Caenorhabditis elegans

92 known processes

plk-1 (CELE_C14B9.4)

Protein PLK-1

plk-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development ending in birth or egg hatching GO:0009792 2992 0.845
embryo development GO:0009790 3052 0.650
meiotic chromosome segregation GO:0045132 139 0.588
protein metabolic process GO:0019538 422 0.563
Human Yeast Mouse Rat Fly
chromosome segregation GO:0007059 180 0.526
multicellular organism reproduction GO:0032504 819 0.516
positive regulation of catalytic activity GO:0043085 59 0.486
Human Yeast
cell cycle GO:0007049 526 0.460
female meiotic division GO:0007143 17 0.414
apoptotic process GO:0006915 478 0.409
endocytosis GO:0006897 819 0.407
Fly
locomotion GO:0040011 1634 0.383
aging GO:0007568 812 0.346
regulation of developmental process GO:0050793 684 0.344
Fly
post embryonic development GO:0009791 2152 0.341
organelle fission GO:0048285 363 0.290
negative regulation of metabolic process GO:0009892 240 0.283
Human
determination of adult lifespan GO:0008340 812 0.277
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.268
multicellular organismal reproductive process GO:0048609 815 0.256
receptor mediated endocytosis GO:0006898 715 0.254
sexual reproduction GO:0019953 546 0.253
meiotic cell cycle process GO:1903046 170 0.245
cell development GO:0048468 696 0.241
sister chromatid segregation GO:0000819 46 0.236
Human
transport GO:0006810 1093 0.223
Fly
meiosis i GO:0007127 19 0.222
Yeast Worm
oocyte development GO:0048599 44 0.219
protein catabolic process GO:0030163 162 0.218
Human
regulation of metabolic process GO:0019222 478 0.218
Human Yeast
organ development GO:0048513 1102 0.216
gamete generation GO:0007276 461 0.203
multicellular organismal aging GO:0010259 812 0.202
regulation of mitotic cell cycle GO:0007346 76 0.200
Human
vesicle mediated transport GO:0016192 852 0.199
Fly
regulation of catalytic activity GO:0050790 78 0.195
Human Yeast
post embryonic organ development GO:0048569 336 0.193
phosphate containing compound metabolic process GO:0006796 232 0.188
Human Yeast Mouse Rat Fly
negative regulation of biological process GO:0048519 567 0.187
Human Fly
cell death GO:0008219 547 0.186
protein phosphorylation GO:0006468 85 0.185
Human Yeast Mouse Rat Fly
single organism organelle organization GO:1902589 501 0.184
cell cycle process GO:0022402 482 0.177
regulation of multicellular organismal process GO:0051239 726 0.175
Fly
developmental process involved in reproduction GO:0003006 1165 0.174
reproductive structure development GO:0048608 850 0.162
regulation of phosphate metabolic process GO:0019220 81 0.151
Human
germ cell development GO:0007281 351 0.150
anatomical structure formation involved in morphogenesis GO:0048646 250 0.147
macromolecule localization GO:0033036 771 0.145
Human Yeast Fly
protein modification process GO:0036211 207 0.142
Human Yeast Mouse Rat Fly
vulval development GO:0040025 333 0.140
gonad development GO:0008406 840 0.140
gene expression GO:0010467 412 0.138
Human
female gamete generation GO:0007292 254 0.129
oviposition GO:0018991 364 0.127
cellular protein metabolic process GO:0044267 279 0.127
Human Yeast Mouse Rat Fly
regulation of cell cycle process GO:0010564 145 0.125
Human Yeast Worm
regulation of nematode larval development GO:0061062 260 0.125
establishment of localization GO:0051234 1171 0.123
Human Fly
cell division GO:0051301 262 0.120
meiotic nuclear division GO:0007126 300 0.120
positive regulation of molecular function GO:0044093 61 0.119
Human Yeast
single organism reproductive process GO:0044702 1196 0.118
neurogenesis GO:0022008 236 0.117
Fly
cellular catabolic process GO:0044248 199 0.112
Human
protein complex assembly GO:0006461 186 0.110
Yeast Fly
organelle assembly GO:0070925 214 0.108
Yeast Fly
developmental growth GO:0048589 412 0.108
oogenesis GO:0048477 229 0.105
regulation of vulval development GO:0040028 248 0.105
macromolecular complex subunit organization GO:0043933 320 0.098
