Caenorhabditis elegans

119 known processes

daf-18 (CELE_T07A9.6)

Protein DAF-18

daf-18 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.791
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 2992 0.593
cell cycle process GO:0022402 482 0.524
Human Mouse
organelle fission GO:0048285 363 0.353
Human Mouse
sex differentiation GO:0007548 909 0.307
regulation of meiotic cell cycle GO:0051445 136 0.288
endocytosis GO:0006897 819 0.272
rna metabolic process GO:0016070 228 0.264
Human
developmental process involved in reproduction GO:0003006 1165 0.247
Mouse
nucleobase containing compound metabolic process GO:0006139 406 0.237
Human
post embryonic development GO:0009791 2152 0.234
regulation of macromolecule metabolic process GO:0060255 421 0.233
Human Mouse
cell development GO:0048468 696 0.233
Zebrafish Mouse Fly
organelle organization GO:0006996 783 0.209
Human Mouse Fly
protein metabolic process GO:0019538 422 0.208
meiotic cell cycle GO:0051321 335 0.207
reproductive system development GO:0061458 850 0.204
Mouse
establishment of localization GO:0051234 1171 0.198
regulation of developmental process GO:0050793 684 0.182
Mouse Fly
organ development GO:0048513 1102 0.171
regulation of cellular component organization GO:0051128 248 0.168
Human Mouse Fly
cell division GO:0051301 262 0.165
Human Mouse
nucleic acid metabolic process GO:0090304 299 0.157
Human
sexual reproduction GO:0019953 546 0.142
Mouse
macromolecule localization GO:0033036 771 0.139
meiotic nuclear division GO:0007126 300 0.134
developmental growth GO:0048589 412 0.134
Mouse Fly
regulation of multicellular organismal process GO:0051239 726 0.131
Mouse Fly
gene expression GO:0010467 412 0.128
Human
cellular component biogenesis GO:0044085 297 0.126
Human Mouse Fly
locomotion GO:0040011 1634 0.121
multicellular organism reproduction GO:0032504 819 0.120
Mouse
single organism reproductive process GO:0044702 1196 0.118
Mouse
signaling GO:0023052 401 0.116
Human Zebrafish Mouse Fly
development of primary sexual characteristics GO:0045137 840 0.116
apoptotic process GO:0006915 478 0.114
Mouse Fly
regulation of vulval development GO:0040028 248 0.111
cellular localization GO:0051641 360 0.110
regulation of metabolic process GO:0019222 478 0.109
Human Mouse Fly
meiotic cell cycle process GO:1903046 170 0.102
negative regulation of metabolic process GO:0009892 240 0.101
Human
regulation of cell cycle GO:0051726 194 0.099
Human Mouse Fly
gene silencing GO:0016458 143 0.089
gamete generation GO:0007276 461 0.085
regulation of multicellular organismal development GO:2000026 317 0.084
Mouse Fly
negative regulation of gene expression GO:0010629 217 0.083
vesicle mediated transport GO:0016192 852 0.083
lipid localization GO:0010876 573 0.083
Fly
maintenance of location GO:0051235 580 0.082
Fly
female gamete generation GO:0007292 254 0.082
growth GO:0040007 562 0.080
Mouse Fly
protein modification process GO:0036211 207 0.079
regulation of cell division GO:0051302 142 0.078
Human Mouse
lipid storage GO:0019915 565 0.077
Fly
generation of neurons GO:0048699 235 0.077
Mouse Fly
single organism organelle organization GO:1902589 501 0.075
Human Mouse Fly
regulation of nematode larval development GO:0061062 260 0.074
germ cell development GO:0007281 351 0.073
reproductive structure development GO:0048608 850 0.072
Mouse
hermaphrodite genitalia development GO:0040035 734 0.072
cell death GO:0008219 547 0.071
Mouse Fly
multi organism reproductive process GO:0044703 867 0.071
Mouse
multicellular organism growth GO:0035264 385 0.070
Fly
neurogenesis GO:0022008 236 0.068
Mouse Fly
regulation of gene expression epigenetic GO:0040029 163 0.068
regulation of signaling GO:0023051 172 0.067
Human Zebrafish Mouse
regulation of biological quality GO:0065008 741 0.066
Human Mouse Fly
regulation of post embryonic development GO:0048580 260 0.066
cellular component assembly GO:0022607 293 0.066
Human Mouse Fly
programmed cell death GO:0012501 500 0.065
Mouse Fly
vulval development GO:0040025 333 0.065
