Caenorhabditis elegans

129 known processes

epi-1 (CELE_K08C7.3)

Protein EPI-1

epi-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell motility GO:0048870 313 0.967
cell migration GO:0016477 306 0.955
locomotion GO:0040011 1634 0.920
organ development GO:0048513 1102 0.911
embryo development GO:0009790 3052 0.872
skeletal muscle organ development GO:0060538 3 0.850
Zebrafish
cellular component movement GO:0006928 388 0.835
chemotaxis GO:0006935 120 0.820
Fly
embryo development ending in birth or egg hatching GO:0009792 2992 0.810
localization of cell GO:0051674 313 0.798
positive regulation of locomotion GO:0040017 42 0.789
organ morphogenesis GO:0009887 67 0.780
Mouse Fly
body morphogenesis GO:0010171 620 0.756
cellular component morphogenesis GO:0032989 318 0.733
Human Mouse Fly
post embryonic development GO:0009791 2152 0.711
muscle organ development GO:0007517 26 0.701
Zebrafish Mouse
nervous system development GO:0007399 253 0.656
cell adhesion GO:0007155 21 0.637
Human Zebrafish
signal transduction GO:0007165 317 0.634
Human
tube morphogenesis GO:0035239 79 0.608
Human Mouse
cell part morphogenesis GO:0032990 152 0.601
Mouse Fly
organelle organization GO:0006996 783 0.586
Mouse Fly
cell morphogenesis GO:0000902 163 0.578
Human Mouse Fly
axonogenesis GO:0007409 102 0.572
Fly
muscle structure development GO:0061061 191 0.565
Zebrafish Mouse
embryonic morphogenesis GO:0048598 152 0.536
Human Mouse
single organism reproductive process GO:0044702 1196 0.531
epithelium development GO:0060429 68 0.503
Mouse
cell development GO:0048468 696 0.496
extracellular matrix organization GO:0030198 6 0.480
tissue morphogenesis GO:0048729 65 0.476
Mouse
single organism signaling GO:0044700 401 0.453
Human Fly
extracellular structure organization GO:0043062 7 0.452
tissue development GO:0009888 112 0.445
Human Mouse Fly
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.441
Fly
axon guidance GO:0007411 82 0.417
Fly
regulation of developmental process GO:0050793 684 0.407
muscle tissue development GO:0060537 1 0.407
neuron differentiation GO:0030182 217 0.405
biological adhesion GO:0022610 21 0.398
Human Zebrafish
single organism localization GO:1902578 518 0.387
Mouse
regulation of multicellular organismal process GO:0051239 726 0.385
multicellular organismal reproductive process GO:0048609 815 0.382
taxis GO:0042330 128 0.373
Fly
single organism organelle organization GO:1902589 501 0.365
Mouse
cell projection morphogenesis GO:0048858 148 0.353
Mouse Fly
regulation of vulval development GO:0040028 248 0.352
basement membrane organization GO:0071711 3 0.350
protein metabolic process GO:0019538 422 0.341
establishment of localization GO:0051234 1171 0.320
regulation of cell migration GO:0030334 55 0.320
cellular localization GO:0051641 360 0.314
Mouse
single organism transport GO:0044765 447 0.311
neuron projection guidance GO:0097485 82 0.308
Fly
neuron projection development GO:0031175 187 0.307
developmental growth GO:0048589 412 0.297
Worm Fly
response to chemical GO:0042221 356 0.291
negative regulation of biological process GO:0048519 567 0.288
multicellular organism reproduction GO:0032504 819 0.285
macromolecular complex subunit organization GO:0043933 320 0.278
axon development GO:0061564 163 0.262
neuron development GO:0048666 199 0.260
digestive tract development GO:0048565 122 0.259
Human
generation of neurons GO:0048699 235 0.247
muscle attachment GO:0016203 3 0.236
Zebrafish
response to wounding GO:0009611 4 0.235
sexual reproduction GO:0019953 546 0.230
reproductive structure development GO:0048608 850 0.224
endocytosis GO:0006897 819 0.224
developmental process involved in reproduction GO:0003006 1165 0.221
wnt signaling pathway GO:0016055 27 0.217
transport GO:0006810 1093 0.215
regulation of multicellular organismal development GO:2000026 317 0.213
intracellular signal transduction GO:0035556 96 0.211
