Caenorhabditis elegans

76 known processes

let-268 (CELE_F52H3.1)

Protein LET-268

let-268 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extracellular structure organization GO:0043062 7 0.512
Mouse
single organism reproductive process GO:0044702 1196 0.433
Worm
post embryonic development GO:0009791 2152 0.384
gonad development GO:0008406 840 0.382
Worm
skeletal muscle organ development GO:0060538 3 0.358
cell motility GO:0048870 313 0.338
Zebrafish
vesicle mediated transport GO:0016192 852 0.326
locomotion GO:0040011 1634 0.319
Zebrafish Worm
aging GO:0007568 812 0.318
embryo development GO:0009790 3052 0.318
reproductive structure development GO:0048608 850 0.313
Worm
developmental process involved in reproduction GO:0003006 1165 0.281
Worm
organ development GO:0048513 1102 0.278
Zebrafish Mouse Worm
embryo development ending in birth or egg hatching GO:0009792 2992 0.272
axon development GO:0061564 163 0.250
Zebrafish
reproductive system development GO:0061458 850 0.242
Worm
cellular component movement GO:0006928 388 0.241
Zebrafish
multicellular organism reproduction GO:0032504 819 0.222
multicellular organismal aging GO:0010259 812 0.209
development of primary sexual characteristics GO:0045137 840 0.208
Worm
determination of adult lifespan GO:0008340 812 0.205
multicellular organismal reproductive process GO:0048609 815 0.205
sex differentiation GO:0007548 909 0.200
Worm
organelle organization GO:0006996 783 0.195
positive regulation of developmental growth GO:0048639 354 0.194
receptor mediated endocytosis GO:0006898 715 0.193
macromolecule localization GO:0033036 771 0.191
Mouse
hermaphrodite genitalia development GO:0040035 734 0.189
Worm
sexual reproduction GO:0019953 546 0.181
transport GO:0006810 1093 0.171
muscle tissue development GO:0060537 1 0.170
cellular component morphogenesis GO:0032989 318 0.169
Zebrafish Mouse
muscle attachment GO:0016203 3 0.168
nervous system development GO:0007399 253 0.164
Zebrafish Mouse
regulation of multicellular organismal development GO:2000026 317 0.163
cell migration GO:0016477 306 0.160
Zebrafish
response to chemical GO:0042221 356 0.151
Zebrafish
regulation of developmental process GO:0050793 684 0.151
multi organism reproductive process GO:0044703 867 0.151
genitalia development GO:0048806 741 0.149
Worm
muscle organ morphogenesis GO:0048644 4 0.143
axonogenesis GO:0007409 102 0.139
Zebrafish
anatomical structure formation involved in morphogenesis GO:0048646 250 0.134
establishment of localization GO:0051234 1171 0.129
regulation of multicellular organismal process GO:0051239 726 0.128
muscle organ development GO:0007517 26 0.123
neuron projection morphogenesis GO:0048812 114 0.123
Zebrafish
muscle structure development GO:0061061 191 0.122
single organism organelle organization GO:1902589 501 0.118
protein localization GO:0008104 205 0.118
Mouse
macromolecular complex subunit organization GO:0043933 320 0.117
Mouse
striated muscle cell differentiation GO:0051146 158 0.117
cell development GO:0048468 696 0.114
Zebrafish Mouse
multicellular organismal reproductive behavior GO:0033057 384 0.110
multicellular organism growth GO:0035264 385 0.109
oviposition GO:0018991 364 0.107
positive regulation of growth GO:0045927 369 0.103
cellular protein metabolic process GO:0044267 279 0.102
generation of neurons GO:0048699 235 0.101
Zebrafish
cytoskeleton organization GO:0007010 339 0.100
chemotaxis GO:0006935 120 0.100
Zebrafish
lipid localization GO:0010876 573 0.099
regulation of metabolic process GO:0019222 478 0.099
regulation of multicellular organism growth GO:0040014 373 0.098
endocytosis GO:0006897 819 0.095
growth GO:0040007 562 0.094
positive regulation of multicellular organism growth GO:0040018 352 0.094
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.092
extracellular matrix organization GO:0030198 6 0.092
Mouse
system process GO:0003008 136 0.090