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.062
regulation of developmental growth GO:0048638 389 0.061
Mouse Fly
aging GO:0007568 812 0.061
determination of adult lifespan GO:0008340 812 0.060
meiotic chromosome segregation GO:0045132 139 0.059
gene silencing by rna GO:0031047 143 0.058
positive regulation of multicellular organismal process GO:0051240 417 0.058
negative regulation of biological process GO:0048519 567 0.058
protein localization GO:0008104 205 0.057
signal transduction GO:0007165 317 0.055
Human Zebrafish Mouse Fly
behavior GO:0007610 527 0.054
oogenesis GO:0048477 229 0.054
cell proliferation GO:0008283 116 0.054
Human Mouse Fly
body morphogenesis GO:0010171 620 0.052
death GO:0016265 547 0.052
Mouse Fly
macromolecule modification GO:0043412 218 0.052
regulation of cell proliferation GO:0042127 105 0.052
Human Mouse Fly
receptor mediated endocytosis GO:0006898 715 0.051
cell motility GO:0048870 313 0.051
Human Mouse
digestive tract morphogenesis GO:0048546 76 0.050
Zebrafish
regulation of organelle organization GO:0033043 164 0.050
Human Mouse
transport GO:0006810 1093 0.049
positive regulation of growth GO:0045927 369 0.047
posttranscriptional gene silencing by rna GO:0035194 143 0.047
positive regulation of developmental growth GO:0048639 354 0.045
positive regulation of developmental process GO:0051094 408 0.045
regulation of nitrogen compound metabolic process GO:0051171 222 0.044
Human
regulation of multicellular organism growth GO:0040014 373 0.043
Fly
single organism signaling GO:0044700 401 0.042
Human Zebrafish Mouse Fly
microtubule based process GO:0007017 182 0.041
cell cycle GO:0007049 526 0.040
Human Mouse Fly
cellular component movement GO:0006928 388 0.040
Human Mouse
nervous system development GO:0007399 253 0.040
Mouse Fly
positive regulation of cell cycle GO:0045787 55 0.039
Human Mouse
posttranscriptional gene silencing GO:0016441 143 0.038
regulation of rna biosynthetic process GO:2001141 165 0.038
Human
macromolecular complex assembly GO:0065003 193 0.038
regulation of meiosis GO:0040020 94 0.038
cell migration GO:0016477 306 0.038
Human Mouse
establishment of localization in cell GO:0051649 318 0.038
cellular protein metabolic process GO:0044267 279 0.038
gonad development GO:0008406 840 0.036
regulation of gene expression GO:0010468 366 0.036
Human
regulation of localization GO:0032879 194 0.036
post embryonic organ development GO:0048569 336 0.035
negative regulation of cellular process GO:0048523 239 0.035
cell cell signaling GO:0007267 118 0.034
Mouse
cellular protein modification process GO:0006464 207 0.034
single organism localization GO:1902578 518 0.033
regulation of growth GO:0040008 409 0.033
Mouse Fly
regulation of cell cycle process GO:0010564 145 0.033
Human Mouse
catabolic process GO:0009056 318 0.033
Human Mouse Fly
regulation of nuclear division GO:0051783 115 0.033
Human Mouse
rna interference GO:0016246 137 0.033
negative regulation of macromolecule metabolic process GO:0010605 229 0.032
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.032
posttranscriptional regulation of gene expression GO:0010608 166 0.032
Human
negative regulation of developmental process GO:0051093 227 0.032
Mouse Fly
establishment of organelle localization GO:0051656 123 0.031
transcription dna templated GO:0006351 168 0.031
Human
negative regulation of nematode larval development GO:0061064 208 0.030
macromolecule biosynthetic process GO:0009059 250 0.030
Human
negative regulation of multicellular organismal process GO:0051241 236 0.029
Mouse Fly
cellular macromolecule biosynthetic process GO:0034645 247 0.028
Human
asymmetric protein localization GO:0008105 35 0.028
protein complex subunit organization GO:0071822 280 0.028
Fly
positive regulation of multicellular organism growth GO:0040018 352 0.027
heterocycle biosynthetic process GO:0018130 187 0.027
Human
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.026
Human
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.026
Human
positive regulation of metabolic process GO:0009893 187 0.026
