Caenorhabditis elegans

112 known processes

hlh-8 (CELE_C02B8.4)

Protein HLH-8

hlh-8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.316
locomotion GO:0040011 1634 0.271
Human Mouse Worm
post embryonic development GO:0009791 2152 0.237
Worm
determination of adult lifespan GO:0008340 812 0.160
embryo development ending in birth or egg hatching GO:0009792 2992 0.153
Human Zebrafish Mouse Worm
aging GO:0007568 812 0.144
Human
growth GO:0040007 562 0.131
cell development GO:0048468 696 0.128
Human Mouse Worm Fly
establishment of localization GO:0051234 1171 0.116
Human Mouse Worm
multicellular organismal aging GO:0010259 812 0.116
positive regulation of multicellular organismal process GO:0051240 417 0.109
Human Mouse
regulation of developmental process GO:0050793 684 0.109
Human Mouse Fly
sex differentiation GO:0007548 909 0.109
Worm
regulation of multicellular organismal process GO:0051239 726 0.104
Human Mouse Fly
body morphogenesis GO:0010171 620 0.104
Mouse Worm
single organism reproductive process GO:0044702 1196 0.096
Worm
regulation of biological quality GO:0065008 741 0.094
Worm
digestive system development GO:0055123 122 0.092
macromolecule localization GO:0033036 771 0.091
Human Worm
sensory organ morphogenesis GO:0090596 2 0.088
Human
reproductive system development GO:0061458 850 0.087
Worm
apoptotic process GO:0006915 478 0.087
Mouse Rat
developmental process involved in reproduction GO:0003006 1165 0.084
Worm
endocytosis GO:0006897 819 0.084
Worm
organelle organization GO:0006996 783 0.082
Human Mouse Worm Fly
digestive tract development GO:0048565 122 0.079
organ development GO:0048513 1102 0.079
Human Mouse Worm Fly
death GO:0016265 547 0.077
Mouse Rat
developmental growth GO:0048589 412 0.072
hermaphrodite genitalia development GO:0040035 734 0.072
multi multicellular organism process GO:0044706 390 0.071
genitalia development GO:0048806 741 0.071
lipid localization GO:0010876 573 0.069
Worm
lipid storage GO:0019915 565 0.067
Worm
cellular component morphogenesis GO:0032989 318 0.066
Human Mouse
regulation of cellular component organization GO:0051128 248 0.064
Human Mouse Worm
maintenance of location GO:0051235 580 0.064
Worm
transport GO:0006810 1093 0.063
Human Mouse Worm
vesicle mediated transport GO:0016192 852 0.062
Worm
cell fate commitment GO:0045165 139 0.062
response to external stimulus GO:0009605 289 0.060
regulation of vulval development GO:0040028 248 0.060
positive regulation of developmental process GO:0051094 408 0.056
Human Mouse
reproductive structure development GO:0048608 850 0.056
Worm
development of primary sexual characteristics GO:0045137 840 0.055
Worm
head development GO:0060322 1 0.054
Mouse
positive regulation of growth GO:0045927 369 0.054
receptor mediated endocytosis GO:0006898 715 0.053
Worm
cell projection organization GO:0030030 231 0.053
Worm
multicellular organism growth GO:0035264 385 0.053
protein metabolic process GO:0019538 422 0.053
Human Mouse
gonad development GO:0008406 840 0.052
Worm
tube development GO:0035295 126 0.051
behavior GO:0007610 527 0.051
multi organism reproductive process GO:0044703 867 0.051
anatomical structure formation involved in morphogenesis GO:0048646 250 0.050
programmed cell death GO:0012501 500 0.049
Mouse Rat
regulation of growth GO:0040008 409 0.049
oviposition GO:0018991 364 0.049
regulation of gene expression GO:0010468 366 0.047
positive regulation of developmental growth GO:0048639 354 0.046
negative regulation of biological process GO:0048519 567 0.046
Human Mouse Rat Fly
protein modification process GO:0036211 207 0.045
Human Mouse
