Caenorhabditis elegans

51 known processes

let-381 (CELE_F26B1.7)

Protein LET-381

let-381 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.377
locomotion GO:0040011 1634 0.303
post embryonic development GO:0009791 2152 0.243
embryo development ending in birth or egg hatching GO:0009792 2992 0.200
Worm
reproductive system development GO:0061458 850 0.173
signaling GO:0023052 401 0.172
regulation of locomotion GO:0040012 161 0.165
establishment of localization GO:0051234 1171 0.144
Worm
meiotic nuclear division GO:0007126 300 0.135
transport GO:0006810 1093 0.135
Worm
cell cycle process GO:0022402 482 0.121
growth GO:0040007 562 0.120
Worm
endocytosis GO:0006897 819 0.116
Worm
gonad development GO:0008406 840 0.114
meiotic cell cycle GO:0051321 335 0.108
macromolecule localization GO:0033036 771 0.107
Worm
regulation of multicellular organismal process GO:0051239 726 0.104
Worm
regulation of developmental process GO:0050793 684 0.101
Worm
development of primary sexual characteristics GO:0045137 840 0.101
receptor mediated endocytosis GO:0006898 715 0.101
Worm
organ development GO:0048513 1102 0.098
response to chemical GO:0042221 356 0.098
Worm
vulval development GO:0040025 333 0.097
Worm
multicellular organismal aging GO:0010259 812 0.097
Worm
regulation of biological quality GO:0065008 741 0.095
Worm
regulation of metabolic process GO:0019222 478 0.095
Worm Fly
negative regulation of vulval development GO:0040027 206 0.094
Worm
cilium morphogenesis GO:0060271 33 0.094
Worm
regulation of vulval development GO:0040028 248 0.092
Worm
aging GO:0007568 812 0.091
Worm
single organism reproductive process GO:0044702 1196 0.089
post embryonic organ development GO:0048569 336 0.088
Worm
regulation of cellular metabolic process GO:0031323 305 0.086
Worm Fly
organelle organization GO:0006996 783 0.086
Worm
reproductive structure development GO:0048608 850 0.085
developmental process involved in reproduction GO:0003006 1165 0.085
transcription from rna polymerase ii promoter GO:0006366 149 0.085
Worm Fly
regulation of macromolecule metabolic process GO:0060255 421 0.081
Worm Fly
multi organism reproductive process GO:0044703 867 0.080
Worm
vesicle mediated transport GO:0016192 852 0.078
Worm
positive regulation of developmental growth GO:0048639 354 0.078
Worm
organelle fission GO:0048285 363 0.078
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.077
Worm
cell division GO:0051301 262 0.077
determination of adult lifespan GO:0008340 812 0.076
Worm
single organism signaling GO:0044700 401 0.076
taxis GO:0042330 128 0.075
Worm
regulation of meiosis GO:0040020 94 0.075
positive regulation of multicellular organismal process GO:0051240 417 0.073
Worm
body morphogenesis GO:0010171 620 0.072
negative regulation of biological process GO:0048519 567 0.072
Worm
lipid storage GO:0019915 565 0.071
maintenance of location GO:0051235 580 0.071
Worm
cell development GO:0048468 696 0.069
Worm
lipid localization GO:0010876 573 0.068
positive regulation of developmental process GO:0051094 408 0.067
Worm
cellular component morphogenesis GO:0032989 318 0.066
Worm
positive regulation of cellular metabolic process GO:0031325 178 0.066
Worm
regulation of meiotic cell cycle GO:0051445 136 0.065
negative regulation of post embryonic development GO:0048581 208 0.065
Worm
multicellular organism reproduction GO:0032504 819 0.064
Worm
regulation of developmental growth GO:0048638 389 0.064
Worm
single organism transport GO:0044765 447 0.064
heterocycle biosynthetic process GO:0018130 187 0.063
Worm Fly
behavior GO:0007610 527 0.062
Worm
positive regulation of cellular process GO:0048522 332 0.062
Worm
regulation of multicellular organismal development GO:2000026 317 0.061
Worm
anatomical structure formation involved in morphogenesis GO:0048646 250 0.059
cell death GO:0008219 547 0.059
single organism localization GO:1902578 518 0.059
multi organism reproductive behavior GO:0044705 387 0.058
Worm
positive regulation of growth GO:0045927 369 0.057
