fly
regulation of hydrolase activity GO:0051336 45 0.064
regulation of nucleotide catabolic process GO:0030811 35 0.064
response to peptide hormone GO:0043434 14 0.062
lipid storage GO:0019915 565 0.062
regulation of apoptotic signaling pathway GO:2001233 1 0.061
Fly
stem cell proliferation GO:0072089 9 0.061
Fly
positive regulation of organ growth GO:0046622 4 0.060
purine ribonucleotide metabolic process GO:0009150 95 0.057
neuron projection extension GO:1990138 37 0.057
organic cyclic compound catabolic process GO:1901361 119 0.057
cell cell signaling GO:0007267 118 0.056
Mouse
cell cycle phase transition GO:0044770 19 0.056
Human
regulation of growth GO:0040008 409 0.056
Fly
regulation of embryonic development GO:0045995 16 0.056
oocyte differentiation GO:0009994 45 0.055
Fly
regulation of programmed cell death GO:0043067 50 0.055
Mouse Fly
stem cell fate commitment GO:0048865 5 0.055
Fly
intracellular transport GO:0046907 77 0.054
Fly
neuroblast proliferation GO:0007405 9 0.054
ovulation GO:0030728 33 0.053
positive regulation of map kinase activity GO:0043406 9 0.053
Human
mesoderm development GO:0007498 27 0.053
activation of protein kinase activity GO:0032147 11 0.053
specification of axis polarity GO:0065001 13 0.053
cell junction organization GO:0034330 18 0.053
negative regulation of cellular metabolic process GO:0031324 95 0.053
Human Fly
peptidyl serine modification GO:0018209 20 0.052
lipid localization GO:0010876 573 0.052
muscle system process GO:0003012 43 0.052
positive regulation of mapk cascade GO:0043410 14 0.051
Human Fly
neurological system process GO:0050877 53 0.051
Mouse
positive regulation of multicellular organismal process GO:0051240 417 0.050
organ morphogenesis GO:0009887 67 0.050
Zebrafish Mouse Fly
muscle cell differentiation GO:0042692 171 0.049
Mouse
phagocytosis GO:0006909 115 0.049
protein complex biogenesis GO:0070271 186 0.048
engulfment of apoptotic cell GO:0043652 94 0.048
establishment of protein localization to membrane GO:0090150 3 0.047
cell matrix adhesion GO:0007160 1 0.047
regulation of cell cell adhesion GO:0022407 1 0.047
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.047
negative regulation of metabolic process GO:0009892 240 0.047
Human Fly
positive regulation of protein metabolic process GO:0051247 45 0.046
Human
regulation of developmental growth GO:0048638 389 0.046
Fly
positive regulation of transferase activity GO:0051347 21 0.046
Human
epithelial cell proliferation GO:0050673 1 0.045
Human
positive regulation of protein kinase activity GO:0045860 18 0.045
Human
negative regulation of cell cycle GO:0045786 53 0.045
Human
negative regulation of cellular component organization GO:0051129 33 0.045
negative regulation of signaling GO:0023057 61 0.045
Fly
actin cytoskeleton organization GO:0030036 184 0.045
Human Mouse
mitotic cell cycle process GO:1903047 194 0.044
Human
muscle organ development GO:0007517 26 0.044
phagocytosis engulfment GO:0006911 98 0.044
regulation of small gtpase mediated signal transduction GO:0051056 41 0.043
regulation of epithelial cell proliferation GO:0050678 1 0.043
Human
regulation of reproductive process GO:2000241 66 0.043
developmental induction GO:0031128 1 0.042
membrane invagination GO:0010324 98 0.042
apoptotic cell clearance GO:0043277 111 0.042
extracellular matrix organization GO:0030198 6 0.041
cellular protein complex assembly GO:0043623 178 0.041
single organism membrane organization GO:0044802 35 0.041
positive regulation of catabolic process GO:0009896 38 0.041
organic substance transport GO:0071702 113 0.041
Fly
protein complex assembly GO:0006461 186 0.040
mesodermal cell migration GO:0008078 9 0.040
regulation of axon extension GO:0030516 20 0.040
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.039
regulation of nervous system development GO:0051960 41 0.039
Fly
regulation of nucleocytoplasmic transport GO:0046822 3 0.039
somatic stem cell division GO:0048103 9 0.039
single organism intracellular transport GO:1902582 70 0.038
Fly

let-60 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.061
cardiovascular system disease DOID:1287 0 0.061
disease of cellular proliferation DOID:14566 0 0.050
Human
cancer DOID:162 0 0.044
Human