Caenorhabditis elegans

92 known processes

pdi-3 (CELE_H06O01.1)

Protein PDI-3

pdi-3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to topologically incorrect protein GO:0035967 76 0.451
Worm
establishment of localization GO:0051234 1171 0.423
transport GO:0006810 1093 0.413
embryo development GO:0009790 3052 0.406
programmed cell death GO:0012501 500 0.367
Mouse
er nucleus signaling pathway GO:0006984 66 0.325
Worm
response to topologically incorrect protein GO:0035966 82 0.322
Worm
endoplasmic reticulum unfolded protein response GO:0030968 66 0.305
Worm
organ development GO:0048513 1102 0.303
cell death GO:0008219 547 0.275
Mouse
apoptotic process GO:0006915 478 0.273
Mouse
post embryonic development GO:0009791 2152 0.272
response to endoplasmic reticulum stress GO:0034976 71 0.250
Worm
protein localization to endoplasmic reticulum GO:0070972 2 0.247
response to unfolded protein GO:0006986 71 0.227
Worm
cellular response to unfolded protein GO:0034620 71 0.208
Worm
vesicle mediated transport GO:0016192 852 0.188
endocytosis GO:0006897 819 0.183
receptor mediated endocytosis GO:0006898 715 0.182
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.181
death GO:0016265 547 0.154
Mouse
meiotic nuclear division GO:0007126 300 0.152
determination of adult lifespan GO:0008340 812 0.147
embryo development ending in birth or egg hatching GO:0009792 2992 0.142
Worm
molting cycle GO:0042303 281 0.138
cell motility GO:0048870 313 0.137
signal transduction GO:0007165 317 0.127
Mouse Worm
locomotion GO:0040011 1634 0.120
small molecule metabolic process GO:0044281 186 0.119
aging GO:0007568 812 0.114
head development GO:0060322 1 0.112
multicellular organismal aging GO:0010259 812 0.101
cellular localization GO:0051641 360 0.100
macromolecule localization GO:0033036 771 0.099
purine nucleoside monophosphate biosynthetic process GO:0009127 4 0.093
single organism reproductive process GO:0044702 1196 0.090
purine nucleoside triphosphate metabolic process GO:0009144 87 0.089
regulation of meiotic cell cycle GO:0051445 136 0.089
response to external stimulus GO:0009605 289 0.088
signaling GO:0023052 401 0.088
Mouse Worm
sex differentiation GO:0007548 909 0.087
meiotic cell cycle GO:0051321 335 0.083
organic substance biosynthetic process GO:1901576 323 0.083
cellular component assembly GO:0022607 293 0.083
meiotic cell cycle process GO:1903046 170 0.082
positive regulation of hydrolase activity GO:0051345 38 0.082
regulation of multicellular organismal process GO:0051239 726 0.082
cellular protein localization GO:0034613 75 0.080
response to abiotic stimulus GO:0009628 152 0.077
regulation of biological quality GO:0065008 741 0.076
regulation of locomotion GO:0040012 161 0.069
cellular macromolecule localization GO:0070727 75 0.069
maintenance of location GO:0051235 580 0.069
cellular response to chemical stimulus GO:0070887 129 0.067
Worm
maintenance of protein location GO:0045185 15 0.066
organelle organization GO:0006996 783 0.065
lipid localization GO:0010876 573 0.065
multicellular organism reproduction GO:0032504 819 0.065
developmental process involved in reproduction GO:0003006 1165 0.064
lipid storage GO:0019915 565 0.063
cellular component movement GO:0006928 388 0.061
cell cycle GO:0007049 526 0.061
reproductive system development GO:0061458 850 0.061
organic cyclic compound biosynthetic process GO:1901362 195 0.061
protein metabolic process GO:0019538 422 0.057
phosphorus metabolic process GO:0006793 232 0.057
regulation of growth GO:0040008 409 0.057
cellular protein metabolic process GO:0044267 279 0.056
regulation of multicellular organism growth GO:0040014 373 0.056
actin filament based process GO:0030029 191 0.054
purine ribonucleotide metabolic process GO:0009150 95 0.054
single organism organelle organization GO:1902589 501 0.053
positive regulation of multicellular organism growth GO:0040018 352 0.053
single organism localization GO:1902578 518 0.052
oocyte axis specification GO:0007309 2 0.052
cell development GO:0048468 696 0.051
cell cycle process GO:0022402 482 0.050
negative regulation of multicellular organismal process GO:0051241 236 0.050
hermaphrodite genitalia development GO:0040035 734 0.050
multicellular organism growth GO:0035264 385 0.048
organophosphate metabolic process GO:0019637 125 0.046
carbohydrate derivative metabolic process GO:1901135 141 0.046
localization of cell GO:0051674 313 0.046
positive regulation of developmental growth GO:0048639 354 0.045
response to oxygen containing compound GO:1901700 44 0.044
single organism transport GO:0044765 447 0.044