Mouse
body morphogenesis GO:0010171 620 0.090
germ cell development GO:0007281 351 0.089
regulation of biological quality GO:0065008 741 0.085
Mouse
reproductive behavior GO:0019098 387 0.083
positive regulation of multicellular organismal process GO:0051240 417 0.083
cell cycle GO:0007049 526 0.083
basement membrane organization GO:0071711 3 0.083
Mouse
negative regulation of biological process GO:0048519 567 0.082
localization of cell GO:0051674 313 0.081
Zebrafish
positive regulation of developmental process GO:0051094 408 0.080
signaling GO:0023052 401 0.080
post embryonic organ development GO:0048569 336 0.078
maintenance of location GO:0051235 580 0.077
regulation of developmental growth GO:0048638 389 0.077
muscle cell differentiation GO:0042692 171 0.076
organonitrogen compound metabolic process GO:1901564 151 0.076
multi multicellular organism process GO:0044706 390 0.076
developmental growth GO:0048589 412 0.076
catabolic process GO:0009056 318 0.075
actin cytoskeleton organization GO:0030036 184 0.075
lipid storage GO:0019915 565 0.074
regulation of vulval development GO:0040028 248 0.073
multi organism reproductive behavior GO:0044705 387 0.072
gamete generation GO:0007276 461 0.072
protein metabolic process GO:0019538 422 0.071
neuron recognition GO:0008038 83 0.071
single organism transport GO:0044765 447 0.071
cellular localization GO:0051641 360 0.068
organic substance catabolic process GO:1901575 294 0.068
protein catabolic process GO:0030163 162 0.067
regulation of nematode larval development GO:0061062 260 0.066
nucleoside phosphate metabolic process GO:0006753 108 0.066
oogenesis GO:0048477 229 0.065
vulval development GO:0040025 333 0.064
neuron projection guidance GO:0097485 82 0.064
Zebrafish
multi organism behavior GO:0051705 389 0.063
cell cycle process GO:0022402 482 0.063
regulation of growth GO:0040008 409 0.063
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.062
negative regulation of cellular process GO:0048523 239 0.062
behavior GO:0007610 527 0.061
cell morphogenesis GO:0000902 163 0.061
Zebrafish Mouse
neuron differentiation GO:0030182 217 0.060
Zebrafish
negative regulation of vulval development GO:0040027 206 0.059
regulation of macromolecule metabolic process GO:0060255 421 0.059
female gamete generation GO:0007292 254 0.059
single organism signaling GO:0044700 401 0.058
positive regulation of locomotion GO:0040017 42 0.058
positive regulation of cellular process GO:0048522 332 0.058
organelle assembly GO:0070925 214 0.057
neuron projection development GO:0031175 187 0.057
Zebrafish
cellular component biogenesis GO:0044085 297 0.057
Mouse
neurogenesis GO:0022008 236 0.057
Zebrafish
cell death GO:0008219 547 0.055
cell projection organization GO:0030030 231 0.055
Zebrafish
ribonucleoside triphosphate metabolic process GO:0009199 87 0.053
myofibril assembly GO:0030239 154 0.053
cuticle development GO:0042335 100 0.053
neuron development GO:0048666 199 0.053
Zebrafish
signal transduction GO:0007165 317 0.051
protein complex biogenesis GO:0070271 186 0.050
cell projection morphogenesis GO:0048858 148 0.050
Zebrafish
negative regulation of multicellular organismal process GO:0051241 236 0.050
actomyosin structure organization GO:0031032 154 0.050
negative regulation of metabolic process GO:0009892 240 0.049
regulation of cellular metabolic process GO:0031323 305 0.049
cellular component assembly involved in morphogenesis GO:0010927 183 0.049
macromolecule biosynthetic process GO:0009059 250 0.049
meiotic cell cycle GO:0051321 335 0.049
regulation of post embryonic development GO:0048580 260 0.048
biosynthetic process GO:0009058 323 0.048
carbohydrate derivative metabolic process GO:1901135 141 0.047
cell surface receptor signaling pathway GO:0007166 149 0.047
single organism localization GO:1902578 518 0.047
macromolecule catabolic process GO:0009057 202 0.045
