Caenorhabditis elegans

98 known processes

ref-1 (CELE_T01E8.2)

Protein REF-1

ref-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development ending in birth or egg hatching GO:0009792 2992 0.500
embryo development GO:0009790 3052 0.297
positive regulation of cellular biosynthetic process GO:0031328 109 0.266
growth GO:0040007 562 0.252
locomotion GO:0040011 1634 0.217
positive regulation of multicellular organismal process GO:0051240 417 0.203
positive regulation of rna metabolic process GO:0051254 103 0.195
sex differentiation GO:0007548 909 0.194
neuron projection guidance GO:0097485 82 0.183
regulation of multicellular organismal development GO:2000026 317 0.179
organic cyclic compound biosynthetic process GO:1901362 195 0.172
regulation of multicellular organismal process GO:0051239 726 0.165
cell development GO:0048468 696 0.164
positive regulation of rna biosynthetic process GO:1902680 102 0.164
cellular component morphogenesis GO:0032989 318 0.162
nucleic acid templated transcription GO:0097659 169 0.162
tube development GO:0035295 126 0.153
single organism reproductive process GO:0044702 1196 0.151
multicellular organismal reproductive process GO:0048609 815 0.148
nervous system development GO:0007399 253 0.145
multicellular organism growth GO:0035264 385 0.145
positive regulation of gene expression GO:0010628 112 0.131
regulation of cell differentiation GO:0045595 81 0.129
multi organism reproductive process GO:0044703 867 0.129
determination of adult lifespan GO:0008340 812 0.128
aging GO:0007568 812 0.122
developmental process involved in reproduction GO:0003006 1165 0.122
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.115
multicellular organismal aging GO:0010259 812 0.110
behavior GO:0007610 527 0.110
sensory organ morphogenesis GO:0090596 2 0.109
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.108
regulation of cellular metabolic process GO:0031323 305 0.108
organ development GO:0048513 1102 0.106
regulation of biological quality GO:0065008 741 0.103
gonad development GO:0008406 840 0.102
positive regulation of multicellular organism growth GO:0040018 352 0.102
regulation of nucleic acid templated transcription GO:1903506 165 0.101
reproductive structure development GO:0048608 850 0.101
regulation of macromolecule metabolic process GO:0060255 421 0.101
multi multicellular organism process GO:0044706 390 0.101
tissue development GO:0009888 112 0.100
development of primary sexual characteristics GO:0045137 840 0.100
positive regulation of growth GO:0045927 369 0.098
positive regulation of macromolecule metabolic process GO:0010604 149 0.097
negative regulation of biological process GO:0048519 567 0.094
heterocycle biosynthetic process GO:0018130 187 0.093
generation of neurons GO:0048699 235 0.092
positive regulation of developmental process GO:0051094 408 0.091
digestive tract development GO:0048565 122 0.090
post embryonic development GO:0009791 2152 0.090
cell projection organization GO:0030030 231 0.089
regulation of growth GO:0040008 409 0.089
negative regulation of multicellular organismal process GO:0051241 236 0.089
positive regulation of transcription dna templated GO:0045893 102 0.088
positive regulation of developmental growth GO:0048639 354 0.088
macromolecule localization GO:0033036 771 0.086
organelle organization GO:0006996 783 0.086
neurogenesis GO:0022008 236 0.084
oviposition GO:0018991 364 0.083
positive regulation of transcription from rna polymerase ii promoter in response to osmotic stress GO:0061393 1 0.083
reproductive system development GO:0061458 850 0.082
maintenance of location GO:0051235 580 0.081
regulation of cellular biosynthetic process GO:0031326 189 0.081
regulation of rna biosynthetic process GO:2001141 165 0.080
lipid localization GO:0010876 573 0.080
negative regulation of developmental process GO:0051093 227 0.080
positive regulation of neurogenesis GO:0050769 4 0.079
