Caenorhabditis elegans

94 known processes

mkk-4 (CELE_F42G10.2)

Protein MKK-4

mkk-4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell development GO:0048468 696 0.215
Rat Worm Fly
positive regulation of transcription from rna polymerase ii promoter involved in defense response to gram negative bacterium GO:1902097 4 0.200
Worm
multi organism reproductive process GO:0044703 867 0.193
Worm
nucleobase containing compound metabolic process GO:0006139 406 0.172
Rat Worm
multi multicellular organism process GO:0044706 390 0.145
Worm
gamete generation GO:0007276 461 0.129
Worm
developmental process involved in reproduction GO:0003006 1165 0.128
Worm
positive regulation of cellular process GO:0048522 332 0.121
regulation of biological quality GO:0065008 741 0.120
response to external stimulus GO:0009605 289 0.120
Human Worm
multicellular organismal reproductive behavior GO:0033057 384 0.112
Worm
nucleic acid metabolic process GO:0090304 299 0.109
Rat Worm
regulation of primary metabolic process GO:0080090 292 0.107
regulation of metabolic process GO:0019222 478 0.107
post embryonic development GO:0009791 2152 0.106
Worm
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.101
Rat Worm
protein metabolic process GO:0019538 422 0.100
macromolecule localization GO:0033036 771 0.098
multicellular organismal reproductive process GO:0048609 815 0.096
Worm
positive regulation of multicellular organismal process GO:0051240 417 0.095
Worm
muscle tissue development GO:0060537 1 0.094
Rat
growth GO:0040007 562 0.090
Rat Worm
localization of cell GO:0051674 313 0.089
post embryonic organ development GO:0048569 336 0.088
tissue development GO:0009888 112 0.088
Rat
multicellular organism reproduction GO:0032504 819 0.088
Worm
positive regulation of macromolecule metabolic process GO:0010604 149 0.087
muscle structure development GO:0061061 191 0.087
Rat
organic substance biosynthetic process GO:1901576 323 0.086
Rat Worm
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.084
Rat Worm
multicellular organismal aging GO:0010259 812 0.083
reproductive behavior GO:0019098 387 0.082
Worm
multi organism behavior GO:0051705 389 0.081
Worm
embryo development ending in birth or egg hatching GO:0009792 2992 0.080
positive regulation of biosynthetic process GO:0009891 109 0.076
Rat Worm
positive regulation of transcription from rna polymerase ii promoter in response to osmotic stress GO:0061393 1 0.076
positive regulation of developmental process GO:0051094 408 0.073
regulation of nitrogen compound metabolic process GO:0051171 222 0.073
Rat Worm
organelle organization GO:0006996 783 0.072
Worm
lipid localization GO:0010876 573 0.072
p38mapk cascade GO:0038066 2 0.071
Worm
biosynthetic process GO:0009058 323 0.070
Rat Worm
regulation of biosynthetic process GO:0009889 189 0.070
Rat Worm
cell death GO:0008219 547 0.069
Rat
positive regulation of transcription dna templated GO:0045893 102 0.069
Worm
negative regulation of biological process GO:0048519 567 0.069
Worm
vulval development GO:0040025 333 0.069
rna biosynthetic process GO:0032774 169 0.068
Worm
gonad development GO:0008406 840 0.068
transcription dna templated GO:0006351 168 0.066
Worm
neurogenesis GO:0022008 236 0.066
Fly
positive regulation of cellular metabolic process GO:0031325 178 0.064
lipid storage GO:0019915 565 0.064
cell fate commitment GO:0045165 139 0.063
muscle organ morphogenesis GO:0048644 4 0.062
organ development GO:0048513 1102 0.061
Rat
gene expression GO:0010467 412 0.061
Worm
maintenance of location GO:0051235 580 0.061
determination of adult lifespan GO:0008340 812 0.061
head development GO:0060322 1 0.059
regulation of post embryonic development GO:0048580 260 0.059
regulation of macromolecule metabolic process GO:0060255 421 0.057
aging GO:0007568 812 0.055
heterocycle biosynthetic process GO:0018130 187 0.055
Worm
regulation of multicellular organismal process GO:0051239 726 0.055
Worm Fly
