Caenorhabditis elegans

50 known processes

let-99 (CELE_K08E7.3)

Protein LET-99

let-99 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.981
embryo development ending in birth or egg hatching GO:0009792 2992 0.915
cell cycle GO:0007049 526 0.784
female gamete generation GO:0007292 254 0.758
single organism organelle organization GO:1902589 501 0.742
meiotic cell cycle process GO:1903046 170 0.715
post embryonic development GO:0009791 2152 0.709
sexual reproduction GO:0019953 546 0.669
germ cell development GO:0007281 351 0.652
genitalia development GO:0048806 741 0.646
single organism reproductive process GO:0044702 1196 0.636
oogenesis GO:0048477 229 0.633
microtubule based process GO:0007017 182 0.631
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.618
cell cycle process GO:0022402 482 0.595
multicellular organism reproduction GO:0032504 819 0.569
sex differentiation GO:0007548 909 0.546
meiotic chromosome segregation GO:0045132 139 0.540
locomotion GO:0040011 1634 0.539
organelle organization GO:0006996 783 0.519
reproductive system development GO:0061458 850 0.517
apoptotic process GO:0006915 478 0.505
multicellular organismal reproductive process GO:0048609 815 0.497
chromosome segregation GO:0007059 180 0.482
developmental process involved in reproduction GO:0003006 1165 0.474
meiotic cell cycle GO:0051321 335 0.462
establishment of organelle localization GO:0051656 123 0.440
regulation of nematode larval development GO:0061062 260 0.440
gamete generation GO:0007276 461 0.428
macromolecule catabolic process GO:0009057 202 0.393
death GO:0016265 547 0.393
organelle localization GO:0051640 127 0.361
cell development GO:0048468 696 0.351
body morphogenesis GO:0010171 620 0.333
gonad development GO:0008406 840 0.325
aging GO:0007568 812 0.322
cell death GO:0008219 547 0.321
development of primary sexual characteristics GO:0045137 840 0.313
programmed cell death GO:0012501 500 0.300
vesicle mediated transport GO:0016192 852 0.296
meiotic nuclear division GO:0007126 300 0.293
multicellular organismal aging GO:0010259 812 0.290
determination of adult lifespan GO:0008340 812 0.283
endocytosis GO:0006897 819 0.282
macromolecular complex subunit organization GO:0043933 320 0.282
cytoskeleton organization GO:0007010 339 0.273
chromosome organization involved in meiosis GO:0070192 25 0.262
negative regulation of biological process GO:0048519 567 0.261
vulval development GO:0040025 333 0.258
regulation of cell cycle GO:0051726 194 0.256
organelle fission GO:0048285 363 0.251
cell motility GO:0048870 313 0.232
transport GO:0006810 1093 0.217
establishment of localization GO:0051234 1171 0.207
regulation of meiotic cell cycle GO:0051445 136 0.200
hermaphrodite genitalia development GO:0040035 734 0.195
cellular component biogenesis GO:0044085 297 0.194
multi organism reproductive process GO:0044703 867 0.189
mitotic cell cycle process GO:1903047 194 0.189
organic substance catabolic process GO:1901575 294 0.188
single fertilization GO:0007338 61 0.185
regulation of mitotic cell cycle GO:0007346 76 0.184
single organism signaling GO:0044700 401 0.183
cell division GO:0051301 262 0.178
catabolic process GO:0009056 318 0.176
signal transduction GO:0007165 317 0.173
macromolecule localization GO:0033036 771 0.173
regulation of multicellular organismal process GO:0051239 726 0.172
regulation of vulval development GO:0040028 248 0.166
cell migration GO:0016477 306 0.163
protein complex subunit organization GO:0071822 280 0.158
regulation of biological quality GO:0065008 741 0.156
regulation of macromolecule metabolic process GO:0060255 421 0.147
organ development GO:0048513 1102 0.136
fertilization GO:0009566 63 0.132
defense response GO:0006952 296 0.129
regulation of phosphate metabolic process GO:0019220 81 0.124
chromosome organization GO:0051276 104 0.124
localization of cell GO:0051674 313 0.120
nucleic acid metabolic process GO:0090304 299 0.119
