Caenorhabditis elegans

35 known processes

twk-18 (CELE_C24A3.6)

Protein TWK-18

twk-18 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
muscle contraction GO:0006936 43 0.842
cellular component biogenesis GO:0044085 297 0.687
post embryonic development GO:0009791 2152 0.677
muscle structure development GO:0061061 191 0.677
striated muscle cell differentiation GO:0051146 158 0.668
establishment of localization GO:0051234 1171 0.651
muscle tissue development GO:0060537 1 0.638
regulation of muscle contraction GO:0006937 20 0.609
Worm
cellular component morphogenesis GO:0032989 318 0.574
embryo development GO:0009790 3052 0.565
Worm
striated muscle cell development GO:0055002 157 0.492
anatomical structure formation involved in morphogenesis GO:0048646 250 0.462
organ development GO:0048513 1102 0.452
muscle cell differentiation GO:0042692 171 0.446
myofibril assembly GO:0030239 154 0.426
signaling GO:0023052 401 0.425
cell development GO:0048468 696 0.406
transport GO:0006810 1093 0.398
endocytosis GO:0006897 819 0.374
muscle cell development GO:0055001 158 0.355
single organism organelle organization GO:1902589 501 0.354
embryo development ending in birth or egg hatching GO:0009792 2992 0.354
Worm
actomyosin structure organization GO:0031032 154 0.349
organelle assembly GO:0070925 214 0.344
protein catabolic process GO:0030163 162 0.343
single organism transport GO:0044765 447 0.341
protein complex subunit organization GO:0071822 280 0.323
organic substance catabolic process GO:1901575 294 0.312
locomotion GO:0040011 1634 0.309
cytoskeleton organization GO:0007010 339 0.306
single organism signaling GO:0044700 401 0.301
macromolecular complex subunit organization GO:0043933 320 0.300
actin cytoskeleton organization GO:0030036 184 0.297
organelle organization GO:0006996 783 0.294
receptor mediated endocytosis GO:0006898 715 0.291
vesicle mediated transport GO:0016192 852 0.291
muscle system process GO:0003012 43 0.282
protein complex biogenesis GO:0070271 186 0.279
skeletal muscle organ development GO:0060538 3 0.267
cell morphogenesis GO:0000902 163 0.265
cellular component assembly involved in morphogenesis GO:0010927 183 0.260
actin filament based process GO:0030029 191 0.258
cellular component assembly GO:0022607 293 0.255
protein complex assembly GO:0006461 186 0.242
sarcomere organization GO:0045214 10 0.238
cellular macromolecular complex assembly GO:0034622 184 0.237
catabolic process GO:0009056 318 0.233
regulation of locomotion GO:0040012 161 0.216
regulation of cell motility GO:2000145 57 0.210
myosin filament assembly GO:0031034 138 0.201
response to wounding GO:0009611 4 0.193
regulation of cell migration GO:0030334 55 0.191
protein metabolic process GO:0019538 422 0.189
multicellular organism reproduction GO:0032504 819 0.185
multicellular organismal reproductive process GO:0048609 815 0.182
cell cycle process GO:0022402 482 0.174
negative regulation of biological process GO:0048519 567 0.168
body morphogenesis GO:0010171 620 0.166
Worm
system process GO:0003008 136 0.164
regulation of multicellular organismal process GO:0051239 726 0.160
Worm
cell substrate adhesion GO:0031589 1 0.155
regulation of biological quality GO:0065008 741 0.154
cellular protein complex assembly GO:0043623 178 0.153
regulation of localization GO:0032879 194 0.147
cell migration GO:0016477 306 0.145
hermaphrodite genitalia development GO:0040035 734 0.141
regulation of cellular metabolic process GO:0031323 305 0.141
response to chemical GO:0042221 356 0.140
oviposition GO:0018991 364 0.138
multi organism reproductive process GO:0044703 867 0.137
Worm
macromolecule catabolic process GO:0009057 202 0.131
macromolecular complex assembly GO:0065003 193 0.128
developmental process involved in reproduction GO:0003006 1165 0.126
regulation of response to stimulus GO:0048583 243 0.118
growth GO:0040007 562 0.117
regulation of cell adhesion GO:0030155 6 0.116
signal transduction GO:0007165 317 0.115
negative regulation of cellular process GO:0048523 239 0.114
mitotic nuclear division GO:0007067 89 0.114
cell motility GO:0048870 313 0.112
regulation of developmental process GO:0050793 684 0.110
striated muscle myosin thick filament assembly GO:0071688 138 0.105
metal ion transport GO:0030001 49 0.103
multi multicellular organism process GO:0044706 390 0.100
Worm