regulation of post embryonic development GO:0048580 260 0.097
negative regulation of developmental process GO:0051093 227 0.095
Fly
growth GO:0040007 562 0.092
regulation of protein serine threonine kinase activity GO:0071900 18 0.092
Human
organelle organization GO:0006996 783 0.087
regulation of cellular component organization GO:0051128 248 0.087
Human Yeast Worm
regulation of cell cycle GO:0051726 194 0.085
regulation of phosphorus metabolic process GO:0051174 81 0.083
Human
positive regulation of nucleoside metabolic process GO:0045979 28 0.083
protein localization GO:0008104 205 0.082
Human Yeast Fly
cellular component biogenesis GO:0044085 297 0.080
Yeast Fly
maintenance of location GO:0051235 580 0.077
phosphorus metabolic process GO:0006793 232 0.077
Human Yeast Mouse Rat Fly
negative regulation of macromolecule metabolic process GO:0010605 229 0.075
Human
cellular protein localization GO:0034613 75 0.074
Human Fly
macromolecule modification GO:0043412 218 0.070
Human Yeast Mouse Rat Fly
regulation of gene expression GO:0010468 366 0.069
Human
protein complex subunit organization GO:0071822 280 0.068
meiotic cell cycle GO:0051321 335 0.068
macromolecule catabolic process GO:0009057 202 0.068
Human
regulation of cellular protein metabolic process GO:0032268 75 0.068
Human
cell cycle phase transition GO:0044770 19 0.067
Human
phosphorylation GO:0016310 116 0.067
Human Yeast Mouse Rat Fly
behavior GO:0007610 527 0.067
reproductive system development GO:0061458 850 0.067
chromosome organization GO:0051276 104 0.065
Human Yeast
posttranscriptional regulation of gene expression GO:0010608 166 0.065
Human
cellular protein modification process GO:0006464 207 0.065
Human Yeast Mouse Rat Fly
death GO:0016265 547 0.063
positive regulation of developmental process GO:0051094 408 0.062
regulation of multicellular organism growth GO:0040014 373 0.061
single organism localization GO:1902578 518 0.061
Fly
cytokinesis GO:0000910 80 0.060
regulation of microtubule cytoskeleton organization GO:0070507 21 0.060
Yeast
negative regulation of cell cycle GO:0045786 53 0.058
Human
catabolic process GO:0009056 318 0.058
Human
positive regulation of multicellular organismal process GO:0051240 417 0.058
oocyte differentiation GO:0009994 45 0.058
Fly
membrane organization GO:0061024 135 0.057
regulation of biological quality GO:0065008 741 0.057
Human
neuron projection development GO:0031175 187 0.056
lipid localization GO:0010876 573 0.056
regulation of developmental growth GO:0048638 389 0.056
cellular response to stress GO:0033554 162 0.055
Human
lipid storage GO:0019915 565 0.055
cytoskeleton organization GO:0007010 339 0.054
positive regulation of developmental growth GO:0048639 354 0.054
hermaphrodite genitalia development GO:0040035 734 0.054
mitotic nuclear division GO:0007067 89 0.053
programmed cell death GO:0012501 500 0.053
single organism cellular localization GO:1902580 72 0.052
cellular macromolecule localization GO:0070727 75 0.052
Human Fly
regulation of growth GO:0040008 409 0.052
cellular biosynthetic process GO:0044249 315 0.052
Human
regulation of cell division GO:0051302 142 0.051
Human Worm
multi organism reproductive process GO:0044703 867 0.051
regulation of meiosis GO:0040020 94 0.051
Worm
development of primary sexual characteristics GO:0045137 840 0.051
establishment of organelle localization GO:0051656 123 0.050
Fly
regulation of phosphorylation GO:0042325 45 0.050
Human
negative regulation of cellular metabolic process GO:0031324 95 0.049
Human
cellular component assembly GO:0022607 293 0.048
Yeast Fly
cell fate commitment GO:0045165 139 0.048
Fly
single organism biosynthetic process GO:0044711 91 0.048
synaptonemal complex assembly GO:0007130 6 0.047
nucleobase containing compound catabolic process GO:0034655 114 0.045
negative regulation of cellular process GO:0048523 239 0.045
Human Fly
multicellular organismal reproductive behavior GO:0033057 384 0.044
genitalia development GO:0048806 741 0.044
positive regulation of growth GO:0045927 369 0.044