regulation of developmental process GO:0050793 684 0.078
negative regulation of macromolecule metabolic process GO:0010605 229 0.078
positive regulation of nucleic acid templated transcription GO:1903508 102 0.078
aromatic compound biosynthetic process GO:0019438 192 0.074
regulation of developmental growth GO:0048638 389 0.073
regulation of metabolic process GO:0019222 478 0.073
axon guidance GO:0007411 82 0.073
digestive system development GO:0055123 122 0.072
cellular biosynthetic process GO:0044249 315 0.070
lipid storage GO:0019915 565 0.070
anatomical structure formation involved in morphogenesis GO:0048646 250 0.069
transcription from rna polymerase ii promoter GO:0006366 149 0.068
multi organism reproductive behavior GO:0044705 387 0.067
multicellular organism reproduction GO:0032504 819 0.065
endocytosis GO:0006897 819 0.064
sexual reproduction GO:0019953 546 0.062
reproductive behavior GO:0019098 387 0.061
single organism signaling GO:0044700 401 0.060
regulation of biosynthetic process GO:0009889 189 0.060
regulation of multicellular organism growth GO:0040014 373 0.058
neuron development GO:0048666 199 0.058
multicellular organismal reproductive behavior GO:0033057 384 0.058
regulation of transcription dna templated GO:0006355 164 0.056
neuron projection development GO:0031175 187 0.055
rna metabolic process GO:0016070 228 0.055
rna biosynthetic process GO:0032774 169 0.054
multi organism behavior GO:0051705 389 0.053
cell motility GO:0048870 313 0.053
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.053
neuron recognition GO:0008038 83 0.053
taxis GO:0042330 128 0.052
developmental growth GO:0048589 412 0.050
gene expression GO:0010467 412 0.050
cell death GO:0008219 547 0.049
nucleobase containing compound metabolic process GO:0006139 406 0.049
regulation of nematode larval development GO:0061062 260 0.049
neuron projection morphogenesis GO:0048812 114 0.049
cell proliferation GO:0008283 116 0.049
positive regulation of transcription from rna polymerase ii promoter in response to salt stress GO:0036251 1 0.049
genitalia development GO:0048806 741 0.048
signal transduction GO:0007165 317 0.048
negative regulation of vulval development GO:0040027 206 0.048
cellular nitrogen compound biosynthetic process GO:0044271 192 0.047
positive regulation of cellular metabolic process GO:0031325 178 0.047
regulation of primary metabolic process GO:0080090 292 0.047
transcription dna templated GO:0006351 168 0.046
response to external stimulus GO:0009605 289 0.046
secretion GO:0046903 147 0.045
neuroblast fate determination GO:0007400 1 0.045
body morphogenesis GO:0010171 620 0.044
molting cycle GO:0042303 281 0.043
head development GO:0060322 1 0.043
protein modification process GO:0036211 207 0.043
receptor mediated endocytosis GO:0006898 715 0.042
digestive tract morphogenesis GO:0048546 76 0.042
regulation of locomotion GO:0040012 161 0.042
positive regulation of neuron differentiation GO:0045666 4 0.041
response to chemical GO:0042221 356 0.041
macromolecule biosynthetic process GO:0009059 250 0.041
hermaphrodite genitalia development GO:0040035 734 0.040
embryonic morphogenesis GO:0048598 152 0.040
regulation of cell cycle process GO:0010564 145 0.040
cellular macromolecular complex assembly GO:0034622 184 0.040
regulation of gene expression GO:0010468 366 0.039
negative regulation of rna biosynthetic process GO:1902679 53 0.039
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.039
secretion by cell GO:0032940 138 0.039
dauer larval development GO:0040024 92 0.039
male sex differentiation GO:0046661 86 0.038
inductive cell migration GO:0040039 145 0.038
transport GO:0006810 1093 0.037
mesodermal cell differentiation GO:0048333 15 0.037
regulation of cell proliferation GO:0042127 105 0.036
positive regulation of biosynthetic process GO:0009891 109 0.036
protein complex biogenesis GO:0070271 186 0.035
