Caenorhabditis elegans

57 known processes

brc-1 (CELE_C36A4.8)

Protein BRC-1

brc-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.940
embryo development ending in birth or egg hatching GO:0009792 2992 0.855
cell cycle GO:0007049 526 0.793
organelle fission GO:0048285 363 0.680
chromosome segregation GO:0007059 180 0.641
reproductive structure development GO:0048608 850 0.634
meiotic chromosome segregation GO:0045132 139 0.610
organ development GO:0048513 1102 0.594
meiotic cell cycle process GO:1903046 170 0.588
single organism organelle organization GO:1902589 501 0.538
meiotic cell cycle GO:0051321 335 0.504
reproductive system development GO:0061458 850 0.502
regulation of gene expression GO:0010468 366 0.496
sex differentiation GO:0007548 909 0.427
cell cycle process GO:0022402 482 0.401
meiotic nuclear division GO:0007126 300 0.400
negative regulation of biological process GO:0048519 567 0.380
mitotic cell cycle process GO:1903047 194 0.369
multicellular organismal reproductive process GO:0048609 815 0.346
regulation of macromolecule metabolic process GO:0060255 421 0.333
regulation of transcription dna templated GO:0006355 164 0.329
post embryonic development GO:0009791 2152 0.328
chromosome organization GO:0051276 104 0.324
cell division GO:0051301 262 0.321
regulation of rna metabolic process GO:0051252 173 0.318
cellular macromolecule biosynthetic process GO:0034645 247 0.280
regulation of metabolic process GO:0019222 478 0.273
macromolecule biosynthetic process GO:0009059 250 0.271
nucleic acid metabolic process GO:0090304 299 0.267
organelle organization GO:0006996 783 0.258
cellular biosynthetic process GO:0044249 315 0.257
oviposition GO:0018991 364 0.248
negative regulation of metabolic process GO:0009892 240 0.245
biosynthetic process GO:0009058 323 0.244
response to chemical GO:0042221 356 0.240
gene expression GO:0010467 412 0.224
genitalia development GO:0048806 741 0.220
aromatic compound biosynthetic process GO:0019438 192 0.214
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.208
gonad development GO:0008406 840 0.199
regulation of cellular biosynthetic process GO:0031326 189 0.197
negative regulation of cellular process GO:0048523 239 0.194
nucleobase containing compound metabolic process GO:0006139 406 0.190
hermaphrodite genitalia development GO:0040035 734 0.180
pronuclear migration GO:0035046 51 0.176
nucleic acid templated transcription GO:0097659 169 0.174
multicellular organism reproduction GO:0032504 819 0.170
negative regulation of gene expression GO:0010629 217 0.160
multi multicellular organism process GO:0044706 390 0.157
transcription dna templated GO:0006351 168 0.153
negative regulation of macromolecule metabolic process GO:0010605 229 0.147
multi organism reproductive process GO:0044703 867 0.145
dna metabolic process GO:0006259 74 0.140
regulation of cell cycle process GO:0010564 145 0.140
single organism reproductive process GO:0044702 1196 0.140
regulation of rna biosynthetic process GO:2001141 165 0.140
cellular component movement GO:0006928 388 0.138
regulation of primary metabolic process GO:0080090 292 0.138
developmental process involved in reproduction GO:0003006 1165 0.132
organic substance biosynthetic process GO:1901576 323 0.131
heterocycle biosynthetic process GO:0018130 187 0.129
rna biosynthetic process GO:0032774 169 0.127
regulation of biosynthetic process GO:0009889 189 0.124
chromosome organization involved in meiosis GO:0070192 25 0.124
rna metabolic process GO:0016070 228 0.122
locomotion GO:0040011 1634 0.118
mitotic spindle organization GO:0007052 81 0.114
sister chromatid segregation GO:0000819 46 0.112
cell development GO:0048468 696 0.110
post embryonic organ development GO:0048569 336 0.109
negative regulation of nematode larval development GO:0061064 208 0.108
regulation of mitotic metaphase anaphase transition GO:0030071 5 0.106
regulation of nitrogen compound metabolic process GO:0051171 222 0.105
localization of cell GO:0051674 313 0.099
regulation of multicellular organismal process GO:0051239 726 0.098
multi organism reproductive behavior GO:0044705 387 0.097
vulval development GO:0040025 333 0.097
macromolecule localization GO:0033036 771 0.096
organic cyclic compound biosynthetic process GO:1901362 195 0.095
regulation of nucleic acid templated transcription GO:1903506 165 0.091
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.091
regulation of vulval development GO:0040028 248 0.090
neurogenesis GO:0022008 236 0.089
protein metabolic process GO:0019538 422 0.087
death GO:0016265 547 0.087
macromolecule modification GO:0043412 218 0.087