multicellular organism growth GO:0035264 385 0.044
negative regulation of multicellular organismal process GO:0051241 236 0.044
Fly
sex differentiation GO:0007548 909 0.043
dna duplex unwinding GO:0032508 3 0.042
positive regulation of multicellular organism growth GO:0040018 352 0.042
regulation of gtp catabolic process GO:0033124 32 0.041
organonitrogen compound metabolic process GO:1901564 151 0.040
regulation of macromolecule biosynthetic process GO:0010556 189 0.040
Human
negative regulation of cellular protein metabolic process GO:0032269 27 0.040
Human
negative regulation of vulval development GO:0040027 206 0.039
mitotic cell cycle process GO:1903047 194 0.039
regulation of protein metabolic process GO:0051246 81 0.039
Human
reproductive behavior GO:0019098 387 0.038
regulation of gene expression epigenetic GO:0040029 163 0.038
digestive system development GO:0055123 122 0.038
negative regulation of gene expression GO:0010629 217 0.038
Human
establishment of localization in cell GO:0051649 318 0.038
Fly
cellular protein catabolic process GO:0044257 37 0.037
Human
body morphogenesis GO:0010171 620 0.037
organic substance biosynthetic process GO:1901576 323 0.037
Human
generation of neurons GO:0048699 235 0.036
Fly
small molecule metabolic process GO:0044281 186 0.036
regulation of organ morphogenesis GO:2000027 4 0.036
phagocytosis GO:0006909 115 0.036
Fly
macromolecule biosynthetic process GO:0009059 250 0.036
Human
negative regulation of cell cycle process GO:0010948 12 0.035
Human
regulation of multicellular organismal development GO:2000026 317 0.034
Fly
cell morphogenesis GO:0000902 163 0.034
microtubule based process GO:0007017 182 0.034
cell part morphogenesis GO:0032990 152 0.033
apoptotic cell clearance GO:0043277 111 0.032
cellular component morphogenesis GO:0032989 318 0.032
regulation of cell death GO:0010941 65 0.032
Human
nucleoside metabolic process GO:0009116 99 0.032
tube morphogenesis GO:0035239 79 0.031
neuron differentiation GO:0030182 217 0.030
gene silencing GO:0016458 143 0.030
regulation of cellular catabolic process GO:0031329 51 0.030
Human
axonogenesis GO:0007409 102 0.030
regulation of cellular metabolic process GO:0031323 305 0.029
Human
multi organism reproductive behavior GO:0044705 387 0.029
organic substance catabolic process GO:1901575 294 0.028
Human
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.028
Human
system process GO:0003008 136 0.028
regulation of molecular function GO:0065009 89 0.028
Human Yeast
nervous system development GO:0007399 253 0.028
Fly
axon development GO:0061564 163 0.027
gene silencing by rna GO:0031047 143 0.026
positive regulation of phosphorus metabolic process GO:0010562 56 0.025
Human
digestive tract morphogenesis GO:0048546 76 0.025
spindle organization GO:0007051 92 0.025
cellular macromolecular complex assembly GO:0034622 184 0.025
Fly
phagocytosis engulfment GO:0006911 98 0.024
synapsis GO:0007129 10 0.024
multi multicellular organism process GO:0044706 390 0.024
cell projection morphogenesis GO:0048858 148 0.024
posttranscriptional gene silencing GO:0016441 143 0.024
regulation of macromolecule metabolic process GO:0060255 421 0.023
Human
cellular component movement GO:0006928 388 0.023
cytokinetic process GO:0032506 10 0.023
Fly
signal transduction GO:0007165 317 0.023
regulation of behavior GO:0050795 97 0.023
digestive tract development GO:0048565 122 0.023
mitotic spindle organization GO:0007052 81 0.023
regulation of programmed cell death GO:0043067 50 0.023
Human
engulfment of apoptotic cell GO:0043652 94 0.022
pronuclear migration GO:0035046 51 0.022
Fly
membrane invagination GO:0010324 98 0.022
negative regulation of nematode larval development GO:0061064 208 0.022
cellular macromolecule biosynthetic process GO:0034645 247 0.021
Human
macromolecular complex assembly GO:0065003 193 0.021
Yeast Fly
mitotic sister chromatid segregation GO:0000070 38 0.021
Human
negative regulation of mitotic cell cycle GO:0045930 42 0.021