negative regulation of gene expression GO:0010629 217 0.055
Worm
oviposition GO:0018991 364 0.054
Worm
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.054
Worm
multi organism reproductive behavior GO:0044705 387 0.054
Worm
response to osmotic stress GO:0006970 29 0.053
Worm
germ cell development GO:0007281 351 0.052
Worm
cellular response to stress GO:0033554 162 0.052
Zebrafish Rat Worm Fly
positive regulation of developmental growth GO:0048639 354 0.052
positive regulation of nucleic acid templated transcription GO:1903508 102 0.051
Worm
striated muscle cell differentiation GO:0051146 158 0.051
Rat
single organism signaling GO:0044700 401 0.051
muscle cell differentiation GO:0042692 171 0.051
Rat
phosphorus metabolic process GO:0006793 232 0.051
regulation of developmental growth GO:0048638 389 0.050
organ morphogenesis GO:0009887 67 0.049
epithelial tube morphogenesis GO:0060562 1 0.048
cell morphogenesis GO:0000902 163 0.047
Fly
anatomical structure formation involved in morphogenesis GO:0048646 250 0.046
cellular component morphogenesis GO:0032989 318 0.046
Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.045
Rat Worm
cellular component movement GO:0006928 388 0.045
regulation of macromolecule biosynthetic process GO:0010556 189 0.045
Rat Worm
cell migration GO:0016477 306 0.044
cell motility GO:0048870 313 0.044
small molecule metabolic process GO:0044281 186 0.044
single organism organelle organization GO:1902589 501 0.043
transcription from rna polymerase ii promoter GO:0006366 149 0.043
Worm
striated muscle cell development GO:0055002 157 0.043
Rat
embryo development GO:0009790 3052 0.043
regulation of multicellular organism growth GO:0040014 373 0.043
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.043
Worm
regulation of vulval development GO:0040028 248 0.043
cytoskeleton organization GO:0007010 339 0.042
positive regulation of metabolic process GO:0009893 187 0.042
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.042
pattern specification process GO:0007389 59 0.042
Zebrafish
meiotic cell cycle GO:0051321 335 0.042
Worm
nucleobase containing compound biosynthetic process GO:0034654 184 0.042
Worm
regulation of cellular biosynthetic process GO:0031326 189 0.042
Rat Worm
actin cytoskeleton organization GO:0030036 184 0.042
regulation of nematode larval development GO:0061062 260 0.042
regulation of growth GO:0040008 409 0.042
Worm
rna metabolic process GO:0016070 228 0.041
Worm
nucleic acid templated transcription GO:0097659 169 0.041
Worm
muscle cell development GO:0055001 158 0.041
Rat
myofibril assembly GO:0030239 154 0.040
regeneration GO:0031099 4 0.040
single organism transport GO:0044765 447 0.040
cellular protein modification process GO:0006464 207 0.040
regulation of response to stimulus GO:0048583 243 0.039
positive regulation of rna biosynthetic process GO:1902680 102 0.039
Worm
cellular biosynthetic process GO:0044249 315 0.038
Rat Worm
cellular response to abiotic stimulus GO:0071214 4 0.038
Human
regulation of rna metabolic process GO:0051252 173 0.038
Worm
developmental growth GO:0048589 412 0.038
Rat
negative regulation of biosynthetic process GO:0009890 65 0.038
protein phosphorylation GO:0006468 85 0.038
hermaphrodite genitalia development GO:0040035 734 0.037
macromolecule biosynthetic process GO:0009059 250 0.037
Rat Worm
positive regulation of growth GO:0045927 369 0.037
sex differentiation GO:0007548 909 0.036
posttranscriptional regulation of gene expression GO:0010608 166 0.036
Worm
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.036
protein localization GO:0008104 205 0.036
genitalia development GO:0048806 741 0.036
regulation of gene expression GO:0010468 366 0.036
Worm
negative regulation of transcription dna templated GO:0045892 53 0.036
development of primary sexual characteristics GO:0045137 840 0.035
locomotion GO:0040011 1634 0.035
Worm
positive regulation of gene expression GO:0010628 112 0.035
Worm