negative regulation of multicellular organismal process GO:0051241 236 0.210
anatomical structure formation involved in morphogenesis GO:0048646 250 0.208
Human Mouse
tube development GO:0035295 126 0.203
Human Mouse
positive regulation of cellular process GO:0048522 332 0.199
multi organism reproductive process GO:0044703 867 0.197
inductive cell migration GO:0040039 145 0.196
neurogenesis GO:0022008 236 0.195
cellular component assembly involved in morphogenesis GO:0010927 183 0.192
Mouse
receptor mediated endocytosis GO:0006898 715 0.188
organic substance biosynthetic process GO:1901576 323 0.187
negative regulation of vulval development GO:0040027 206 0.186
striated muscle cell development GO:0055002 157 0.186
biosynthetic process GO:0009058 323 0.184
cellular component biogenesis GO:0044085 297 0.184
Mouse Fly
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.177
epithelial tube morphogenesis GO:0060562 1 0.177
Mouse
embryonic body morphogenesis GO:0010172 49 0.174
growth GO:0040007 562 0.173
Worm Fly
system process GO:0003008 136 0.171
Fly
signaling GO:0023052 401 0.171
Human Fly
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.170
programmed cell death GO:0012501 500 0.169
germ cell development GO:0007281 351 0.165
genitalia development GO:0048806 741 0.162
muscle cell differentiation GO:0042692 171 0.161
protein catabolic process GO:0030163 162 0.161
regulation of response to stimulus GO:0048583 243 0.159
cytoskeleton organization GO:0007010 339 0.156
gamete generation GO:0007276 461 0.156
cell projection organization GO:0030030 231 0.155
post embryonic organ development GO:0048569 336 0.147
regulation of multicellular organism growth GO:0040014 373 0.146
Worm
female gamete generation GO:0007292 254 0.143
protein modification process GO:0036211 207 0.142
regulation of locomotion GO:0040012 161 0.137
meiotic cell cycle GO:0051321 335 0.135
Fly
positive regulation of developmental process GO:0051094 408 0.132
Worm
regulation of post embryonic development GO:0048580 260 0.131
protein localization GO:0008104 205 0.130
Zebrafish Mouse
striated muscle cell differentiation GO:0051146 158 0.129
organelle assembly GO:0070925 214 0.128
Mouse
actin filament based process GO:0030029 191 0.128
positive regulation of developmental growth GO:0048639 354 0.128
Worm
negative regulation of developmental process GO:0051093 227 0.127
macromolecule catabolic process GO:0009057 202 0.124
sex differentiation GO:0007548 909 0.123
protein complex subunit organization GO:0071822 280 0.120
meiotic nuclear division GO:0007126 300 0.113
Fly
muscle cell development GO:0055001 158 0.113
negative regulation of post embryonic development GO:0048581 208 0.110
multicellular organism growth GO:0035264 385 0.110
Worm
multi multicellular organism process GO:0044706 390 0.108
response to organic substance GO:0010033 131 0.108
muscle organ morphogenesis GO:0048644 4 0.108
positive regulation of multicellular organism growth GO:0040018 352 0.107
Worm
regulation of biological quality GO:0065008 741 0.105
Fly
regulation of cell motility GO:2000145 57 0.104
cellular macromolecular complex assembly GO:0034622 184 0.102
vulval development GO:0040025 333 0.102
gene expression GO:0010467 412 0.101
regulation of metabolic process GO:0019222 478 0.101
determination of adult lifespan GO:0008340 812 0.100
catabolic process GO:0009056 318 0.099
regulation of signaling GO:0023051 172 0.098
neuron recognition GO:0008038 83 0.098
positive regulation of cell migration GO:0030335 3 0.095
cellular response to chemical stimulus GO:0070887 129 0.094
macromolecule localization GO:0033036 771 0.094
Zebrafish Mouse
regulation of nematode larval development GO:0061062 260 0.093
multicellular organismal reproductive behavior GO:0033057 384 0.093
cellular biosynthetic process GO:0044249 315 0.092
response to external stimulus GO:0009605 289 0.091
Fly
organic substance catabolic process GO:1901575 294 0.089