Worm
single organism organelle organization GO:1902589 501 0.056
Worm
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.056
Worm
gene expression GO:0010467 412 0.056
Worm Fly
cell migration GO:0016477 306 0.053
sex differentiation GO:0007548 909 0.053
regulation of cell communication GO:0010646 176 0.052
Worm
developmental growth GO:0048589 412 0.052
Worm
regulation of multicellular organism growth GO:0040014 373 0.052
Worm
regulation of nematode larval development GO:0061062 260 0.052
Worm
regulation of nuclear division GO:0051783 115 0.051
axon development GO:0061564 163 0.051
Worm
cell cycle GO:0007049 526 0.051
regulation of nitrogen compound metabolic process GO:0051171 222 0.051
Worm Fly
multicellular organism growth GO:0035264 385 0.051
Worm
cell motility GO:0048870 313 0.050
cellular component assembly GO:0022607 293 0.050
Worm
regulation of primary metabolic process GO:0080090 292 0.050
Worm Fly
multi organism behavior GO:0051705 389 0.050
Worm
cellular localization GO:0051641 360 0.049
generation of neurons GO:0048699 235 0.049
Worm
transcription dna templated GO:0006351 168 0.049
Worm Fly
multicellular organismal reproductive process GO:0048609 815 0.048
Worm
regulation of cellular biosynthetic process GO:0031326 189 0.047
Worm Fly
molting cycle GO:0042303 281 0.046
Mouse
neuron projection development GO:0031175 187 0.046
Worm
positive regulation of biosynthetic process GO:0009891 109 0.046
Worm
nervous system development GO:0007399 253 0.046
Worm
regulation of gene expression GO:0010468 366 0.045
Worm Fly
inductive cell migration GO:0040039 145 0.045
cell projection organization GO:0030030 231 0.045
Worm
localization of cell GO:0051674 313 0.045
cellular response to stress GO:0033554 162 0.045
Worm
regulation of localization GO:0032879 194 0.045
organelle assembly GO:0070925 214 0.044
Worm
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.044
Worm
reproductive behavior GO:0019098 387 0.043
Worm
regulation of growth GO:0040008 409 0.043
Worm
negative regulation of developmental process GO:0051093 227 0.043
Worm
cell cell signaling GO:0007267 118 0.043
cellular component movement GO:0006928 388 0.043
Worm
macromolecular complex subunit organization GO:0043933 320 0.043
positive regulation of multicellular organism growth GO:0040018 352 0.043
Worm
protein metabolic process GO:0019538 422 0.042
Worm
multi multicellular organism process GO:0044706 390 0.042
Worm
nucleic acid metabolic process GO:0090304 299 0.042
Worm Fly
nucleobase containing compound metabolic process GO:0006139 406 0.042
Worm Fly
hermaphrodite genitalia development GO:0040035 734 0.041
neuron development GO:0048666 199 0.041
Worm
oviposition GO:0018991 364 0.041
Worm
multicellular organismal reproductive behavior GO:0033057 384 0.040
Worm
regulation of response to stimulus GO:0048583 243 0.040
Worm
regulation of organelle organization GO:0033043 164 0.040
regulation of post embryonic development GO:0048580 260 0.039
Worm
positive regulation of nucleic acid templated transcription GO:1903508 102 0.038
Worm
muscle tissue development GO:0060537 1 0.038
positive regulation of cellular biosynthetic process GO:0031328 109 0.038
Worm
negative regulation of multicellular organismal process GO:0051241 236 0.038
Worm
response to external stimulus GO:0009605 289 0.038
Worm
cell fate commitment GO:0045165 139 0.037
regulation of macromolecule biosynthetic process GO:0010556 189 0.037
Worm Fly
cellular macromolecule biosynthetic process GO:0034645 247 0.037
Worm Fly
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.037
genitalia development GO:0048806 741 0.036
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.036
macromolecule biosynthetic process GO:0009059 250 0.036
Worm Fly
biosynthetic process GO:0009058 323 0.036
Worm Fly
signal transduction GO:0007165 317 0.035
cellular protein modification process GO:0006464 207 0.034
cellular biosynthetic process GO:0044249 315 0.034
Worm Fly
establishment of localization in cell GO:0051649 318 0.034