positive regulation of cellular biosynthetic process GO:0031328 109 0.035
Rat Worm
meiotic nuclear division GO:0007126 300 0.035
Worm
cellular nitrogen compound biosynthetic process GO:0044271 192 0.035
Worm
regulation of developmental process GO:0050793 684 0.034
Fly
nervous system development GO:0007399 253 0.034
Fly
neuron projection development GO:0031175 187 0.034
Fly
actin filament based process GO:0030029 191 0.033
oogenesis GO:0048477 229 0.033
Worm
negative regulation of cellular process GO:0048523 239 0.033
sexual reproduction GO:0019953 546 0.032
Worm
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.032
Rat Worm
cell cycle GO:0007049 526 0.032
Worm
regulation of cellular component organization GO:0051128 248 0.032
cellular protein metabolic process GO:0044267 279 0.032
positive regulation of multicellular organism growth GO:0040018 352 0.032
response to external biotic stimulus GO:0043207 101 0.032
Worm
reproductive structure development GO:0048608 850 0.031
sensory organ morphogenesis GO:0090596 2 0.031
signaling GO:0023052 401 0.031
multicellular organism growth GO:0035264 385 0.031
cell cycle process GO:0022402 482 0.030
molting cycle GO:0042303 281 0.030
Fly
neuron differentiation GO:0030182 217 0.029
Fly
regulation of transcription from rna polymerase ii promoter in response to osmotic stress GO:0061392 1 0.029
negative regulation of cellular metabolic process GO:0031324 95 0.029
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.029
cellular component assembly involved in morphogenesis GO:0010927 183 0.029
death GO:0016265 547 0.029
Rat
response to chemical GO:0042221 356 0.029
Rat Worm
intracellular signal transduction GO:0035556 96 0.029
response to wounding GO:0009611 4 0.028
negative regulation of nematode larval development GO:0061064 208 0.028
female gamete generation GO:0007292 254 0.028
Worm
regulation of rna biosynthetic process GO:2001141 165 0.027
Worm
negative regulation of cellular biosynthetic process GO:0031327 65 0.027
response to other organism GO:0051707 101 0.027
Worm
negative regulation of developmental process GO:0051093 227 0.027
positive regulation of neurogenesis GO:0050769 4 0.026
negative regulation of rna biosynthetic process GO:1902679 53 0.026
negative regulation of post embryonic development GO:0048581 208 0.026
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 2 0.026
organelle assembly GO:0070925 214 0.026
oxoacid metabolic process GO:0043436 47 0.026
myosin filament assembly GO:0031034 138 0.025
cellular protein complex assembly GO:0043623 178 0.025
protein modification process GO:0036211 207 0.025
programmed cell death GO:0012501 500 0.025
Rat
cell morphogenesis involved in differentiation GO:0000904 112 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.025
cell projection morphogenesis GO:0048858 148 0.024
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.024
Rat Worm
defense response GO:0006952 296 0.024
aromatic compound catabolic process GO:0019439 116 0.024
negative regulation of vulval development GO:0040027 206 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.023
macromolecular complex subunit organization GO:0043933 320 0.023
cellular macromolecule biosynthetic process GO:0034645 247 0.023
Rat Worm
macromolecule modification GO:0043412 218 0.023
immune response GO:0006955 192 0.023
Worm
neuron projection guidance GO:0097485 82 0.023
negative regulation of multicellular organismal process GO:0051241 236 0.023
body morphogenesis GO:0010171 620 0.023
cellular component assembly GO:0022607 293 0.022
regulation of localization GO:0032879 194 0.022
posttranscriptional gene silencing GO:0016441 143 0.022
Worm
defense response to bacterium GO:0042742 86 0.022
Worm
cellular component biogenesis GO:0044085 297 0.022
axon development GO:0061564 163 0.021
generation of neurons GO:0048699 235 0.021
Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.021
transport GO:0006810 1093 0.021
cell projection organization GO:0030030 231 0.021
Fly
