Caenorhabditis elegans

80 known processes

dpl-1 (CELE_T23G7.1)

Protein DPL-1

dpl-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.899
embryo development ending in birth or egg hatching GO:0009792 2992 0.750
meiotic cell cycle GO:0051321 335 0.715
meiotic cell cycle process GO:1903046 170 0.581
meiotic nuclear division GO:0007126 300 0.533
sex differentiation GO:0007548 909 0.530
regulation of developmental process GO:0050793 684 0.515
developmental process involved in reproduction GO:0003006 1165 0.470
positive regulation of cellular process GO:0048522 332 0.443
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.426
Mouse
negative regulation of biological process GO:0048519 567 0.413
regulation of cell cycle process GO:0010564 145 0.402
cellular component movement GO:0006928 388 0.371
organ development GO:0048513 1102 0.367
chromosome segregation GO:0007059 180 0.363
axon development GO:0061564 163 0.353
gonad development GO:0008406 840 0.351
positive regulation of multicellular organismal process GO:0051240 417 0.313
regulation of cell division GO:0051302 142 0.293
regulation of multicellular organismal process GO:0051239 726 0.292
establishment of organelle localization GO:0051656 123 0.278
meiotic chromosome segregation GO:0045132 139 0.277
multicellular organismal reproductive process GO:0048609 815 0.276
chromosome organization GO:0051276 104 0.268
cell division GO:0051301 262 0.267
single organism reproductive process GO:0044702 1196 0.254
organelle fission GO:0048285 363 0.249
hermaphrodite genitalia development GO:0040035 734 0.249
establishment of localization GO:0051234 1171 0.246
cell cycle process GO:0022402 482 0.232
nucleic acid metabolic process GO:0090304 299 0.231
Mouse
apoptotic process GO:0006915 478 0.224
Mouse
regulation of cell cycle GO:0051726 194 0.219
genitalia development GO:0048806 741 0.218
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.213
Mouse
multicellular organism reproduction GO:0032504 819 0.212
development of primary sexual characteristics GO:0045137 840 0.204
mitotic spindle organization GO:0007052 81 0.198
sexual reproduction GO:0019953 546 0.196
positive regulation of developmental process GO:0051094 408 0.196
organelle organization GO:0006996 783 0.195
neuron projection development GO:0031175 187 0.193
mitotic cell cycle process GO:1903047 194 0.187
gamete generation GO:0007276 461 0.182
cell death GO:0008219 547 0.181
multi organism reproductive process GO:0044703 867 0.174
reproductive structure development GO:0048608 850 0.173
mitotic sister chromatid segregation GO:0000070 38 0.172
positive regulation of transcription dna templated GO:0045893 102 0.170
Mouse
programmed cell death GO:0012501 500 0.168
cell fate commitment GO:0045165 139 0.168
transport GO:0006810 1093 0.162
post embryonic development GO:0009791 2152 0.160
biosynthetic process GO:0009058 323 0.155
Mouse
positive regulation of cellular metabolic process GO:0031325 178 0.153
Mouse
negative regulation of cell cycle GO:0045786 53 0.151
macromolecule biosynthetic process GO:0009059 250 0.150
Mouse
organelle localization GO:0051640 127 0.149
growth GO:0040007 562 0.143
locomotion GO:0040011 1634 0.143
pronuclear migration GO:0035046 51 0.142
developmental growth GO:0048589 412 0.140
endocytosis GO:0006897 819 0.136
cell cycle GO:0007049 526 0.136
nucleobase containing compound metabolic process GO:0006139 406 0.133
Mouse
reproductive system development GO:0061458 850 0.130
regulation of macromolecule metabolic process GO:0060255 421 0.127
Mouse
regulation of meiosis GO:0040020 94 0.127
vulval development GO:0040025 333 0.127
single organism transport GO:0044765 447 0.127
tissue development GO:0009888 112 0.123
Mouse
signaling GO:0023052 401 0.120
response to chemical GO:0042221 356 0.120
positive regulation of metabolic process GO:0009893 187 0.119
Mouse
regulation of biological quality GO:0065008 741 0.119
regulation of meiotic cell cycle GO:0051445 136 0.119
protein metabolic process GO:0019538 422 0.115
regulation of cellular component organization GO:0051128 248 0.110
transcription from rna polymerase ii promoter GO:0006366 149 0.108
microtubule based process GO:0007017 182 0.107
multicellular organism growth GO:0035264 385 0.103
positive regulation of developmental growth GO:0048639 354 0.103