regulation of biological quality GO:0065008 741 0.087
apoptotic process GO:0006915 478 0.086
nucleobase containing compound biosynthetic process GO:0034654 184 0.085
nucleus organization GO:0006997 38 0.085
regulation of nematode larval development GO:0061062 260 0.085
regulation of cell division GO:0051302 142 0.084
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.083
regulation of multicellular organism growth GO:0040014 373 0.079
transport GO:0006810 1093 0.079
regulation of cell cycle GO:0051726 194 0.078
cellular response to dna damage stimulus GO:0006974 41 0.076
negative regulation of cellular biosynthetic process GO:0031327 65 0.076
protein modification process GO:0036211 207 0.076
cellular nitrogen compound biosynthetic process GO:0044271 192 0.075
negative regulation of vulval development GO:0040027 206 0.073
response to external stimulus GO:0009605 289 0.073
cellular response to stress GO:0033554 162 0.069
single fertilization GO:0007338 61 0.068
regulation of developmental process GO:0050793 684 0.067
negative regulation of transcription dna templated GO:0045892 53 0.067
cellular protein metabolic process GO:0044267 279 0.066
regulation of macromolecule biosynthetic process GO:0010556 189 0.066
mitotic cell cycle checkpoint GO:0007093 5 0.065
fertilization GO:0009566 63 0.065
epithelial tube morphogenesis GO:0060562 1 0.064
maintenance of location GO:0051235 580 0.064
cellular component morphogenesis GO:0032989 318 0.064
negative regulation of chromosome segregation GO:0051985 4 0.063
establishment of localization GO:0051234 1171 0.061
cell projection organization GO:0030030 231 0.060
anatomical structure formation involved in morphogenesis GO:0048646 250 0.060
gene silencing GO:0016458 143 0.059
multicellular organismal reproductive behavior GO:0033057 384 0.059
negative regulation of mitotic cell cycle phase transition GO:1901991 5 0.058
nuclear migration GO:0007097 54 0.057
development of primary sexual characteristics GO:0045137 840 0.057
nervous system development GO:0007399 253 0.057
generation of neurons GO:0048699 235 0.057
lipid storage GO:0019915 565 0.056
transcription from rna polymerase ii promoter GO:0006366 149 0.055
negative regulation of rna biosynthetic process GO:1902679 53 0.055
gamete generation GO:0007276 461 0.055
germ cell development GO:0007281 351 0.054
behavior GO:0007610 527 0.054
cell part morphogenesis GO:0032990 152 0.054
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.054
negative regulation of biosynthetic process GO:0009890 65 0.054
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.053
negative regulation of mitotic cell cycle GO:0045930 42 0.053
positive regulation of developmental process GO:0051094 408 0.052
regulation of gene expression epigenetic GO:0040029 163 0.052
tissue development GO:0009888 112 0.052
mitotic nuclear division GO:0007067 89 0.051
multi organism behavior GO:0051705 389 0.051
reproductive behavior GO:0019098 387 0.050
posttranscriptional gene silencing GO:0016441 143 0.050
rna processing GO:0006396 34 0.049
negative regulation of multicellular organismal process GO:0051241 236 0.049
protein complex subunit organization GO:0071822 280 0.049
regulation of cellular metabolic process GO:0031323 305 0.049
posttranscriptional regulation of gene expression GO:0010608 166 0.048
developmental growth GO:0048589 412 0.047
positive regulation of cellular process GO:0048522 332 0.047
cellular protein modification process GO:0006464 207 0.047
negative regulation of developmental process GO:0051093 227 0.047
macromolecular complex subunit organization GO:0043933 320 0.047
organonitrogen compound metabolic process GO:1901564 151 0.046
negative regulation of post embryonic development GO:0048581 208 0.046
positive regulation of multicellular organism growth GO:0040018 352 0.046
microtubule based process GO:0007017 182 0.045
positive regulation of developmental growth GO:0048639 354 0.045
positive regulation of rna metabolic process GO:0051254 103 0.045
regulation of developmental growth GO:0048638 389 0.044
lipid localization GO:0010876 573 0.044
immune response GO:0006955 192 0.043
posttranscriptional gene silencing by rna GO:0035194 143 0.043
cell proliferation GO:0008283 116 0.043
growth GO:0040007 562 0.043
multicellular organismal aging GO:0010259 812 0.041
cell motility GO:0048870 313 0.041
programmed cell death GO:0012501 500 0.040
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.040
aging GO:0007568 812 0.039
positive regulation of multicellular organismal process GO:0051240 417 0.039
protein complex assembly GO:0006461 186 0.038
