Caenorhabditis elegans

54 known processes

sir-2.1 (CELE_R11A8.4)

Protein SIR-2.1

sir-2.1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gonad development GO:0008406 840 0.663
Mouse
single organism reproductive process GO:0044702 1196 0.472
Mouse
post embryonic development GO:0009791 2152 0.424
genitalia development GO:0048806 741 0.400
organelle organization GO:0006996 783 0.392
development of primary sexual characteristics GO:0045137 840 0.389
Mouse
embryo development GO:0009790 3052 0.375
single organism organelle organization GO:1902589 501 0.352
developmental process involved in reproduction GO:0003006 1165 0.315
Mouse
hermaphrodite genitalia development GO:0040035 734 0.302
multicellular organismal reproductive process GO:0048609 815 0.277
Mouse
multicellular organism reproduction GO:0032504 819 0.234
Mouse
embryo development ending in birth or egg hatching GO:0009792 2992 0.197
locomotion GO:0040011 1634 0.192
multi multicellular organism process GO:0044706 390 0.185
sex differentiation GO:0007548 909 0.159
Mouse
gamete generation GO:0007276 461 0.156
Mouse
reproductive system development GO:0061458 850 0.137
Mouse
aging GO:0007568 812 0.134
multicellular organismal reproductive behavior GO:0033057 384 0.133
establishment of localization GO:0051234 1171 0.133
Human Mouse
organ development GO:0048513 1102 0.124
Mouse
meiotic cell cycle GO:0051321 335 0.122
cell division GO:0051301 262 0.120
multi organism reproductive process GO:0044703 867 0.117
Mouse
negative regulation of biological process GO:0048519 567 0.113
Human Mouse Fly
determination of adult lifespan GO:0008340 812 0.113
oviposition GO:0018991 364 0.112
reproductive structure development GO:0048608 850 0.107
Mouse
multi organism behavior GO:0051705 389 0.101
cell cycle process GO:0022402 482 0.090
positive regulation of gene expression GO:0010628 112 0.083
Human Mouse
regulation of cell cycle GO:0051726 194 0.079
Human
endocytosis GO:0006897 819 0.078
cellular localization GO:0051641 360 0.077
Human
rrna metabolic process GO:0016072 3 0.075
germ cell development GO:0007281 351 0.074
cellular component morphogenesis GO:0032989 318 0.072
sexual reproduction GO:0019953 546 0.071
Mouse
regulation of developmental process GO:0050793 684 0.069
Human Mouse
macromolecular complex subunit organization GO:0043933 320 0.064
multi organism reproductive behavior GO:0044705 387 0.064
transport GO:0006810 1093 0.063
Human Mouse
reproductive behavior GO:0019098 387 0.063
cellular component assembly involved in morphogenesis GO:0010927 183 0.061
programmed cell death GO:0012501 500 0.059
Human Mouse Fly
multicellular organismal aging GO:0010259 812 0.059
cell death GO:0008219 547 0.058
Human Mouse Fly
lipid storage GO:0019915 565 0.058
maintenance of location GO:0051235 580 0.057
cellular component biogenesis GO:0044085 297 0.053
cytoskeleton organization GO:0007010 339 0.051
lipid localization GO:0010876 573 0.049
Mouse
signaling GO:0023052 401 0.049
Human Mouse
actin filament based process GO:0030029 191 0.048
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.048
Human Mouse
gene expression GO:0010467 412 0.046
Human Mouse Fly
protein complex subunit organization GO:0071822 280 0.045
cell proliferation GO:0008283 116 0.045
Human
vesicle mediated transport GO:0016192 852 0.045
regulation of growth GO:0040008 409 0.045
Human
nucleic acid metabolic process GO:0090304 299 0.044
Human Mouse Fly
regulation of biological quality GO:0065008 741 0.044
Mouse
regulation of multicellular organismal process GO:0051239 726 0.041
body morphogenesis GO:0010171 620 0.040