inactivation of mapkkk activity GO:0051390 2 0.099
reproductive structure development GO:0048608 850 0.099
establishment of localization in cell GO:0051649 318 0.099
secretion GO:0046903 147 0.094
single organism reproductive process GO:0044702 1196 0.091
cellular component movement GO:0006928 388 0.091
regulation of cellular component organization GO:0051128 248 0.090
gastrulation GO:0007369 58 0.090
female gamete generation GO:0007292 254 0.089
muscle organ development GO:0007517 26 0.089
tissue development GO:0009888 112 0.088
synaptic transmission GO:0007268 106 0.086
localization of cell GO:0051674 313 0.086
regulation of transport GO:0051049 91 0.086
regulation of cell communication GO:0010646 176 0.085
regulation of developmental growth GO:0048638 389 0.085
developmental growth GO:0048589 412 0.084
membrane organization GO:0061024 135 0.082
inductive cell migration GO:0040039 145 0.082
multi organism reproductive behavior GO:0044705 387 0.082
genitalia development GO:0048806 741 0.081
intracellular signal transduction GO:0035556 96 0.081
regulation of signaling GO:0023051 172 0.080
behavior GO:0007610 527 0.080
germ cell development GO:0007281 351 0.079
neuron development GO:0048666 199 0.076
regulation of muscle system process GO:0090257 20 0.076
Worm
regulation of growth GO:0040008 409 0.073
multicellular organismal reproductive behavior GO:0033057 384 0.072
macromolecule modification GO:0043412 218 0.072
multicellular organismal aging GO:0010259 812 0.072
cell cell signaling GO:0007267 118 0.071
multi organism behavior GO:0051705 389 0.069
regulation of actin filament based process GO:0032970 22 0.069
nucleoside phosphate metabolic process GO:0006753 108 0.068
single organism localization GO:1902578 518 0.067
phosphorylation GO:0016310 116 0.066
cell cycle GO:0007049 526 0.066
lipid localization GO:0010876 573 0.066
neuron projection development GO:0031175 187 0.066
macromolecule localization GO:0033036 771 0.065
gonad development GO:0008406 840 0.065
striated muscle contraction GO:0006941 17 0.064
phosphate containing compound metabolic process GO:0006796 232 0.063
regulation of macromolecule metabolic process GO:0060255 421 0.063
multicellular organism growth GO:0035264 385 0.063
digestive tract morphogenesis GO:0048546 76 0.063
regulation of nitrogen compound metabolic process GO:0051171 222 0.061
organonitrogen compound catabolic process GO:1901565 90 0.060
protein phosphorylation GO:0006468 85 0.060
regulation of feeding behavior GO:0060259 38 0.060
regulation of metabolic process GO:0019222 478 0.058
lipid storage GO:0019915 565 0.058
regulation of striated muscle contraction GO:0006942 4 0.057
single organism cellular localization GO:1902580 72 0.056
maintenance of location GO:0051235 580 0.056
aging GO:0007568 812 0.056
organonitrogen compound metabolic process GO:1901564 151 0.056
reproductive behavior GO:0019098 387 0.055
nucleobase containing compound metabolic process GO:0006139 406 0.054
development of primary sexual characteristics GO:0045137 840 0.053
positive regulation of multicellular organismal process GO:0051240 417 0.053
regulation of oviposition GO:0046662 43 0.051
striated muscle contraction involved in embryonic body morphogenesis GO:0061199 13 0.051
embryonic morphogenesis GO:0048598 152 0.051
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.050
death GO:0016265 547 0.049
neurogenesis GO:0022008 236 0.048
determination of adult lifespan GO:0008340 812 0.048
response to abiotic stimulus GO:0009628 152 0.047
regulation of pharyngeal pumping GO:0043051 36 0.047
regulation of behavior GO:0050795 97 0.047
regulation of phosphate metabolic process GO:0019220 81 0.047
cellular protein metabolic process GO:0044267 279 0.046
regulation of gene expression GO:0010468 366 0.046
cellular localization GO:0051641 360 0.044
positive regulation of growth GO:0045927 369 0.044
excretion GO:0007588 49 0.044
positive regulation of cellular process GO:0048522 332 0.043
cell projection organization GO:0030030 231 0.042
regulation of multicellular organism growth GO:0040014 373 0.042
regulation of multicellular organismal development GO:2000026 317 0.042
phagocytosis GO:0006909 115 0.042
negative regulation of developmental process GO:0051093 227 0.041
myosin filament organization GO:0031033 138 0.041
regulation of signal transduction GO:0009966 135 0.041