vulval development GO:0040025 333 0.035
striated muscle myosin thick filament assembly GO:0071688 138 0.034
post embryonic organ development GO:0048569 336 0.034
establishment of localization GO:0051234 1171 0.034
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.033
axon development GO:0061564 163 0.033
signaling GO:0023052 401 0.033
positive regulation of transcription from rna polymerase ii promoter involved in defense response to fungus GO:1901244 1 0.033
positive regulation of metabolic process GO:0009893 187 0.033
cell surface receptor signaling pathway GO:0007166 149 0.031
muscle structure development GO:0061061 191 0.031
calcium mediated signaling GO:0019722 3 0.031
male anatomical structure morphogenesis GO:0090598 78 0.031
negative regulation of post embryonic development GO:0048581 208 0.031
regulation of meiosis GO:0040020 94 0.030
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.030
vesicle mediated transport GO:0016192 852 0.030
regulation of localization GO:0032879 194 0.030
regulation of post embryonic development GO:0048580 260 0.030
positive regulation of cellular process GO:0048522 332 0.030
system process GO:0003008 136 0.030
cellular protein modification process GO:0006464 207 0.030
pharynx development GO:0060465 51 0.030
programmed cell death GO:0012501 500 0.030
muscle cell development GO:0055001 158 0.029
cell fate commitment GO:0045165 139 0.029
tube morphogenesis GO:0035239 79 0.029
cell migration GO:0016477 306 0.029
negative regulation of cellular process GO:0048523 239 0.029
actomyosin structure organization GO:0031032 154 0.029
muscle cell differentiation GO:0042692 171 0.029
regulation of transcription from rna polymerase ii promoter in response to osmotic stress GO:0061392 1 0.029
single organism organelle organization GO:1902589 501 0.029
myosin filament assembly GO:0031034 138 0.028
axonal fasciculation GO:0007413 79 0.028
biosynthetic process GO:0009058 323 0.028
neuron differentiation GO:0030182 217 0.028
cell cycle process GO:0022402 482 0.028
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 2 0.028
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.028
striated muscle cell differentiation GO:0051146 158 0.027
myosin filament organization GO:0031033 138 0.027
regulation of signaling GO:0023051 172 0.027
actin cytoskeleton organization GO:0030036 184 0.027
meiotic cell cycle GO:0051321 335 0.027
protein metabolic process GO:0019538 422 0.027
organic substance transport GO:0071702 113 0.027
dendrite development GO:0016358 42 0.027
response to acid chemical GO:0001101 4 0.027
negative regulation of neurogenesis GO:0050768 4 0.027
negative regulation of response to stimulus GO:0048585 73 0.026
single organism transport GO:0044765 447 0.025
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.025
pattern specification process GO:0007389 59 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.025
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.025
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.025
single organism behavior GO:0044708 83 0.025
nucleobase containing compound biosynthetic process GO:0034654 184 0.024
hormone transport GO:0009914 2 0.024
negative regulation of metabolic process GO:0009892 240 0.024
macromolecular complex subunit organization GO:0043933 320 0.024
cytoskeleton organization GO:0007010 339 0.024
mitotic cell cycle process GO:1903047 194 0.024
establishment of localization in cell GO:0051649 318 0.024
negative regulation of signal transduction GO:0009968 60 0.023
mesodermal cell fate specification GO:0007501 13 0.023
regulation of neuron differentiation GO:0045664 40 0.023
endodermal cell fate determination GO:0007493 2 0.023
protein complex subunit organization GO:0071822 280 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.023
regulation of nuclear division GO:0051783 115 0.022
positive regulation of transcription from rna polymerase ii promoter in response to increased salt GO:0061404 1 0.022