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.101
single fertilization GO:0007338 61 0.100
regulation of mitotic cell cycle GO:0007346 76 0.099
cellular biosynthetic process GO:0044249 315 0.099
Mouse
chromatin modification GO:0016568 32 0.095
regulation of metabolic process GO:0019222 478 0.095
Mouse
cell development GO:0048468 696 0.094
cell motility GO:0048870 313 0.093
regulation of developmental growth GO:0048638 389 0.093
regulation of multicellular organism growth GO:0040014 373 0.091
regulation of multicellular organismal development GO:2000026 317 0.091
positive regulation of growth GO:0045927 369 0.091
cell projection organization GO:0030030 231 0.090
cellular protein modification process GO:0006464 207 0.088
macromolecule modification GO:0043412 218 0.088
multicellular organismal aging GO:0010259 812 0.087
regulation of rna biosynthetic process GO:2001141 165 0.087
Mouse
negative regulation of macromolecule metabolic process GO:0010605 229 0.086
aging GO:0007568 812 0.083
sensory organ morphogenesis GO:0090596 2 0.081
tissue morphogenesis GO:0048729 65 0.079
regulation of gene expression GO:0010468 366 0.079
Mouse
tube formation GO:0035148 2 0.078
canonical wnt signaling pathway GO:0060070 3 0.077
death GO:0016265 547 0.077
macromolecule localization GO:0033036 771 0.076
body morphogenesis GO:0010171 620 0.076
generation of neurons GO:0048699 235 0.074
vesicle mediated transport GO:0016192 852 0.073
chromosome organization involved in meiosis GO:0070192 25 0.072
positive regulation of rna metabolic process GO:0051254 103 0.071
Mouse
transcription dna templated GO:0006351 168 0.071
Mouse
regulation of growth GO:0040008 409 0.071
positive regulation of rna biosynthetic process GO:1902680 102 0.070
Mouse
regulation of catabolic process GO:0009894 57 0.070
ribonucleoprotein complex assembly GO:0022618 4 0.070
fertilization GO:0009566 63 0.069
localization of cell GO:0051674 313 0.068
germ cell development GO:0007281 351 0.068
posttranscriptional gene silencing GO:0016441 143 0.068
regulation of gene expression epigenetic GO:0040029 163 0.068
post embryonic organ development GO:0048569 336 0.067
single organism localization GO:1902578 518 0.067
establishment of localization in cell GO:0051649 318 0.067
positive regulation of biosynthetic process GO:0009891 109 0.067
Mouse
regulation of vulval development GO:0040028 248 0.066
tube morphogenesis GO:0035239 79 0.065
maintenance of location GO:0051235 580 0.065
determination of adult lifespan GO:0008340 812 0.065
neuron development GO:0048666 199 0.065
posttranscriptional gene silencing by rna GO:0035194 143 0.065
protein modification process GO:0036211 207 0.065
regulation of nematode larval development GO:0061062 260 0.065
cellular macromolecule biosynthetic process GO:0034645 247 0.064
Mouse
lipid localization GO:0010876 573 0.062
cellular localization GO:0051641 360 0.061
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.060
regulation of cell differentiation GO:0045595 81 0.060
positive regulation of chromosome organization GO:2001252 2 0.059
regulation of cellular metabolic process GO:0031323 305 0.059
Mouse
digestive tract morphogenesis GO:0048546 76 0.059
neuron projection morphogenesis GO:0048812 114 0.058
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.058
rna metabolic process GO:0016070 228 0.058
Mouse
lipid storage GO:0019915 565 0.058
cell part morphogenesis GO:0032990 152 0.058
gene silencing GO:0016458 143 0.057
dna conformation change GO:0071103 11 0.057
response to organic substance GO:0010033 131 0.057
cell migration GO:0016477 306 0.057
neuron differentiation GO:0030182 217 0.057
regulation of primary metabolic process GO:0080090 292 0.056
Mouse
embryonic morphogenesis GO:0048598 152 0.056
cellular response to stress GO:0033554 162 0.055
sister chromatid segregation GO:0000819 46 0.054
cytoskeleton organization GO:0007010 339 0.054
positive regulation of macromolecule metabolic process GO:0010604 149 0.054
Mouse
multi multicellular organism process GO:0044706 390 0.054
regulation of response to stimulus GO:0048583 243 0.053
neurogenesis GO:0022008 236 0.053
digestive tract development GO:0048565 122 0.053
small molecule metabolic process GO:0044281 186 0.053
positive regulation of multicellular organism growth GO:0040018 352 0.053
negative regulation of post embryonic development GO:0048581 208 0.052