cellular nitrogen compound biosynthetic process GO:0044271 192 0.034
Worm Fly
cellular component assembly involved in morphogenesis GO:0010927 183 0.034
Worm
cilium organization GO:0044782 32 0.033
Worm
chemotaxis GO:0006935 120 0.033
Worm
organic substance biosynthetic process GO:1901576 323 0.033
Worm Fly
protein modification process GO:0036211 207 0.033
cellular response to organic substance GO:0071310 119 0.032
positive regulation of metabolic process GO:0009893 187 0.032
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.032
Worm Fly
death GO:0016265 547 0.032
rna metabolic process GO:0016070 228 0.032
Worm Fly
cytoskeleton organization GO:0007010 339 0.032
regulation of signal transduction GO:0009966 135 0.030
regulation of cell division GO:0051302 142 0.030
negative regulation of nematode larval development GO:0061064 208 0.029
Worm
sensory organ morphogenesis GO:0090596 2 0.029
negative regulation of metabolic process GO:0009892 240 0.029
Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.029
Worm Fly
neuron recognition GO:0008038 83 0.028
muscle organ morphogenesis GO:0048644 4 0.028
organ morphogenesis GO:0009887 67 0.028
Mouse Fly
positive regulation of epithelial cell proliferation GO:0050679 1 0.028
muscle structure development GO:0061061 191 0.028
striated muscle cell development GO:0055002 157 0.027
cellular component biogenesis GO:0044085 297 0.027
Worm
cellular protein metabolic process GO:0044267 279 0.027
Worm
muscle cell differentiation GO:0042692 171 0.027
nucleobase containing compound biosynthetic process GO:0034654 184 0.027
Worm Fly
regulation of rna biosynthetic process GO:2001141 165 0.027
Worm Fly
response to organic substance GO:0010033 131 0.027
organic substance catabolic process GO:1901575 294 0.027
negative regulation of cellular process GO:0048523 239 0.026
Worm
digestive system development GO:0055123 122 0.026
rna biosynthetic process GO:0032774 169 0.026
Worm Fly
regulation of transcription dna templated GO:0006355 164 0.026
Worm Fly
negative regulation of gene expression GO:0010629 217 0.026
Worm
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.026
Worm Fly
striated muscle cell differentiation GO:0051146 158 0.025
male anatomical structure morphogenesis GO:0090598 78 0.025
Worm
digestive tract development GO:0048565 122 0.025
neuron differentiation GO:0030182 217 0.025
Worm
regulation of cell migration GO:0030334 55 0.025
muscle cell development GO:0055001 158 0.025
cellular response to chemical stimulus GO:0070887 129 0.025
regulation of cell cycle process GO:0010564 145 0.025
head development GO:0060322 1 0.024
membrane organization GO:0061024 135 0.024
germ cell development GO:0007281 351 0.024
positive regulation of rna metabolic process GO:0051254 103 0.024
Worm
regulation of cell cycle GO:0051726 194 0.024
macromolecule modification GO:0043412 218 0.024
myofibril assembly GO:0030239 154 0.024
mesodermal cell fate specification GO:0007501 13 0.023
organic cyclic compound biosynthetic process GO:1901362 195 0.023
Worm Fly
protein localization GO:0008104 205 0.023
Worm
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.023
Worm
gastrulation GO:0007369 58 0.023
synaptic transmission GO:0007268 106 0.023
tube morphogenesis GO:0035239 79 0.022
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.022
Worm
regulation of biosynthetic process GO:0009889 189 0.022
Worm Fly
positive regulation of rna biosynthetic process GO:1902680 102 0.022
Worm
muscle system process GO:0003012 43 0.022
cell projection assembly GO:0030031 35 0.022
Worm
regulation of organ morphogenesis GO:2000027 4 0.022
tube development GO:0035295 126 0.022
cilium assembly GO:0042384 28 0.022
Worm
sexual reproduction GO:0019953 546 0.022
actin cytoskeleton organization GO:0030036 184 0.022
dauer larval development GO:0040024 92 0.022
secretion GO:0046903 147 0.021
striated muscle myosin thick filament assembly GO:0071688 138 0.021
response to wounding GO:0009611 4 0.021
