Caenorhabditis elegans

117 known processes

sem-4 (CELE_F15C11.1)

Protein SEM-4

sem-4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signaling GO:0023052 401 0.688
Zebrafish Mouse
transport GO:0006810 1093 0.631
post embryonic development GO:0009791 2152 0.555
single organism reproductive process GO:0044702 1196 0.553
establishment of localization GO:0051234 1171 0.528
single organism signaling GO:0044700 401 0.496
Zebrafish Mouse
embryo development GO:0009790 3052 0.466
embryo development ending in birth or egg hatching GO:0009792 2992 0.400
Mouse
locomotion GO:0040011 1634 0.370
tube development GO:0035295 126 0.370
vesicle mediated transport GO:0016192 852 0.353
anatomical structure formation involved in morphogenesis GO:0048646 250 0.321
sex differentiation GO:0007548 909 0.316
single organism transport GO:0044765 447 0.304
reproductive system development GO:0061458 850 0.278
organelle localization GO:0051640 127 0.277
development of primary sexual characteristics GO:0045137 840 0.276
behavior GO:0007610 527 0.267
cell fate commitment GO:0045165 139 0.266
Mouse
single organism localization GO:1902578 518 0.264
cell migration GO:0016477 306 0.256
body morphogenesis GO:0010171 620 0.253
regulation of multicellular organismal process GO:0051239 726 0.243
Mouse
sexual reproduction GO:0019953 546 0.238
developmental process involved in reproduction GO:0003006 1165 0.226
digestive tract development GO:0048565 122 0.223
multicellular organismal reproductive process GO:0048609 815 0.222
positive regulation of multicellular organismal process GO:0051240 417 0.216
Mouse
nervous system development GO:0007399 253 0.201
macromolecule localization GO:0033036 771 0.201
positive regulation of rna biosynthetic process GO:1902680 102 0.196
Mouse
regulation of developmental process GO:0050793 684 0.194
Mouse
cytoskeleton organization GO:0007010 339 0.193
positive regulation of developmental process GO:0051094 408 0.187
Mouse
aromatic compound biosynthetic process GO:0019438 192 0.185
signal transduction GO:0007165 317 0.173
Zebrafish Mouse
digestive tract morphogenesis GO:0048546 76 0.167
multicellular organism reproduction GO:0032504 819 0.158
reproductive structure development GO:0048608 850 0.156
regulation of cell communication GO:0010646 176 0.150
Zebrafish Mouse
cell development GO:0048468 696 0.149
Mouse
regulation of biological quality GO:0065008 741 0.149
system process GO:0003008 136 0.147
regulation of growth GO:0040008 409 0.142
negative regulation of gene expression GO:0010629 217 0.142
regulation of cell morphogenesis involved in differentiation GO:0010769 29 0.141
Mouse
membrane organization GO:0061024 135 0.138
regulation of signaling GO:0023051 172 0.134
Zebrafish Mouse
genitalia development GO:0048806 741 0.133
multi organism behavior GO:0051705 389 0.128
cell motility GO:0048870 313 0.128
positive regulation of nucleic acid templated transcription GO:1903508 102 0.128
Mouse
cell division GO:0051301 262 0.127
organelle organization GO:0006996 783 0.127
Mouse
establishment of organelle localization GO:0051656 123 0.127
gonad development GO:0008406 840 0.121
hermaphrodite genitalia development GO:0040035 734 0.120
oviposition GO:0018991 364 0.118
cellular macromolecular complex assembly GO:0034622 184 0.118
regulation of multicellular organismal development GO:2000026 317 0.118
Mouse
multi organism reproductive behavior GO:0044705 387 0.117
positive regulation of cell communication GO:0010647 69 0.117
Zebrafish
embryonic morphogenesis GO:0048598 152 0.116
response to chemical GO:0042221 356 0.115
Zebrafish
regulation of cell differentiation GO:0045595 81 0.114
Mouse
cellular protein complex assembly GO:0043623 178 0.112
cell death GO:0008219 547 0.112
positive regulation of developmental growth GO:0048639 354 0.110
endocytosis GO:0006897 819 0.109
regulation of nematode larval development GO:0061062 260 0.109
multicellular organism growth GO:0035264 385 0.108
positive regulation of cell projection organization GO:0031346 4 0.108
localization of cell GO:0051674 313 0.107