positive regulation of nucleic acid templated transcription GO:1903508 102 0.052
Mouse
oviposition GO:0018991 364 0.052
negative regulation of gene expression GO:0010629 217 0.051
cuticle development GO:0042335 100 0.050
negative regulation of vulval development GO:0040027 206 0.049
regulation of signaling GO:0023051 172 0.048
axonogenesis GO:0007409 102 0.047
negative regulation of nematode larval development GO:0061064 208 0.047
receptor mediated endocytosis GO:0006898 715 0.047
gene expression GO:0010467 412 0.046
Mouse
negative regulation of metabolic process GO:0009892 240 0.046
regulation of chromosome organization GO:0033044 20 0.045
cellular protein metabolic process GO:0044267 279 0.045
behavior GO:0007610 527 0.045
negative regulation of cellular process GO:0048523 239 0.044
organic substance catabolic process GO:1901575 294 0.044
positive regulation of cellular catabolic process GO:0031331 35 0.043
collagen and cuticulin based cuticle development GO:0040002 99 0.043
ubiquitin dependent protein catabolic process GO:0006511 32 0.043
multicellular organismal reproductive behavior GO:0033057 384 0.043
spindle organization GO:0007051 92 0.042
catabolic process GO:0009056 318 0.042
regulation of organelle organization GO:0033043 164 0.042
single organism organelle organization GO:1902589 501 0.041
nervous system development GO:0007399 253 0.041
mitotic nuclear division GO:0007067 89 0.041
response to external stimulus GO:0009605 289 0.041
gene silencing by rna GO:0031047 143 0.040
single organism cellular localization GO:1902580 72 0.040
organic cyclic compound biosynthetic process GO:1901362 195 0.039
Mouse
positive regulation of catalytic activity GO:0043085 59 0.038
positive regulation of neurogenesis GO:0050769 4 0.038
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.038
Mouse
modification dependent macromolecule catabolic process GO:0043632 32 0.037
regulation of biosynthetic process GO:0009889 189 0.037
Mouse
digestive system development GO:0055123 122 0.037
muscle tissue development GO:0060537 1 0.036
head development GO:0060322 1 0.036
organonitrogen compound metabolic process GO:1901564 151 0.035
negative regulation of developmental process GO:0051093 227 0.035
posttranscriptional regulation of gene expression GO:0010608 166 0.034
histone modification GO:0016570 30 0.034
rna interference GO:0016246 137 0.034
tube development GO:0035295 126 0.034
cell morphogenesis GO:0000902 163 0.034
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.034
Mouse
reproductive behavior GO:0019098 387 0.033
signal transduction GO:0007165 317 0.033
positive regulation of gene expression GO:0010628 112 0.033
Mouse
macromolecular complex subunit organization GO:0043933 320 0.033
protein localization GO:0008104 205 0.033
regulation of post embryonic development GO:0048580 260 0.032
regulation of cellular amine metabolic process GO:0033238 0 0.031
cellular component assembly GO:0022607 293 0.031
rna biosynthetic process GO:0032774 169 0.031
Mouse
taxis GO:0042330 128 0.030
protein phosphorylation GO:0006468 85 0.030
response to abiotic stimulus GO:0009628 152 0.030
anatomical structure formation involved in morphogenesis GO:0048646 250 0.029
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.029
Mouse
regulation of transcription dna templated GO:0006355 164 0.029
Mouse
multi organism behavior GO:0051705 389 0.029
cellular catabolic process GO:0044248 199 0.029
chromatin organization GO:0006325 32 0.029
nucleus localization GO:0051647 55 0.028
positive regulation of molecular function GO:0044093 61 0.028
chromatin assembly or disassembly GO:0006333 1 0.028
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.028
negative regulation of multicellular organismal process GO:0051241 236 0.027
positive regulation of cell cycle GO:0045787 55 0.027
membrane organization GO:0061024 135 0.027
regulation of nuclear division GO:0051783 115 0.027
regulation of phosphorus metabolic process GO:0051174 81 0.027
regulation of intracellular signal transduction GO:1902531 77 0.026
macromolecule catabolic process GO:0009057 202 0.026
regulation of cellular biosynthetic process GO:0031326 189 0.026
Mouse
chemotaxis GO:0006935 120 0.026
epithelium development GO:0060429 68 0.025
Mouse
regulation of signal transduction GO:0009966 135 0.025