axon guidance GO:0007411 82 0.021
Worm
mesodermal cell differentiation GO:0048333 15 0.021
cell surface receptor signaling pathway GO:0007166 149 0.020
skeletal muscle organ development GO:0060538 3 0.020
cell morphogenesis involved in differentiation GO:0000904 112 0.020
Worm
programmed cell death GO:0012501 500 0.020
protein complex biogenesis GO:0070271 186 0.020
gamete generation GO:0007276 461 0.020
regulation of cell motility GO:2000145 57 0.019
axonal fasciculation GO:0007413 79 0.019
cuticle development GO:0042335 100 0.019
Worm
regulation of cellular component organization GO:0051128 248 0.019
catabolic process GO:0009056 318 0.019
Worm
organic substance transport GO:0071702 113 0.019
posttranscriptional regulation of gene expression GO:0010608 166 0.019
Worm
regulation of response to wounding GO:1903034 1 0.018
nonmotile primary cilium assembly GO:0035058 18 0.018
Worm
intracellular signal transduction GO:0035556 96 0.018
negative regulation of macromolecule metabolic process GO:0010605 229 0.018
Worm
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.018
cellular macromolecular complex assembly GO:0034622 184 0.018
ribonucleoprotein complex assembly GO:0022618 4 0.018
digestive tract morphogenesis GO:0048546 76 0.018
system process GO:0003008 136 0.018
embryonic body morphogenesis GO:0010172 49 0.018
macromolecular complex assembly GO:0065003 193 0.018
collagen and cuticulin based cuticle development GO:0040002 99 0.017
Worm
positive regulation of transcription dna templated GO:0045893 102 0.017
Worm
actin filament based process GO:0030029 191 0.017
cell fate specification involved in pattern specification GO:0060573 4 0.017
Worm
female gamete generation GO:0007292 254 0.017
dendrite development GO:0016358 42 0.017
Worm
neuron projection guidance GO:0097485 82 0.017
Worm
regulation of epithelial cell proliferation GO:0050678 1 0.017
positive regulation of cell migration GO:0030335 3 0.017
cell part morphogenesis GO:0032990 152 0.017
Worm
regulation of intracellular signal transduction GO:1902531 77 0.016
aromatic compound biosynthetic process GO:0019438 192 0.016
Worm Fly
protein complex subunit organization GO:0071822 280 0.016
axonogenesis GO:0007409 102 0.016
Worm
nucleic acid templated transcription GO:0097659 169 0.016
Worm Fly
regulation of cellular ketone metabolic process GO:0010565 3 0.016
myosin filament organization GO:0031033 138 0.016
phosphorus metabolic process GO:0006793 232 0.016
regulation of synaptic transmission GO:0050804 34 0.016
memory GO:0007613 3 0.016
negative regulation of cellular metabolic process GO:0031324 95 0.016
Worm
protein complex assembly GO:0006461 186 0.016
epithelial cell proliferation GO:0050673 1 0.016
phosphate containing compound metabolic process GO:0006796 232 0.016
phosphorylation GO:0016310 116 0.016
myosin filament assembly GO:0031034 138 0.016
response to abiotic stimulus GO:0009628 152 0.016
neurogenesis GO:0022008 236 0.016
Worm
cellular catabolic process GO:0044248 199 0.015
Worm
canonical wnt signaling pathway GO:0060070 3 0.015
defense response GO:0006952 296 0.015
posttranscriptional gene silencing GO:0016441 143 0.015
regulation of cellular component movement GO:0051270 62 0.015
cell substrate adhesion GO:0031589 1 0.015
regulation of signaling GO:0023051 172 0.015
regeneration GO:0031099 4 0.015
regulation of gene expression epigenetic GO:0040029 163 0.015
apoptotic process GO:0006915 478 0.015
regulation of filopodium assembly GO:0051489 2 0.015
protein oligomerization GO:0051259 4 0.015
posttranscriptional gene silencing by rna GO:0035194 143 0.015
single organism catabolic process GO:0044712 129 0.015
Worm
regulation of catalytic activity GO:0050790 78 0.015
regulation of cell proliferation GO:0042127 105 0.015
secretion by cell GO:0032940 138 0.015
cell projection morphogenesis GO:0048858 148 0.014
Worm
apoptotic cell clearance GO:0043277 111 0.014
cellular amine metabolic process GO:0044106 15 0.014
cellular protein complex assembly GO:0043623 178 0.014