head development GO:0060322 1 0.088
Fly
death GO:0016265 547 0.088
neuron projection morphogenesis GO:0048812 114 0.088
Fly
cell surface receptor signaling pathway GO:0007166 149 0.087
Human
cellular protein modification process GO:0006464 207 0.087
development of primary sexual characteristics GO:0045137 840 0.086
multicellular organismal aging GO:0010259 812 0.084
establishment of localization in cell GO:0051649 318 0.082
regulation of developmental growth GO:0048638 389 0.082
Worm Fly
gonad development GO:0008406 840 0.081
cellular component assembly GO:0022607 293 0.080
Mouse Fly
regulation of cell communication GO:0010646 176 0.080
regulation of macromolecule metabolic process GO:0060255 421 0.079
positive regulation of growth GO:0045927 369 0.078
Worm
organic cyclic compound biosynthetic process GO:1901362 195 0.076
small molecule metabolic process GO:0044281 186 0.073
cell recognition GO:0008037 85 0.072
digestive tract morphogenesis GO:0048546 76 0.072
Human
regulation of cellular metabolic process GO:0031323 305 0.072
macromolecule biosynthetic process GO:0009059 250 0.071
regulation of signal transduction GO:0009966 135 0.070
hermaphrodite genitalia development GO:0040035 734 0.070
regulation of primary metabolic process GO:0080090 292 0.069
regulation of gene expression GO:0010468 366 0.069
vesicle mediated transport GO:0016192 852 0.069
nucleobase containing compound metabolic process GO:0006139 406 0.066
calcium ion transmembrane transport GO:0070588 13 0.066
macromolecular complex assembly GO:0065003 193 0.066
protein complex biogenesis GO:0070271 186 0.065
cellular protein metabolic process GO:0044267 279 0.065
endoderm development GO:0007492 20 0.064
Human
protein hydroxylation GO:0018126 5 0.063
reproductive system development GO:0061458 850 0.062
phosphate containing compound metabolic process GO:0006796 232 0.062
apoptotic process GO:0006915 478 0.061
oxoacid metabolic process GO:0043436 47 0.061
cellular protein complex assembly GO:0043623 178 0.060
organelle fission GO:0048285 363 0.059
Fly
cell death GO:0008219 547 0.059
multi organism behavior GO:0051705 389 0.058
Fly
negative regulation of nematode larval development GO:0061064 208 0.057
oviposition GO:0018991 364 0.056
striated muscle myosin thick filament assembly GO:0071688 138 0.056
cell morphogenesis involved in differentiation GO:0000904 112 0.055
Human Fly
behavior GO:0007610 527 0.055
Fly
cell substrate adhesion GO:0031589 1 0.054
Human
actin filament based movement GO:0030048 4 0.053
myofibril assembly GO:0030239 154 0.053
myosin filament assembly GO:0031034 138 0.052
oogenesis GO:0048477 229 0.052
actomyosin structure organization GO:0031032 154 0.052
maintenance of location GO:0051235 580 0.050
lipid storage GO:0019915 565 0.050
phosphorus metabolic process GO:0006793 232 0.050
organonitrogen compound metabolic process GO:1901564 151 0.047
regulation of cellular component organization GO:0051128 248 0.047
Fly
lipid localization GO:0010876 573 0.046
single organism biosynthetic process GO:0044711 91 0.045
cell matrix adhesion GO:0007160 1 0.045
phosphorylation GO:0016310 116 0.044
regulation of cation channel activity GO:2001257 3 0.044
pharynx development GO:0060465 51 0.043
macromolecule modification GO:0043412 218 0.042
digestive system development GO:0055123 122 0.042
Human
regulation of molecular function GO:0065009 89 0.042
ovulation GO:0030728 33 0.041
nucleobase containing compound biosynthetic process GO:0034654 184 0.040
cell cycle process GO:0022402 482 0.040
Fly
myosin filament organization GO:0031033 138 0.040
er nucleus signaling pathway GO:0006984 66 0.040
actin cytoskeleton organization GO:0030036 184 0.040
neurological system process GO:0050877 53 0.039
Fly
reproductive behavior GO:0019098 387 0.038
regulation of anatomical structure size GO:0090066 46 0.038
secretion GO:0046903 147 0.038
nucleic acid metabolic process GO:0090304 299 0.037