ras protein signal transduction GO:0007265 31 0.025
meiosis i GO:0007127 19 0.025
establishment of nucleus localization GO:0040023 55 0.025
covalent chromatin modification GO:0016569 30 0.025
nucleobase containing compound biosynthetic process GO:0034654 184 0.024
Mouse
regulation of phosphorylation GO:0042325 45 0.024
regulation of cellular ketone metabolic process GO:0010565 3 0.024
negative regulation of neurogenesis GO:0050768 4 0.023
organic acid metabolic process GO:0006082 47 0.023
single organism catabolic process GO:0044712 129 0.023
multi organism reproductive behavior GO:0044705 387 0.023
regeneration GO:0031099 4 0.022
phosphorylation GO:0016310 116 0.022
regulation of phosphate metabolic process GO:0019220 81 0.022
small gtpase mediated signal transduction GO:0007264 32 0.022
regulation of rna metabolic process GO:0051252 173 0.022
Mouse
positive regulation of gtpase activity GO:0043547 28 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.022
cellular component biogenesis GO:0044085 297 0.021
epithelial tube morphogenesis GO:0060562 1 0.021
muscle structure development GO:0061061 191 0.021
regulation of cellular catabolic process GO:0031329 51 0.021
endoderm development GO:0007492 20 0.020
synapsis GO:0007129 10 0.020
regulation of cell death GO:0010941 65 0.020
cell cycle phase transition GO:0044770 19 0.020
regulation of cell communication GO:0010646 176 0.020
heterocycle biosynthetic process GO:0018130 187 0.020
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 192 0.020
Mouse
cellular macromolecule catabolic process GO:0044265 73 0.020
regulation of localization GO:0032879 194 0.019
cellular protein localization GO:0034613 75 0.019
protein catabolic process GO:0030163 162 0.019
negative regulation of cellular biosynthetic process GO:0031327 65 0.019
regulation of apoptotic process GO:0042981 36 0.019
chromosome separation GO:0051304 19 0.019
negative regulation of mitotic cell cycle GO:0045930 42 0.019
system process GO:0003008 136 0.019
adult behavior GO:0030534 3 0.018
regulation of nitrogen compound metabolic process GO:0051171 222 0.018
Mouse
positive regulation of cell communication GO:0010647 69 0.018
regulation of programmed cell death GO:0043067 50 0.018
positive regulation of cellular biosynthetic process GO:0031328 109 0.018
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.018
dna metabolic process GO:0006259 74 0.018
Mouse
positive regulation of mitotic sister chromatid separation GO:1901970 1 0.018
nucleobase containing small molecule metabolic process GO:0055086 115 0.018
response to wounding GO:0009611 4 0.018
oxoacid metabolic process GO:0043436 47 0.018
negative regulation of gene expression epigenetic GO:0045814 2 0.018
cytokinesis GO:0000910 80 0.018
negative regulation of transcription dna templated GO:0045892 53 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.018
nucleic acid templated transcription GO:0097659 169 0.017
Mouse
regulation of chromatin modification GO:1903308 2 0.017
negative regulation of cellular component organization GO:0051129 33 0.017
oogenesis GO:0048477 229 0.017
organic substance biosynthetic process GO:1901576 323 0.017
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 32 0.017
regulation of cell development GO:0060284 49 0.017
aromatic compound biosynthetic process GO:0019438 192 0.017
Mouse
chromatin assembly GO:0031497 1 0.016
response to external biotic stimulus GO:0043207 101 0.016
female gamete generation GO:0007292 254 0.016
negative regulation of cell cycle process GO:0010948 12 0.016
neuron projection guidance GO:0097485 82 0.016
regulation of cell cycle phase transition GO:1901987 13 0.016
response to other organism GO:0051707 101 0.016
cellular response to dna damage stimulus GO:0006974 41 0.015
nucleoside phosphate catabolic process GO:1901292 77 0.015
dna geometric change GO:0032392 3 0.015
synaptic growth at neuromuscular junction GO:0051124 1 0.015
cell projection assembly GO:0030031 35 0.015
axon guidance GO:0007411 82 0.015
reciprocal meiotic recombination GO:0007131 11 0.015
positive regulation of phosphorus metabolic process GO:0010562 56 0.015
gastrulation GO:0007369 58 0.015
single organism signaling GO:0044700 401 0.015
regulation of macromolecule biosynthetic process GO:0010556 189 0.015
Mouse
long term memory GO:0007616 2 0.015