multi organism reproductive process GO:0044703 867 0.044
positive regulation of locomotion GO:0040017 42 0.044
reproductive structure development GO:0048608 850 0.042
meiotic chromosome segregation GO:0045132 139 0.042
cell migration GO:0016477 306 0.042
organelle fission GO:0048285 363 0.042
purine nucleoside metabolic process GO:0042278 92 0.042
regulation of developmental growth GO:0048638 389 0.042
regulation of metabolic process GO:0019222 478 0.041
gonad development GO:0008406 840 0.041
establishment of localization in cell GO:0051649 318 0.041
positive regulation of growth GO:0045927 369 0.041
development of primary sexual characteristics GO:0045137 840 0.041
regulation of multicellular organismal development GO:2000026 317 0.041
positive regulation of cell migration GO:0030335 3 0.041
oogenesis GO:0048477 229 0.040
cellular response to organic substance GO:0071310 119 0.040
Worm
posttranscriptional regulation of gene expression GO:0010608 166 0.040
cellular protein modification process GO:0006464 207 0.040
protein localization GO:0008104 205 0.040
cellular component morphogenesis GO:0032989 318 0.039
dauer larval development GO:0040024 92 0.039
oocyte construction GO:0007308 2 0.038
cytoskeleton organization GO:0007010 339 0.038
cellular biosynthetic process GO:0044249 315 0.038
multicellular organismal reproductive process GO:0048609 815 0.038
nucleobase containing small molecule metabolic process GO:0055086 115 0.036
regulation of organelle organization GO:0033043 164 0.036
negative regulation of vulval development GO:0040027 206 0.036
protein modification process GO:0036211 207 0.035
system process GO:0003008 136 0.035
adult behavior GO:0030534 3 0.035
germ cell development GO:0007281 351 0.035
response to chemical GO:0042221 356 0.034
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.034
regulation of meiosis GO:0040020 94 0.034
growth GO:0040007 562 0.034
transmembrane transport GO:0055085 110 0.034
macromolecule modification GO:0043412 218 0.033
single organism signaling GO:0044700 401 0.033
Mouse Worm
multi organism behavior GO:0051705 389 0.033
cellular component biogenesis GO:0044085 297 0.033
nucleobase containing compound metabolic process GO:0006139 406 0.032
oviposition GO:0018991 364 0.031
developmental growth GO:0048589 412 0.031
catabolic process GO:0009056 318 0.031
positive regulation of multicellular organismal process GO:0051240 417 0.031
regulation of cell communication GO:0010646 176 0.031
Mouse
response to other organism GO:0051707 101 0.031
regulation of cell cycle GO:0051726 194 0.030
adult locomotory behavior GO:0008344 1 0.030
protein modification by small protein conjugation or removal GO:0070647 40 0.030
oocyte development GO:0048599 44 0.030
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.030
establishment of protein localization to membrane GO:0090150 3 0.029
regulation of apoptotic signaling pathway GO:2001233 1 0.029
Mouse
positive regulation of developmental process GO:0051094 408 0.029
single organism cellular localization GO:1902580 72 0.029
regulation of cellular metabolic process GO:0031323 305 0.029
intracellular protein transmembrane transport GO:0065002 4 0.028
organic acid metabolic process GO:0006082 47 0.028
regulation of cellular biosynthetic process GO:0031326 189 0.028
protein complex biogenesis GO:0070271 186 0.027
regulation of developmental process GO:0050793 684 0.027
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 5 0.027
glycosyl compound metabolic process GO:1901657 100 0.027
protein folding GO:0006457 7 0.026
female gamete generation GO:0007292 254 0.026
single organism intracellular transport GO:1902582 70 0.026
behavior GO:0007610 527 0.026
biosynthetic process GO:0009058 323 0.026
cation transport GO:0006812 78 0.026
oxidation reduction process GO:0055114 59 0.025
positive regulation of metabolic process GO:0009893 187 0.025
response to biotic stimulus GO:0009607 101 0.025
protein transmembrane transport GO:0071806 4 0.025
regulation of catalytic activity GO:0050790 78 0.025
nucleoside metabolic process GO:0009116 99 0.025
nervous system development GO:0007399 253 0.025
organelle assembly GO:0070925 214 0.024
cellular response to stress GO:0033554 162 0.024
Worm
cellular protein complex assembly GO:0043623 178 0.024
protein catabolic process GO:0030163 162 0.024
purine nucleotide metabolic process GO:0006163 95 0.023
carboxylic acid metabolic process GO:0019752 34 0.023
regulation of phosphate metabolic process GO:0019220 81 0.023
developmental maturation GO:0021700 26 0.023
phosphate containing compound metabolic process GO:0006796 232 0.023