single organism organelle organization GO:1902589 501 0.045
Human Mouse Fly
localization of cell GO:0051674 313 0.044
Human Mouse Worm
positive regulation of multicellular organism growth GO:0040018 352 0.044
regulation of developmental growth GO:0048638 389 0.043
tube morphogenesis GO:0035239 79 0.042
signaling GO:0023052 401 0.040
Human Mouse Worm
cell death GO:0008219 547 0.040
Mouse Rat
regulation of multicellular organism growth GO:0040014 373 0.040
vulval development GO:0040025 333 0.040
macromolecular complex subunit organization GO:0043933 320 0.040
Human Mouse
multi organism behavior GO:0051705 389 0.039
single organism transport GO:0044765 447 0.039
Human Mouse
post embryonic organ development GO:0048569 336 0.039
regulation of nematode larval development GO:0061062 260 0.039
cellular component assembly GO:0022607 293 0.038
generation of neurons GO:0048699 235 0.038
Mouse Worm
multicellular organismal reproductive process GO:0048609 815 0.038
cytoskeleton organization GO:0007010 339 0.037
Fly
striated muscle cell development GO:0055002 157 0.037
Fly
cellular component biogenesis GO:0044085 297 0.037
muscle cell differentiation GO:0042692 171 0.036
Fly
tissue development GO:0009888 112 0.036
single organism signaling GO:0044700 401 0.036
Human Mouse Worm
regulation of metabolic process GO:0019222 478 0.035
regeneration GO:0031099 4 0.035
phosphate containing compound metabolic process GO:0006796 232 0.035
Human
cell motility GO:0048870 313 0.034
Human Mouse Worm
reproductive behavior GO:0019098 387 0.034
taxis GO:0042330 128 0.034
multicellular organism reproduction GO:0032504 819 0.034
epithelial tube morphogenesis GO:0060562 1 0.033
Mouse Fly
cellular protein metabolic process GO:0044267 279 0.033
Human Mouse
muscle structure development GO:0061061 191 0.033
Mouse Fly
regulation of localization GO:0032879 194 0.032
Human Mouse
regulation of post embryonic development GO:0048580 260 0.032
cell migration GO:0016477 306 0.031
Mouse Worm
neuron projection development GO:0031175 187 0.031
Worm
response to chemical GO:0042221 356 0.031
Human Mouse Worm
catabolic process GO:0009056 318 0.031
Human
neuron differentiation GO:0030182 217 0.030
Worm
regulation of behavior GO:0050795 97 0.030
negative regulation of developmental process GO:0051093 227 0.030
Human Mouse
cellular protein complex assembly GO:0043623 178 0.030
single organism localization GO:1902578 518 0.030
Human Mouse
cellular component movement GO:0006928 388 0.030
Human Mouse Worm
response to wounding GO:0009611 4 0.029
cellular biosynthetic process GO:0044249 315 0.029
regulation of macromolecule metabolic process GO:0060255 421 0.029
biosynthetic process GO:0009058 323 0.029
positive regulation of neurogenesis GO:0050769 4 0.029
organic cyclic compound biosynthetic process GO:1901362 195 0.028
inductive cell migration GO:0040039 145 0.028
Worm
negative regulation of macromolecule metabolic process GO:0010605 229 0.028
Human Mouse Fly
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.028
regulation of response to stimulus GO:0048583 243 0.028
Human Mouse
nucleic acid metabolic process GO:0090304 299 0.027
digestive tract morphogenesis GO:0048546 76 0.027
actin cytoskeleton organization GO:0030036 184 0.027
Fly
neurogenesis GO:0022008 236 0.027
Mouse Worm
protein complex subunit organization GO:0071822 280 0.026
positive regulation of cellular process GO:0048522 332 0.026
developmental growth involved in morphogenesis GO:0060560 37 0.026
nucleobase containing compound metabolic process GO:0006139 406 0.026
axon development GO:0061564 163 0.026
Worm
muscle cell development GO:0055001 158 0.025
Fly