response to external stimulus GO:0009605 289 0.045
Zebrafish
cell substrate adhesion GO:0031589 1 0.045
striated muscle cell development GO:0055002 157 0.044
actin filament based process GO:0030029 191 0.043
secretion GO:0046903 147 0.043
embryonic body morphogenesis GO:0010172 49 0.042
cellular protein modification process GO:0006464 207 0.042
death GO:0016265 547 0.042
regulation of nitrogen compound metabolic process GO:0051171 222 0.042
negative regulation of nematode larval development GO:0061064 208 0.040
protein complex subunit organization GO:0071822 280 0.040
Mouse
signal transduction by phosphorylation GO:0023014 31 0.039
negative regulation of macromolecule metabolic process GO:0010605 229 0.038
cell recognition GO:0008037 85 0.038
tissue development GO:0009888 112 0.038
Zebrafish Mouse
striated muscle myosin thick filament assembly GO:0071688 138 0.038
small molecule metabolic process GO:0044281 186 0.037
positive regulation of cell migration GO:0030335 3 0.036
embryonic morphogenesis GO:0048598 152 0.036
taxis GO:0042330 128 0.035
Zebrafish
myosin filament assembly GO:0031034 138 0.035
negative regulation of cellular metabolic process GO:0031324 95 0.035
regulation of catalytic activity GO:0050790 78 0.034
inductive cell migration GO:0040039 145 0.034
regulation of primary metabolic process GO:0080090 292 0.033
positive regulation of molecular function GO:0044093 61 0.033
response to organic substance GO:0010033 131 0.032
axon guidance GO:0007411 82 0.032
Zebrafish
cellular component assembly GO:0022607 293 0.031
Mouse
regulation of localization GO:0032879 194 0.031
negative regulation of post embryonic development GO:0048581 208 0.031
apoptotic process GO:0006915 478 0.031
cell part morphogenesis GO:0032990 152 0.031
Zebrafish
macromolecule modification GO:0043412 218 0.030
muscle cell development GO:0055001 158 0.030
organ morphogenesis GO:0009887 67 0.030
Mouse
cellular protein complex assembly GO:0043623 178 0.030
programmed cell death GO:0012501 500 0.030
nucleobase containing compound metabolic process GO:0006139 406 0.030
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.030
Zebrafish
negative regulation of developmental process GO:0051093 227 0.030
meiotic nuclear division GO:0007126 300 0.029
cellular macromolecular complex assembly GO:0034622 184 0.029
purine containing compound metabolic process GO:0072521 95 0.029
regulation of cell migration GO:0030334 55 0.029
nucleobase containing compound biosynthetic process GO:0034654 184 0.029
response to wounding GO:0009611 4 0.029
cellular biosynthetic process GO:0044249 315 0.028
cell morphogenesis involved in differentiation GO:0000904 112 0.028
Zebrafish Mouse
organic substance biosynthetic process GO:1901576 323 0.028
regulation of locomotion GO:0040012 161 0.028
rna metabolic process GO:0016070 228 0.027
organelle fission GO:0048285 363 0.027
positive regulation of hydrolase activity GO:0051345 38 0.027
macromolecular complex assembly GO:0065003 193 0.027
collagen and cuticulin based cuticle development GO:0040002 99 0.027
regulation of cell communication GO:0010646 176 0.026
purine ribonucleoside catabolic process GO:0046130 75 0.025
aromatic compound catabolic process GO:0019439 116 0.025
response to abiotic stimulus GO:0009628 152 0.025
Human
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.025
nucleoside metabolic process GO:0009116 99 0.024
cellular response to chemical stimulus GO:0070887 129 0.024
meiotic cell cycle process GO:1903046 170 0.023
endodermal cell differentiation GO:0035987 18 0.023
cellular nitrogen compound biosynthetic process GO:0044271 192 0.023
head development GO:0060322 1 0.023
negative regulation of gene expression GO:0010629 217 0.023
epithelial tube morphogenesis GO:0060562 1 0.022
membrane organization GO:0061024 135 0.022
cell matrix adhesion GO:0007160 1 0.022