epithelial tube morphogenesis GO:0060562 1 0.023
positive regulation of catalytic activity GO:0043085 59 0.022
regulation of cellular component movement GO:0051270 62 0.022
single organism catabolic process GO:0044712 129 0.022
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.022
protein complex subunit organization GO:0071822 280 0.022
carbohydrate derivative biosynthetic process GO:1901137 46 0.022
cation transmembrane transport GO:0098655 59 0.021
glycosylation GO:0070085 20 0.021
regulation of nitrogen compound metabolic process GO:0051171 222 0.021
myosin filament assembly GO:0031034 138 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.021
organ morphogenesis GO:0009887 67 0.021
purine nucleoside catabolic process GO:0006152 75 0.021
pattern specification process GO:0007389 59 0.020
multi organism reproductive behavior GO:0044705 387 0.020
protein glycosylation GO:0006486 17 0.020
regulation of primary metabolic process GO:0080090 292 0.020
nucleotide metabolic process GO:0009117 108 0.020
negative regulation of biological process GO:0048519 567 0.020
cilium morphogenesis GO:0060271 33 0.020
response to organic substance GO:0010033 131 0.020
Worm
localization within membrane GO:0051668 2 0.020
cell division GO:0051301 262 0.020
cellular response to starvation GO:0009267 13 0.020
regulation of cell death GO:0010941 65 0.020
Mouse
single organism behavior GO:0044708 83 0.020
organophosphate catabolic process GO:0046434 81 0.020
cellular catabolic process GO:0044248 199 0.019
regulation of cytoskeleton organization GO:0051493 41 0.019
protein phosphorylation GO:0006468 85 0.019
positive regulation of cellular biosynthetic process GO:0031328 109 0.019
macromolecule glycosylation GO:0043413 18 0.019
macromolecule catabolic process GO:0009057 202 0.018
mitotic cell cycle process GO:1903047 194 0.018
monovalent inorganic cation transport GO:0015672 33 0.018
glycoprotein metabolic process GO:0009100 29 0.018
ion transmembrane transport GO:0034220 91 0.018
actin cytoskeleton organization GO:0030036 184 0.018
maintenance of location in cell GO:0051651 12 0.018
regulation of biosynthetic process GO:0009889 189 0.018
macromolecular complex assembly GO:0065003 193 0.017
defense response GO:0006952 296 0.017
regulation of programmed cell death GO:0043067 50 0.017
Mouse
tube development GO:0035295 126 0.017
heterocycle catabolic process GO:0046700 119 0.017
protein complex assembly GO:0006461 186 0.017
regulation of cellular component size GO:0032535 40 0.017
cell morphogenesis GO:0000902 163 0.017
multicellular organismal reproductive behavior GO:0033057 384 0.017
sulfur compound metabolic process GO:0006790 22 0.017
intracellular transport GO:0046907 77 0.017
regulation of molecular function GO:0065009 89 0.017
phosphorylation GO:0016310 116 0.016
regulation of apoptotic process GO:0042981 36 0.016
Mouse
organic substance transport GO:0071702 113 0.016
maintenance of protein location in cell GO:0032507 12 0.016
oocyte differentiation GO:0009994 45 0.016
body morphogenesis GO:0010171 620 0.016
sexual reproduction GO:0019953 546 0.016
negative regulation of developmental process GO:0051093 227 0.016
glycosyl compound catabolic process GO:1901658 79 0.016
negative regulation of post embryonic development GO:0048581 208 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.016
myosin filament organization GO:0031033 138 0.016
nucleoside triphosphate metabolic process GO:0009141 87 0.016
neurogenesis GO:0022008 236 0.016
regulation of cellular component organization GO:0051128 248 0.016
protein targeting to membrane GO:0006612 1 0.015
ribose phosphate metabolic process GO:0019693 99 0.015
inorganic ion transmembrane transport GO:0098660 54 0.015
cellular macromolecule biosynthetic process GO:0034645 247 0.015
regulation of signaling GO:0023051 172 0.015
Mouse
regulation of hydrolase activity GO:0051336 45 0.015
macromolecule biosynthetic process GO:0009059 250 0.015
cytokinesis GO:0000910 80 0.015
negative regulation of nematode larval development GO:0061064 208 0.015
generation of neurons GO:0048699 235 0.015
regulation of macromolecule biosynthetic process GO:0010556 189 0.015
cellular amino acid metabolic process GO:0006520 15 0.015
immune response GO:0006955 192 0.015
ubiquitin dependent protein catabolic process GO:0006511 32 0.015
positive regulation of cellular process GO:0048522 332 0.015
Mouse
organonitrogen compound metabolic process GO:1901564 151 0.015
cell part morphogenesis GO:0032990 152 0.015
negative regulation of gene expression GO:0010629 217 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