Human Mouse
secretion by cell GO:0032940 138 0.026
inductive cell migration GO:0040039 145 0.025
cellular response to stress GO:0033554 162 0.025
Fly
positive regulation of gene expression GO:0010628 112 0.025
response to chemical GO:0042221 356 0.024
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.024
multicellular organismal reproductive process GO:0048609 815 0.024
Mouse
multicellular organismal aging GO:0010259 812 0.023
single organism transport GO:0044765 447 0.023
regulation of protein localization GO:0032880 50 0.023
response to external stimulus GO:0009605 289 0.023
protein complex biogenesis GO:0070271 186 0.022
localization of cell GO:0051674 313 0.022
Human Mouse
macromolecular complex subunit organization GO:0043933 320 0.022
Fly
cellular nitrogen compound biosynthetic process GO:0044271 192 0.022
Human
reproductive behavior GO:0019098 387 0.021
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 250 0.020
Mouse
rna biosynthetic process GO:0032774 169 0.020
Human
aromatic compound biosynthetic process GO:0019438 192 0.020
Human
negative regulation of vulval development GO:0040027 206 0.020
regulation of cell communication GO:0010646 176 0.020
Human Zebrafish Mouse
regulation of transcription dna templated GO:0006355 164 0.020
Human
macromolecule catabolic process GO:0009057 202 0.020
Human Mouse
transcription from rna polymerase ii promoter GO:0006366 149 0.019
regulation of biosynthetic process GO:0009889 189 0.019
Human
defense response GO:0006952 296 0.019
Fly
regulation of ribosome biogenesis GO:0090069 1 0.019
Mouse
nucleic acid templated transcription GO:0097659 169 0.019
Human
protein complex assembly GO:0006461 186 0.019
cell type specific apoptotic process GO:0097285 4 0.019
Mouse
positive regulation of proteasomal protein catabolic process GO:1901800 1 0.019
Human Mouse
positive regulation of cellular process GO:0048522 332 0.019
Human Mouse
neuron differentiation GO:0030182 217 0.018
Mouse Fly
regulation of primary metabolic process GO:0080090 292 0.018
Human Mouse
axon development GO:0061564 163 0.018
Mouse Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.018
system process GO:0003008 136 0.018
organelle localization GO:0051640 127 0.018
Mouse
regulation of response to stimulus GO:0048583 243 0.017
organic substance biosynthetic process GO:1901576 323 0.017
Human
digestive tract development GO:0048565 122 0.017
Zebrafish
regulation of epithelial cell proliferation GO:0050678 1 0.017
Mouse
response to wounding GO:0009611 4 0.017
Fly
chromosome organization involved in meiosis GO:0070192 25 0.017
cellular macromolecular complex assembly GO:0034622 184 0.016
multicellular organismal reproductive behavior GO:0033057 384 0.016
Mouse
establishment of nucleus localization GO:0040023 55 0.016
canonical wnt signaling pathway GO:0060070 3 0.016
Human
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.016
dna recombination GO:0006310 19 0.016
multi organism behavior GO:0051705 389 0.016
Mouse
cell substrate adhesion GO:0031589 1 0.015
Human
regulation of cellular ketone metabolic process GO:0010565 3 0.015
cell adhesion GO:0007155 21 0.015
Human Fly
cellular protein complex assembly GO:0043623 178 0.015
biological adhesion GO:0022610 21 0.015
Human Fly
protein catabolic process GO:0030163 162 0.015
Human Mouse
cytoskeleton organization GO:0007010 339 0.015
Mouse Fly
cellular biosynthetic process GO:0044249 315 0.014
Human
regulation of rna metabolic process GO:0051252 173 0.014
Human
negative regulation of rna metabolic process GO:0051253 53 0.014
rna localization GO:0006403 3 0.014
response to organic substance GO:0010033 131 0.014
Fly
response to other organism GO:0051707 101 0.014
sensory organ morphogenesis GO:0090596 2 0.014
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.014
biosynthetic process GO:0009058 323 0.014
Human
secretion GO:0046903 147 0.014
molting cycle GO:0042303 281 0.014
cell surface receptor signaling pathway GO:0007166 149 0.013
Human Fly
positive regulation of meiotic cell cycle GO:0051446 47 0.013