reproductive structure development GO:0048608 850 0.116
gene expression GO:0010467 412 0.115
phosphorylation GO:0016310 116 0.113
oviposition GO:0018991 364 0.112
neuron differentiation GO:0030182 217 0.108
regulation of gene expression GO:0010468 366 0.108
receptor mediated endocytosis GO:0006898 715 0.108
regulation of cellular component organization GO:0051128 248 0.103
post embryonic organ development GO:0048569 336 0.102
organelle assembly GO:0070925 214 0.101
negative regulation of developmental process GO:0051093 227 0.100
oocyte development GO:0048599 44 0.099
dna metabolic process GO:0006259 74 0.099
regulation of cell cycle process GO:0010564 145 0.098
cellular protein modification process GO:0006464 207 0.097
cellular localization GO:0051641 360 0.095
regulation of multicellular organismal development GO:2000026 317 0.095
protein metabolic process GO:0019538 422 0.094
negative regulation of multicellular organismal process GO:0051241 236 0.092
oocyte differentiation GO:0009994 45 0.088
negative regulation of metabolic process GO:0009892 240 0.088
negative regulation of nematode larval development GO:0061064 208 0.086
establishment of localization in cell GO:0051649 318 0.086
regulation of organelle organization GO:0033043 164 0.085
negative regulation of post embryonic development GO:0048581 208 0.085
nucleobase containing compound catabolic process GO:0034655 114 0.084
protein modification process GO:0036211 207 0.083
regulation of metabolic process GO:0019222 478 0.083
macromolecular complex assembly GO:0065003 193 0.082
cellular biosynthetic process GO:0044249 315 0.082
establishment of spindle localization GO:0051293 51 0.081
actin filament based process GO:0030029 191 0.080
developmental growth GO:0048589 412 0.079
multicellular organismal reproductive behavior GO:0033057 384 0.078
organic substance biosynthetic process GO:1901576 323 0.078
neuron projection morphogenesis GO:0048812 114 0.077
secretion by cell GO:0032940 138 0.076
maintenance of location GO:0051235 580 0.074
regulation of developmental process GO:0050793 684 0.074
lipid storage GO:0019915 565 0.073
purine containing compound metabolic process GO:0072521 95 0.073
lipid localization GO:0010876 573 0.072
posttranscriptional regulation of gene expression GO:0010608 166 0.071
generation of neurons GO:0048699 235 0.071
regulation of macromolecule biosynthetic process GO:0010556 189 0.070
neurogenesis GO:0022008 236 0.069
regulation of post embryonic development GO:0048580 260 0.069
response to biotic stimulus GO:0009607 101 0.068
phosphorus metabolic process GO:0006793 232 0.068
signaling GO:0023052 401 0.066
regulation of cellular biosynthetic process GO:0031326 189 0.065
cellular protein metabolic process GO:0044267 279 0.063
cellular catabolic process GO:0044248 199 0.063
regulation of response to stimulus GO:0048583 243 0.063
regulation of cell division GO:0051302 142 0.062
single organism localization GO:1902578 518 0.062
nucleobase containing compound metabolic process GO:0006139 406 0.061
cellular component assembly GO:0022607 293 0.061
cell surface receptor signaling pathway GO:0007166 149 0.060
positive regulation of multicellular organism growth GO:0040018 352 0.060
biosynthetic process GO:0009058 323 0.059
reproductive behavior GO:0019098 387 0.059
positive regulation of cell cycle GO:0045787 55 0.058
neuron development GO:0048666 199 0.058
positive regulation of cellular process GO:0048522 332 0.056
enzyme linked receptor protein signaling pathway GO:0007167 50 0.056
phosphate containing compound metabolic process GO:0006796 232 0.056
cell projection organization GO:0030030 231 0.055
positive regulation of developmental process GO:0051094 408 0.054
regulation of gene expression epigenetic GO:0040029 163 0.051
sister chromatid segregation GO:0000819 46 0.051
cellular component movement GO:0006928 388 0.050
mitotic nuclear division GO:0007067 89 0.050