Human
regulation of microtubule based process GO:0032886 21 0.021
Yeast
positive regulation of protein metabolic process GO:0051247 45 0.021
Human
endomembrane system organization GO:0010256 22 0.020
rna interference GO:0016246 137 0.020
multi organism behavior GO:0051705 389 0.020
dna metabolic process GO:0006259 74 0.020
Yeast
spindle localization GO:0051653 51 0.020
response to chemical GO:0042221 356 0.020
Rat
aromatic compound catabolic process GO:0019439 116 0.020
muscle structure development GO:0061061 191 0.020
response to abiotic stimulus GO:0009628 152 0.020
epithelium development GO:0060429 68 0.019
Fly
biosynthetic process GO:0009058 323 0.019
Human
ribonucleoside triphosphate metabolic process GO:0009199 87 0.019
cellular macromolecule catabolic process GO:0044265 73 0.019
Human
dna conformation change GO:0071103 11 0.019
positive regulation of transferase activity GO:0051347 21 0.018
Human
cellular nitrogen compound catabolic process GO:0044270 119 0.018
signaling GO:0023052 401 0.018
purine nucleoside metabolic process GO:0042278 92 0.018
regulation of meiotic cell cycle GO:0051445 136 0.018
Worm
negative regulation of gene expression epigenetic GO:0045814 2 0.018
cytoskeleton dependent cytokinesis GO:0061640 35 0.018
regulation of hydrolase activity GO:0051336 45 0.018
carbohydrate derivative catabolic process GO:1901136 82 0.017
regulation of protein kinase activity GO:0045859 28 0.017
Human
regulation of transferase activity GO:0051338 31 0.017
Human
protein complex biogenesis GO:0070271 186 0.017
Yeast Fly
cell migration GO:0016477 306 0.017
regulation of catabolic process GO:0009894 57 0.017
Human
heterocycle catabolic process GO:0046700 119 0.017
single organism transport GO:0044765 447 0.017
Fly
organism emergence from protective structure GO:0071684 48 0.017
ribose phosphate metabolic process GO:0019693 99 0.016
regulation of protein localization GO:0032880 50 0.016
single organism catabolic process GO:0044712 129 0.016
Human
response to heat GO:0009408 50 0.016
cell projection organization GO:0030030 231 0.016
g1 s transition of mitotic cell cycle GO:0000082 2 0.016
nucleoside triphosphate metabolic process GO:0009141 87 0.016
organonitrogen compound catabolic process GO:1901565 90 0.016
dna geometric change GO:0032392 3 0.016
dauer larval development GO:0040024 92 0.016
transcription from rna polymerase ii promoter GO:0006366 149 0.016
Human
positive regulation of cell cycle GO:0045787 55 0.015
Human Yeast
carbohydrate derivative metabolic process GO:1901135 141 0.015
regulation of cytoskeleton organization GO:0051493 41 0.015
Yeast
ribosome biogenesis GO:0042254 4 0.015
organophosphate metabolic process GO:0019637 125 0.015
mitotic g2 m transition checkpoint GO:0044818 1 0.015
nucleobase containing small molecule metabolic process GO:0055086 115 0.015
regulation of nucleoside metabolic process GO:0009118 37 0.015
cellular component assembly involved in morphogenesis GO:0010927 183 0.015
localization of cell GO:0051674 313 0.015
glycosyl compound catabolic process GO:1901658 79 0.015
purine nucleoside triphosphate metabolic process GO:0009144 87 0.015
sensory organ morphogenesis GO:0090596 2 0.015
regulation of apoptotic signaling pathway GO:2001233 1 0.014
modification dependent macromolecule catabolic process GO:0043632 32 0.014
Human
purine ribonucleoside catabolic process GO:0046130 75 0.014
single organism signaling GO:0044700 401 0.014
myosin filament organization GO:0031033 138 0.014
nucleoside catabolic process GO:0009164 78 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.014
cell cycle dna replication GO:0044786 3 0.014
mitotic cell cycle phase transition GO:0044772 13 0.014
Human
posttranscriptional gene silencing by rna GO:0035194 143 0.014
embryonic morphogenesis GO:0048598 152 0.014
negative regulation of signal transduction GO:0009968 60 0.014
regulation of nuclear division GO:0051783 115 0.013
Human Worm
chromosome condensation GO:0030261 6 0.013