post embryonic organ development GO:0048569 336 0.103
aging GO:0007568 812 0.101
developmental growth GO:0048589 412 0.101
Mouse
cellular component movement GO:0006928 388 0.100
multi organism reproductive process GO:0044703 867 0.099
tube morphogenesis GO:0035239 79 0.099
organ morphogenesis GO:0009887 67 0.098
Mouse
cell morphogenesis GO:0000902 163 0.098
Mouse
single organism organelle organization GO:1902589 501 0.097
Mouse
negative regulation of transcription dna templated GO:0045892 53 0.097
neurogenesis GO:0022008 236 0.095
developmental cell growth GO:0048588 39 0.094
regulation of cell morphogenesis GO:0022604 40 0.094
Mouse
molting cycle GO:0042303 281 0.093
axon development GO:0061564 163 0.092
neuron differentiation GO:0030182 217 0.092
Mouse
positive regulation of growth GO:0045927 369 0.091
vulval development GO:0040025 333 0.089
protein localization GO:0008104 205 0.088
multi multicellular organism process GO:0044706 390 0.085
lipid localization GO:0010876 573 0.085
multicellular organismal aging GO:0010259 812 0.084
single organism cellular localization GO:1902580 72 0.084
ion transport GO:0006811 113 0.082
regulation of developmental growth GO:0048638 389 0.081
cellular component assembly GO:0022607 293 0.079
regulation of multicellular organism growth GO:0040014 373 0.079
generation of neurons GO:0048699 235 0.079
maintenance of location GO:0051235 580 0.078
gene expression GO:0010467 412 0.077
developmental growth involved in morphogenesis GO:0060560 37 0.076
Mouse
synaptic transmission GO:0007268 106 0.075
tissue development GO:0009888 112 0.075
lipid storage GO:0019915 565 0.074
negative regulation of macromolecule metabolic process GO:0010605 229 0.074
tissue morphogenesis GO:0048729 65 0.073
regulation of cellular component size GO:0032535 40 0.072
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.070
Mouse
mechanosensory behavior GO:0007638 25 0.070
epithelial tube morphogenesis GO:0060562 1 0.068
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 53 0.068
response to mechanical stimulus GO:0009612 28 0.067
digestive system development GO:0055123 122 0.067
synaptic vesicle recycling GO:0036465 3 0.066
receptor mediated endocytosis GO:0006898 715 0.066
neurological system process GO:0050877 53 0.064
positive regulation of metabolic process GO:0009893 187 0.062
Mouse
negative regulation of metabolic process GO:0009892 240 0.061
cellular localization GO:0051641 360 0.058
positive regulation of multicellular organism growth GO:0040018 352 0.058
regulation of signal transduction GO:0009966 135 0.058
Zebrafish Mouse
cell cell signaling GO:0007267 118 0.058
Mouse
muscle cell differentiation GO:0042692 171 0.057
ion transmembrane transport GO:0034220 91 0.056
growth GO:0040007 562 0.055
Mouse
regulation of neuron differentiation GO:0045664 40 0.054
Mouse
organelle assembly GO:0070925 214 0.053
cellular component morphogenesis GO:0032989 318 0.052
Mouse
response to abiotic stimulus GO:0009628 152 0.052
reproductive behavior GO:0019098 387 0.051
actin cytoskeleton organization GO:0030036 184 0.051
mesodermal cell fate specification GO:0007501 13 0.050
regulation of macromolecule metabolic process GO:0060255 421 0.050
neuron projection development GO:0031175 187 0.049
cellular component biogenesis GO:0044085 297 0.049
epithelium development GO:0060429 68 0.049
Mouse
multicellular organismal reproductive behavior GO:0033057 384 0.049
regulation of biosynthetic process GO:0009889 189 0.049
mesoderm development GO:0007498 27 0.048
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.048
response to external stimulus GO:0009605 289 0.048
gamete generation GO:0007276 461 0.047
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.046
negative regulation of biological process GO:0048519 567 0.046
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.045
macromolecular complex assembly GO:0065003 193 0.044
regulation of metabolic process GO:0019222 478 0.043
organ development GO:0048513 1102 0.042
Mouse
regulation of cellular biosynthetic process GO:0031326 189 0.042