epithelial tube morphogenesis GO:0060562 1 0.014
regulation of rna metabolic process GO:0051252 173 0.014
Worm Fly
positive regulation of vulval development GO:0040026 52 0.014
actomyosin structure organization GO:0031032 154 0.014
negative regulation of response to stimulus GO:0048585 73 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 34 0.014
chromosome segregation GO:0007059 180 0.014
nematode male tail tip morphogenesis GO:0045138 77 0.014
Worm
small molecule metabolic process GO:0044281 186 0.014
positive regulation of neurogenesis GO:0050769 4 0.014
single organism behavior GO:0044708 83 0.014
mitotic cell cycle process GO:1903047 194 0.014
regulation of apoptotic signaling pathway GO:2001233 1 0.014
mesoderm development GO:0007498 27 0.014
regulation of cell projection assembly GO:0060491 3 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
positive regulation of signaling GO:0023056 66 0.014
mitotic nuclear division GO:0007067 89 0.013
oogenesis GO:0048477 229 0.013
gene silencing GO:0016458 143 0.013
macromolecule catabolic process GO:0009057 202 0.013
positive regulation of cell communication GO:0010647 69 0.013
Worm
amine metabolic process GO:0009308 15 0.013
adult behavior GO:0030534 3 0.013
muscle fiber development GO:0048747 2 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
cell type specific apoptotic process GO:0097285 4 0.013
rna localization GO:0006403 3 0.013
organonitrogen compound metabolic process GO:1901564 151 0.013
positive regulation of locomotion GO:0040017 42 0.013
cell morphogenesis GO:0000902 163 0.013
Worm
embryonic morphogenesis GO:0048598 152 0.013
cellular response to abiotic stimulus GO:0071214 4 0.013
positive regulation of macromolecule metabolic process GO:0010604 149 0.013
Worm
neuron projection morphogenesis GO:0048812 114 0.012
Worm
protein phosphorylation GO:0006468 85 0.012
regulation of behavior GO:0050795 97 0.012
positive regulation of gene expression GO:0010628 112 0.012
Worm
sex determination GO:0007530 60 0.012
Worm
negative regulation of gene expression epigenetic GO:0045814 2 0.012
regulation of cell death GO:0010941 65 0.012
neuromuscular junction development GO:0007528 2 0.012
tissue development GO:0009888 112 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.012
Worm
development of primary male sexual characteristics GO:0046546 4 0.012
Worm
organic cyclic compound catabolic process GO:1901361 119 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.011
negative regulation of signaling GO:0023057 61 0.011
regulation of cytoplasmic transport GO:1903649 3 0.011
germ line sex determination GO:0018992 51 0.011
Worm
negative regulation of cell communication GO:0010648 61 0.011
negative regulation of neurogenesis GO:0050768 4 0.011
engulfment of apoptotic cell GO:0043652 94 0.011
pattern specification process GO:0007389 59 0.011
Worm
organophosphate catabolic process GO:0046434 81 0.011
positive regulation of molecular function GO:0044093 61 0.011
ion transport GO:0006811 113 0.011
gene silencing by rna GO:0031047 143 0.011
cell recognition GO:0008037 85 0.011
negative regulation of biosynthetic process GO:0009890 65 0.011
Worm
rna interference GO:0016246 137 0.011
g1 s transition of mitotic cell cycle GO:0000082 2 0.010
cytokinesis GO:0000910 80 0.010
response to nutrient levels GO:0031667 35 0.010
Worm
protein catabolic process GO:0030163 162 0.010
regulation of protein metabolic process GO:0051246 81 0.010
Worm
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.010
Worm
meiotic cell cycle process GO:1903046 170 0.010
mesoderm morphogenesis GO:0048332 24 0.010
response to acid chemical GO:0001101 4 0.010
regulation of stem cell differentiation GO:2000736 1 0.010
cellular amino acid metabolic process GO:0006520 15 0.010
microtubule based process GO:0007017 182 0.010
regulation of transport GO:0051049 91 0.010
phagocytosis engulfment GO:0006911 98 0.010

let-381 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.014