carbohydrate derivative catabolic process GO:1901136 82 0.015
purine ribonucleoside metabolic process GO:0046128 92 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 32 0.015
chromosome segregation GO:0007059 180 0.015
peptidyl proline hydroxylation to 4 hydroxy l proline GO:0018401 3 0.015
small gtpase mediated signal transduction GO:0007264 32 0.015
oxoacid metabolic process GO:0043436 47 0.015
response to external biotic stimulus GO:0043207 101 0.014
guanosine containing compound catabolic process GO:1901069 48 0.014
cellular macromolecular complex assembly GO:0034622 184 0.014
cellular nitrogen compound biosynthetic process GO:0044271 192 0.014
cellular response to nutrient levels GO:0031669 13 0.014
nucleoside catabolic process GO:0009164 78 0.014
genitalia development GO:0048806 741 0.014
regulation of cellular protein metabolic process GO:0032268 75 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.014
secretion GO:0046903 147 0.014
modification dependent macromolecule catabolic process GO:0043632 32 0.014
gamete generation GO:0007276 461 0.014
negative regulation of metabolic process GO:0009892 240 0.014
chemotaxis GO:0006935 120 0.014
macromolecular complex subunit organization GO:0043933 320 0.014
chemosensory behavior GO:0007635 33 0.014
guanosine containing compound metabolic process GO:1901068 49 0.013
phagocytosis GO:0006909 115 0.013
regulation of signal transduction GO:0009966 135 0.013
Mouse
cellular macromolecule catabolic process GO:0044265 73 0.013
pigmentation GO:0043473 2 0.013
ribonucleoside metabolic process GO:0009119 98 0.013
ion transport GO:0006811 113 0.013
organelle localization GO:0051640 127 0.013
regulation of nuclear division GO:0051783 115 0.013
ribonucleotide catabolic process GO:0009261 75 0.013
neuromuscular junction development GO:0007528 2 0.013
cell substrate adhesion GO:0031589 1 0.013
nucleotide catabolic process GO:0009166 77 0.013
purine nucleoside biosynthetic process GO:0042451 5 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.012
modification dependent protein catabolic process GO:0019941 32 0.012
protein hydroxylation GO:0018126 5 0.012
protein transport GO:0015031 45 0.012
cell proliferation GO:0008283 116 0.012
regulation of localization GO:0032879 194 0.012
innate immune response GO:0045087 190 0.012
regulation of protein stability GO:0031647 3 0.012
regulation of cell motility GO:2000145 57 0.012
tissue development GO:0009888 112 0.012
purine containing compound catabolic process GO:0072523 75 0.012
regulation of nematode larval development GO:0061062 260 0.012
nucleoside monophosphate metabolic process GO:0009123 46 0.012
cellular protein catabolic process GO:0044257 37 0.012
positive regulation of rna biosynthetic process GO:1902680 102 0.012
mitotic nuclear division GO:0007067 89 0.012
regulation of anatomical structure size GO:0090066 46 0.012
cell projection assembly GO:0030031 35 0.012
nucleoside phosphate catabolic process GO:1901292 77 0.012
protein polymerization GO:0051258 26 0.012
cellular component assembly involved in morphogenesis GO:0010927 183 0.012
heterocycle biosynthetic process GO:0018130 187 0.011
single organism biosynthetic process GO:0044711 91 0.011
secretion by cell GO:0032940 138 0.011
ribonucleotide metabolic process GO:0009259 99 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 16 0.011
striated muscle cell differentiation GO:0051146 158 0.011
rna localization GO:0006403 3 0.011
skeletal muscle thin filament assembly GO:0030240 3 0.011
cellular nitrogen compound catabolic process GO:0044270 119 0.011
chromosome organization GO:0051276 104 0.011
membrane organization GO:0061024 135 0.011
vesicle localization GO:0051648 24 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.011
regulation of post embryonic development GO:0048580 260 0.011
aromatic compound biosynthetic process GO:0019438 192 0.011
peptidyl proline modification GO:0018208 9 0.011
muscle cell differentiation GO:0042692 171 0.011
golgi vesicle transport GO:0048193 3 0.011
vulval development GO:0040025 333 0.010
regulation of vulval development GO:0040028 248 0.010
nucleoside triphosphate catabolic process GO:0009143 72 0.010
reproductive behavior GO:0019098 387 0.010
response to heat GO:0009408 50 0.010
nucleoside phosphate metabolic process GO:0006753 108 0.010
actomyosin structure organization GO:0031032 154 0.010

pdi-3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.018
disease of anatomical entity DOID:7 0 0.018
anemia DOID:2355 0 0.018
hematopoietic system disease DOID:74 0 0.018