positive regulation of macromolecule metabolic process GO:0010604 149 0.048
cellular macromolecule catabolic process GO:0044265 73 0.048
multi multicellular organism process GO:0044706 390 0.047
regulation of signaling GO:0023051 172 0.047
pattern specification process GO:0007389 59 0.046
growth GO:0040007 562 0.046
regulation of signal transduction GO:0009966 135 0.046
regulation of growth GO:0040008 409 0.046
regulation of multi organism process GO:0043900 69 0.045
cellular macromolecule biosynthetic process GO:0034645 247 0.045
cellular protein complex assembly GO:0043623 178 0.045
regulation of multicellular organism growth GO:0040014 373 0.045
protein localization GO:0008104 205 0.044
cellular component morphogenesis GO:0032989 318 0.044
cellular macromolecular complex assembly GO:0034622 184 0.044
spindle localization GO:0051653 51 0.044
establishment of cell polarity GO:0030010 46 0.044
multi organism behavior GO:0051705 389 0.043
positive regulation of growth GO:0045927 369 0.043
regulation of mitosis GO:0007088 18 0.042
single organism catabolic process GO:0044712 129 0.042
response to organic substance GO:0010033 131 0.042
response to external stimulus GO:0009605 289 0.042
rna metabolic process GO:0016070 228 0.041
protein catabolic process GO:0030163 162 0.041
molting cycle GO:0042303 281 0.040
positive regulation of multicellular organismal process GO:0051240 417 0.039
aromatic compound catabolic process GO:0019439 116 0.039
cytokinesis GO:0000910 80 0.038
response to other organism GO:0051707 101 0.038
multicellular organism growth GO:0035264 385 0.038
posttranscriptional gene silencing GO:0016441 143 0.037
regulation of nuclear division GO:0051783 115 0.037
protein phosphorylation GO:0006468 85 0.037
negative regulation of cellular process GO:0048523 239 0.037
cellular nitrogen compound catabolic process GO:0044270 119 0.037
regulation of cell communication GO:0010646 176 0.036
mitotic sister chromatid segregation GO:0000070 38 0.036
behavior GO:0007610 527 0.036
negative regulation of gene expression GO:0010629 217 0.035
regulation of localization GO:0032879 194 0.035
macromolecule biosynthetic process GO:0009059 250 0.034
protein complex biogenesis GO:0070271 186 0.034
cell cell signaling GO:0007267 118 0.033
anatomical structure formation involved in morphogenesis GO:0048646 250 0.033
cellular response to stress GO:0033554 162 0.033
cell maturation GO:0048469 26 0.033
defense response to bacterium GO:0042742 86 0.032
negative regulation of cell cycle GO:0045786 53 0.032
nucleobase containing compound biosynthetic process GO:0034654 184 0.032
protein complex assembly GO:0006461 186 0.031
regulation of cellular metabolic process GO:0031323 305 0.031
regulation of developmental growth GO:0048638 389 0.031
positive regulation of developmental growth GO:0048639 354 0.030
organophosphate metabolic process GO:0019637 125 0.030
spindle organization GO:0007051 92 0.030
synaptic transmission GO:0007268 106 0.029
hermaphrodite germ line sex determination GO:0040021 48 0.029
single organism cellular localization GO:1902580 72 0.029
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.029
cell fate commitment GO:0045165 139 0.029
negative regulation of macromolecule metabolic process GO:0010605 229 0.028
cell morphogenesis GO:0000902 163 0.028
response to external biotic stimulus GO:0043207 101 0.028
actin cytoskeleton organization GO:0030036 184 0.028
rna interference GO:0016246 137 0.027
negative regulation of signal transduction GO:0009968 60 0.027
carbohydrate derivative metabolic process GO:1901135 141 0.027
regulation of phosphorylation GO:0042325 45 0.027
regulation of protein metabolic process GO:0051246 81 0.026
microtubule polymerization or depolymerization GO:0031109 22 0.026
multi organism reproductive behavior GO:0044705 387 0.026
inductive cell migration GO:0040039 145 0.025
regulation of meiosis GO:0040020 94 0.025
regulation of phosphorus metabolic process GO:0051174 81 0.025