protein complex biogenesis GO:0070271 186 0.025
multi organism reproductive behavior GO:0044705 387 0.025
regulation of locomotion GO:0040012 161 0.025
Human Mouse
molting cycle GO:0042303 281 0.025
negative regulation of cellular process GO:0048523 239 0.025
Human Mouse Rat
regulation of nitrogen compound metabolic process GO:0051171 222 0.025
neuron recognition GO:0008038 83 0.025
Worm
cell cycle GO:0007049 526 0.024
Worm
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.024
actin filament based process GO:0030029 191 0.024
Fly
regulation of cellular metabolic process GO:0031323 305 0.024
skeletal muscle organ development GO:0060538 3 0.024
Mouse
cell part morphogenesis GO:0032990 152 0.024
mitotic cell cycle process GO:1903047 194 0.024
protein complex assembly GO:0006461 186 0.024
cell projection morphogenesis GO:0048858 148 0.024
multicellular organismal reproductive behavior GO:0033057 384 0.023
negative regulation of post embryonic development GO:0048581 208 0.023
organic substance biosynthetic process GO:1901576 323 0.023
sexual reproduction GO:0019953 546 0.023
actomyosin structure organization GO:0031032 154 0.023
Fly
regulation of organ morphogenesis GO:2000027 4 0.023
Mouse
negative regulation of multicellular organismal process GO:0051241 236 0.022
Human Mouse
protein localization GO:0008104 205 0.022
Human
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.022
organic substance catabolic process GO:1901575 294 0.022
Human
axon guidance GO:0007411 82 0.022
system process GO:0003008 136 0.022
cell morphogenesis GO:0000902 163 0.022
Human Mouse
cellular component assembly involved in morphogenesis GO:0010927 183 0.021
negative regulation of metabolic process GO:0009892 240 0.021
Human Mouse Fly
regulation of multicellular organismal development GO:2000026 317 0.021
Human Mouse Fly
gene expression GO:0010467 412 0.021
macromolecule modification GO:0043412 218 0.021
Human Mouse
defense response GO:0006952 296 0.021
cellular protein modification process GO:0006464 207 0.021
Human Mouse
organelle assembly GO:0070925 214 0.021
cellular macromolecular complex assembly GO:0034622 184 0.020
striated muscle myosin thick filament assembly GO:0071688 138 0.020
cellular macromolecule biosynthetic process GO:0034645 247 0.020
chemotaxis GO:0006935 120 0.020
gastrulation GO:0007369 58 0.020
small molecule metabolic process GO:0044281 186 0.019
Human
striated muscle cell differentiation GO:0051146 158 0.019
Fly
response to abiotic stimulus GO:0009628 152 0.019
Human Mouse
oogenesis GO:0048477 229 0.019
organ morphogenesis GO:0009887 67 0.019
Human Mouse Fly
myosin filament organization GO:0031033 138 0.019
negative regulation of gene expression GO:0010629 217 0.019
Human Mouse Fly
regulation of reproductive process GO:2000241 66 0.019
negative regulation of vulval development GO:0040027 206 0.019
neuron development GO:0048666 199 0.019
Worm
regulation of cell communication GO:0010646 176 0.019
Human Mouse
pharynx development GO:0060465 51 0.019
negative regulation of nematode larval development GO:0061064 208 0.018
negative regulation of response to stimulus GO:0048585 73 0.018
Human Mouse
regulation of meiosis GO:0040020 94 0.018
Worm
neuron projection guidance GO:0097485 82 0.018
phosphorylation GO:0016310 116 0.018
Human
myofibril assembly GO:0030239 154 0.018
female gamete generation GO:0007292 254 0.018
nervous system development GO:0007399 253 0.018
Mouse Worm
neuron projection morphogenesis GO:0048812 114 0.018
regulation of primary metabolic process GO:0080090 292 0.018
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.018
gamete generation GO:0007276 461 0.018