multicellular organism growth GO:0035264 385 0.038
cell migration GO:0016477 306 0.037
embryonic morphogenesis GO:0048598 152 0.037
single organism biosynthetic process GO:0044711 91 0.037
regulation of microtubule cytoskeleton organization GO:0070507 21 0.036
skeletal muscle organ development GO:0060538 3 0.036
muscle structure development GO:0061061 191 0.036
regulation of multicellular organismal development GO:2000026 317 0.036
sexual reproduction GO:0019953 546 0.036
regulation of mitotic cell cycle GO:0007346 76 0.036
gene silencing by rna GO:0031047 143 0.036
cell projection morphogenesis GO:0048858 148 0.035
negative regulation of cell cycle GO:0045786 53 0.035
regulation of growth GO:0040008 409 0.035
positive regulation of growth GO:0045927 369 0.035
cell fate commitment GO:0045165 139 0.035
regulation of post embryonic development GO:0048580 260 0.034
regulation of dna replication GO:0006275 5 0.033
regulation of cellular component organization GO:0051128 248 0.033
regulation of organelle organization GO:0033043 164 0.032
metaphase anaphase transition of mitotic cell cycle GO:0007091 10 0.032
sensory organ morphogenesis GO:0090596 2 0.031
neuron projection development GO:0031175 187 0.031
regeneration GO:0031099 4 0.031
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.030
body morphogenesis GO:0010171 620 0.029
catabolic process GO:0009056 318 0.029
chromatin modification GO:0016568 32 0.029
response to abiotic stimulus GO:0009628 152 0.028
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.028
spindle organization GO:0007051 92 0.027
negative regulation of cellular metabolic process GO:0031324 95 0.026
regulation of meiosis GO:0040020 94 0.026
signal transduction GO:0007165 317 0.026
signaling GO:0023052 401 0.025
negative regulation of nucleic acid templated transcription GO:1903507 53 0.025
epithelial cell proliferation GO:0050673 1 0.024
spindle assembly GO:0051225 8 0.024
cell death GO:0008219 547 0.024
small molecule metabolic process GO:0044281 186 0.024
mitotic sister chromatid separation GO:0051306 13 0.024
cytoskeleton dependent cytokinesis GO:0061640 35 0.024
phosphorus metabolic process GO:0006793 232 0.024
positive regulation of chromosome organization GO:2001252 2 0.024
polar body extrusion after meiotic divisions GO:0040038 14 0.023
organophosphate catabolic process GO:0046434 81 0.023
cellular localization GO:0051641 360 0.023
neuron differentiation GO:0030182 217 0.023
nucleus localization GO:0051647 55 0.023
protein complex biogenesis GO:0070271 186 0.023
organic substance catabolic process GO:1901575 294 0.022
mitotic g2 m transition checkpoint GO:0044818 1 0.022
defense response GO:0006952 296 0.022
receptor mediated endocytosis GO:0006898 715 0.022
tube morphogenesis GO:0035239 79 0.022
regulation of cell proliferation GO:0042127 105 0.021
neuron development GO:0048666 199 0.021
cell morphogenesis GO:0000902 163 0.021
dsrna fragmentation GO:0031050 10 0.021
cell cycle phase transition GO:0044770 19 0.021
regulation of cell death GO:0010941 65 0.021
chromatin remodeling GO:0006338 2 0.021
organophosphate metabolic process GO:0019637 125 0.020
negative regulation of cell cycle process GO:0010948 12 0.020
mitotic sister chromatid segregation GO:0000070 38 0.020
protein phosphorylation GO:0006468 85 0.020
positive regulation of neurogenesis GO:0050769 4 0.020
phosphorylation GO:0016310 116 0.019
carbohydrate derivative metabolic process GO:1901135 141 0.019
single organism localization GO:1902578 518 0.019
male sex differentiation GO:0046661 86 0.019
vesicle mediated transport GO:0016192 852 0.019
spindle checkpoint GO:0031577 4 0.019
regulation of cell cycle phase transition GO:1901987 13 0.019
cellular nitrogen compound catabolic process GO:0044270 119 0.019
response to dsrna GO:0043331 10 0.019
response to organic substance GO:0010033 131 0.019
cell cycle dna replication GO:0044786 3 0.018
cytoskeleton organization GO:0007010 339 0.018
negative regulation of mitotic metaphase anaphase transition GO:0045841 4 0.017
ion transport GO:0006811 113 0.017
synaptonemal complex assembly GO:0007130 6 0.017
negative regulation of rna metabolic process GO:0051253 53 0.017
regulation of multi organism process GO:0043900 69 0.017
single organism signaling GO:0044700 401 0.017
determination of adult lifespan GO:0008340 812 0.016
response to nitrogen compound GO:1901698 25 0.016
meiosis i GO:0007127 19 0.016
cellular catabolic process GO:0044248 199 0.016
microtubule polymerization or depolymerization GO:0031109 22 0.016
cellular component biogenesis GO:0044085 297 0.016