regulation of cellular component movement GO:0051270 62 0.041
positive regulation of multicellular organism growth GO:0040018 352 0.040
positive regulation of cellular metabolic process GO:0031325 178 0.040
regulation of primary metabolic process GO:0080090 292 0.040
reproductive system development GO:0061458 850 0.040
feeding behavior GO:0007631 70 0.040
neuron differentiation GO:0030182 217 0.039
response to transforming growth factor beta GO:0071559 13 0.038
gamete generation GO:0007276 461 0.038
ras protein signal transduction GO:0007265 31 0.037
oogenesis GO:0048477 229 0.037
heterocycle catabolic process GO:0046700 119 0.037
ion transport GO:0006811 113 0.037
regulation of transcription dna templated GO:0006355 164 0.036
regulation of intracellular signal transduction GO:1902531 77 0.036
endoderm development GO:0007492 20 0.035
nucleoside metabolic process GO:0009116 99 0.035
positive regulation of developmental process GO:0051094 408 0.035
regulation of ion transport GO:0043269 39 0.034
phagocytosis engulfment GO:0006911 98 0.033
cellular nitrogen compound catabolic process GO:0044270 119 0.033
pharyngeal pumping GO:0043050 58 0.033
nucleobase containing small molecule metabolic process GO:0055086 115 0.032
cellular macromolecule biosynthetic process GO:0034645 247 0.032
receptor metabolic process GO:0043112 6 0.032
small gtpase mediated signal transduction GO:0007264 32 0.032
regulation of protein metabolic process GO:0051246 81 0.032
programmed cell death GO:0012501 500 0.031
cell morphogenesis involved in differentiation GO:0000904 112 0.031
defecation rhythm GO:0035882 3 0.031
nervous system development GO:0007399 253 0.031
protein modification process GO:0036211 207 0.031
cellular protein modification process GO:0006464 207 0.030
tube development GO:0035295 126 0.030
positive regulation of phosphate metabolic process GO:0045937 56 0.030
sodium ion transmembrane transport GO:0035725 8 0.030
carbohydrate derivative catabolic process GO:1901136 82 0.030
apoptotic cell clearance GO:0043277 111 0.030
cell junction organization GO:0034330 18 0.030
regulation of cell morphogenesis GO:0022604 40 0.029
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.028
sex differentiation GO:0007548 909 0.028
single organism catabolic process GO:0044712 129 0.028
engulfment of apoptotic cell GO:0043652 94 0.028
secretion by cell GO:0032940 138 0.027
positive regulation of cell migration GO:0030335 3 0.027
regulation of phosphorus metabolic process GO:0051174 81 0.026
purine nucleotide catabolic process GO:0006195 75 0.026
sexual reproduction GO:0019953 546 0.025
positive regulation of macromolecule metabolic process GO:0010604 149 0.025
neuromuscular junction development GO:0007528 2 0.025
muscle organ morphogenesis GO:0048644 4 0.025
cell matrix adhesion GO:0007160 1 0.025
tube morphogenesis GO:0035239 79 0.024
organic substance transport GO:0071702 113 0.024
regulation of vesicle mediated transport GO:0060627 27 0.024
divalent inorganic cation transport GO:0072511 17 0.024
regulation of transcription from rna polymerase ii promoter in response to salt stress GO:0061416 1 0.024
negative regulation of cell communication GO:0010648 61 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.024
regulation of organelle organization GO:0033043 164 0.024
regulation of system process GO:0044057 27 0.024
Worm
generation of neurons GO:0048699 235 0.024
protein localization GO:0008104 205 0.023
biosynthetic process GO:0009058 323 0.023
negative regulation of signaling GO:0023057 61 0.023
regulation of secretion GO:0051046 29 0.023
cellular response to transforming growth factor beta stimulus GO:0071560 13 0.023
aromatic compound biosynthetic process GO:0019438 192 0.023
cellular catabolic process GO:0044248 199 0.023
eating behavior GO:0042755 59 0.023
regulation of synapse assembly GO:0051963 2 0.023
protein oligomerization GO:0051259 4 0.022
neuron projection morphogenesis GO:0048812 114 0.022
muscle attachment GO:0016203 3 0.022
regulation of molecular function GO:0065009 89 0.022
synaptic vesicle endocytosis GO:0048488 3 0.022
cell adhesion GO:0007155 21 0.022
biological adhesion GO:0022610 21 0.021
mitotic cell cycle process GO:1903047 194 0.021
response to anesthetic GO:0072347 1 0.021
glycosyl compound catabolic process GO:1901658 79 0.020