axonogenesis GO:0007409 102 0.017
rna metabolic process GO:0016070 228 0.017
macromolecular complex assembly GO:0065003 193 0.017
cellular response to stress GO:0033554 162 0.017
Human Mouse
regulation of cell division GO:0051302 142 0.017
Worm
regulation of cellular ketone metabolic process GO:0010565 3 0.017
Human
regulation of transcription dna templated GO:0006355 164 0.017
macromolecule biosynthetic process GO:0009059 250 0.017
regulation of organelle organization GO:0033043 164 0.016
Human Mouse Worm
regulation of signal transduction GO:0009966 135 0.016
Human Mouse
positive regulation of cellular metabolic process GO:0031325 178 0.016
macromolecule catabolic process GO:0009057 202 0.016
positive regulation of macromolecule metabolic process GO:0010604 149 0.016
carboxylic acid metabolic process GO:0019752 34 0.016
Human
germ cell development GO:0007281 351 0.016
cell proliferation GO:0008283 116 0.016
Human Mouse Worm
dauer larval development GO:0040024 92 0.016
Worm
posttranscriptional regulation of gene expression GO:0010608 166 0.016
regulation of cell cycle process GO:0010564 145 0.016
Worm
cell division GO:0051301 262 0.016
Worm
developmental cell growth GO:0048588 39 0.016
male anatomical structure morphogenesis GO:0090598 78 0.015
Worm
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.015
regulation of meiotic cell cycle GO:0051445 136 0.015
Worm
organonitrogen compound metabolic process GO:1901564 151 0.015
regulation of cellular component movement GO:0051270 62 0.015
Human Mouse
single organism behavior GO:0044708 83 0.015
positive regulation of metabolic process GO:0009893 187 0.015
cell cycle process GO:0022402 482 0.015
Worm
positive regulation of neuron differentiation GO:0045666 4 0.015
regulation of nuclear division GO:0051783 115 0.015
Worm
neuron projection extension GO:1990138 37 0.015
rna interference GO:0016246 137 0.015
regulation of striated muscle contraction GO:0006942 4 0.014
posttranscriptional gene silencing GO:0016441 143 0.014
muscle tissue development GO:0060537 1 0.014
Mouse Fly
meiotic nuclear division GO:0007126 300 0.014
Worm
apoptotic cell clearance GO:0043277 111 0.014
myosin filament assembly GO:0031034 138 0.014
regulation of anatomical structure morphogenesis GO:0022603 51 0.014
Human Mouse
protein catabolic process GO:0030163 162 0.014
posttranscriptional gene silencing by rna GO:0035194 143 0.014
canonical wnt signaling pathway GO:0060070 3 0.014
embryonic morphogenesis GO:0048598 152 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.014
microtubule based process GO:0007017 182 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
memory GO:0007613 3 0.014
chromosome segregation GO:0007059 180 0.014
organelle fission GO:0048285 363 0.013
Worm
acetate ester metabolic process GO:1900619 4 0.013
negative regulation of response to external stimulus GO:0032102 3 0.013
cellular ketone metabolic process GO:0042180 14 0.013
Human
cell substrate adhesion GO:0031589 1 0.013
regulation of cell proliferation GO:0042127 105 0.013
Mouse Worm
regulation of transport GO:0051049 91 0.013
Human Mouse
response to external biotic stimulus GO:0043207 101 0.013
cell cell signaling GO:0007267 118 0.013
cellular nitrogen compound biosynthetic process GO:0044271 192 0.013
epithelium development GO:0060429 68 0.013
Mouse Fly
regulation of bmp signaling pathway GO:0030510 3 0.013
cell surface receptor signaling pathway GO:0007166 149 0.013
Worm
gene silencing by rna GO:0031047 143 0.013
positive regulation of cell migration GO:0030335 3 0.013
neurotransmitter catabolic process GO:0042135 4 0.013
oxoacid metabolic process GO:0043436 47 0.013