regulation of cell communication GO:0010646 176 0.022
single organism localization GO:1902578 518 0.022
cellular protein complex assembly GO:0043623 178 0.022
enzyme linked receptor protein signaling pathway GO:0007167 50 0.022
organic substance biosynthetic process GO:1901576 323 0.022
cell type specific apoptotic process GO:0097285 4 0.022
myofibril assembly GO:0030239 154 0.022
cellular macromolecule biosynthetic process GO:0034645 247 0.022
negative regulation of cellular metabolic process GO:0031324 95 0.021
chemotaxis GO:0006935 120 0.021
negative regulation of nematode larval development GO:0061064 208 0.021
bmp signaling pathway GO:0030509 3 0.021
macromolecular complex assembly GO:0065003 193 0.021
regulation of neurogenesis GO:0050767 40 0.021
death GO:0016265 547 0.021
macromolecule modification GO:0043412 218 0.021
localization of cell GO:0051674 313 0.021
nucleic acid metabolic process GO:0090304 299 0.021
immune response GO:0006955 192 0.020
cell cycle GO:0007049 526 0.020
positive regulation of cell cycle GO:0045787 55 0.020
chemosensory behavior GO:0007635 33 0.020
actin filament based process GO:0030029 191 0.020
cell recognition GO:0008037 85 0.020
cellular component biogenesis GO:0044085 297 0.020
regulation of meiotic cell cycle GO:0051445 136 0.020
striated muscle cell development GO:0055002 157 0.020
epidermal cell fate specification GO:0009957 5 0.019
protein complex assembly GO:0006461 186 0.019
peptide hormone secretion GO:0030072 2 0.019
nematode male tail tip morphogenesis GO:0045138 77 0.019
cellular response to organic substance GO:0071310 119 0.019
meiotic nuclear division GO:0007126 300 0.019
regulation of nitrogen compound metabolic process GO:0051171 222 0.019
apoptotic process GO:0006915 478 0.019
organelle assembly GO:0070925 214 0.018
regulation of reproductive process GO:2000241 66 0.018
homeostatic process GO:0042592 51 0.018
response to organic substance GO:0010033 131 0.018
response to oxygen containing compound GO:1901700 44 0.018
stem cell proliferation GO:0072089 9 0.018
regulation of cell development GO:0060284 49 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.018
cellular component movement GO:0006928 388 0.017
embryonic body morphogenesis GO:0010172 49 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.017
cellular localization GO:0051641 360 0.017
cell projection morphogenesis GO:0048858 148 0.017
catabolic process GO:0009056 318 0.017
synaptic transmission GO:0007268 106 0.017
cell part morphogenesis GO:0032990 152 0.017
axonogenesis GO:0007409 102 0.017
defecation GO:0030421 47 0.017
organelle fission GO:0048285 363 0.017
regulation of epithelial cell differentiation GO:0030856 4 0.017
cellular component assembly involved in morphogenesis GO:0010927 183 0.017
protein catabolic process GO:0030163 162 0.016
oogenesis GO:0048477 229 0.016
response to wounding GO:0009611 4 0.016
cellular response to stress GO:0033554 162 0.016
cellular hyperosmotic salinity response GO:0071475 1 0.016
regulation of gastrulation GO:0010470 4 0.016
regulation of response to stimulus GO:0048583 243 0.016
nitrogen compound transport GO:0071705 49 0.016
cellular component assembly GO:0022607 293 0.016
neuron fate specification GO:0048665 8 0.015
regulation of rna metabolic process GO:0051252 173 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.015
excretion GO:0007588 49 0.015
regulation of axon extension GO:0030516 20 0.015
regulation of system process GO:0044057 27 0.015
regulation of nucleocytoplasmic transport GO:0046822 3 0.015
cellular protein metabolic process GO:0044267 279 0.015
regulation of bmp signaling pathway GO:0030510 3 0.015
germ cell development GO:0007281 351 0.015
epithelial tube morphogenesis GO:0060562 1 0.014
neurological system process GO:0050877 53 0.014
notch signaling pathway GO:0007219 22 0.014
gamete generation GO:0007276 461 0.014