behavior GO:0007610 527 0.040
Fly
cell cycle GO:0007049 526 0.040
Human
death GO:0016265 547 0.040
Human Mouse Fly
microtubule based process GO:0007017 182 0.040
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.038
cellular response to stress GO:0033554 162 0.037
Human Mouse
gene silencing GO:0016458 143 0.037
Human Fly
cellular protein modification process GO:0006464 207 0.036
positive regulation of metabolic process GO:0009893 187 0.035
Human Mouse
muscle structure development GO:0061061 191 0.035
macromolecule localization GO:0033036 771 0.034
Human Mouse
regulation of metabolic process GO:0019222 478 0.034
Human Mouse Fly
negative regulation of developmental process GO:0051093 227 0.033
Human Mouse
single organism transport GO:0044765 447 0.033
Human Mouse
cellular response to organic substance GO:0071310 119 0.032
Human Mouse
regulation of lipid metabolic process GO:0019216 4 0.032
Mouse
protein metabolic process GO:0019538 422 0.031
response to extracellular stimulus GO:0009991 38 0.030
Human Mouse Fly
regulation of multicellular organism growth GO:0040014 373 0.030
chromosome organization GO:0051276 104 0.030
negative regulation of gene expression GO:0010629 217 0.029
Human Mouse Fly
macromolecular complex assembly GO:0065003 193 0.029
regulation of cell division GO:0051302 142 0.029
macromolecule modification GO:0043412 218 0.029
anatomical structure formation involved in morphogenesis GO:0048646 250 0.029
Human
intracellular signal transduction GO:0035556 96 0.028
Human Mouse
rna localization GO:0006403 3 0.028
cellular protein complex assembly GO:0043623 178 0.026
negative regulation of metabolic process GO:0009892 240 0.026
Human Mouse Fly
receptor mediated endocytosis GO:0006898 715 0.026
single organism localization GO:1902578 518 0.025
Human Mouse
apoptotic cell clearance GO:0043277 111 0.025
organelle assembly GO:0070925 214 0.024
protein modification process GO:0036211 207 0.023
growth GO:0040007 562 0.023
Human
regulation of localization GO:0032879 194 0.023
Human Mouse
regulation of developmental growth GO:0048638 389 0.023
cellular component assembly GO:0022607 293 0.022
vulval development GO:0040025 333 0.022
positive regulation of multicellular organismal process GO:0051240 417 0.021
rna metabolic process GO:0016070 228 0.021
Human Mouse Fly
protein complex assembly GO:0006461 186 0.021
cellular ketone metabolic process GO:0042180 14 0.021
Mouse
apoptotic process GO:0006915 478 0.020
Human Mouse Fly
cell migration GO:0016477 306 0.020
negative regulation of multicellular organismal process GO:0051241 236 0.020
response to wounding GO:0009611 4 0.020
positive regulation of cellular process GO:0048522 332 0.020
Human Mouse
rna interference GO:0016246 137 0.020
actin cytoskeleton organization GO:0030036 184 0.020
cellular macromolecular complex assembly GO:0034622 184 0.020
multicellular organism growth GO:0035264 385 0.019
myosin filament assembly GO:0031034 138 0.019
protein localization GO:0008104 205 0.019
Human
negative regulation of cellular process GO:0048523 239 0.019
Human Mouse Fly
developmental growth GO:0048589 412 0.019
inductive cell migration GO:0040039 145 0.019
positive regulation of developmental growth GO:0048639 354 0.019
organelle fission GO:0048285 363 0.019
myofibril assembly GO:0030239 154 0.018
oocyte construction GO:0007308 2 0.018
regulation of response to stimulus GO:0048583 243 0.017
Human Mouse Fly
oocyte axis specification GO:0007309 2 0.017
muscle cell development GO:0055001 158 0.017
biosynthetic process GO:0009058 323 0.017
Human Mouse Fly