positive regulation of multicellular organismal process GO:0051240 417 0.037
Worm
molting cycle GO:0042303 281 0.036
Mouse
cell division GO:0051301 262 0.036
secretion by cell GO:0032940 138 0.036
cuticle development GO:0042335 100 0.036
response to oxygen levels GO:0070482 22 0.035
aging GO:0007568 812 0.035
axonal defasciculation GO:0007414 1 0.035
phagocytosis GO:0006909 115 0.035
homeostatic process GO:0042592 51 0.034
posttranscriptional regulation of gene expression GO:0010608 166 0.033
nucleobase containing small molecule metabolic process GO:0055086 115 0.033
regulation of growth GO:0040008 409 0.033
Worm Fly
protein complex assembly GO:0006461 186 0.031
organic acid metabolic process GO:0006082 47 0.030
heterocycle biosynthetic process GO:0018130 187 0.029
bmp signaling pathway GO:0030509 3 0.029
regulation of atp catabolic process GO:1903289 3 0.029
response to growth factor GO:0070848 18 0.028
carboxylic acid metabolic process GO:0019752 34 0.028
transmembrane transport GO:0055085 110 0.028
collagen and cuticulin based cuticle development GO:0040002 99 0.028
organonitrogen compound biosynthetic process GO:1901566 44 0.028
enzyme linked receptor protein signaling pathway GO:0007167 50 0.028
inorganic cation transmembrane transport GO:0098662 46 0.028
cellular macromolecule biosynthetic process GO:0034645 247 0.027
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.027
cellular amino acid metabolic process GO:0006520 15 0.027
regulation of organelle organization GO:0033043 164 0.027
regulation of nuclear division GO:0051783 115 0.026
mitotic nuclear division GO:0007067 89 0.026
striated muscle contraction involved in embryonic body morphogenesis GO:0061199 13 0.026
response to anesthetic GO:0072347 1 0.026
regulation of localization GO:0032879 194 0.025
cell proliferation GO:0008283 116 0.025
dorsal ventral axon guidance GO:0033563 19 0.024
regulation of phosphorylation GO:0042325 45 0.024
negative regulation of signaling GO:0023057 61 0.024
positive regulation of cysteine type endopeptidase activity GO:2001056 3 0.024
negative regulation of cellular process GO:0048523 239 0.024
Fly
regulation of cell division GO:0051302 142 0.023
negative regulation of response to stimulus GO:0048585 73 0.023
cell cycle GO:0007049 526 0.022
Fly
response to unfolded protein GO:0006986 71 0.022
response to topologically incorrect protein GO:0035966 82 0.022
regulation of muscle contraction GO:0006937 20 0.022
axonal fasciculation GO:0007413 79 0.022
single organism behavior GO:0044708 83 0.022
calcium mediated signaling GO:0019722 3 0.022
amine metabolic process GO:0009308 15 0.021
regulation of cell cycle process GO:0010564 145 0.021
nucleotide metabolic process GO:0009117 108 0.021
cellular amine metabolic process GO:0044106 15 0.021
regulation of cellular component movement GO:0051270 62 0.020
gastrulation GO:0007369 58 0.020
Human
cellular response to stress GO:0033554 162 0.020
negative regulation of metabolic process GO:0009892 240 0.020
rna metabolic process GO:0016070 228 0.020
chromosome organization GO:0051276 104 0.019
regulation of biosynthetic process GO:0009889 189 0.019
membrane organization GO:0061024 135 0.019
Mouse
mesodermal cell migration GO:0008078 9 0.018
multi organism reproductive behavior GO:0044705 387 0.018
transcription from rna polymerase ii promoter GO:0006366 149 0.018
ion transmembrane transport GO:0034220 91 0.017
regulation of phosphate metabolic process GO:0019220 81 0.017
cellular macromolecule localization GO:0070727 75 0.017
Mouse
actin mediated cell contraction GO:0070252 3 0.017
cell junction organization GO:0034330 18 0.017
mesoderm development GO:0007498 27 0.017
Fly
negative regulation of signal transduction GO:0009968 60 0.017
response to abiotic stimulus GO:0009628 152 0.016
aromatic compound biosynthetic process GO:0019438 192 0.016
epithelial cell differentiation GO:0030855 17 0.016