macromolecular complex subunit organization GO:0043933 320 0.042
Mouse
heterocycle biosynthetic process GO:0018130 187 0.042
cell projection organization GO:0030030 231 0.042
negative regulation of cellular process GO:0048523 239 0.041
regulation of primary metabolic process GO:0080090 292 0.041
negative regulation of developmental process GO:0051093 227 0.041
Mouse
single organism behavior GO:0044708 83 0.041
protein complex subunit organization GO:0071822 280 0.041
neuron development GO:0048666 199 0.041
Mouse
regulation of localization GO:0032879 194 0.039
nucleic acid templated transcription GO:0097659 169 0.039
positive regulation of macromolecule metabolic process GO:0010604 149 0.038
Mouse
pattern specification process GO:0007389 59 0.037
cell cycle process GO:0022402 482 0.037
defense response GO:0006952 296 0.036
positive regulation of cellular biosynthetic process GO:0031328 109 0.036
Mouse
regulation of rna metabolic process GO:0051252 173 0.036
positive regulation of cellular metabolic process GO:0031325 178 0.036
Mouse
protein complex assembly GO:0006461 186 0.036
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.035
regulation of axonogenesis GO:0050770 24 0.035
regulation of vulval development GO:0040028 248 0.035
negative regulation of cell morphogenesis involved in differentiation GO:0010771 2 0.035
Mouse
neuron projection extension GO:1990138 37 0.034
protein complex biogenesis GO:0070271 186 0.034
negative regulation of cellular biosynthetic process GO:0031327 65 0.033
regulation of locomotion GO:0040012 161 0.032
striated muscle cell development GO:0055002 157 0.032
regulation of response to stimulus GO:0048583 243 0.032
Zebrafish Mouse
synaptic vesicle localization GO:0097479 22 0.031
establishment of localization in cell GO:0051649 318 0.031
cell cycle GO:0007049 526 0.031
programmed cell death GO:0012501 500 0.030
protein metabolic process GO:0019538 422 0.030
Mouse
actin filament based process GO:0030029 191 0.030
nucleobase containing compound metabolic process GO:0006139 406 0.030
positive regulation of gene expression GO:0010628 112 0.030
Mouse
response to other organism GO:0051707 101 0.030
establishment of cell polarity GO:0030010 46 0.030
regulation of extent of cell growth GO:0061387 20 0.030
death GO:0016265 547 0.029
cell type specific apoptotic process GO:0097285 4 0.029
regulation of cellular component organization GO:0051128 248 0.029
Mouse
determination of adult lifespan GO:0008340 812 0.029
regulation of anatomical structure morphogenesis GO:0022603 51 0.028
Mouse
response to organic substance GO:0010033 131 0.027
Zebrafish
rna metabolic process GO:0016070 228 0.027
regulation of rna biosynthetic process GO:2001141 165 0.027
neuron recognition GO:0008038 83 0.027
positive regulation of cellular process GO:0048522 332 0.027
Zebrafish Mouse
asymmetric protein localization GO:0008105 35 0.027
apoptotic process GO:0006915 478 0.027
regulation of cell projection organization GO:0031344 38 0.027
defense response to bacterium GO:0042742 86 0.027
nucleobase containing compound biosynthetic process GO:0034654 184 0.027
germ cell development GO:0007281 351 0.026
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.026
muscle structure development GO:0061061 191 0.026
rho protein signal transduction GO:0007266 2 0.026
regulation of post embryonic development GO:0048580 260 0.026
negative regulation of biosynthetic process GO:0009890 65 0.026
cell growth GO:0016049 44 0.026
macromolecule catabolic process GO:0009057 202 0.026
vesicle localization GO:0051648 24 0.026
cellular response to abiotic stimulus GO:0071214 4 0.025
male sex differentiation GO:0046661 86 0.025
response to biotic stimulus GO:0009607 101 0.025
striated muscle cell differentiation GO:0051146 158 0.025
hormone metabolic process GO:0042445 3 0.024
organic substance biosynthetic process GO:1901576 323 0.024
positive regulation of neuron projection development GO:0010976 4 0.024
positive regulation of rna metabolic process GO:0051254 103 0.024
Mouse
regulation of catalytic activity GO:0050790 78 0.024