positive regulation of transcription from rna polymerase ii promoter involved in defense response to gram negative bacterium GO:1902097 4 0.014
regulation of vulval development GO:0040028 248 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.014
regulation of cation channel activity GO:2001257 3 0.013
regulation of cellular component movement GO:0051270 62 0.013
tissue morphogenesis GO:0048729 65 0.013
response to biotic stimulus GO:0009607 101 0.013
negative regulation of cell communication GO:0010648 61 0.013
negative regulation of cellular biosynthetic process GO:0031327 65 0.013
regulation of cellular component organization GO:0051128 248 0.013
developmental maturation GO:0021700 26 0.013
negative regulation of transcription dna templated GO:0045892 53 0.013
cell division GO:0051301 262 0.013
neuron projection extension GO:1990138 37 0.013
inactivation of mapkkk activity GO:0051390 2 0.013
regulation of cell projection organization GO:0031344 38 0.013
protein localization GO:0008104 205 0.013
small molecule metabolic process GO:0044281 186 0.012
regulation of organelle organization GO:0033043 164 0.012
regulation of neuromuscular synaptic transmission GO:1900073 1 0.012
positive regulation of epithelial cell proliferation GO:0050679 1 0.012
response to abiotic stimulus GO:0009628 152 0.012
cuticle development GO:0042335 100 0.012
positive regulation of mitotic sister chromatid separation GO:1901970 1 0.012
muscle tissue development GO:0060537 1 0.012
organism emergence from protective structure GO:0071684 48 0.012
organic substance catabolic process GO:1901575 294 0.012
signal release GO:0023061 28 0.012
sex determination GO:0007530 60 0.012
memory GO:0007613 3 0.012
macromolecule catabolic process GO:0009057 202 0.012
axon extension involved in axon guidance GO:0048846 13 0.012
negative regulation of gene expression GO:0010629 217 0.012
cellular response to chemical stimulus GO:0070887 129 0.012
regulation of protein import into nucleus GO:0042306 3 0.012
insulin secretion GO:0030073 2 0.012
regulation of cell division GO:0051302 142 0.012
regulation of synaptic plasticity GO:0048167 1 0.011
negative regulation of signaling GO:0023057 61 0.011
response to other organism GO:0051707 101 0.011
gabaergic neuron differentiation GO:0097154 1 0.011
negative regulation of mitotic cell cycle GO:0045930 42 0.011
asymmetric cell division GO:0008356 36 0.011
regulation of synaptic transmission GO:0050804 34 0.011
negative regulation of neuron differentiation GO:0045665 4 0.011
positive regulation of post embryonic development GO:0048582 54 0.011
female gamete generation GO:0007292 254 0.011
regulation of signal transduction GO:0009966 135 0.011
hormone secretion GO:0046879 2 0.011
regeneration GO:0031099 4 0.011
adult behavior GO:0030534 3 0.011
eating behavior GO:0042755 59 0.011
regulation of mitotic cell cycle GO:0007346 76 0.011
ion transmembrane transport GO:0034220 91 0.011
positive regulation of nematode larval development GO:0061063 54 0.011
response to external biotic stimulus GO:0043207 101 0.011
mesoderm morphogenesis GO:0048332 24 0.011
positive regulation of intracellular transport GO:0032388 2 0.011
cell maturation GO:0048469 26 0.011
intracellular signal transduction GO:0035556 96 0.011
positive regulation of protein transport GO:0051222 4 0.011
membrane fusion GO:0061025 16 0.011
negative regulation of nucleic acid templated transcription GO:1903507 53 0.010
gastrulation GO:0007369 58 0.010
regulation of defecation rhythm GO:2000746 3 0.010
regulation of cell morphogenesis GO:0022604 40 0.010
regulation of cell motility GO:2000145 57 0.010
cell cell signaling GO:0007267 118 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.010
neuroblast proliferation GO:0007405 9 0.010

ref-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
disease of metabolism DOID:0014667 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011