engulfment of apoptotic cell GO:0043652 94 0.016
carbohydrate derivative metabolic process GO:1901135 141 0.016
cell type specific apoptotic process GO:0097285 4 0.016
regulation of nitrogen compound metabolic process GO:0051171 222 0.016
cellular homeostasis GO:0019725 22 0.016
anatomical structure homeostasis GO:0060249 11 0.016
skeletal muscle thin filament assembly GO:0030240 3 0.015
regulation of rna biosynthetic process GO:2001141 165 0.015
regulation of cell morphogenesis GO:0022604 40 0.015
transcription dna templated GO:0006351 168 0.015
skin development GO:0043588 24 0.015
Mouse
regulation of catalytic activity GO:0050790 78 0.014
nucleoside phosphate metabolic process GO:0006753 108 0.014
cellular nitrogen compound biosynthetic process GO:0044271 192 0.014
response to nutrient levels GO:0031667 35 0.014
cytokinesis GO:0000910 80 0.014
aromatic compound catabolic process GO:0019439 116 0.014
positive regulation of molecular function GO:0044093 61 0.014
negative regulation of cellular metabolic process GO:0031324 95 0.014
regulation of nucleotide metabolic process GO:0006140 37 0.014
backward locomotion GO:0043057 11 0.014
microtubule based process GO:0007017 182 0.014
positive regulation of cellular metabolic process GO:0031325 178 0.014
regulation of cellular response to stress GO:0080135 19 0.013
cation transmembrane transport GO:0098655 59 0.013
regulation of phagocytosis engulfment GO:0060099 17 0.013
regulation of cell cycle GO:0051726 194 0.013
regulation of apoptotic signaling pathway GO:2001233 1 0.013
somatic muscle development GO:0007525 1 0.013
endodermal cell differentiation GO:0035987 18 0.013
Human
cellular response to transforming growth factor beta stimulus GO:0071560 13 0.013
sarcomere organization GO:0045214 10 0.013
organophosphate metabolic process GO:0019637 125 0.013
sensory organ morphogenesis GO:0090596 2 0.013
regulation of hydrolase activity GO:0051336 45 0.012
ribosome biogenesis GO:0042254 4 0.012
protein phosphorylation GO:0006468 85 0.012
negative regulation of gene expression GO:0010629 217 0.012
regulation of phosphorus metabolic process GO:0051174 81 0.012
negative regulation of cell communication GO:0010648 61 0.012
cellular response to organic substance GO:0071310 119 0.012
multicellular organismal movement GO:0050879 2 0.011
regulation of cellular ketone metabolic process GO:0010565 3 0.011
muscle fiber development GO:0048747 2 0.011
actin filament organization GO:0007015 21 0.011
apoptotic cell clearance GO:0043277 111 0.011
regulation of multi organism process GO:0043900 69 0.011
response to acid chemical GO:0001101 4 0.011
chemical homeostasis GO:0048878 29 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
response to oxygen containing compound GO:1901700 44 0.011
response to endogenous stimulus GO:0009719 33 0.011
purine nucleoside triphosphate metabolic process GO:0009144 87 0.011
nucleotide sugar metabolic process GO:0009225 6 0.011
regulation of response to stress GO:0080134 28 0.011
regulation of nucleic acid templated transcription GO:1903506 165 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.011
regulation of striated muscle contraction GO:0006942 4 0.011
regulation of cellular protein metabolic process GO:0032268 75 0.010
positive regulation of muscle contraction GO:0045933 8 0.010
posttranscriptional gene silencing GO:0016441 143 0.010
regulation of macromolecule biosynthetic process GO:0010556 189 0.010
regulation of cell differentiation GO:0045595 81 0.010

epi-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.102
Human
nervous system disease DOID:863 0 0.017
myopathy DOID:423 0 0.014
Human
muscular disease DOID:0080000 0 0.014
Human
heart disease DOID:114 0 0.014
Human
cardiomyopathy DOID:0050700 0 0.014
Human
cardiovascular system disease DOID:1287 0 0.014
Human
musculoskeletal system disease DOID:17 0 0.014
Human
muscle tissue disease DOID:66 0 0.014
Human