regulation of molecular function GO:0065009 89 0.022
cell division GO:0051301 262 0.022
positive regulation of phosphate metabolic process GO:0045937 56 0.021
regulation of biosynthetic process GO:0009889 189 0.021
cellular macromolecule biosynthetic process GO:0034645 247 0.021
tube development GO:0035295 126 0.021
Mouse
myosin filament organization GO:0031033 138 0.021
regulation of organelle organization GO:0033043 164 0.021
regulation of cellular biosynthetic process GO:0031326 189 0.021
ribonucleoside triphosphate catabolic process GO:0009203 72 0.020
gene expression GO:0010467 412 0.020
oxoacid metabolic process GO:0043436 47 0.020
regulation of response to stimulus GO:0048583 243 0.020
regulation of reproductive process GO:2000241 66 0.019
protein complex assembly GO:0006461 186 0.019
nucleotide catabolic process GO:0009166 77 0.019
purine nucleotide catabolic process GO:0006195 75 0.019
organic cyclic compound catabolic process GO:1901361 119 0.019
digestive tract development GO:0048565 122 0.019
chromosome segregation GO:0007059 180 0.019
regulation of organ morphogenesis GO:2000027 4 0.019
muscle system process GO:0003012 43 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 28 0.019
intracellular signal transduction GO:0035556 96 0.019
purine nucleoside triphosphate metabolic process GO:0009144 87 0.019
posttranscriptional regulation of gene expression GO:0010608 166 0.019
cytokinesis GO:0000910 80 0.019
regulation of rna biosynthetic process GO:2001141 165 0.019
regulation of transcription dna templated GO:0006355 164 0.019
enzyme linked receptor protein signaling pathway GO:0007167 50 0.018
regulation of nucleoside metabolic process GO:0009118 37 0.018
nucleobase containing small molecule metabolic process GO:0055086 115 0.018
organic substance transport GO:0071702 113 0.018
tissue morphogenesis GO:0048729 65 0.018
Mouse
axonal defasciculation GO:0007414 1 0.018
regulation of purine nucleotide metabolic process GO:1900542 37 0.018
regulation of gene expression GO:0010468 366 0.017
positive regulation of catalytic activity GO:0043085 59 0.017
heterocycle biosynthetic process GO:0018130 187 0.017
regulation of cell motility GO:2000145 57 0.017
integrin mediated signaling pathway GO:0007229 1 0.017
striated muscle contraction involved in embryonic body morphogenesis GO:0061199 13 0.017
apoptotic cell clearance GO:0043277 111 0.017
cilium assembly GO:0042384 28 0.017
single organism biosynthetic process GO:0044711 91 0.017
nucleic acid templated transcription GO:0097659 169 0.016
digestive system development GO:0055123 122 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.016
phagocytosis GO:0006909 115 0.016
ribonucleoside metabolic process GO:0009119 98 0.016
purine ribonucleotide metabolic process GO:0009150 95 0.016
regulation of anatomical structure size GO:0090066 46 0.016
Mouse
establishment of protein localization to membrane GO:0090150 3 0.016
cellular amino acid metabolic process GO:0006520 15 0.016
cell type specific apoptotic process GO:0097285 4 0.015
regulation of protein metabolic process GO:0051246 81 0.015
purine ribonucleoside metabolic process GO:0046128 92 0.015
engulfment of apoptotic cell GO:0043652 94 0.015
regulation of nucleotide metabolic process GO:0006140 37 0.015
regulation of cellular component movement GO:0051270 62 0.015
regulation of macromolecule biosynthetic process GO:0010556 189 0.015
rna interference GO:0016246 137 0.015
transcription from rna polymerase ii promoter GO:0006366 149 0.015
peptidyl proline hydroxylation to 4 hydroxy l proline GO:0018401 3 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.015
regulation of cellular component organization GO:0051128 248 0.015
nucleic acid metabolic process GO:0090304 299 0.014
eating behavior GO:0042755 59 0.014
glycosyl compound catabolic process GO:1901658 79 0.014
somatic muscle development GO:0007525 1 0.014