rna localization GO:0006403 3 0.025
ribosome biogenesis GO:0042254 4 0.025
regulation of catalytic activity GO:0050790 78 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.025
female meiotic division GO:0007143 17 0.025
glycosyl compound metabolic process GO:1901657 100 0.024
single organism transport GO:0044765 447 0.024
negative regulation of vulval development GO:0040027 206 0.024
organophosphate catabolic process GO:0046434 81 0.024
regulation of locomotion GO:0040012 161 0.024
pole plasm assembly GO:0007315 2 0.023
cell cycle switching mitotic to meiotic cell cycle GO:0051728 35 0.023
organic cyclic compound catabolic process GO:1901361 119 0.023
establishment or maintenance of cell polarity GO:0007163 63 0.023
regulation of reproductive process GO:2000241 66 0.023
establishment of mitotic spindle orientation GO:0000132 28 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.023
actomyosin structure organization GO:0031032 154 0.023
cell part morphogenesis GO:0032990 152 0.022
embryonic morphogenesis GO:0048598 152 0.022
cellular protein localization GO:0034613 75 0.021
protein oligomerization GO:0051259 4 0.021
gene silencing by rna GO:0031047 143 0.021
apoptotic cell clearance GO:0043277 111 0.020
purine nucleotide catabolic process GO:0006195 75 0.020
ribonucleoside triphosphate metabolic process GO:0009199 87 0.020
gene silencing GO:0016458 143 0.020
response to chemical GO:0042221 356 0.020
ribonucleotide metabolic process GO:0009259 99 0.019
small molecule metabolic process GO:0044281 186 0.019
macromolecule modification GO:0043412 218 0.019
pronuclear migration GO:0035046 51 0.019
cell morphogenesis involved in differentiation GO:0000904 112 0.019
regulation of transcription dna templated GO:0006355 164 0.019
neuron projection development GO:0031175 187 0.019
purine containing compound catabolic process GO:0072523 75 0.019
regulation of intracellular signal transduction GO:1902531 77 0.019
sex determination GO:0007530 60 0.019
nucleoside phosphate catabolic process GO:1901292 77 0.019
olfactory behavior GO:0042048 27 0.019
heterocycle catabolic process GO:0046700 119 0.019
ribonucleoside triphosphate catabolic process GO:0009203 72 0.018
nucleotide catabolic process GO:0009166 77 0.018
regulation of cell motility GO:2000145 57 0.018
negative regulation of signaling GO:0023057 61 0.018
secretion GO:0046903 147 0.018
positive regulation of meiotic cell cycle GO:0051446 47 0.018
regulation of translation GO:0006417 19 0.018
posttranscriptional gene silencing by rna GO:0035194 143 0.018
regulation of cytoskeleton organization GO:0051493 41 0.018
negative regulation of cellular metabolic process GO:0031324 95 0.018
regulation of primary metabolic process GO:0080090 292 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.017
single organism biosynthetic process GO:0044711 91 0.017
nervous system development GO:0007399 253 0.017
membrane organization GO:0061024 135 0.017
system process GO:0003008 136 0.017
apical junction assembly GO:0043297 1 0.017
negative regulation of cellular component organization GO:0051129 33 0.017
cell proliferation GO:0008283 116 0.017
protein modification by small protein conjugation or removal GO:0070647 40 0.017
muscle contraction GO:0006936 43 0.017
regulation of rna metabolic process GO:0051252 173 0.016
muscle tissue development GO:0060537 1 0.016
establishment of spindle orientation GO:0051294 34 0.016
regulation of transferase activity GO:0051338 31 0.016
positive regulation of catalytic activity GO:0043085 59 0.016
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.016
intracellular signal transduction GO:0035556 96 0.016
spermatogenesis GO:0007283 41 0.016
establishment of mitotic spindle localization GO:0040001 41 0.016
negative regulation of mitotic cell cycle GO:0045930 42 0.016
nucleoside catabolic process GO:0009164 78 0.016
cellular component assembly involved in morphogenesis GO:0010927 183 0.015