positive regulation of transcription from rna polymerase ii promoter involved in defense response to fungus GO:1901244 1 0.020
positive regulation of locomotion GO:0040017 42 0.020
ribonucleoside triphosphate catabolic process GO:0009203 72 0.020
cell surface receptor signaling pathway GO:0007166 149 0.020
organic cyclic compound catabolic process GO:1901361 119 0.020
cellular protein localization GO:0034613 75 0.020
regulation of catalytic activity GO:0050790 78 0.020
gene expression GO:0010467 412 0.020
meiotic cell cycle GO:0051321 335 0.020
negative regulation of ion transmembrane transport GO:0034766 3 0.020
epithelium development GO:0060429 68 0.020
organic substance biosynthetic process GO:1901576 323 0.020
purine containing compound metabolic process GO:0072521 95 0.019
homeostatic process GO:0042592 51 0.019
positive regulation of developmental growth GO:0048639 354 0.019
regulation of multi organism process GO:0043900 69 0.019
cellular biosynthetic process GO:0044249 315 0.019
regulation of apoptotic signaling pathway GO:2001233 1 0.019
negative regulation of response to stimulus GO:0048585 73 0.019
regulation of neuromuscular synaptic transmission GO:1900073 1 0.019
regulation of cell cell adhesion GO:0022407 1 0.019
regulation of synaptic transmission GO:0050804 34 0.019
negative regulation of signal transduction GO:0009968 60 0.019
integrin mediated signaling pathway GO:0007229 1 0.019
regulation of anatomical structure size GO:0090066 46 0.018
single organism membrane organization GO:0044802 35 0.018
apoptotic process GO:0006915 478 0.018
neurological system process GO:0050877 53 0.018
glycosyl compound metabolic process GO:1901657 100 0.018
regulation of macromolecule biosynthetic process GO:0010556 189 0.018
acetylcholine transport GO:0015870 16 0.018
regulation of neurotransmitter levels GO:0001505 36 0.018
regulation of biosynthetic process GO:0009889 189 0.018
taxis GO:0042330 128 0.018
collagen and cuticulin based cuticle development GO:0040002 99 0.018
cation transport GO:0006812 78 0.018
intercellular transport GO:0010496 1 0.018
defecation GO:0030421 47 0.017
peptidyl tyrosine phosphorylation GO:0018108 2 0.017
positive regulation of transport GO:0051050 32 0.017
cellular nitrogen compound biosynthetic process GO:0044271 192 0.017
ribonucleotide metabolic process GO:0009259 99 0.017
positive regulation of secretion by cell GO:1903532 14 0.017
regulation of reproductive process GO:2000241 66 0.017
nucleic acid metabolic process GO:0090304 299 0.017
organelle fission GO:0048285 363 0.017
nucleoside triphosphate catabolic process GO:0009143 72 0.017
aromatic compound catabolic process GO:0019439 116 0.016
response to growth factor GO:0070848 18 0.016
lamellipodium assembly GO:0030032 2 0.016
nucleoside phosphate catabolic process GO:1901292 77 0.016
single organism behavior GO:0044708 83 0.016
neurotransmitter transport GO:0006836 32 0.016
organic cyclic compound biosynthetic process GO:1901362 195 0.016
signal transduction by phosphorylation GO:0023014 31 0.016
macromolecule biosynthetic process GO:0009059 250 0.016
inorganic ion transmembrane transport GO:0098660 54 0.016
regulation of hydrolase activity GO:0051336 45 0.016
meiotic nuclear division GO:0007126 300 0.016
response to other organism GO:0051707 101 0.015
cellular response to organic substance GO:0071310 119 0.015
inorganic cation transmembrane transport GO:0098662 46 0.015
regulation of phosphorylation GO:0042325 45 0.015
cellular homeostasis GO:0019725 22 0.015
positive regulation of metabolic process GO:0009893 187 0.015
actin filament bundle assembly GO:0051017 3 0.015
cell growth GO:0016049 44 0.015
organelle localization GO:0051640 127 0.015
regulation of atp catabolic process GO:1903289 3 0.015
somatic muscle development GO:0007525 1 0.015
molting cycle GO:0042303 281 0.015
cell death GO:0008219 547 0.014
negative regulation of nematode larval development GO:0061064 208 0.014
cuticle development GO:0042335 100 0.014
purine nucleoside triphosphate metabolic process GO:0009144 87 0.014
axon extension GO:0048675 37 0.014
positive regulation of transcription from rna polymerase ii promoter in response to salt stress GO:0036251 1 0.014
positive regulation of phosphorus metabolic process GO:0010562 56 0.014
guanosine containing compound catabolic process GO:1901069 48 0.014