ubiquitin dependent protein catabolic process GO:0006511 32 0.013
Human
organophosphate catabolic process GO:0046434 81 0.013
cell cycle g1 s phase transition GO:0044843 2 0.013
chromatin remodeling GO:0006338 2 0.013
head development GO:0060322 1 0.013
regulation of purine nucleotide catabolic process GO:0033121 35 0.013
regulation of dna catabolic process GO:1903624 1 0.013
positive regulation of protein kinase activity GO:0045860 18 0.013
nucleoside phosphate catabolic process GO:1901292 77 0.013
purine ribonucleoside metabolic process GO:0046128 92 0.013
glycosyl compound metabolic process GO:1901657 100 0.013
regulation of organelle organization GO:0033043 164 0.013
Human Yeast Worm
protein localization to organelle GO:0033365 37 0.012
Human
neuron projection morphogenesis GO:0048812 114 0.012
nucleoside triphosphate catabolic process GO:0009143 72 0.012
fertilization GO:0009566 63 0.012
Fly
nematode male tail tip morphogenesis GO:0045138 77 0.012
positive regulation of cellular metabolic process GO:0031325 178 0.012
Human
pattern specification process GO:0007389 59 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.012
Human
single organism membrane organization GO:0044802 35 0.012
protein oligomerization GO:0051259 4 0.012
neuron development GO:0048666 199 0.012
peptidyl amino acid modification GO:0018193 58 0.012
Human
positive regulation of phosphate metabolic process GO:0045937 56 0.012
Human
negative regulation of post embryonic development GO:0048581 208 0.012
actin filament based process GO:0030029 191 0.012
Fly
organ morphogenesis GO:0009887 67 0.012
cellular localization GO:0051641 360 0.012
Human Fly
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.012
Human
muscle cell development GO:0055001 158 0.012
nucleus localization GO:0051647 55 0.012
Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
positive regulation of gtpase activity GO:0043547 28 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 5 0.011
Human
purine nucleoside catabolic process GO:0006152 75 0.011
nucleotide metabolic process GO:0009117 108 0.011
actomyosin structure organization GO:0031032 154 0.011
Fly
negative regulation of chromosome segregation GO:0051985 4 0.011
Human
ribonucleoside catabolic process GO:0042454 77 0.011
regulation of localization GO:0032879 194 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.011
chromosome organization involved in meiosis GO:0070192 25 0.011
cell cycle g2 m phase transition GO:0044839 1 0.011
Human
male gamete generation GO:0048232 41 0.011
Fly
cellular ketone metabolic process GO:0042180 14 0.011
translation GO:0006412 37 0.011
establishment of protein localization GO:0045184 50 0.011
Human
positive regulation of post embryonic development GO:0048582 54 0.011
protein transport GO:0015031 45 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
guanosine containing compound metabolic process GO:1901068 49 0.010
cell cycle switching mitotic to meiotic cell cycle GO:0051728 35 0.010
tube development GO:0035295 126 0.010
Fly
negative regulation of cell cycle phase transition GO:1901988 6 0.010
Human
chromatin assembly GO:0031497 1 0.010
spindle checkpoint GO:0031577 4 0.010
Human
regulation of nucleotide catabolic process GO:0030811 35 0.010
purine ribonucleotide metabolic process GO:0009150 95 0.010
purine containing compound metabolic process GO:0072521 95 0.010
positive regulation of mitotic sister chromatid separation GO:1901970 1 0.010
Human
organic acid metabolic process GO:0006082 47 0.010
myosin filament assembly GO:0031034 138 0.010
regulation of purine nucleotide metabolic process GO:1900542 37 0.010
actin cytoskeleton organization GO:0030036 184 0.010
Fly
regulation of epithelial cell differentiation GO:0030856 4 0.010

plk-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
head and neck squamous cell carcinoma DOID:5520 0 0.010
head and neck carcinoma DOID:1542 0 0.010
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010
head and neck cancer DOID:11934 0 0.010