oocyte construction GO:0007308 2 0.015
muscle structure development GO:0061061 191 0.015
regulation of chromosome segregation GO:0051983 20 0.015
regulation of biosynthetic process GO:0009889 189 0.015
meiotic sister chromatid segregation GO:0045144 15 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 32 0.015
regulation of cell differentiation GO:0045595 81 0.015
regulation of kinase activity GO:0043549 29 0.015
cellular nitrogen compound biosynthetic process GO:0044271 192 0.015
cellular response to chemical stimulus GO:0070887 129 0.014
collagen and cuticulin based cuticle development GO:0040002 99 0.014
ribonucleoside monophosphate metabolic process GO:0009161 45 0.014
meiosis i GO:0007127 19 0.014
cell cycle phase transition GO:0044770 19 0.014
nucleus localization GO:0051647 55 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 34 0.014
cellular protein catabolic process GO:0044257 37 0.014
ribonucleoside metabolic process GO:0009119 98 0.014
lipid metabolic process GO:0006629 77 0.013
translation GO:0006412 37 0.013
cuticle development GO:0042335 100 0.013
polar body extrusion after meiotic divisions GO:0040038 14 0.013
regulation of cellular response to oxidative stress GO:1900407 1 0.013
regulation of nitrogen compound metabolic process GO:0051171 222 0.013
myofibril assembly GO:0030239 154 0.013
nucleoside phosphate metabolic process GO:0006753 108 0.013
male gamete generation GO:0048232 41 0.013
purine nucleoside metabolic process GO:0042278 92 0.013
defense response to gram negative bacterium GO:0050829 64 0.013
ion transport GO:0006811 113 0.013
germ line sex determination GO:0018992 51 0.013
dendrite development GO:0016358 42 0.013
purine nucleoside catabolic process GO:0006152 75 0.013
organic substance transport GO:0071702 113 0.013
purine nucleoside monophosphate catabolic process GO:0009128 28 0.012
histone h3 k27 demethylation GO:0071557 3 0.012
mitotic spindle organization GO:0007052 81 0.012
mitotic cell cycle phase transition GO:0044772 13 0.012
cell projection morphogenesis GO:0048858 148 0.012
purine ribonucleoside metabolic process GO:0046128 92 0.012
membrane invagination GO:0010324 98 0.012
glycosyl compound catabolic process GO:1901658 79 0.012
cellular response to dna damage stimulus GO:0006974 41 0.012
muscle cell differentiation GO:0042692 171 0.012
axis specification GO:0009798 23 0.012
engulfment of apoptotic cell GO:0043652 94 0.012
regulation of apoptotic signaling pathway GO:2001233 1 0.011
regulation of lipid metabolic process GO:0019216 4 0.011
regulation of cell proliferation GO:0042127 105 0.011
purine nucleoside monophosphate metabolic process GO:0009126 43 0.011
regulation of microtubule cytoskeleton organization GO:0070507 21 0.011
oocyte axis specification GO:0007309 2 0.011
positive regulation of biosynthetic process GO:0009891 109 0.011
cellular macromolecule localization GO:0070727 75 0.011
ribonucleotide catabolic process GO:0009261 75 0.011
phagocytosis engulfment GO:0006911 98 0.011
nucleobase containing small molecule metabolic process GO:0055086 115 0.011
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 35 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.011
response to bacterium GO:0009617 86 0.011
defense response to other organism GO:0098542 100 0.011
mesodermal cell migration GO:0008078 9 0.011
nucleoside triphosphate metabolic process GO:0009141 87 0.011
neurological system process GO:0050877 53 0.011
immune response GO:0006955 192 0.010
mitotic sister chromatid separation GO:0051306 13 0.010
regulation of epithelial cell differentiation GO:0030856 4 0.010
negative regulation of neurogenesis GO:0050768 4 0.010
purine ribonucleotide metabolic process GO:0009150 95 0.010

let-99 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 0 0.010
developmental disorder of mental health DOID:0060037 0 0.010
specific developmental disorder DOID:0060038 0 0.010
intellectual disability DOID:1059 0 0.010