positive regulation of stem cell differentiation GO:2000738 1 0.014
positive regulation of striated muscle contraction GO:0045989 2 0.014
response to osmotic stress GO:0006970 29 0.014
negative regulation of transporter activity GO:0032410 3 0.013
meiotic cell cycle process GO:1903046 170 0.013
single organism intracellular transport GO:1902582 70 0.013
small molecule metabolic process GO:0044281 186 0.013
transcription from rna polymerase ii promoter GO:0006366 149 0.013
mitotic spindle organization GO:0007052 81 0.013
cellular amino acid metabolic process GO:0006520 15 0.013
mapk cascade GO:0000165 31 0.013
negative regulation of multicellular organismal process GO:0051241 236 0.013
positive regulation of gene expression GO:0010628 112 0.013
regulation of defecation rhythm GO:2000746 3 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
pattern specification process GO:0007389 59 0.013
membrane invagination GO:0010324 98 0.013
ribose phosphate metabolic process GO:0019693 99 0.013
positive regulation of catalytic activity GO:0043085 59 0.013
positive regulation of molecular function GO:0044093 61 0.013
response to external stimulus GO:0009605 289 0.013
cell projection morphogenesis GO:0048858 148 0.013
axon development GO:0061564 163 0.013
regulation of cellular biosynthetic process GO:0031326 189 0.013
mitochondrion organization GO:0007005 20 0.013
positive regulation of secretion GO:0051047 17 0.013
regulation of cell proliferation GO:0042127 105 0.013
microtubule based process GO:0007017 182 0.012
establishment of protein localization to membrane GO:0090150 3 0.012
ion transmembrane transport GO:0034220 91 0.012
synaptic transmission cholinergic GO:0007271 21 0.012
transcription dna templated GO:0006351 168 0.012
nucleotide catabolic process GO:0009166 77 0.012
cellular response to stress GO:0033554 162 0.012
purine ribonucleotide metabolic process GO:0009150 95 0.012
regulation of cellular protein metabolic process GO:0032268 75 0.012
carbohydrate derivative metabolic process GO:1901135 141 0.012
regulation of endocytosis GO:0030100 25 0.012
ribonucleoside catabolic process GO:0042454 77 0.012
regulation of cytoskeleton organization GO:0051493 41 0.012
regulation of cell differentiation GO:0045595 81 0.012
ovulation GO:0030728 33 0.012
chemotaxis GO:0006935 120 0.012
rna metabolic process GO:0016070 228 0.012
nucleotide metabolic process GO:0009117 108 0.012
axonal defasciculation GO:0007414 1 0.012
negative regulation of ion transmembrane transporter activity GO:0032413 3 0.012
adult locomotory behavior GO:0008344 1 0.012
positive regulation of rna metabolic process GO:0051254 103 0.011
negative regulation of transmembrane transport GO:0034763 3 0.011
cellular amine metabolic process GO:0044106 15 0.011
nitrogen compound transport GO:0071705 49 0.011
amine metabolic process GO:0009308 15 0.011
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.011
rna biosynthetic process GO:0032774 169 0.011
chromosome segregation GO:0007059 180 0.011
embryonic body morphogenesis GO:0010172 49 0.011
positive regulation of transcription dna templated GO:0045893 102 0.011
epithelial tube morphogenesis GO:0060562 1 0.011
organophosphate metabolic process GO:0019637 125 0.011
adult behavior GO:0030534 3 0.011
cyclic nucleotide metabolic process GO:0009187 2 0.011
regulation of cellular ketone metabolic process GO:0010565 3 0.011
nucleoside triphosphate metabolic process GO:0009141 87 0.011
regulation of cellular localization GO:0060341 42 0.010
monovalent inorganic cation transport GO:0015672 33 0.010
nucleobase containing compound biosynthetic process GO:0034654 184 0.010
cellular protein complex localization GO:0034629 3 0.010
ribonucleoside metabolic process GO:0009119 98 0.010
muscle fiber development GO:0048747 2 0.010
post embryonic organ development GO:0048569 336 0.010

twk-18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
cardiovascular system disease DOID:1287 0 0.033
heart disease DOID:114 0 0.025
myopathy DOID:423 0 0.022
muscular disease DOID:0080000 0 0.022
cardiomyopathy DOID:0050700 0 0.022
musculoskeletal system disease DOID:17 0 0.022
muscle tissue disease DOID:66 0 0.022
nervous system disease DOID:863 0 0.014
hypertrophic cardiomyopathy DOID:11984 0 0.012
intrinsic cardiomyopathy DOID:0060036 0 0.012
dilated cardiomyopathy DOID:12930 0 0.011