regulation of cellular metabolic process GO:0031323 305 0.021
cellular macromolecular complex assembly GO:0034622 184 0.021
positive regulation of post embryonic development GO:0048582 54 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.020
Worm
positive regulation of cell projection organization GO:0031346 4 0.020
establishment of localization GO:0051234 1171 0.020
organonitrogen compound metabolic process GO:1901564 151 0.020
cell part morphogenesis GO:0032990 152 0.020
Fly
cellular catabolic process GO:0044248 199 0.020
reproductive system development GO:0061458 850 0.020
response to bacterium GO:0009617 86 0.020
Worm
apoptotic process GO:0006915 478 0.020
Rat
receptor mediated endocytosis GO:0006898 715 0.020
tube development GO:0035295 126 0.020
wnt signaling pathway GO:0016055 27 0.020
cell division GO:0051301 262 0.020
regulation of cell cycle process GO:0010564 145 0.020
regulation of cell cycle GO:0051726 194 0.019
lamellipodium assembly GO:0030032 2 0.019
defense response to other organism GO:0098542 100 0.019
Worm
catabolic process GO:0009056 318 0.019
aromatic compound biosynthetic process GO:0019438 192 0.019
Worm
actomyosin structure organization GO:0031032 154 0.019
single organism reproductive process GO:0044702 1196 0.019
Worm
positive regulation of rna metabolic process GO:0051254 103 0.019
Worm
single organism localization GO:1902578 518 0.019
phosphorylation GO:0016310 116 0.019
protein complex subunit organization GO:0071822 280 0.018
organic cyclic compound catabolic process GO:1901361 119 0.018
organic cyclic compound biosynthetic process GO:1901362 195 0.018
Worm
response to organic substance GO:0010033 131 0.018
Rat
tissue morphogenesis GO:0048729 65 0.018
organic acid metabolic process GO:0006082 47 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.018
striated muscle myosin thick filament assembly GO:0071688 138 0.018
positive regulation of neuron differentiation GO:0045666 4 0.018
skeletal muscle organ development GO:0060538 3 0.018
myosin filament organization GO:0031033 138 0.018
axonogenesis GO:0007409 102 0.017
regulation of apoptotic signaling pathway GO:2001233 1 0.017
chemotaxis GO:0006935 120 0.017
cell type specific apoptotic process GO:0097285 4 0.017
Rat
regulation of multicellular organismal development GO:2000026 317 0.017
Fly
canonical wnt signaling pathway GO:0060070 3 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.017
response to endoplasmic reticulum stress GO:0034976 71 0.017
macromolecule catabolic process GO:0009057 202 0.017
lamellipodium organization GO:0097581 2 0.017
cell surface receptor signaling pathway GO:0007166 149 0.017
innate immune response GO:0045087 190 0.016
Worm
regulation of molecular function GO:0065009 89 0.016
regulation of reproductive process GO:2000241 66 0.016
Worm
neuron development GO:0048666 199 0.016
Fly
neuromuscular junction development GO:0007528 2 0.016
cellular amino acid metabolic process GO:0006520 15 0.015
regulation of transcription dna templated GO:0006355 164 0.015
Worm
response to biotic stimulus GO:0009607 101 0.015
Worm
negative regulation of rna metabolic process GO:0051253 53 0.015
developmental cell growth GO:0048588 39 0.015
Rat
negative regulation of nucleic acid templated transcription GO:1903507 53 0.015
mesodermal cell migration GO:0008078 9 0.015
behavior GO:0007610 527 0.015
Worm
posttranscriptional gene silencing by rna GO:0035194 143 0.015
Worm
negative regulation of cell communication GO:0010648 61 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.014
lipid metabolic process GO:0006629 77 0.014
gene silencing GO:0016458 143 0.014
Worm
hyperosmotic response GO:0006972 19 0.014
Worm
endocytosis GO:0006897 819 0.014
positive regulation of neuron projection development GO:0010976 4 0.014
regulation of organ morphogenesis GO:2000027 4 0.014
cellular response to chemical stimulus GO:0070887 129 0.014
Rat
apoptotic cell clearance GO:0043277 111 0.014