oogenesis GO:0048477 229 0.016
aromatic compound catabolic process GO:0019439 116 0.016
establishment of localization in cell GO:0051649 318 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.015
male gamete generation GO:0048232 41 0.015
cytokinesis GO:0000910 80 0.015
negative regulation of neurogenesis GO:0050768 4 0.015
negative regulation of nuclear division GO:0051784 6 0.015
macromolecule catabolic process GO:0009057 202 0.015
rna interference GO:0016246 137 0.015
regulation of cellular protein metabolic process GO:0032268 75 0.015
cell type specific apoptotic process GO:0097285 4 0.015
cellular response to organic substance GO:0071310 119 0.015
asymmetric cell division GO:0008356 36 0.015
organelle localization GO:0051640 127 0.015
regulation of mitotic cell cycle phase transition GO:1901990 7 0.015
single organism catabolic process GO:0044712 129 0.014
microtubule cytoskeleton organization involved in mitosis GO:1902850 12 0.014
positive regulation of chromosome segregation GO:0051984 1 0.014
inductive cell migration GO:0040039 145 0.014
regulation of cell differentiation GO:0045595 81 0.014
negative regulation of mitosis GO:0045839 4 0.014
regulation of phosphate metabolic process GO:0019220 81 0.014
cellular component assembly GO:0022607 293 0.014
dna packaging GO:0006323 7 0.014
regulation of phosphorylation GO:0042325 45 0.013
tissue morphogenesis GO:0048729 65 0.013
positive regulation of cell cycle GO:0045787 55 0.013
regulation of kinase activity GO:0043549 29 0.013
response to other organism GO:0051707 101 0.013
dna recombination GO:0006310 19 0.013
metaphase anaphase transition of cell cycle GO:0044784 15 0.013
defense response to other organism GO:0098542 100 0.013
regulation of localization GO:0032879 194 0.013
positive regulation of macromolecule metabolic process GO:0010604 149 0.013
taxis GO:0042330 128 0.013
phosphate containing compound metabolic process GO:0006796 232 0.013
cellular component assembly involved in morphogenesis GO:0010927 183 0.013
dna conformation change GO:0071103 11 0.013
establishment of nucleus localization GO:0040023 55 0.013
regulation of epithelial cell proliferation GO:0050678 1 0.013
synaptonemal complex organization GO:0070193 8 0.012
regulation of cytoplasmic transport GO:1903649 3 0.012
female gamete generation GO:0007292 254 0.012
regulation of cell communication GO:0010646 176 0.012
nucleoside phosphate metabolic process GO:0006753 108 0.012
regulation of epithelial cell differentiation GO:0030856 4 0.012
homeostatic process GO:0042592 51 0.012
intracellular signal transduction GO:0035556 96 0.012
regulation of programmed cell death GO:0043067 50 0.012
chromatin assembly or disassembly GO:0006333 1 0.012
dna duplex unwinding GO:0032508 3 0.012
organic acid metabolic process GO:0006082 47 0.012
regulation of phosphorus metabolic process GO:0051174 81 0.011
cellular response to chemical stimulus GO:0070887 129 0.011
cell surface receptor signaling pathway GO:0007166 149 0.011
protein oligomerization GO:0051259 4 0.011
negative regulation of cell cycle phase transition GO:1901988 6 0.011
regulation of chromosome organization GO:0033044 20 0.011
regulation of sister chromatid segregation GO:0033045 16 0.011
cellular macromolecule catabolic process GO:0044265 73 0.011
meiosis ii GO:0007135 16 0.011
meiotic sister chromatid segregation GO:0045144 15 0.011
neuron projection guidance GO:0097485 82 0.011
regulation of molecular function GO:0065009 89 0.011
chromatin organization GO:0006325 32 0.011
positive regulation of cell death GO:0010942 38 0.011
cellular response to nitrogen compound GO:1901699 24 0.011
establishment of organelle localization GO:0051656 123 0.011
regulation of meiotic cell cycle GO:0051445 136 0.011
regulation of microtubule based process GO:0032886 21 0.010
regulation of protein import into nucleus GO:0042306 3 0.010
digestive tract development GO:0048565 122 0.010
regulation of transferase activity GO:0051338 31 0.010
nematode male tail tip morphogenesis GO:0045138 77 0.010
chromatin assembly GO:0031497 1 0.010
negative regulation of mitotic sister chromatid segregation GO:0033048 4 0.010
organelle assembly GO:0070925 214 0.010
regulation of mitotic sister chromatid segregation GO:0033047 16 0.010

brc-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.027
disease of cellular proliferation DOID:14566 0 0.027
organ system cancer DOID:0050686 0 0.027
disease of mental health DOID:150 0 0.011
developmental disorder of mental health DOID:0060037 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011
disease of anatomical entity DOID:7 0 0.011