positive regulation of developmental process GO:0051094 408 0.017
Human
protein complex biogenesis GO:0070271 186 0.017
positive regulation of growth GO:0045927 369 0.016
molting cycle GO:0042303 281 0.016
nucleoside monophosphate metabolic process GO:0009123 46 0.016
gene silencing by rna GO:0031047 143 0.016
striated muscle cell development GO:0055002 157 0.016
cellular component movement GO:0006928 388 0.016
positive regulation of macromolecule metabolic process GO:0010604 149 0.015
Human Mouse
single organism cellular localization GO:1902580 72 0.015
Human
response to external stimulus GO:0009605 289 0.015
Human Mouse Fly
phagocytosis GO:0006909 115 0.015
cellular response to chemical stimulus GO:0070887 129 0.015
Human Mouse
positive regulation of cellular metabolic process GO:0031325 178 0.014
Human Mouse
actomyosin structure organization GO:0031032 154 0.014
positive regulation of dephosphorylation GO:0035306 1 0.014
regulation of gene expression GO:0010468 366 0.014
Human Mouse Fly
signal transduction GO:0007165 317 0.014
Human Mouse
positive regulation of intracellular transport GO:0032388 2 0.014
regulation of multi organism process GO:0043900 69 0.014
striated muscle cell differentiation GO:0051146 158 0.013
nucleobase containing compound metabolic process GO:0006139 406 0.013
Human Mouse Fly
rna processing GO:0006396 34 0.013
muscle cell differentiation GO:0042692 171 0.013
myosin filament organization GO:0031033 138 0.013
canonical wnt signaling pathway GO:0060070 3 0.013
rna transport GO:0050658 3 0.013
oogenesis GO:0048477 229 0.012
negative regulation of macromolecule metabolic process GO:0010605 229 0.012
Human Mouse Fly
post embryonic organ development GO:0048569 336 0.012
ribosome biogenesis GO:0042254 4 0.012
dna metabolic process GO:0006259 74 0.012
Human Mouse
regulation of cellular component organization GO:0051128 248 0.012
Human Fly
regulation of nematode larval development GO:0061062 260 0.012
neuron apoptotic process GO:0051402 4 0.012
mrna metabolic process GO:0016071 31 0.012
cell type specific apoptotic process GO:0097285 4 0.012
Mouse
cell development GO:0048468 696 0.012
regulation of macromolecule metabolic process GO:0060255 421 0.011
Human Mouse Fly
regulation of protein serine threonine kinase activity GO:0071900 18 0.011
Human Mouse
regulation of apoptotic process GO:0042981 36 0.011
Human Mouse Fly
feeding behavior GO:0007631 70 0.011
Fly
female gamete generation GO:0007292 254 0.011
Mouse
regulation of endocytosis GO:0030100 25 0.011
regulation of gene expression epigenetic GO:0040029 163 0.011
Human Fly
organelle localization GO:0051640 127 0.011
organic substance catabolic process GO:1901575 294 0.011
Human
striated muscle myosin thick filament assembly GO:0071688 138 0.011
cellular protein metabolic process GO:0044267 279 0.011
cytokinesis GO:0000910 80 0.011
sister chromatid segregation GO:0000819 46 0.011
regulation of canonical wnt signaling pathway GO:0060828 1 0.011
sex determination GO:0007530 60 0.011
response to chemical GO:0042221 356 0.011
Human Mouse Fly
meiotic nuclear division GO:0007126 300 0.010
carboxylic acid metabolic process GO:0019752 34 0.010
Mouse
regulation of primary metabolic process GO:0080090 292 0.010
Human Mouse Fly
pigmentation GO:0043473 2 0.010
regulation of cell cycle process GO:0010564 145 0.010
establishment of rna localization GO:0051236 3 0.010
regulation of protein stability GO:0031647 3 0.010
Mouse
regulation of cell proliferation GO:0042127 105 0.010
Human

sir-2.1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
nervous system disease DOID:863 0 0.011