positive regulation of nematode larval development GO:0061063 54 0.014
cellular lipid metabolic process GO:0044255 40 0.014
regulation of muscle cell differentiation GO:0051147 1 0.014
digestive tract development GO:0048565 122 0.014
stress activated mapk cascade GO:0051403 10 0.014
Zebrafish Rat Worm Fly
organic substance catabolic process GO:1901575 294 0.014
cellular response to inorganic substance GO:0071241 3 0.013
positive regulation of epithelial cell proliferation GO:0050679 1 0.013
cellular localization GO:0051641 360 0.013
negative regulation of macromolecule metabolic process GO:0010605 229 0.013
Worm
cellular response to metal ion GO:0071248 3 0.013
gene silencing by rna GO:0031047 143 0.013
Worm
protein complex biogenesis GO:0070271 186 0.013
regulation of epithelial cell differentiation GO:0030856 4 0.013
negative regulation of metabolic process GO:0009892 240 0.013
Worm
hormone metabolic process GO:0042445 3 0.013
rna interference GO:0016246 137 0.012
Worm
regulation of striated muscle contraction GO:0006942 4 0.012
macromolecular complex assembly GO:0065003 193 0.012
regulation of lipid metabolic process GO:0019216 4 0.012
response to heat GO:0009408 50 0.012
regulation of cell motility GO:2000145 57 0.012
phagocytosis GO:0006909 115 0.012
organophosphate metabolic process GO:0019637 125 0.012
nucleobase containing compound catabolic process GO:0034655 114 0.012
carboxylic acid metabolic process GO:0019752 34 0.012
regulation of lipid transport GO:0032368 4 0.012
positive regulation of cell migration GO:0030335 3 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.012
Zebrafish Rat Worm Fly
regulation of mitotic cell cycle GO:0007346 76 0.012
positive regulation of cell cycle GO:0045787 55 0.012
pigment metabolic process GO:0042440 2 0.012
response to abiotic stimulus GO:0009628 152 0.012
Human Worm
regulation of anatomical structure morphogenesis GO:0022603 51 0.011
heterocycle catabolic process GO:0046700 119 0.011
cellular response to organic substance GO:0071310 119 0.011
Rat
protein oligomerization GO:0051259 4 0.011
positive regulation of cell morphogenesis involved in differentiation GO:0010770 4 0.011
response to inorganic substance GO:0010035 50 0.011
Worm
regulation of cell proliferation GO:0042127 105 0.011
dendrite development GO:0016358 42 0.011
regulation of cell migration GO:0030334 55 0.011
system process GO:0003008 136 0.011
Rat
phosphate containing compound metabolic process GO:0006796 232 0.011
regulation of signaling GO:0023051 172 0.011
regulation of cation channel activity GO:2001257 3 0.011
regulation of lipid biosynthetic process GO:0046890 1 0.011
transmembrane transport GO:0055085 110 0.011
chromosome organization GO:0051276 104 0.011
axonal fasciculation GO:0007413 79 0.011
regulation of cell differentiation GO:0045595 81 0.011
single organism biosynthetic process GO:0044711 91 0.011
neural precursor cell proliferation GO:0061351 9 0.011
defense response to gram negative bacterium GO:0050829 64 0.011
Worm
regulation of cellular protein metabolic process GO:0032268 75 0.011
positive regulation of phosphate metabolic process GO:0045937 56 0.011
tube formation GO:0035148 2 0.011
covalent chromatin modification GO:0016569 30 0.010
cell proliferation GO:0008283 116 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
protein complex assembly GO:0006461 186 0.010
positive regulation of vulval development GO:0040026 52 0.010
regulation of protein localization GO:0032880 50 0.010
positive regulation of stress activated mapk cascade GO:0032874 3 0.010
Zebrafish Rat Worm Fly
response to temperature stimulus GO:0009266 66 0.010
Worm
cellular amine metabolic process GO:0044106 15 0.010
inductive cell migration GO:0040039 145 0.010
intracellular receptor signaling pathway GO:0030522 2 0.010
regulation of epithelial cell proliferation GO:0050678 1 0.010
membrane organization GO:0061024 135 0.010

mkk-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012