Human
axonal fasciculation GO:0007413 79 0.013
Worm
secretion GO:0046903 147 0.012
Human
regulation of catalytic activity GO:0050790 78 0.012
neurological system process GO:0050877 53 0.012
regulation of macromolecule biosynthetic process GO:0010556 189 0.012
immune response GO:0006955 192 0.012
defense response to bacterium GO:0042742 86 0.012
phagocytosis GO:0006909 115 0.012
negative regulation of neuron differentiation GO:0045665 4 0.012
organophosphate metabolic process GO:0019637 125 0.012
regulation of anatomical structure size GO:0090066 46 0.012
embryonic body morphogenesis GO:0010172 49 0.012
negative regulation of neurogenesis GO:0050768 4 0.012
cellular amine metabolic process GO:0044106 15 0.012
epithelial cell proliferation GO:0050673 1 0.012
Mouse
protein phosphorylation GO:0006468 85 0.012
Human
organic acid metabolic process GO:0006082 47 0.012
Human
membrane organization GO:0061024 135 0.012
acetylcholine metabolic process GO:0008291 4 0.012
establishment of localization in cell GO:0051649 318 0.012
Human
positive regulation of post embryonic development GO:0048582 54 0.012
regulation of epithelial cell differentiation GO:0030856 4 0.012
nematode male tail tip morphogenesis GO:0045138 77 0.012
Worm
gene silencing GO:0016458 143 0.012
regulation of endocytosis GO:0030100 25 0.012
regulation of cell cycle GO:0051726 194 0.012
Worm
regulation of cell migration GO:0030334 55 0.012
heterocycle biosynthetic process GO:0018130 187 0.012
lipid metabolic process GO:0006629 77 0.012
Human
adult behavior GO:0030534 3 0.012
regulation of canonical wnt signaling pathway GO:0060828 1 0.011
cellular amino acid metabolic process GO:0006520 15 0.011
cuticle development GO:0042335 100 0.011
regulation of gene expression epigenetic GO:0040029 163 0.011
regulation of epithelial cell proliferation GO:0050678 1 0.011
Mouse
ion transmembrane transport GO:0034220 91 0.011
signal transduction GO:0007165 317 0.011
Human Mouse Worm
protein oligomerization GO:0051259 4 0.011
male sex differentiation GO:0046661 86 0.011
Worm
amine metabolic process GO:0009308 15 0.011
cell recognition GO:0008037 85 0.011
Worm
dendrite development GO:0016358 42 0.011
cell projection assembly GO:0030031 35 0.011
muscle organ morphogenesis GO:0048644 4 0.011
regulation of multi organism process GO:0043900 69 0.011
g1 s transition of mitotic cell cycle GO:0000082 2 0.011
axon extension GO:0048675 37 0.011
engulfment of apoptotic cell GO:0043652 94 0.011
ribonucleoprotein complex assembly GO:0022618 4 0.011
negative regulation of signal transduction GO:0009968 60 0.011
Human Mouse
cellular localization GO:0051641 360 0.011
Human
response to acid chemical GO:0001101 4 0.011
response to other organism GO:0051707 101 0.010
regulation of gastrulation GO:0010470 4 0.010
ribonucleotide metabolic process GO:0009259 99 0.010
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.010
Human Mouse
cellular nitrogen compound catabolic process GO:0044270 119 0.010
regulation of oviposition GO:0046662 43 0.010
transmembrane transport GO:0055085 110 0.010
Mouse
positive regulation of nematode larval development GO:0061063 54 0.010
positive regulation of cell morphogenesis involved in differentiation GO:0010770 4 0.010
Human Mouse
meiotic cell cycle GO:0051321 335 0.010
Worm
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.010
Human Mouse
single organism biosynthetic process GO:0044711 91 0.010
feeding behavior GO:0007631 70 0.010

hlh-8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
Human
cardiovascular system disease DOID:1287 0 0.011
nervous system disease DOID:863 0 0.010