axonal fasciculation GO:0007413 79 0.014
response to oxygen levels GO:0070482 22 0.014
Human
nucleotide metabolic process GO:0009117 108 0.013
pharyngeal pumping GO:0043050 58 0.013
regulation of purine nucleotide catabolic process GO:0033121 35 0.013
pharynx development GO:0060465 51 0.013
regulation of apoptotic signaling pathway GO:2001233 1 0.013
innate immune response GO:0045087 190 0.013
phosphate containing compound metabolic process GO:0006796 232 0.013
purine nucleotide metabolic process GO:0006163 95 0.013
ribonucleotide catabolic process GO:0009261 75 0.013
positive regulation of metabolic process GO:0009893 187 0.013
axon extension GO:0048675 37 0.013
establishment of nucleus localization GO:0040023 55 0.013
cellular response to organic substance GO:0071310 119 0.013
purine nucleoside metabolic process GO:0042278 92 0.013
organic cyclic compound biosynthetic process GO:1901362 195 0.013
regulation of multi organism process GO:0043900 69 0.013
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.012
regulation of catabolic process GO:0009894 57 0.012
regulation of behavior GO:0050795 97 0.012
ribose phosphate metabolic process GO:0019693 99 0.012
epithelial cell proliferation GO:0050673 1 0.012
cellular nitrogen compound catabolic process GO:0044270 119 0.012
nematode male tail tip morphogenesis GO:0045138 77 0.012
regulation of epithelial cell proliferation GO:0050678 1 0.012
organic acid metabolic process GO:0006082 47 0.012
cellular response to stress GO:0033554 162 0.012
regulation of muscle cell differentiation GO:0051147 1 0.012
calcium mediated signaling GO:0019722 3 0.012
response to growth factor GO:0070848 18 0.012
heterocycle catabolic process GO:0046700 119 0.012
regulation of hydrolase activity GO:0051336 45 0.012
posttranscriptional gene silencing GO:0016441 143 0.012
positive regulation of nucleotide metabolic process GO:0045981 28 0.012
regulation of gene expression epigenetic GO:0040029 163 0.011
specification of axis polarity GO:0065001 13 0.011
neurological system process GO:0050877 53 0.011
positive regulation of nucleotide catabolic process GO:0030813 28 0.011
chromosome organization GO:0051276 104 0.011
negative regulation of biosynthetic process GO:0009890 65 0.011
positive regulation of nucleoside metabolic process GO:0045979 28 0.011
ribonucleoside catabolic process GO:0042454 77 0.011
nucleoside phosphate catabolic process GO:1901292 77 0.011
protein modification process GO:0036211 207 0.011
single organism cellular localization GO:1902580 72 0.011
glycosyl compound metabolic process GO:1901657 100 0.011
excretion GO:0007588 49 0.011
immune response GO:0006955 192 0.011
regulation of nucleotide catabolic process GO:0030811 35 0.011
response to endogenous stimulus GO:0009719 33 0.010
dopamine metabolic process GO:0042417 4 0.010
regulation of nucleic acid templated transcription GO:1903506 165 0.010
purine nucleoside catabolic process GO:0006152 75 0.010
response to oxygen containing compound GO:1901700 44 0.010
carbohydrate derivative catabolic process GO:1901136 82 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 13 0.010
backward locomotion GO:0043057 11 0.010
cell adhesion GO:0007155 21 0.010
purine nucleoside triphosphate catabolic process GO:0009146 72 0.010
memory GO:0007613 3 0.010
regulation of signaling GO:0023051 172 0.010
protein hydroxylation GO:0018126 5 0.010
sensory organ morphogenesis GO:0090596 2 0.010
regulation of cell cycle GO:0051726 194 0.010

let-268 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.067
myopathy DOID:423 0 0.042
muscular disease DOID:0080000 0 0.042
heart disease DOID:114 0 0.042
cardiomyopathy DOID:0050700 0 0.042
cardiovascular system disease DOID:1287 0 0.042
musculoskeletal system disease DOID:17 0 0.042
muscle tissue disease DOID:66 0 0.042
dilated cardiomyopathy DOID:12930 0 0.012
intrinsic cardiomyopathy DOID:0060036 0 0.012