nuclear migration GO:0007097 54 0.013
positive regulation of cellular metabolic process GO:0031325 178 0.013
Human Mouse
synapse organization GO:0050808 24 0.013
Mouse
negative regulation of transcription dna templated GO:0045892 53 0.013
nucleus localization GO:0051647 55 0.013
regulation of locomotion GO:0040012 161 0.013
regulation of nucleic acid templated transcription GO:1903506 165 0.013
Human
sex determination GO:0007530 60 0.012
positive regulation of neurogenesis GO:0050769 4 0.012
regulation of anatomical structure morphogenesis GO:0022603 51 0.012
Mouse Fly
nucleobase containing compound biosynthetic process GO:0034654 184 0.012
Human
regulation of molecular function GO:0065009 89 0.012
Human Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.012
epithelial tube morphogenesis GO:0060562 1 0.012
cellular response to organic substance GO:0071310 119 0.012
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.011
response to abiotic stimulus GO:0009628 152 0.011
oocyte differentiation GO:0009994 45 0.011
neuromuscular junction development GO:0007528 2 0.011
regulation of programmed cell death GO:0043067 50 0.011
Mouse
negative regulation of post embryonic development GO:0048581 208 0.011
chromosome organization GO:0051276 104 0.011
Human Mouse
muscle structure development GO:0061061 191 0.011
Fly
muscle cell differentiation GO:0042692 171 0.011
developmental growth involved in morphogenesis GO:0060560 37 0.011
positive regulation of epithelial cell proliferation GO:0050679 1 0.011
establishment or maintenance of cell polarity GO:0007163 63 0.011
actin cytoskeleton organization GO:0030036 184 0.011
Fly
organic substance transport GO:0071702 113 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.011
Human
epithelial cell proliferation GO:0050673 1 0.010
Mouse
response to bacterium GO:0009617 86 0.010
dna metabolic process GO:0006259 74 0.010
negative regulation of neurogenesis GO:0050768 4 0.010
Mouse Fly
organic substance catabolic process GO:1901575 294 0.010
Human Mouse
organism emergence from protective structure GO:0071684 48 0.010
cellular amine metabolic process GO:0044106 15 0.010
negative regulation of cellular metabolic process GO:0031324 95 0.010
Human
positive regulation of biosynthetic process GO:0009891 109 0.010
establishment of spindle localization GO:0051293 51 0.010
muscle tissue development GO:0060537 1 0.010
Mouse
regulation of cell differentiation GO:0045595 81 0.010
Mouse Fly
oviposition GO:0018991 364 0.010

daf-18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
head and neck squamous cell carcinoma DOID:5520 0 0.023
Human
head and neck carcinoma DOID:1542 0 0.023
Human
cancer DOID:162 0 0.023
Human
disease of cellular proliferation DOID:14566 0 0.023
Human
organ system cancer DOID:0050686 0 0.023
Human
head and neck cancer DOID:11934 0 0.023
Human
thyroid carcinoma DOID:3963 0 0.021
Human
endocrine gland cancer DOID:170 0 0.021
Human
thyroid cancer DOID:1781 0 0.021
Human
endometrial carcinoma DOID:2871 0 0.019
Human
reproductive organ cancer DOID:193 0 0.019
Human
female reproductive organ cancer DOID:120 0 0.019
Human
uterine cancer DOID:363 0 0.019
Human
endometrial cancer DOID:1380 0 0.019
Human
prostate cancer DOID:10283 0 0.018
Human
male reproductive organ cancer DOID:3856 0 0.018
Human
disease of anatomical entity DOID:7 0 0.015
epilepsy syndrome DOID:1826 0 0.012
central nervous system disease DOID:331 0 0.012
brain disease DOID:936 0 0.012
variable age at onset electroclinical syndrome DOID:0050706 0 0.012
electroclinical syndrome DOID:0050701 0 0.012
nervous system disease DOID:863 0 0.012
organ system benign neoplasm DOID:0060085 0 0.012
benign neoplasm DOID:0060072 0 0.012
integumentary system benign neoplasm DOID:0060121 0 0.012
familial meningioma DOID:4586 0 0.011
Human
nervous system cancer DOID:3093 0 0.011
Human
central nervous system cancer DOID:3620 0 0.011
Human
meningioma DOID:3565 0 0.011
Human
heart disease DOID:114 0 0.010
heart valve disease DOID:4079 0 0.010
cardiovascular system disease DOID:1287 0 0.010