transcription from rna polymerase ii promoter GO:0006366 149 0.024
enzyme linked receptor protein signaling pathway GO:0007167 50 0.023
Zebrafish
negative regulation of nematode larval development GO:0061064 208 0.023
transcription dna templated GO:0006351 168 0.023
positive regulation of catalytic activity GO:0043085 59 0.023
muscle cell development GO:0055001 158 0.023
positive regulation of cell morphogenesis involved in differentiation GO:0010770 4 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.022
organic substance catabolic process GO:1901575 294 0.022
dauer larval development GO:0040024 92 0.022
positive regulation of epithelial cell proliferation GO:0050679 1 0.022
feeding behavior GO:0007631 70 0.021
cation transport GO:0006812 78 0.021
regulation of gene expression epigenetic GO:0040029 163 0.021
response to endogenous stimulus GO:0009719 33 0.021
Zebrafish
myofibril assembly GO:0030239 154 0.021
protein catabolic process GO:0030163 162 0.021
establishment of vesicle localization GO:0051650 23 0.021
establishment of spindle localization GO:0051293 51 0.021
synaptic vesicle transport GO:0048489 21 0.021
negative regulation of post embryonic development GO:0048581 208 0.021
nucleic acid metabolic process GO:0090304 299 0.020
negative regulation of response to stimulus GO:0048585 73 0.020
Mouse
oogenesis GO:0048477 229 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.019
collagen and cuticulin based cuticle development GO:0040002 99 0.019
cellular nitrogen compound biosynthetic process GO:0044271 192 0.019
regulation of cellular metabolic process GO:0031323 305 0.019
phosphate containing compound metabolic process GO:0006796 232 0.019
sensory organ morphogenesis GO:0090596 2 0.019
cell part morphogenesis GO:0032990 152 0.019
actomyosin structure organization GO:0031032 154 0.019
cuticle development GO:0042335 100 0.019
negative regulation of multicellular organismal process GO:0051241 236 0.018
Mouse
establishment of nucleus localization GO:0040023 55 0.018
positive regulation of signal transduction GO:0009967 40 0.018
Zebrafish
regulation of organelle organization GO:0033043 164 0.018
regulation of cell fate specification GO:0042659 22 0.018
myosin filament organization GO:0031033 138 0.018
regulation of apoptotic signaling pathway GO:2001233 1 0.018
negative regulation of rna biosynthetic process GO:1902679 53 0.018
cellular protein localization GO:0034613 75 0.018
negative regulation of cellular metabolic process GO:0031324 95 0.018
neurotransmitter transport GO:0006836 32 0.018
regulation of intracellular signal transduction GO:1902531 77 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.018
Mouse
intracellular signal transduction GO:0035556 96 0.017
defense response to other organism GO:0098542 100 0.017
response to heat GO:0009408 50 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.017
positive regulation of neuron differentiation GO:0045666 4 0.017
Mouse
neurotransmitter secretion GO:0007269 26 0.017
striated muscle myosin thick filament assembly GO:0071688 138 0.017
chemosensory behavior GO:0007635 33 0.017
cellular biosynthetic process GO:0044249 315 0.017
secretion by cell GO:0032940 138 0.017
meiotic cell cycle GO:0051321 335 0.017
negative regulation of rna metabolic process GO:0051253 53 0.017
phosphorus metabolic process GO:0006793 232 0.016
cellular macromolecule localization GO:0070727 75 0.016
axonal fasciculation GO:0007413 79 0.016
nucleus localization GO:0051647 55 0.016
response to external biotic stimulus GO:0043207 101 0.016
microtubule based process GO:0007017 182 0.016
nematode male tail tip morphogenesis GO:0045138 77 0.016
regulation of gene expression GO:0010468 366 0.016
developmental maturation GO:0021700 26 0.015
regulation of behavior GO:0050795 97 0.015
mitotic cell cycle process GO:1903047 194 0.015
axonogenesis GO:0007409 102 0.015
regulation of neuron projection development GO:0010975 31 0.015
regulation of lipid metabolic process GO:0019216 4 0.015
rna biosynthetic process GO:0032774 169 0.014