proteolysis GO:0006508 61 0.015
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.014
cellular component morphogenesis GO:0032989 318 0.014
nuclear migration GO:0007097 54 0.014
cell surface receptor signaling pathway GO:0007166 149 0.014
metaphase anaphase transition of mitotic cell cycle GO:0007091 10 0.014
positive regulation of cellular protein catabolic process GO:1903364 3 0.014
ion transport GO:0006811 113 0.014
phagocytosis engulfment GO:0006911 98 0.014
amine metabolic process GO:0009308 15 0.014
regulation of epithelial cell proliferation GO:0050678 1 0.014
single organism behavior GO:0044708 83 0.014
mitotic cell cycle checkpoint GO:0007093 5 0.014
carbohydrate derivative catabolic process GO:1901136 82 0.014
positive regulation of catabolic process GO:0009896 38 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 5 0.014
positive regulation of hydrolase activity GO:0051345 38 0.013
phosphorus metabolic process GO:0006793 232 0.013
organ morphogenesis GO:0009887 67 0.013
cell proliferation GO:0008283 116 0.013
oocyte differentiation GO:0009994 45 0.013
regulation of cytoplasmic transport GO:1903649 3 0.013
regulation of protein targeting GO:1903533 3 0.013
regulation of nucleic acid templated transcription GO:1903506 165 0.013
Mouse
regulation of canonical wnt signaling pathway GO:0060828 1 0.013
purine nucleoside metabolic process GO:0042278 92 0.013
defense response GO:0006952 296 0.013
regulation of mitotic sister chromatid segregation GO:0033047 16 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.012
carbohydrate derivative metabolic process GO:1901135 141 0.012
response to biotic stimulus GO:0009607 101 0.012
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.012
regulation of protein import into nucleus GO:0042306 3 0.012
cell cell signaling GO:0007267 118 0.012
rna processing GO:0006396 34 0.012
regulation of protein metabolic process GO:0051246 81 0.012
protein localization to organelle GO:0033365 37 0.012
modification dependent protein catabolic process GO:0019941 32 0.012
chromatin remodeling GO:0006338 2 0.012
endodermal cell differentiation GO:0035987 18 0.012
cytoskeleton dependent cytokinesis GO:0061640 35 0.012
organophosphate metabolic process GO:0019637 125 0.012
negative regulation of cellular metabolic process GO:0031324 95 0.012
spindle checkpoint GO:0031577 4 0.011
positive regulation of post embryonic development GO:0048582 54 0.011
wnt signaling pathway GO:0016055 27 0.011
mitotic nuclear envelope reassembly GO:0007084 3 0.011
heterocycle catabolic process GO:0046700 119 0.011
positive regulation of vulval development GO:0040026 52 0.011
cellular macromolecule localization GO:0070727 75 0.011
regulation of dna replication GO:0006275 5 0.011
dna duplex unwinding GO:0032508 3 0.011
positive regulation of response to stimulus GO:0048584 55 0.011
regulation of mitosis GO:0007088 18 0.011
regulation of molecular function GO:0065009 89 0.011
cellular macromolecular complex assembly GO:0034622 184 0.011
regulation of stem cell differentiation GO:2000736 1 0.011
regulation of multi organism process GO:0043900 69 0.011
protein modification by small protein conjugation or removal GO:0070647 40 0.011
inductive cell migration GO:0040039 145 0.011
intracellular signal transduction GO:0035556 96 0.011
reciprocal dna recombination GO:0035825 11 0.011
synapse organization GO:0050808 24 0.011
cellular amino acid metabolic process GO:0006520 15 0.010
positive regulation of chromosome segregation GO:0051984 1 0.010
nucleobase containing compound catabolic process GO:0034655 114 0.010
cell morphogenesis involved in differentiation GO:0000904 112 0.010
protein complex subunit organization GO:0071822 280 0.010
regulation of histone modification GO:0031056 1 0.010
purine ribonucleotide metabolic process GO:0009150 95 0.010
internal peptidyl lysine acetylation GO:0018393 3 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010

dpl-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.027
disease of anatomical entity DOID:7 0 0.025
cancer DOID:162 0 0.018
organ system cancer DOID:0050686 0 0.016
organ system benign neoplasm DOID:0060085 0 0.013
hair follicle neoplasm DOID:5375 0 0.013
benign neoplasm DOID:0060072 0 0.013
skin benign neoplasm DOID:3165 0 0.013
integumentary system benign neoplasm DOID:0060121 0 0.013