cellular component assembly involved in morphogenesis GO:0010927 183 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.014
posttranscriptional gene silencing by rna GO:0035194 143 0.014
cellular response to stress GO:0033554 162 0.014
amine metabolic process GO:0009308 15 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 34 0.014
Zebrafish
regulation of pharyngeal pumping GO:0043051 36 0.013
myosin filament assembly GO:0031034 138 0.013
cell projection morphogenesis GO:0048858 148 0.013
cytokinesis GO:0000910 80 0.013
biosynthetic process GO:0009058 323 0.013
lipid metabolic process GO:0006629 77 0.013
posttranscriptional gene silencing GO:0016441 143 0.013
cellular response to chemical stimulus GO:0070887 129 0.013
Zebrafish
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.013
establishment of mitotic spindle localization GO:0040001 41 0.013
hindgut development GO:0061525 3 0.013
regulation of cell death GO:0010941 65 0.013
monovalent inorganic cation transport GO:0015672 33 0.013
catabolic process GO:0009056 318 0.013
meiotic cell cycle process GO:1903046 170 0.013
protein modification process GO:0036211 207 0.013
Mouse
negative regulation of axon extension GO:0030517 2 0.013
phagocytosis engulfment GO:0006911 98 0.013
cellular response to organic substance GO:0071310 119 0.013
Zebrafish
negative regulation of cell communication GO:0010648 61 0.012
Mouse
male anatomical structure morphogenesis GO:0090598 78 0.012
taxis GO:0042330 128 0.012
positive regulation of signaling GO:0023056 66 0.012
Zebrafish
muscle tissue development GO:0060537 1 0.012
organelle fusion GO:0048284 8 0.012
mesodermal cell differentiation GO:0048333 15 0.012
cell proliferation GO:0008283 116 0.012
Mouse
regulation of mitotic cell cycle GO:0007346 76 0.012
gene silencing GO:0016458 143 0.012
regulation of axon extension GO:0030516 20 0.012
negative regulation of axonogenesis GO:0050771 2 0.012
gastrulation GO:0007369 58 0.012
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.012
regulation of nervous system development GO:0051960 41 0.012
Mouse
neuroblast division GO:0055057 9 0.012
cellular protein metabolic process GO:0044267 279 0.012
Mouse
neuromuscular junction development GO:0007528 2 0.012
signal release GO:0023061 28 0.012
organic substance transport GO:0071702 113 0.011
sensory perception of taste GO:0050909 4 0.011
asymmetric cell division GO:0008356 36 0.011
response to wounding GO:0009611 4 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.011
Mouse
hormone transport GO:0009914 2 0.011
regulation of multi organism process GO:0043900 69 0.011
positive regulation of protein kinase activity GO:0045860 18 0.011
small molecule metabolic process GO:0044281 186 0.011
regulation of cell cycle GO:0051726 194 0.011
asymmetric protein localization involved in cell fate determination GO:0045167 18 0.011
positive regulation of phosphorus metabolic process GO:0010562 56 0.011
regulation of epithelial cell proliferation GO:0050678 1 0.011
organelle fission GO:0048285 363 0.011
apical junction assembly GO:0043297 1 0.011
intraspecies interaction between organisms GO:0051703 3 0.011
establishment of synaptic vesicle localization GO:0097480 21 0.011
mating GO:0007618 34 0.011
positive regulation of neurotransmitter transport GO:0051590 11 0.011
negative regulation of cellular component organization GO:0051129 33 0.010
Mouse
synaptic vesicle endocytosis GO:0048488 3 0.010
apoptotic cell clearance GO:0043277 111 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
striated muscle contraction GO:0006941 17 0.010
synaptic vesicle priming GO:0016082 2 0.010
excretion GO:0007588 49 0.010
regulation of hormone secretion GO:0046883 2 0.010

sem-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
large intestine cancer DOID:5672 0 0.013
gastrointestinal system cancer DOID:3119 0 0.013
intestinal cancer DOID:10155 0 0.013
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
disease of metabolism DOID:0014667 0 0.011
carbohydrate metabolic disorder DOID:2978 0 0.011
inherited metabolic disorder DOID:655 0 0.011